Protein name:
ADP-ribosyl cyclase 1 ;
Alternative:
T10 ;Cyclic ADP-ribose hydrolase 1 (cADPr hydrolase 1) ;
CD:
CD38 ;
Organism:
Human (Homo sapiens).
General Annotation
Function:
Synthesizes cyclic ADP-ribose, a second messenger for glucose-induced insulin secretion. Also has cADPr hydrolase activity. Also moonlights as a receptor in cells of the immune system.
Subcellular Location:
Membrane
Single-pass type II membrane protein
Protein Attributes:
50:
MANCEFSPVS | GDKPCCRLSR | RAQLCLGVSI | LVLILVVVLA | VVVPRWRQQW |
100:
SGPGTTKRFP | ETVLARCVKY | TEIHPEMRHV | DCQSVWDAFK | GAFISKHPCN |
150:
ITEEDYQPLM | KLGTQTVPCN | KILLWSRIKD | LAHQFTQVQR | DMFTLEDTLL |
200:
GYLADDLTWC | GEFNTSKINY | QSCPDWRKDC | SNNPVSVFWK | TVSRRFAEAA |
250:
CDVVHVMLNG | SRSKIFDKNS | TFGSVEVHNL | QPEKVQTLEA | WVIHGGREDS |
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Human
Rabbit
Rat
Mouse
ELISA Kit for Human ADP-ribosyl cyclase 1
ELISA Kit for Human ADP-ribosyl cyclase 1
ELISA Kit for Human ADP-ribosyl cyclase 1
ELISA Kit for Human ADP-ribosyl cyclase 1
CLIA Kit for Human ADP-ribosyl cyclase 1
CLIA Kit for Human ADP-ribosyl cyclase 1
CLIA Kit for Human ADP-ribosyl cyclase 1
CLIA Kit for Human ADP-ribosyl cyclase 1
Polyclonal Antibody for Human ADP-ribosyl cyclase 1
Polyclonal Antibody for Human ADP-ribosyl cyclase 1
Polyclonal Antibody for Human ADP-ribosyl cyclase 1
Polyclonal Antibody for Human ADP-ribosyl cyclase 1
Monoclonal Antibody for Human ADP-ribosyl cyclase 1
Monoclonal Antibody for Human ADP-ribosyl cyclase 1
Monoclonal Antibody for Human ADP-ribosyl cyclase 1
Monoclonal Antibody for Human ADP-ribosyl cyclase 1
Protein for Human ADP-ribosyl cyclase 1
Protein for Human ADP-ribosyl cyclase 1
Protein for Human ADP-ribosyl cyclase 1
Protein for Human ADP-ribosyl cyclase 1
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
1.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
2.
"Human gene encoding CD38 (ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase): organization, nucleotide sequence and alternative splicing."
Nata K.
,
Takamura T.
,
Karasawa T.
,
Kumagai T.
,
Hashioka W.
,
Tohgo A.
,
Yonekura H.
,
Takasawa S.
,
Nakamura S.
,
Okamoto H.
Gene186:285-292(1997)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [GENOMIC DNA];NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2);TISSUE SPECIFICITY
tissue :
Esophageal carcinoma .
tissue :
Pancreas .
3.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
tissue :
B-cell .
4.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : SIMILARITY TO NADASE
5.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : CHARACTERIZATION
6.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : ACTIVE SITE;MUTAGENESIS OF CYS-119; CYS-160; CYS-173 AND CYS-201
7.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : SPLICE ISOFORM(S) THAT ARE POTENTIAL NMD TARGET(S)
8.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : CATALYTIC ACTIVITY
9.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-100; ASN-209 AND ASN-219
tissue :
Liver .
10.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-219
tissue :
Leukemic T-cell .
11.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
12.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : X-RAY CRYSTALLOGRAPHY (1.91 ANGSTROMS) OF 45-300;DISULFIDE BONDS
13.
"A missense mutation in the CD38 gene, a novel factor for insulin secretion: association with Type II diabetes mellitus in Japanese subjects and evidence of abnormal function when expressed in vitro."
Yagui K.
,
Shimada F.
,
Mimura M.
,
Hashimoto N.
,
Suzuki Y.
,
Tokuyama Y.
,
Nata K.
,
Tohgo A.
,
Ikehata F.
,
Takasawa S.
,
Okamoto H.
,
Makino H.
,
Saito Y.
,
Kanatsuka A.
Diabetologia41:1024-1028(1998)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : VARIANT TRP-140