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Index > Protein center > CD14(Gene name) > Human
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  • CD14 (Gene name),
  • Monocyte differentiation antigen CD14 (Protein name ),  CD14_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    CD14;
    Protein name:
    Monocyte differentiation antigen CD14;
    Alternative:
    Myeloid cell-specific leucine-rich glycoprotein;
    CD:
    CD14;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Belongs to the lipopolysaccharide (LPS) receptor, a multi-protein complex containing at least CD14, MD-2 and TLR4.
    Function:
    Cooperates with MD-2 and TLR4 to mediate the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Up-regulates cell surface molecules, including adhesion molecules.
    Subcellular Location:
    Cell membrane Lipid-anchor GPI-anchor
    Protein Attributes:
    Sequence length:
    375
    Sequence:
    50:
    MERASCLLLL | LLPLVHVSAT | TPEPCELDDE | DFRCVCNFSE | PQPDWSEAFQ | 
    100:
    CVSAVEVEIH | AGGLNLEPFL | KRVDADADPR | QYADTVKALR | VRRLTVGAAQ | 
    150:
    VPAQLLVGAL | RVLAYSRLKE | LTLEDLKITG | TMPPLPLEAT | GLALSSLRLR | 
    200:
    NVSWATGRSW | LAELQQWLKP | GLKVLSIAQA | HSPAFSCEQV | RAFPALTSLD | 
    250:
    LSDNPGLGER | GLMAALCPHK | FPAIQNLALR | NTGMETPTGV | CAALAAAGVQ | 
    300:
    PHSLDLSHNS | LRATVNPSAP | RCMWSSALNS | LNLSFAGLEQ | VPKGLPAKLR | 
    350:
    VLDLSCNRLN | RAPQPDELPE | VDNLTLDGNP | FLVPGTALPH | EGSMNSGVVP | 
    375:
    ACARSTLSVG | VSGTLVLLQG | ARGFA
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    String:
    UniGene:
    SMR:
    MIM:
    KEGG:
    Pfam:
    Uniprot:
     
    FOR
    ELISA Kit for Human Monocyte differentiation antigen CD14
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    ELISA Kit for Human Monocyte differentiation antigen CD14
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    E0685r
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    ELISA Kit for Human Monocyte differentiation antigen CD14
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    E0685h
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    ELISA Kit for Human Monocyte differentiation antigen CD14
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    E0685b
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    ELISA Kit for Human Monocyte differentiation antigen CD14
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    CLIA Kit for Human Monocyte differentiation antigen CD14
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    U0685h
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    Packing:
    96T
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    CLIA Kit for Human Monocyte differentiation antigen CD14
    Cat.:
    U0685r
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    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
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    CLIA Kit for Human Monocyte differentiation antigen CD14
    MSDS:
    Please sign in first.
    CLIA Kit for Human Monocyte differentiation antigen CD14
    Cat.:
    U0685b
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Monocyte differentiation antigen CD14
    Cat.:
    U0685m
    Price:
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    MSDS:
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    Packing:
    96T
    Polyclonal Antibody for Human Monocyte differentiation antigen CD14
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    P0685Rb-m
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Monocyte differentiation antigen CD14
    Polyclonal Antibody for Human Monocyte differentiation antigen CD14
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    P0685Rb-h
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Monocyte differentiation antigen CD14
    Cat.:
    P0685Rb-r
    Price:
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Monocyte differentiation antigen CD14
    Monoclonal Antibody for Human Monocyte differentiation antigen CD14
    Monoclonal Antibody for Human Monocyte differentiation antigen CD14
    Monoclonal Antibody for Human Monocyte differentiation antigen CD14
    Monoclonal Antibody for Human Monocyte differentiation antigen CD14
    Monoclonal Antibody for Human Monocyte differentiation antigen CD14
    Protein for Human Monocyte differentiation antigen CD14
    Protein for Human Monocyte differentiation antigen CD14
    Protein for Human Monocyte differentiation antigen CD14
    Protein for Human Monocyte differentiation antigen CD14
    Protein for Human Monocyte differentiation antigen CD14

    R&D Technical Data
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    Precision
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    Linearity
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    References
    1. 1.
      "The monocyte differentiation antigen, CD14, is anchored to the cell membrane by a phosphatidylinositol linkage."
      Haziot A. , Chen S. , Ferrero E. , Low M.G. , Silber R. , Goyert S.M.
      J. Immunol.141:547-552(1988) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
    2. 2.
      "Nucleotide sequence of the gene encoding the monocyte differentiation antigen, CD14."
      Ferrero E. , Goyert S.M.
      Nucleic Acids Res.16:4173-4173(1988) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
      tissue: Lymphocyte.
    3. 3.
      "Mouse and human CD14 (myeloid cell-specific leucine-rich glycoprotein) primary structure deduced from cDNA clones."
      Setoguchi M. , Nasu N. , Yoshida S. , Higuchi Y. , Akizuki S. , Yamamoto S.
      Biochim. Biophys. Acta1008:213-222(1989) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
      tissue: Macrophage.
    4. 4.
      "Monocyte antigen CD14 is a phospholipid anchored membrane protein."
      Simmons D.L. , Tan S. , Tenen D.G. , Nicholson-Weller A. , Seed B.
      Blood73:284-289(1989) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
    5. 5.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
      tissue: Promyelocytic leukemia.
    6. 6.
      "Natural selection in the TLR-related genes in the course of primate evolution."
      Nakajima T. , Ohtani H. , Satta Y. , Uno Y. , Akari H. , Ishida T. , Kimura A.
      Immunogenetics60:727-735(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
    7. 7.
      "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
      Kalnine N. , Chen X. , Rolfs A. , Halleck A. , Hines L. , Eisenstein S. , Koundinya M. , Raphael J. , Moreira D. , Kelley T. , LaBaer J. , Lin Y. , Phelan M. , Farmer A.
      Submitted (2003-05) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
    8. 8.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    9. 9.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      tissue: Brain.
    10. 10.
      "Expression and secretion of CD14 in glial neoplasms of the brain."
      Deininger M.H. , Meyermann R. , Schluesener H.J.
      Submitted (2001-07) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-125
      tissue: Glioblastoma.
    11. 11.
      "Structural relationship between the soluble and membrane-bound forms of human monocyte surface glycoprotein CD14."
      Bazil V. , Baudys M. , Hilgert I. , Stefanova I. , Low M.G. , Zbrozek J. , Horejsi V.
      Mol. Immunol.26:657-662(1989) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 362-367
    12. 12.
      "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry."
      Liu T. , Qian W.-J. , Gritsenko M.A. , Camp D.G. II , Monroe M.E. , Moore R.J. , Smith R.D.
      J. Proteome Res.4:2070-2080(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-151 AND ASN-282
      tissue: Plasma.
    13. 13.
      "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
      Chen R. , Jiang X. , Sun D. , Han G. , Wang F. , Ye M. , Wang L. , Zou H.
      J. Proteome Res.8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-323
      tissue: Liver.
    14. 14.
      "Enrichment of glycopeptides for glycan structure and attachment site identification."
      Nilsson J. , Rueetschi U. , Halim A. , Hesse C. , Carlsohn E. , Brinkmalm G. , Larson G.
      Nat. Methods6:809-811(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT THR-336;STRUCTURE OF CARBOHYDRATES
      tissue: Cerebrospinal fluid.
    15. 15.
      "The crystal structure of human soluble CD14 reveals a bent solenoid with a hydrophobic amino-terminal pocket."
      Kelley S.L. , Lukk T. , Nair S.K. , Tapping R.I.
      J. Immunol.190:1304-1311(2013) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (4.0 ANGSTROMS) OF 26-335;DISULFIDE BONDS;FUNCTION
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