Ccnd1 ELISA Kit for Rat(Rattus norvegicus) | EIAab.comCcnd1 ELISA Kit for Rat(Rattus norvegicus)

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Index > Protein center > Ccnd1(Gene name) > Rat

Ccnd1 (Gene name),

G1/S-specific cyclin-D1 (Protein name ), CCND1_RAT from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

Citations (1)

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Gene name:

Ccnd1;

Protein name:

G1/S-specific cyclin-D1;

Alternative:

Organism:

Rat (Rattus norvegicus).

General Annotation

Sub Unit:

Interacts with either CDK4 or CDK6 protein kinase to form a serine/threonine kinase holoenzyme complex. The cyclin subunit imparts substrate specificity to the complex. Component of the ternary complex cyclin D/CDK4/CDKN1B required for nuclear translocation and modulation of CDK4-mediated kinase activity. Interacts directly with CDKN1B. Can form similar complexes with either CDKN1A or CDKN2A. Interacts with USP2 and FBXO4.

Function:

Regulatory component of the cyclin D1-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also substrate for SMAD3, phosphorylating SMAD3 in a cell-cycle-dependent manner and repressing its transcriptional activity. Component of the ternary complex, cyclin D1/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex.

Subcellular Location:

Nucleus Cytoplasm Membrane Cyclin D-CDK4 complexes accumulate at the nuclear membrane and are then translocated into the nucleus through interaction with KIP/CIP family members.

Protein Attributes:

Sequence length:

295

Sequence:

50:

100:

150:

200:

250:

295:

IEALLESSLR | QAQQNIDPKA | TEEEGEVEEE | AGLACTPTDV | RDVDI

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

UniGene:

Rn.22279

KEGG:

rno:58919

Pfam:

PF02984

String:

P39948

Uniprot:

P39948

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ELISA Kit for Rat G1/S-specific cyclin-D1

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E0585h

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ELISA Kit for Rat G1/S-specific cyclin-D1

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E0585m

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ELISA Kit for Rat G1/S-specific cyclin-D1

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E0585r

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ELISA Kit for Rat G1/S-specific cyclin-D1

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E0585b

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ELISA Kit for Rat G1/S-specific cyclin-D1

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E0585d

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96T

ELISA Kit for Rat G1/S-specific cyclin-D1

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E0585c

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96T

CLIA Kit for Rat G1/S-specific cyclin-D1

Cat.:

U0585b

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96T

CLIA Kit for Rat G1/S-specific cyclin-D1

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U0585c

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96T

CLIA Kit for Rat G1/S-specific cyclin-D1

Cat.:

U0585h

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Packing:

96T

CLIA Kit for Rat G1/S-specific cyclin-D1

Cat.:

U0585m

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Packing:

96T

CLIA Kit for Rat G1/S-specific cyclin-D1

Cat.:

U0585d

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Packing:

96T

CLIA Kit for Rat G1/S-specific cyclin-D1

Cat.:

U0585r

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Looking for manual.

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Packing:

96T

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Polyclonal Antibody for Rat G1/S-specific cyclin-D1

Cat.:

P0585Rb-m

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Packing:

40ug/0.2ml

Polyclonal Antibody for Rat G1/S-specific cyclin-D1

Cat.:

P0585Rb-h

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40ug/0.2ml

Polyclonal Antibody for Rat G1/S-specific cyclin-D1

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P0585Rb-r

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40ug/0.2ml

Polyclonal Antibody for Rat G1/S-specific cyclin-D1

Monoclonal Antibody for Rat G1/S-specific cyclin-D1

Protein for Rat G1/S-specific cyclin-D1

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

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Linearity

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Citations

[1].

"Cilostazol Hepatoprotective Effect Against Ischemia/Reperfusion: Involvement of GSK-3β, Cyclin D1 and Wnt/β-catenin Pathway"

A Gendy, H El-Abhar, AR Mohsen.

From:Journal of Pharmacology Research

References

1.

"Cyclin G: a new mammalian cyclin with homology to fission yeast Cig1."
Tamura K. , Kanaoka Y. , Jinno S. , Nagata A. , Ogiso Y. , Shimizu K. , Hayakawa T. , Nojima H. , Okayama H.
Oncogene8:2113-2118(1993) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
tissue: Kidney.
2.

"Calcium modulates the cyclin D1 expression in a rat parathyroid cell line."
Bianchi S. , Fabiani S. , Muratori M. , Arnold A. , Sakaguchi K. , Miki T. , Brandi M.L.
Biochem. Biophys. Res. Commun.204:691-700(1994) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]

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