Cdkn2a3 ELISA Kit for Mouse(Mus musculus) | EIAab.comCdkn2a3 ELISA Kit for Mouse(Mus musculus)

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Cdkn2a3 (Gene name),

Cyclin-dependent kinase inhibitor 2A, isoform 3 (Protein name ), CD2A2_MOUSE from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

Cdkn2a;

Protein name:

Cyclin-dependent kinase inhibitor 2A, isoform 3;

Alternative:

p19ARF;

Organism:

Cdkn2a3 (Mus musculus).

General Annotation

Sub Unit:

Does not interact with cyclins, CDK1, CDK2, CDK4, CDK5 or CDK6. Interacts with COMMD1 (By similarity). Binds to BCL6, E2F1, HUWE1, MDM2, MYC, NPM1/B23, TOP1/TOPOI and UBE2I/UBC9. Interacts with TBRG1. Interacts with CDKN2AIP and E4F1.

Function:

Capable of inducing cell cycle arrest in G1 and G2 phases. Acts as a tumor suppressor. Binds to MDM2 and blocks its nucleocytoplasmic shuttling by sequestering it in the nucleolus. This inhibits the oncogenic action of MDM2 by blocking MDM2-induced degradation of p53 and enhancing p53-dependent transactivation and apoptosis. Also induces G2 arrest and apoptosis in a p53-independent manner by preventing the activation of cyclin B1/CDC2 complexes. Binds to BCL6 and down-regulates BCL6-induced transcriptional repression. Binds to E2F1 and MYC and blocks their transcriptional activator activity but has no effect on MYC transcriptional repression. Binds to TOP1/TOPOI and stimulates its activity. This complex binds to rRNA gene promoters and may play a role in rRNA transcription and/or maturation. Interacts with NPM1/B23 and promotes its polyubiquitination and degradation, thus inhibiting rRNA processing. Interacts with COMMD1 and promotes its 'Lys63'-linked polyubiquitination (By similarity). Interacts with UBE2I/UBC9 and enhances sumoylation of a number of its binding partners including MDM2 and E2F1. Binds to HUWE1 and represses its ubiquitin ligase activity. May play a role in controlling cell proliferation and apoptosis during mammary gland development.

Subcellular Location:

Nucleus nucleolus Nucleus nucleoplasm

Protein Attributes:

Sequence length:

169

Sequence:

50:

100:

150:

169:

VFRWVVFVYR | WERRPDRRA

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

KEGG:

mmu:12578

SMR:

Q64364

UniGene:

Mm.4733

Pfam:

PF07392

String:

Q64364

Uniprot:

Q64364

FOR

ELISA Kit for Mouse Cyclin-dependent kinase inhibitor 2A, isoform 3

CLIA Kit for Mouse Cyclin-dependent kinase inhibitor 2A, isoform 3

Polyclonal Antibody for Mouse Cyclin-dependent kinase inhibitor 2A, isoform 3

Monoclonal Antibody for Mouse Cyclin-dependent kinase inhibitor 2A, isoform 3

Protein for Mouse Cyclin-dependent kinase inhibitor 2A, isoform 3

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

References

1.

"Alternative reading frames of the INK4a tumor suppressor gene encode two unrelated proteins capable of inducing cell cycle arrest."
Quelle D.E. , Zindy F. , Ashmun R.A. , Sherr C.J.
Cell83:993-1000(1995) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];FUNCTION;SUBCELLULAR LOCATION
2.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
strain: NMRI.
tissue: Mammary tumor.
3.

"Characterization of the murine p19ARF promoter CpG island and its methylation pattern in primary lymphomas."
Melendez B. , Malumbres M. , de Castro I.P. , Santos J. , Pellicer A. , Fernandez-Piqueras J.
Carcinogenesis21:817-821(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-64
strain: 129/SvJ.
4.

"Sequence variation and chromosomal mapping of the murine Cdkn2a tumor suppressor gene."
Herzog C.R. , You M.
Mamm. Genome8:65-66(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-63
strain: 020.
strain: 129/J.
strain: A/J.
strain: A/Wy.
strain: AKR/J.
strain: B10.A.
strain: B10.D2(58N).
strain: BALB/c.
strain: C3H/21BG.
strain: C3H/HeJ.
strain: C57BL/10SCN.
strain: C57BL/10SN.
strain: C57BL/6By.
strain: C57BL/6J.
strain: C57BR/cdJ.
strain: CBA/J.
strain: DBA/2J.
strain: HS/IBG.
strain: LP/J.
strain: LS/IBG.
strain: MA/M4J.
strain: PL/J.
strain: RF/J.
strain: Sencar.
strain: SJL/J.
strain: SM/J.
strain: ST/J.
strain: SWR/J.
tissue: Lung.
5.

"Induction of ARF tumor suppressor gene expression and cell cycle arrest by transcription factor DMP1."
Inoue K. , Roussel M.F. , Sherr C.J.
Proc. Natl. Acad. Sci. U.S.A.96:3993-3998(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-63
strain: 129/SvjE.
6.

"Tumor suppression at the mouse INK4a locus mediated by the alternative reading frame product p19ARF."
Kamijo T. , Zindy F. , Roussel M.F. , Quelle D.E. , Downing J.R. , Ashmun R.A. , Grosveld G. , Sherr C.J.
Cell91:649-659(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
7.

"Cancer-associated mutations at the INK4a locus cancel cell cycle arrest by p16INK4a but not by the alternative reading frame protein p19ARF."
Quelle D.E. , Cheng M. , Ashmun R.A. , Sherr C.J.
Proc. Natl. Acad. Sci. U.S.A.94:669-673(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: MUTAGENESIS OF LEU-85; PRO-93; ARG-97; 105-GLY-HIS-106 AND ALA-120
8.

"The Ink4a tumor suppressor gene product, p19Arf, interacts with MDM2 and neutralizes MDM2's inhibition of p53."
Pomerantz J. , Schreiber-Agus N. , Liegeois N.J. , Silverman A. , Alland L. , Chin L. , Potes J. , Chen K. , Orlow I. , Lee H.-W. , Cordon-Cardo C. , DePinho R.A.
Cell92:713-723(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH MDM2
9.

"P19(ARF) stabilizes p53 by blocking nucleo-cytoplasmic shuttling of Mdm2."
Tao W. , Levine A.J.
Proc. Natl. Acad. Sci. U.S.A.96:6937-6941(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION
10.

"Disruption of the ARF transcriptional activator DMP1 facilitates cell immortalization, Ras transformation, and tumorigenesis."
Inoue K. , Wen R. , Rehg J.E. , Adachi M. , Cleveland J.L. , Roussel M.F. , Sherr C.J.
Genes Dev.14:1797-1809(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INDUCTION
11.

"CARF is a novel protein that cooperates with mouse p19ARF (human p14ARF) in activating p53."
Hasan M.K. , Yaguchi T. , Sugihara T. , Kumar P.K.R. , Taira K. , Reddel R.R. , Kaul S.C. , Wadhwa R.
J. Biol. Chem.277:37765-37770(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH CDKN2AIP
12.

"p19ARF determines the balance between normal cell proliferation rate and apoptosis during mammary gland development."
Yi Y. , Shepard A. , Kittrell F. , Mulac-Jericevic B. , Medina D. , Said T.K.
Mol. Biol. Cell15:2302-2311(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: DEVELOPMENTAL STAGE;INDUCTION;DISRUPTION PHENOTYPE
13.

"p19ARF directly and differentially controls the functions of c-Myc independently of p53."
Qi Y. , Gregory M.A. , Li Z. , Brousal J.P. , West K. , Hann S.R.
Nature431:712-717(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH MYC
14.

"The ARF tumor suppressor inhibits BCL6-mediated transcriptional repression."
Suzuki H. , Kurita M. , Mizumoto K. , Moriyama M. , Aiso S. , Nishimoto I. , Matsuoka M.
Biochem. Biophys. Res. Commun.326:242-248(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION;INTERACTION WITH BCL6
15.

"Ras-Raf-Arf signaling critically depends on the Dmp1 transcription factor."
Sreeramaneni R. , Chaudhry A. , McMahon M. , Sherr C.J. , Inoue K.
Mol. Cell. Biol.25:220-232(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION;INDUCTION
16.

"A short mitochondrial form of p19ARF induces autophagy and caspase-independent cell death."
Reef S. , Zalckvar E. , Shifman O. , Bialik S. , Sabanay H. , Oren M. , Kimchi A.
Mol. Cell22:463-475(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ALTERNATIVE SPLICING (ISOFORM 4);FUNCTION (ISOFORM 4);SUBCELLULAR LOCATION (ISOFORM 4)
17.

"Mutually exclusive inactivation of DMP1 and ARF/p53 in lung cancer."
Mallakin A. , Sugiyama T. , Taneja P. , Matise L.A. , Frazier D.P. , Choudhary M. , Hawkins G.A. , D'Agostino R.B. Jr. , Willingham M.C. , Inoue K.
Cancer Cell12:381-394(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
18.

"A novel nuclear interactor of ARF and MDM2 (NIAM) that maintains chromosomal stability."
Tompkins V.S. , Hagen J. , Frazier A.A. , Lushnikova T. , Fitzgerald M.P. , di Tommaso A.D. , Ladeveze V. , Domann F.E. , Eischen C.M. , Quelle D.E.
J. Biol. Chem.282:1322-1333(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH TBRG1
19.

"The autophagic inducer smARF interacts with and is stabilized by the mitochondrial p32 protein."
Reef S. , Shifman O. , Oren M. , Kimchi A.
Oncogene26:6677-6683(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH C1QBP
20.

"Repression of Dmp1 and Arf transcription by anthracyclins: critical roles of the NF-kappaB subunit p65."
Taneja P. , Mallakin A. , Matise L.A. , Frazier D.P. , Choudhary M. , Inoue K.
Oncogene26:7457-7466(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INDUCTION
21.

"Solution structure of the p53 regulatory domain of the p19Arf tumor suppressor protein."
DiGiammarino E.L. , Filippov I. , Weber J.D. , Bothner B. , Kriwacki R.W.
Biochemistry40:2379-2386(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE BY NMR OF 1-37

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