CD40LG ELISA Kit for Human(Homo sapiens) | EIAab.comCD40LG ELISA Kit for Human(Homo sapiens)

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CD40LG (Gene name),

CD40 ligand (Protein name ), CD40L_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

CD40LG(CD40L;TNFSF5;TRAP);

Protein name:

CD40 ligand(CD40-L);

Alternative:

TNF-related activation protein(TRAP);T-cell antigen Gp39;Tumor necrosis factor ligand superfamily member 5;

CD:

CD154;

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Homotrimer.

Function:

Release of soluble CD40L from platelets is partially regulated by GP IIb/IIIa, actin polymerization, and an matrix metalloproteinases (MMP) inhibitor-sensitive pathway.

Subcellular Location:

CD40 ligand, soluble form Secreted

Protein Attributes:

Sequence length:

261

Sequence:

50:

100:

150:

200:

250:

261:

TGFTSFGLLK | L

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

Pfam:

PF00229

KEGG:

hsa:959

STRING:

9606.ENSP00000359663

SMR:

P29965

MIM:

300386

UniGene:

Hs.592244

String:

P29965

Uniprot:

P29965

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ELISA Kit for Human CD40-L

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E0119m

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96T

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ELISA Kit for Human CD40-L

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E0119r

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96T

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ELISA Kit for Human CD40-L

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E0119b

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ELISA Kit for Human CD40-L

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E0119c

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ELISA Kit for Human CD40-L

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E0119p

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ELISA Kit for Human CD40-L

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E0119h

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96T

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ELISA Kit for Human CD40-L

Cat.:

E0119d

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96T

CLIA Kit for Human CD40-L

Cat.:

U0119b

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96T

CLIA Kit for Human CD40-L

Cat.:

U0119c

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96T

CLIA Kit for Human CD40-L

Cat.:

U0119d

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96T

CLIA Kit for Human CD40-L

Cat.:

U0119h

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96T

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CLIA Kit for Human CD40-L

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U0119p

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96T

CLIA Kit for Human CD40-L

Cat.:

U0119r

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CLIA Kit for Human CD40-L

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U0119m

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Polyclonal Antibody for Human CD40-L

Cat.:

P0119Rb-m

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40ug/0.2ml

Polyclonal Antibody for Human CD40-L

Cat.:

P0119Rb-h

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40ug/0.2ml

Polyclonal Antibody for Human CD40-L

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P0119Rb-r

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40ug/0.2ml

Polyclonal Antibody for Human CD40-L

Monoclonal Antibody for Human CD40-L

Protein for Human CD40-L

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

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Linearity

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References

1.

"Cloning of TRAP, a ligand for CD40 on human T cells."
Graf D. , Korthaeuer U. , Mages H.W. , Senger G. , Kroczek R.A.
Eur. J. Immunol.22:3191-3194(1992) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
2.

"The human T cell antigen gp39, a member of the TNF gene family, is a ligand for the CD40 receptor: expression of a soluble form of gp39 with B cell co-stimulatory activity."
Hollenbaugh D. , Grosmaire L.S. , Kullas C.D. , Chalupny J.N. , Braesch-Andersen S. , Noelle R.J. , Stamenkovic I. , Ledbetter J.A. , Aruffo A.
EMBO J.11:4313-4321(1992) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
3.

"The CD40 ligand, gp39, is defective in activated T cells from patients with X-linked hyper-IgM syndrome."
Aruffo A. , Farrington M. , Hollenbaugh D. , Li X. , Milatovich A. , Nonoyama S. , Bajorath J. , Grosmaire L.S. , Stenkamp R. , Neubauer M. , Roberts R.L. , Noelle R.J. , Ledbetter J.A. , Francke U. , Ochs H.D.
Cell72:291-300(1993) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];VARIANTS HIGM1 128-ARG-GLY-129 AND PRO-235
4.

"Recombinant human CD40 ligand stimulates B cell proliferation and immunoglobulin E secretion."
Spriggs M.K. , Armitage R.J. , Strockbine L. , Clifford K.N. , Macduff B.M. , Sato T.A. , Maliszewski C.R. , Fanslow W.C.
J. Exp. Med.176:1543-1550(1992) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
5.

"Human CD40-ligand: molecular cloning, cellular distribution and regulation of expression by factors controlling IgE production."
Gauchat J.-F. , Aubry J.-P. , Mazzei G.J. , Life P. , Jomotte T. , Elson G. , Bonnefoy J.-Y.
FEBS Lett.315:259-266(1993) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
6.

"Structural organization of the gene for CD40 ligand: molecular analysis for diagnosis of X-linked hyper-IgM syndrome."
Shimadzu M. , Nunoi H. , Terasaki H. , Ninomiya R. , Iwata M. , Kanegasaka S. , Matsuda I.
Biochim. Biophys. Acta1260:67-72(1995) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
7.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
tissue: Blood.
8.

"Human native soluble CD40L is a biologically active trimer, processed inside microsomes."
Pietravalle F. , Lecoanet-Henchoz S. , Blasey H. , Aubry J.-P. , Elson G. , Edgerton M.D. , Bonnefoy J.-Y. , Gauchat J.-F.
J. Biol. Chem.271:5965-5967(1996) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 113-117;PROTEOLYTIC PROCESSING
9.

"Determination of carbohydrate structures N-linked to soluble CD154 and characterization of the interactions of CD40 with CD154 expressed in Pichia pastoris and Chinese hamster ovary cells."
Khandekar S.S. , Silverman C. , Wells-Marani J. , Bacon A.M. , Birrell H. , Brigham-Burke M. , DeMarini D.J. , Jonak Z.L. , Camilleri P. , Fishman-Lobell J.
Protein Expr. Purif.23:301-310(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE OF CARBOHYDRATE ON ASN-240;IDENTIFICATION BY MASS SPECTROMETRY
10.

"Release of soluble CD40L from platelets is regulated by glycoprotein IIb/IIIa and actin polymerization."
Furman M.I. , Krueger L.A. , Linden M.D. , Barnard M.R. , Frelinger A.L. III , Michelson A.D.
J. Am. Coll. Cardiol.43:2319-2325(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
11.

"2-A crystal structure of an extracellular fragment of human CD40 ligand."
Karpsusas M. , Hsu Y.-M. , Wang J.-H. , Thompson J. , Lederman S. , Chess L. , Thomas D.
Structure3:1031-1039(1995) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS) OF 116-261
12.

"The role of polar interactions in the molecular recognition of CD40L with its receptor CD40."
Singh J. , Garber E. , van Vlijmen H. , Karpsusas M. , Hsu Y.-M. , Zheng Z. , Naismith J.H. , Thomas D.
Protein Sci.7:1124-1135(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: 3D-STRUCTURE MODELING OF COMPLEX WITH CD40
13.

"Defective expression of T-cell CD40 ligand causes X-linked immunodeficiency with hyper-IgM."
Korthaeuer U. , Graf D. , Mages H.W. , Briere F. , Padayachee M. , Malcolm S. , Ugazio A.G. , Notarangelo L.D. , Levinsky R.J. , Kroczek R.A.
Nature361:539-541(1993) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS HIGM1 ARG-36 AND GLY-140
14.

"CD40 ligand mutations in X-linked immunodeficiency with hyper-IgM."
Disanto J.P. , Bonnefoy J.-Y. , Gauchat J.-F. , Fischer A. , de Saint Basile G.
Nature361:541-543(1993) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT HIGM1 GLU-123
15.

"CD40 ligand gene defects responsible for X-linked hyper-IgM syndrome."
Allen R.C. , Armitage R.J. , Conley M.E. , Rosenblatt H. , Jenkins N.A. , Copeland N.G. , Bedell M.A. , Edelhoff S. , Disteche C.M. , Simoneaux D.K. , Fanslow W.C. , Belmont J.W. , Spriggs M.K.
Science259:990-993(1993) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS HIGM1 PRO-155; ASN-211 AND VAL-227
16.

"Characterization of nine novel mutations in the CD40 ligand gene in patients with X-linked hyper IgM syndrome of various ancestry."
Macchi P. , Villa A. , Strina D. , Sacco M.G. , Morali F. , Brugnoni D. , Giliani S. , Mantuano E. , Fasth A. , Andersson B. , Zegers B.J.M. , Cavagni G. , Reznick I. , Levy J. , Zan-Bar I. , Porat Y. , Airo P. , Plebani A. , more...
Am. J. Hum. Genet.56:898-906(1995) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS HIGM1 ALA-126; ARG-140 AND GLU-144
17.

"Signaling through CD40 rescues IgE but not IgG or IgA secretion in X-linked immunodeficiency with hyper-IgM."
Saiki O. , Tanaka T. , Wada Y. , Uda H. , Inoue A. , Katada Y. , Izeki M. , Iwata M. , Nunoi H. , Matsuda I.
J. Clin. Invest.95:510-514(1995) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT HIGM1 GLU-237
18.

"Mutation analysis in CD40 ligand deficiency leading to X-linked hypogammaglobulinemia with hyper IgM syndrome."
Katz F. , Hinshelwood S. , Rutland P. , Jones A. , Kinnon C. , Morgan G.
Hum. Mutat.8:223-228(1996) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS HIGM1 ARG-38; ARG-125; ARG-174 AND SER-257
19.

"A single strand conformation polymorphism study of CD40 ligand. Efficient mutation analysis and carrier detection for X-linked hyper IgM syndrome."
Lin Q. , Rohrer J. , Allen R.C. , Larche M. , Greene J.M. , Shigeoka A.O. , Gatti R.A. , Derauf D.C. , Belmont J.W. , Conley M.E.
J. Clin. Invest.97:196-201(1996) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS HIGM1 PRO-155 AND VAL-227;VARIANT ARG-219
20.

"Mutations of the CD40 ligand gene in 13 Japanese patients with X-linked hyper-IgM syndrome."
Nonoyama S. , Shimadzu M. , Toru H. , Seyama K. , Nunoi H. , Neubauer M. , Yata J. , Och H.D.
Hum. Genet.99:624-627(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS HIGM1 ARG-36; CYS-140; GLY-227 DEL; SER-231 AND MET-254
21.

"Mutations of the CD40 ligand gene and its effect on CD40 ligand expression in patients with X-linked hyper IgM syndrome."
Seyama K. , Nonoyama S. , Gangsaas I. , Hollenbaugh D. , Pabst H.F. , Aruffo A. , Ochs H.D.
Blood92:2421-2434(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS HIGM1 SER-116; ASN-147; CYS-170; VAL-227; SER-231; PRO-235; MET-254 AND SER-258

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