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Index > Protein center > Ccnf(Gene name) > Mouse
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  • Ccnf (Gene name),
  • Cyclin-F (Protein name ),  CCNF_MOUSE from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Gene name:
    Ccnf;
    Protein name:
    Cyclin-F;
    Alternative:

    Organism:
    Mouse (Mus musculus). 
    General Annotation
    Sub Unit:
    Component of the SCF(Cyclin F) complex consisting of CUL1, RBX1, SKP1 and CCNF. Interacts with CCNB1; interaction is required for nuclear localization of CCNB1.
    Function:
    Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of CP110 during G2 phase, thereby acting as an inhibitor of centrosome reduplication.
    Subcellular Location:
    Nucleus Cytoplasm cytoskeleton centrosome centriole Localization in the centrosome is rare in S phase cells and increases in G2 cells, Localizes on both the mother and daughter centrioles. Localization to centrosomes is not dependent on CP110. Also localizes to the nucleus.
    Protein Attributes:
    Sequence length:
    777
    Sequence:
    50:
    MGSGGVIHCR | CAKCFCYPTK | RRIKRRPRNL | TILSLPEDVL | FHILKWLSVG | 
    100:
    DILAVRAVHS | HLKYLVDNHA | SVWASASFQE | LWPSPQNLKL | FERAAEKGNF | 
    150:
    EAAVKLGIAY | LYNEGLSVSD | EACAEVNGLK | ASRFFSMAER | LNTGSEPFIW | 
    200:
    LFIRPPWSVS | GSCCKAVVHD | SLRAECQLQR | SHKASILHCL | GRVLNLFEDE | 
    250:
    EKRKQARSLL | EESSRQGCLI | SSYLLWESDR | KVDMSDPGRC | LHSFRKLRDY | 
    300:
    AAKGCWEAQL | ALAKACAGGS | QLGLEGKACS | ESVCQLFQAS | QAVNKQQIFS | 
    350:
    VQKGLSDTMR | YILIDWLVEV | ATMKDFTSLC | LHLTVECVDR | YLRRRLVPRY | 
    400:
    KLQLLGIACM | VICTRFISKE | ILTIREAVWL | TDNTYKYEDL | VRVMGEIISA | 
    450:
    LEGKIRIPTV | VDYKEVLLTL | VPVAPRTQHL | CSFLCELTLL | HTSLSIYAPA | 
    500:
    RLASAALLLA | RLMHGQTQPW | TTHLWDLTGF | SYSDLVPCVL | SLHKKCFHDD | 
    550:
    APKDYRQVSL | TAVKQRFEDK | CYEEISREEV | LSYADLCSTI | GVKQESPEPP | 
    600:
    SFPSSGEIHT | FLSSPSGRRS | KRKRENSLQE | DRGSFVTTPT | AELSNQEETL | 
    650:
    LGSLLDWSLE | CCSGYEGDQE | SEGEKEGDVT | APSRLLDVTV | VYLNPEEHCC | 
    700:
    QESSDEEAWP | EDKIHPAPGT | QAPPASAPRP | LLCNRGDRAK | DITTSGYSSV | 
    750:
    SSSSPISSLD | GGMGGSPQST | SVLSVGSHSS | TKPCHHQAKK | SCLQCRPPNS | 
    777:
    PESGVHQQPV | KRQNLSVHSD | KDMHLAS
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    KEGG:
    UniGene:
    Pfam:
    String:
    SMR:
    Uniprot:
     
    FOR
    ELISA Kit for Mouse Cyclin-F
    ELISA Kit for Mouse Cyclin-F
    ELISA Kit for Mouse Cyclin-F
    ELISA Kit for Mouse Cyclin-F
    CLIA Kit for Mouse Cyclin-F
    CLIA Kit for Mouse Cyclin-F
    CLIA Kit for Mouse Cyclin-F
    CLIA Kit for Mouse Cyclin-F
    Polyclonal Antibody for Mouse Cyclin-F
    Polyclonal Antibody for Mouse Cyclin-F
    Polyclonal Antibody for Mouse Cyclin-F
    Polyclonal Antibody for Mouse Cyclin-F
    Monoclonal Antibody for Mouse Cyclin-F
    Monoclonal Antibody for Mouse Cyclin-F
    Monoclonal Antibody for Mouse Cyclin-F
    Monoclonal Antibody for Mouse Cyclin-F
    Protein for Mouse Cyclin-F
    Protein for Mouse Cyclin-F
    Protein for Mouse Cyclin-F
    Protein for Mouse Cyclin-F

    R&D Technical Data
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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      "Mouse cyclin F maps to a conserved linkage group on mouse chromosome 17."
      Obermayr F.O. , Sutherland H.F. , Kraus B. , Frischauf A.-M.
      Mamm. Genome6:149-150(1995) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
    2. 2.
      "Expression of cyclin F at early stages of mouse embryonic brain development."
      Croci L. , Stayton C.L. , Bossolasco M. , Bianchi E. , Corradi A.M. , Pardi R. , Consalez G.G.
      Submitted (1995-03) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2)
    3. 3.
      "The transcriptional landscape of the mammalian genome."
      Carninci P. , Kasukawa T. , Katayama S. , Gough J. , Frith M.C. , Maeda N. , Oyama R. , Ravasi T. , Lenhard B. , Wells C. , Kodzius R. , Shimokawa K. , Bajic V.B. , Brenner S.E. , Batalov S. , Forrest A.R. , Zavolan M. , Davis M.J. , more...
      Science309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
      strain: C57BL/6J.
      tissue: Cerebellum.
      tissue: Kidney.
      tissue: Ovary.
      tissue: Uterus.
    4. 4.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
      strain: C57BL/6J.
    5. 5.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3)
      strain: FVB/N.
      tissue: Mammary tumor.
    6. 6.
      "Increased levels of forkhead box M1B transcription factor in transgenic mouse hepatocytes prevent age-related proliferation defects in regenerating liver."
      Wang X. , Quail E. , Hung N.J. , Tan Y. , Ye H. , Costa R.H.
      Proc. Natl. Acad. Sci. U.S.A.98:11468-11473(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INDUCTION
    7. 7.
      "Ubiquitous expression of the forkhead box M1B transgene accelerates proliferation of distinct pulmonary cell types following lung injury."
      Kalinichenko V.V. , Gusarova G.A. , Tan Y. , Wang I.C. , Major M.L. , Wang X. , Yoder H.M. , Costa R.H.
      J. Biol. Chem.278:37888-37894(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INDUCTION
    8. 8.
      "Cyclin F disruption compromises placental development and affects normal cell cycle execution."
      Tetzlaff M.T. , Bai C. , Finegold M. , Wilson J. , Harper J.W. , Mahon K.A. , Elledge S.J.
      Mol. Cell. Biol.24:2487-2498(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: DISRUPTION PHENOTYPE
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