CD59 ELISA Kit for Human(Homo sapiens) | EIAab.comCD59 ELISA Kit for Human(Homo sapiens)

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Index > Protein center > CD59(Gene name) > Human

CD59 (Gene name),

CD59 glycoprotein (Protein name ), CD59_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

Citations (1)

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Gene name:

CD59(MIC11;MIN1;MIN2;MIN3;MSK21);

Protein name:

CD59 glycoprotein;

Alternative:

20 kDa homologous restriction factor(HRF-20;HRF20);1F5 antigen;MEM43 antigen;MAC-inhibitory protein(MAC-IP);Membrane inhibitor of reactive lysis(MIRL);Membrane attack complex inhibition factor(MACIF);Protectin;

CD:

CD59;

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Interacts with T-cell surface antigen CD2.

Function:

The soluble form from urine retains its specific complement binding activity, but exhibits greatly reduced ability to inhibit MAC assembly on cell membranes.

Subcellular Location:

Cell membrane Lipid-anchor GPI-anchor Secreted Soluble form found in a number of tissues.

Protein Attributes:

Sequence length:

128

Sequence:

50:

100:

128:

ENGGTSLSEK | TVLLLVTPFL | AAAWSLHP

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

STRING:

9606.ENSP00000340210

KEGG:

hsa:966

String:

P13987

SMR:

P13987

MIM:

107271

UniGene:

Hs.278573

Pfam:

PF00021

Uniprot:

P13987

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ELISA Kit for Human CD59 glycoprotein

Cat.:

E2116h

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Packing:

96T

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ELISA Kit for Human CD59 glycoprotein

Cat.:

E2116r

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96T

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ELISA Kit for Human CD59 glycoprotein

Cat.:

E2116p

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96T

ELISA Kit for Human CD59 glycoprotein

MSDS:

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CLIA Kit for Human CD59 glycoprotein

Cat.:

U2116p

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Packing:

96T

CLIA Kit for Human CD59 glycoprotein

Cat.:

U2116r

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Manual:

Looking for manual.

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96T

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CLIA Kit for Human CD59 glycoprotein

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CLIA Kit for Human CD59 glycoprotein

Cat.:

U2116h

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96T

Polyclonal Antibody for Human CD59 glycoprotein

Cat.:

P2116Rb-h

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40ug/0.2ml

Polyclonal Antibody for Human CD59 glycoprotein

Cat.:

P2116Rb-r

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Packing:

40ug/0.2ml

Polyclonal Antibody for Human CD59 glycoprotein

Monoclonal Antibody for Human CD59 glycoprotein

Protein for Human CD59 glycoprotein

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

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Linearity

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Citations

[1].

"Effect of IL-6 and IL-8 on the expression of the complement activation inhibitors MAC-inhibitory protein and decay-accelerating factor in ovarian cancer A2780 cells"

Kapka-Skrzypczak L, Popek S, Sawicki K, et al.

From:Oncology Letters

References

1.

"CD59, an LY-6-like protein expressed in human lymphoid cells, regulates the action of the complement membrane attack complex on homologous cells."
Davies A. , Simmons D.L. , Hale G. , Harrison R.A. , Tighe H. , Lachmann P.J. , Waldmann H.
J. Exp. Med.170:637-654(1989) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
tissue: T-cell.
2.

"The CD59 antigen is a structural homologue of murine Ly-6 antigens but lacks interferon inducibility."
Philbrick W.M. , Palfree R.G.E. , Roger G.E. , Maher S.E. , Bridgett M.M. , Sirlin S. , Bothwell A.L.M.
Eur. J. Immunol.20:87-92(1990) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
3.

"20 KDa homologous restriction factor of complement resembles T cell activating protein."
Okada H. , Nagami Y. , Takahashi K. , Okada N. , Hideshima T. , Takizawa H. , Kondo J.
Biochem. Biophys. Res. Commun.162:1553-1559(1989) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
4.

"Molecular cloning and characterization of MACIF, an inhibitor of membrane channel formation of complement."
Sugita Y. , Tobe T. , Oda E. , Tomita M. , Yasukawa K. , Yamaji N. , Takemoto T. , Furuichi K. , Takayama M. , Yano S.
J. Biochem.106:555-557(1989) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
5.

"Isolation and expression of the full-length cDNA encoding CD59 antigen of human lymphocytes."
Sawada R. , Ohashi K. , Anaguchi H. , Okazaki H. , Hattori M. , Minato N. , Naruto M.
DNA Cell Biol.9:213-220(1990) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
6.

"Structure of the CD59-encoding gene: further evidence of a relationship to murine lymphocyte antigen Ly-6 protein."
Petranka J.G. , Fleenor D.E. , Sykes K. , Kaufman R.E. , Rosse W.F.
Proc. Natl. Acad. Sci. U.S.A.89:7876-7879(1992) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
7.

"Gene structure of human CD59 and demonstration that discrete mRNAs are generated by alternative polyadenylation."
Tone M. , Walsh L.A. , Waldmann H.
J. Mol. Biol.227:971-976(1992) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
tissue: Blood.
8.

"Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
Kalnine N. , Chen X. , Rolfs A. , Halleck A. , Hines L. , Eisenstein S. , Koundinya M. , Raphael J. , Moreira D. , Kelley T. , LaBaer J. , Lin Y. , Phelan M. , Farmer A.
Submitted (2003-05) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
9.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
tissue: Colon.
10.

"Complementary DNA sequence and deduced peptide sequence for CD59/MEM-43 antigen, the human homologue of murine lymphocyte antigen Ly-6C."
Sawada R. , Ohashi K. , Okano K. , Hattori M. , Minato N. , Naruto M.
Nucleic Acids Res.17:6728-6728(1989) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 27-128
11.

"Structural composition and functional characterization of soluble CD59: heterogeneity of the oligosaccharide and glycophosphoinositol (GPI) anchor revealed by laser-desorption mass spectrometric analysis."
Meri S. , Lehto T. , Sutton C.W. , Tyynelaa J. , Baumann M.
Biochem. J.316:923-935(1996) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE;IDENTIFICATION BY MASS SPECTROMETRY;GLYCOSYLATION AT ASN-43;STRUCTURE OF CARBOHYDRATES
12.

"Determination of carboxyl-terminal residue and disulfide bonds of MACIF (CD59), a glycosyl-phosphatidylinositol-anchored membrane protein."
Sugita Y. , Nakano Y. , Oda E. , Noda K. , Tobe T. , Miura N.H. , Tomita M.
J. Biochem.114:473-477(1993) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GPI-ANCHOR AT ASN-102;DISULFIDE BONDS
13.

"The human complement regulatory protein CD59 binds to the alpha-chain of C8 and to the ''b'' domain of C9."
Ninomiya H. , Sims P.J.
J. Biol. Chem.267:13675-13680(1992) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH C8 AND C9
14.

"Mapping the regions of the complement inhibitor CD59 responsible for its species selective activity."
Yu J. , Dong S. , Rushmere N.K. , Morgan B.P. , Abagyan R. , Tomlinson S.
Biochemistry36:9423-9428(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION OF COMPLEMENT INHIBITORY DOMAIN
15.

"Mutational analysis of the active site and antibody epitopes of the complement-inhibitory glycoprotein, CD59."
Bodian D.L. , Davis S.J. , Morgan B.P. , Rushmere N.K.
J. Exp. Med.185:507-516(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: MUTAGENESIS
16.

"The glycosylation of the complement regulatory protein, human erythrocyte CD59."
Rudd P.M. , Morgan B.P. , Wormald M.R. , Harvey D.J. , van den Berg C.W. , Davis S.J. , Ferguson M.A. , Dwek R.A.
J. Biol. Chem.272:7229-7244(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE OF CARBOHYDRATES;STRUCTURE OF THE GPI-ANCHOR;PROTEIN SEQUENCE OF N-TERMINUS
17.

"Molecular basis for a link between complement and the vascular complications of diabetes."
Acosta J. , Hettinga J. , Flueckiger R. , Krumrei N. , Goldfine A. , Angarita L. , Halperin J.
Proc. Natl. Acad. Sci. U.S.A.97:5450-5455(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INHIBITION BY GLYCATION;GLYCATION AT LYS-66 AND HIS-69;MUTAGENESIS OF LYS-66 AND HIS-69
18.

"Proteomic analysis of glycosylphosphatidylinositol-anchored membrane proteins."
Elortza F. , Nuehse T.S. , Foster L.J. , Stensballe A. , Peck S.C. , Jensen O.N.
Mol. Cell. Proteomics2:1261-1270(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GPI-ANCHOR [LARGE SCALE ANALYSIS]
tissue: Cervix carcinoma.
19.

"Modification-specific proteomics of plasma membrane proteins: identification and characterization of glycosylphosphatidylinositol-anchored proteins released upon phospholipase D treatment."
Elortza F. , Mohammed S. , Bunkenborg J. , Foster L.J. , Nuehse T.S. , Brodbeck U. , Peck S.C. , Jensen O.N.
J. Proteome Res.5:935-943(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GPI-ANCHOR [LARGE SCALE ANALYSIS]
tissue: Cervix carcinoma.
20.

"Computational approach for identification and characterization of GPI-anchored peptides in proteomics experiments."
Omaetxebarria M.J. , Elortza F. , Rodriguez-Suarez E. , Aloria K. , Arizmendi J.M. , Jensen O.N. , Matthiesen R.
Proteomics7:1951-1960(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GPI-ANCHOR AT ASN-102;IDENTIFICATION BY MASS SPECTROMETRY
21.

"Identification of N-linked glycoproteins in human milk by hydrophilic interaction liquid chromatography and mass spectrometry."
Picariello G. , Ferranti P. , Mamone G. , Roepstorff P. , Addeo F.
Proteomics8:3833-3847(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-43
tissue: Milk.
22.

"Initial characterization of the human central proteome."
Burkard T.R. , Planyavsky M. , Kaupe I. , Breitwieser F.P. , Buerckstuemmer T. , Bennett K.L. , Superti-Furga G. , Colinge J.
BMC Syst. Biol.5:17-17(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
23.

"Three-dimensional solution structure of the extracellular region of the complement regulatory protein CD59, a new cell-surface protein domain related to snake venom neurotoxins."
Kieffer B. , Driscoll P.C. , Campbell I.D. , Willis A.C. , van der Merwe P.A. , Davis S.J.
Biochemistry33:4471-4482(1994) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE BY NMR OF 26-95
24.

"Structure of a soluble, glycosylated form of the human complement regulatory protein CD59."
Fletcher C.M. , Harrison R.A. , Lachmann P.J. , Neuhaus D.
Structure2:185-199(1994) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE BY NMR OF 26-102
tissue: Urine.
25.

"Paroxysmal nocturnal hemoglobinuria due to hereditary nucleotide deletion in the HRF20 (CD59) gene."
Motoyama N. , Okada N. , Yamashina M. , Okada H.
Eur. J. Immunol.22:2669-2673(1992) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INVOLVEMENT IN HACD59
26.

"CD59 deficiency is associated with chronic hemolysis and childhood relapsing immune-mediated polyneuropathy."
Nevo Y. , Ben-Zeev B. , Tabib A. , Straussberg R. , Anikster Y. , Shorer Z. , Fattal-Valevski A. , Ta-Shma A. , Aharoni S. , Rabie M. , Zenvirt S. , Goldshmidt H. , Fellig Y. , Shaag A. , Mevorach D. , Elpeleg O.
Blood121:129-135(2013) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT HACD59 TYR-89

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