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Index > Protein center > CCR3(Gene name) > Human
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  • CCR3 (Gene name),
  • C-C chemokine receptor type 3 (Protein name ),  CCR3_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Gene name:
    CCR3(CMKBR3);
    Protein name:
    C-C chemokine receptor type 3(C-C CKR-3;CC-CKR-3;CCR-3;CCR3;CKR3);
    Alternative:
    Eosinophil eotaxin receptor;
    CD:
    CD193;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Binds to HIV-1 Tat.
    Function:
    Receptor for a C-C type chemokine. Binds to eotaxin, eotaxin-3, MCP-3, MCP-4, RANTES and MIP-1 delta. Subsequently transduces a signal by increasing the intracellular calcium ions level. Alternative coreceptor with CD4 for HIV-1 infection.
    Subcellular Location:
    Cell membrane Multi-pass membrane protein
    Protein Attributes:
    Sequence length:
    355
    Sequence:
    50:
    MTTSLDTVET | FGTTSYYDDV | GLLCEKADTR | ALMAQFVPPL | YSLVFTVGLL | 
    100:
    GNVVVVMILI | KYRRLRIMTN | IYLLNLAISD | LLFLVTLPFW | IHYVRGHNWV | 
    150:
    FGHGMCKLLS | GFYHTGLYSE | IFFIILLTID | RYLAIVHAVF | ALRARTVTFG | 
    200:
    VITSIVTWGL | AVLAALPEFI | FYETEELFEE | TLCSALYPED | TVYSWRHFHT | 
    250:
    LRMTIFCLVL | PLLVMAICYT | GIIKTLLRCP | SKKKYKAIRL | IFVIMAVFFI | 
    300:
    FWTPYNVAIL | LSSYQSILFG | NDCERSKHLD | LVMLVTEVIA | YSHCCMNPVI | 
    350:
    YAFVGERFRK | YLRHFFHRHL | LMHLGRYIPF | LPSEKLERTS | SVSPSTAEPE | 
    355:
    LSIVF
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    UniGene:
    Pfam:
    MIM:
    SMR:
    KEGG:
    String:
    Uniprot:
     
    FOR
    ELISA Kit for Human C-C CKR-3
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    E2077h
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    ELISA Kit for Human C-C CKR-3
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    E2077r
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    96T
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    ELISA Kit for Human C-C CKR-3
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    E2077m
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    ELISA Kit for Human C-C CKR-3
    Cat.:
    E2077d
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    Packing:
    96T
    CLIA Kit for Human C-C CKR-3
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    U2077h
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    Packing:
    96T
    CLIA Kit for Human C-C CKR-3
    Cat.:
    U2077d
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    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human C-C CKR-3
    Cat.:
    U2077m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human C-C CKR-3
    Cat.:
    U2077r
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    MSDS:
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    Packing:
    96T
    Polyclonal Antibody for Human C-C CKR-3
    Cat.:
    P2077Rb-m
    Price:
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human C-C CKR-3
    Cat.:
    P2077Rb-r
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human C-C CKR-3
    Polyclonal Antibody for Human C-C CKR-3
    Cat.:
    P2077Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Human C-C CKR-3
    Monoclonal Antibody for Human C-C CKR-3
    Monoclonal Antibody for Human C-C CKR-3
    Monoclonal Antibody for Human C-C CKR-3
    Protein for Human C-C CKR-3
    Protein for Human C-C CKR-3
    Protein for Human C-C CKR-3
    Protein for Human C-C CKR-3

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    References
    1. 1.
      "Cloning and functional expression of a human eosinophil CC chemokine receptor."
      Combadiere C. , Ahuja S.K. , Murphy P.M.
      J. Biol. Chem.270:16491-16494(1995) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
      tissue: Monocyte.
    2. 2.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ERRATUM
    3. 3.
      "Cloning, expression, and characterization of the human eosinophil eotaxin receptor."
      Daugherty B.L. , Siciliano S.J. , Demartino J.A. , Malkowitz L. , Sirotina A. , Springer M.S.
      J. Exp. Med.183:2349-2354(1996) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 1)
    4. 4.
      "Molecular cloning and characterization of a human eotaxin receptor expressed selectively on eosinophils."
      Ponath P.D. , Qin S. , Post T.W. , Wang J. , Wu L. , Gerard N.P. , Newman W. , Gerard C. , Mackay C.R.
      J. Exp. Med.183:2437-2448(1996) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 1)
    5. 5.
      "Partial resistance to infection by syncytium-inducing primary HIV-1 in exposed uninfected individuals homozygous for CCR5 32bp deletion."
      Xiao L. , Weiss S. , Qari S. , Rudolph D. , Hodge T. , Lal R.
      Submitted (1997-11) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
    6. 6.
      "New variations of human CC-chemokine receptors CCR3 and CCR4."
      Kato H. , Tsuchiya N. , Izumi S. , Miyamasu M. , Nakajima T. , Kawasaki H. , Hirai K. , Tokunaga K.
      Genes Immun.1:97-104(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 1);VARIANT SER-218
    7. 7.
      "Transcription regulation of human chemokine receptor CCR3: evidence for a rare TATA-less promoter structure conserved between Drosophila and humans."
      Vijh S. , Dayhoff D.E. , Wang C.E. , Imam Z. , Ehrenberg P.K. , Michael N.L.
      Genomics80:86-95(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 1)
    8. 8.
      "cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org)."
      Kopatz S.A. , Aronstam R.S. , Sharma S.V.
      Submitted (2003-10) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 1)
    9. 9.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 1)
    10. 10.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
      tissue: Synovium.
    11. 11.
      "The DNA sequence, annotation and analysis of human chromosome 3."
      Muzny D.M. , Scherer S.E. , Kaul R. , Wang J. , Yu J. , Sudbrak R. , Buhay C.J. , Chen R. , Cree A. , Ding Y. , Dugan-Rocha S. , Gill R. , Gunaratne P. , Harris R.A. , Hawes A.C. , Hernandez J. , Hodgson A.V. , Hume J. , more...
      Nature440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    12. 12.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
      tissue: Blood.
    13. 13.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH HIV-1 TAT
    14. 14.
      "Increased expression of chemokine receptor CCR3 and its ligands in ulcerative colitis: the role of colonic epithelial cells in in vitro studies."
      Manousou P. , Kolios G. , Valatas V. , Drygiannakis I. , Bourikas L. , Pyrovolaki K. , Koutroubakis I. , Papadaki H.A. , Kouroumalis E.
      Clin. Exp. Immunol.162:337-347(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: OVEREXPRESSION
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