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Index > Protein center > CD24(Gene name) > Human
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  • CD24 (Gene name),
  • Signal transducer CD24 (Protein name ),  CD24_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Gene name:
    CD24(CD24A);
    Protein name:
    Signal transducer CD24;
    Alternative:
    Small cell lung carcinoma cluster 4 antigen;
    CD:
    CD24;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Interacts with LYN and FGR in a cell-type specific manner. Binds FRG in a small cell cancer line, LYN in the erythroleukemia cell line K562 and in Burkitt's lymphoma.
    Function:
    Modulates B-cell activation responses. Signaling could be triggered by the binding of a lectin-like ligand to the CD24 carbohydrates, and transduced by the release of second messengers derived from the GPI-anchor. Promotes AG-dependent proliferation of B-cells, and prevents their terminal differentiation into antibody-forming cells.
    Subcellular Location:
    Cell membrane Lipid-anchor GPI-anchor
    Protein Attributes:
    Sequence length:
    80
    Sequence:
    50:
    MGRAMVARLG | LGLLLLALLL | PTQIYSSETT | TGTSSNSSQS | TSNTGLAPNP | 
    80:
    TNATTKAAGG | ALQSTASLFV | VSLSLLHLYS | 
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    String:
    MIM:
    UniGene:
    Pfam:
    Uniprot:
     
    FOR
    ELISA Kit for Human Signal transducer CD24
    Cat.:
    E2189m
    Price:
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    MSDS:
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    Packing:
    96T
    ELISA Kit for Human Signal transducer CD24
    Cat.:
    E2189h
    Price:
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    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
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    ELISA Kit for Human Signal transducer CD24
    Cat.:
    E2189r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Signal transducer CD24
    Cat.:
    U2189m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Signal transducer CD24
    Cat.:
    U2189h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Human Signal transducer CD24
    Cat.:
    U2189r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Polyclonal Antibody for Human Signal transducer CD24
    Cat.:
    P2189Rb-r
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Signal transducer CD24
    Cat.:
    P2189Rb-m
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Signal transducer CD24
    Cat.:
    P2189Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Human Signal transducer CD24
    Monoclonal Antibody for Human Signal transducer CD24
    Monoclonal Antibody for Human Signal transducer CD24
    Protein for Human Signal transducer CD24
    Protein for Human Signal transducer CD24
    Protein for Human Signal transducer CD24

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    References
    1. 1.
      "CD24, a signal transducer modulating B cell activation responses, is a very short peptide with a glycosyl phosphatidylinositol membrane anchor."
      Kay R. , Rosten P.M. , Humphries R.K.
      J. Immunol.147:1412-1416(1991) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];VARIANT SER-44
    2. 2.
      "CD24, a signal-transducing molecule expressed on human B cells, is a major surface antigen on small cell lung carcinomas."
      Jackson D. , Waibel R. , Weber E. , Bell J. , Stahel R.A.
      Cancer Res.52:5264-5270(1992) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];VARIANTS SER-44 AND VAL-57
    3. 3.
      "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
      Kalnine N. , Chen X. , Rolfs A. , Halleck A. , Hines L. , Eisenstein S. , Koundinya M. , Raphael J. , Moreira D. , Kelley T. , LaBaer J. , Lin Y. , Phelan M. , Farmer A.
      Submitted (2003-05) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA];VARIANT SER-44
    4. 4.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA];VARIANT SER-44
      tissue: Ovary.
    5. 5.
      "Mapping of CD24 and homologous sequences to multiple chromosomal loci."
      Hough M.R. , Rosten P.M. , Sexton T.L. , Kay R. , Humphries R.K.
      Genomics22:154-161(1994) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-76
    6. 6.
      "Association of CD24 with the kinase c-fgr in a small cell lung cancer cell line and with the kinase lyn in an erythroleukemia cell line."
      Zarn J.A. , Zimmermann S.M. , Pass M.K. , Waibel R. , Stahel R.A.
      Biochem. Biophys. Res. Commun.225:384-391(1996) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH LYN AND FGR;TISSUE SPECIFICITY
    7. 7.
      "CD24 induces apoptosis in human B cells via the glycolipid-enriched membrane domains/rafts-mediated signaling system."
      Suzuki T. , Kiyokawa N. , Taguchi T. , Sekino T. , Katagiri Y.U. , Fujimoto J.
      J. Immunol.166:5567-5577(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH LYN;FUNCTION
    8. 8.
      "The small cell lung cancer antigen cluster-4 and the leukocyte antigen CD24 are allelic isoforms of the same gene (CD24) on chromosome band 6q21."
      Zarn J.A. , Jackson D.G. , Bell M.V. , Jones T. , Weber E. , Sheer D. , Waibel R. , Stahel R.A.
      Cytogenet. Cell Genet.70:119-125(1995) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT VAL-57;IDENTIFICATION
    9. 9.
      "CD24 is a genetic modifier for risk and progression of multiple sclerosis."
      Zhou Q. , Rammohan K. , Lin S. , Robinson N. , Li O. , Liu X. , Bai X.-F. , Yin L. , Scarberry B. , Du P. , You M. , Guan K. , Zheng P. , Liu Y.
      Proc. Natl. Acad. Sci. U.S.A.100:15041-15046(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT VAL-57;TISSUE SPECIFICITY;INVOLVEMENT IN SUSCEPTIBILITY TO MS
    10. 10.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ERRATUM
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