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Index > Protein center > CD38(Gene name) > Human
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  • CD38 (Gene name),
  • ADP-ribosyl cyclase 1 (Protein name ),  CD38_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Gene name:
    CD38;
    Protein name:
    ADP-ribosyl cyclase 1;
    Alternative:
    T10;Cyclic ADP-ribose hydrolase 1(cADPr hydrolase 1);
    CD:
    CD38;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    N/A
    Function:
    Synthesizes cyclic ADP-ribose, a second messenger for glucose-induced insulin secretion. Also has cADPr hydrolase activity. Also moonlights as a receptor in cells of the immune system.
    Subcellular Location:
    Membrane Single-pass type II membrane protein
    Protein Attributes:
    Sequence length:
    300
    Sequence:
    50:
    MANCEFSPVS | GDKPCCRLSR | RAQLCLGVSI | LVLILVVVLA | VVVPRWRQQW | 
    100:
    SGPGTTKRFP | ETVLARCVKY | TEIHPEMRHV | DCQSVWDAFK | GAFISKHPCN | 
    150:
    ITEEDYQPLM | KLGTQTVPCN | KILLWSRIKD | LAHQFTQVQR | DMFTLEDTLL | 
    200:
    GYLADDLTWC | GEFNTSKINY | QSCPDWRKDC | SNNPVSVFWK | TVSRRFAEAA | 
    250:
    CDVVHVMLNG | SRSKIFDKNS | TFGSVEVHNL | QPEKVQTLEA | WVIHGGREDS | 
    300:
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    SMR:
    UniGene:
    String:
    KEGG:
    Pfam:
    MIM:
    Uniprot:
     
    FOR
    ELISA Kit for Human ADP-ribosyl cyclase 1
    Cat.:
    E0752h
    Price:
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    MSDS:
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    Packing:
    96T
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    ELISA Kit for Human ADP-ribosyl cyclase 1
    MSDS:
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    ELISA Kit for Human ADP-ribosyl cyclase 1
    Cat.:
    E0752r
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    MSDS:
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    Packing:
    96T
    ELISA Kit for Human ADP-ribosyl cyclase 1
    Cat.:
    E0752m
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    MSDS:
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    Packing:
    96T
    CLIA Kit for Human ADP-ribosyl cyclase 1
    Cat.:
    U0752r
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    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human ADP-ribosyl cyclase 1
    Cat.:
    U0752h
    Price:
    Please sign in first.
    MSDS:
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    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Human ADP-ribosyl cyclase 1
    MSDS:
    Please sign in first.
    CLIA Kit for Human ADP-ribosyl cyclase 1
    Cat.:
    U0752m
    Price:
    Please sign in first.
    MSDS:
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    Packing:
    96T
    Polyclonal Antibody for Human ADP-ribosyl cyclase 1
    Cat.:
    P0752Rb-m
    Price:
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human ADP-ribosyl cyclase 1
    Cat.:
    P0752Rb-r
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human ADP-ribosyl cyclase 1
    Polyclonal Antibody for Human ADP-ribosyl cyclase 1
    Cat.:
    P0752Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Human ADP-ribosyl cyclase 1
    Monoclonal Antibody for Human ADP-ribosyl cyclase 1
    Monoclonal Antibody for Human ADP-ribosyl cyclase 1
    Monoclonal Antibody for Human ADP-ribosyl cyclase 1
    Protein for Human ADP-ribosyl cyclase 1
    Protein for Human ADP-ribosyl cyclase 1
    Protein for Human ADP-ribosyl cyclase 1
    Protein for Human ADP-ribosyl cyclase 1

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    Precision
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    Linearity
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    References
    1. 1.
      "Isolation of a cDNA encoding the human CD38 (T10) molecule, a cell surface glycoprotein with an unusual discontinuous pattern of expression during lymphocyte differentiation."
      Jackson D.G. , Bell J.I.
      J. Immunol.144:2811-2815(1990) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
    2. 2.
      "Human gene encoding CD38 (ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase): organization, nucleotide sequence and alternative splicing."
      Nata K. , Takamura T. , Karasawa T. , Kumagai T. , Hashioka W. , Tohgo A. , Yonekura H. , Takasawa S. , Nakamura S. , Okamoto H.
      Gene186:285-292(1997) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2);TISSUE SPECIFICITY
      tissue: Esophageal carcinoma.
      tissue: Pancreas.
    3. 3.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
      tissue: B-cell.
    4. 4.
      "Similarities in amino acid sequences of Aplysia ADP-ribosyl cyclase and human lymphocyte antigen CD38."
      States D.J. , Walseth T.F. , Lee H.C.
      Trends Biochem. Sci.17:495-495(1992) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SIMILARITY TO NADASE
    5. 5.
      "Synthesis and hydrolysis of cyclic ADP-ribose by human leukocyte antigen CD38 and inhibition of the hydrolysis by ATP."
      Takasawa S. , Tohgo A. , Noguchi N. , Koguma T. , Nata K. , Sugimoto T. , Yonekura H. , Okamoto H.
      J. Biol. Chem.268:26052-26054(1993) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: CHARACTERIZATION
    6. 6.
      "Essential cysteine residues for cyclic ADP-ribose synthesis and hydrolysis by CD38."
      Tohgo A. , Takasawa S. , Noguchi N. , Koguma T. , Nata K. , Sugimoto T. , Furuya Y. , Yonekura H. , Okamoto H.
      J. Biol. Chem.269:28555-28557(1994) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ACTIVE SITE;MUTAGENESIS OF CYS-119; CYS-160; CYS-173 AND CYS-201
    7. 7.
      "An unappreciated role for RNA surveillance."
      Hillman R.T. , Green R.E. , Brenner S.E.
      Genome Biol.5:R8.1-R8.16(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SPLICE ISOFORM(S) THAT ARE POTENTIAL NMD TARGET(S)
    8. 8.
      "NAADP+ synthesis from cADPRP and nicotinic acid by ADP-ribosyl cyclases."
      Moreschi I. , Bruzzone S. , Melone L. , De Flora A. , Zocchi E.
      Biochem. Biophys. Res. Commun.345:573-580(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: CATALYTIC ACTIVITY
    9. 9.
      "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
      Chen R. , Jiang X. , Sun D. , Han G. , Wang F. , Ye M. , Wang L. , Zou H.
      J. Proteome Res.8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-100; ASN-209 AND ASN-219
      tissue: Liver.
    10. 10.
      "Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins."
      Wollscheid B. , Bausch-Fluck D. , Henderson C. , O'Brien R. , Bibel M. , Schiess R. , Aebersold R. , Watts J.D.
      Nat. Biotechnol.27:378-386(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-219
      tissue: Leukemic T-cell.
    11. 11.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    12. 12.
      "Crystal structure of human CD38 extracellular domain."
      Liu Q. , Kriksunov I.A. , Graeff R. , Munshi C. , Lee H.C. , Hao Q.
      Structure13:1331-1339(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.91 ANGSTROMS) OF 45-300;DISULFIDE BONDS
    13. 13.
      "A missense mutation in the CD38 gene, a novel factor for insulin secretion: association with Type II diabetes mellitus in Japanese subjects and evidence of abnormal function when expressed in vitro."
      Yagui K. , Shimada F. , Mimura M. , Hashimoto N. , Suzuki Y. , Tokuyama Y. , Nata K. , Tohgo A. , Ikehata F. , Takasawa S. , Okamoto H. , Makino H. , Saito Y. , Kanatsuka A.
      Diabetologia41:1024-1028(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT TRP-140
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