Ccnd2 ELISA Kit for Mouse(Mus musculus) | EIAab.comCcnd2 ELISA Kit for Mouse(Mus musculus)

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Index > Protein center > Ccnd2(Gene name) > Mouse

Ccnd2 (Gene name),

G1/S-specific cyclin-D2 (Protein name ), CCND2_MOUSE from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

Ccnd2(Cyl-2);

Protein name:

G1/S-specific cyclin-D2;

Alternative:

Organism:

Mouse (Mus musculus).

General Annotation

Sub Unit:

Interacts with either CDK4 or CDK6 protein kinase to form a serine/threonine kinase holoenzyme complex. The cyclin subunit imparts substrate specificity to the complex. Component of the ternary complex cyclin D/CDK4/CDKN1B required for nuclear translocation and modulation of CDK4-mediated kinase activity.

Function:

Regulatory component of the cyclin D2-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also substrate for SMAD3, phosphorylating SMAD3 in a cell-cycle-dependent manner and repressing its transcriptional activity. Component of the ternary complex, cyclin D2/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex.

Subcellular Location:

Nucleus Cytoplasm Membrane Cyclin D-CDK4 complexes accumulate at the nuclear membrane and are then translocated into the nucleus through interaction with KIP/CIP family members.

Protein Attributes:

Sequence length:

289

Sequence:

50:

100:

150:

200:

250:

289:

ALLLNSLQQF | RQEQHNAGSK | SVEDPDQATT | PTDVRDVDL

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

KEGG:

mmu:12444

STRING:

10090.ENSMUSP00000000188

String:

P30280

SMR:

P30280

Pfam:

PF02984

UniGene:

Mm.333406

Uniprot:

P30280

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ELISA Kit for Mouse G1/S-specific cyclin-D2

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E0586h

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ELISA Kit for Mouse G1/S-specific cyclin-D2

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E0586m

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ELISA Kit for Mouse G1/S-specific cyclin-D2

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E0586p

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ELISA Kit for Mouse G1/S-specific cyclin-D2

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E0586b

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ELISA Kit for Mouse G1/S-specific cyclin-D2

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E0586c

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ELISA Kit for Mouse G1/S-specific cyclin-D2

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E0586r

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96T

CLIA Kit for Mouse G1/S-specific cyclin-D2

Cat.:

U0586c

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96T

CLIA Kit for Mouse G1/S-specific cyclin-D2

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U0586b

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96T

CLIA Kit for Mouse G1/S-specific cyclin-D2

Cat.:

U0586m

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Packing:

96T

CLIA Kit for Mouse G1/S-specific cyclin-D2

Cat.:

U0586r

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96T

CLIA Kit for Mouse G1/S-specific cyclin-D2

Cat.:

U0586h

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96T

CLIA Kit for Mouse G1/S-specific cyclin-D2

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U0586p

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Polyclonal Antibody for Mouse G1/S-specific cyclin-D2

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P0586Rb-h

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40ug/0.2ml

Polyclonal Antibody for Mouse G1/S-specific cyclin-D2

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P0586Rb-m

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40ug/0.2ml

Polyclonal Antibody for Mouse G1/S-specific cyclin-D2

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P0586Rb-r

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Monoclonal Antibody for Mouse G1/S-specific cyclin-D2

Protein for Mouse G1/S-specific cyclin-D2

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

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Linearity

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References

1.

"Cloning of a D-type cyclin from murine erythroleukemia cells."
Kiyokawa H. , Bousquets X. , Powell C.T. , Ngo L. , Rifkind R.A. , Marks P.A.
Proc. Natl. Acad. Sci. U.S.A.89:2444-2447(1992) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
2.

"Colony-stimulating factor 1 regulates novel cyclins during the G1 phase of the cell cycle."
Matsushime H. , Roussel M.F. , Ashmun R.A. , Sherr C.J.
Cell65:701-713(1991) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
3.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
strain: C57BL/6.
tissue: Brain.

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