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Index > Protein center > CD68(Gene name) > Human
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  • CD68 (Gene name),
  • Macrosialin (Protein name ),  CD68_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    CD68;
    Protein name:
    Macrosialin;
    Alternative:
    Gp110;
    CD:
    CD68;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Function:
    Could play a role in phagocytic activities of tissue macrophages, both in intracellular lysosomal metabolism and extracellular cell-cell and cell-pathogen interactions. Binds to tissue- and organ-specific lectins or selectins, allowing homing of macrophage subsets to particular sites. Rapid recirculation of CD68 from endosomes and lysosomes to the plasma membrane may allow macrophages to crawl over selectin-bearing substrates or other cells.
    Subcellular Location:
    Isoform Long Endosome membrane Single-pass type I membrane protein Lysosome membrane Single-pass type I membrane protein
    Protein Attributes:
    Sequence length:
    354
    Sequence:
    50:
    MRLAVLFSGA | LLGLLAAQGT | GNDCPHKKSA | TLLPSFTVTP | TVTESTGTTS | 
    100:
    HRTTKSHKTT | THRTTTTGTT | SHGPTTATHN | PTTTSHGNVT | VHPTSNSTAT | 
    150:
    SQGPSTATHS | PATTSHGNAT | VHPTSNSTAT | SPGFTSSAHP | EPPPPSPSPS | 
    200:
    PTSKETIGDY | TWTNGSQPCV | HLQAQIQIRV | MYTTQGGGEA | WGISVLNPNK | 
    250:
    TKVQGSCEGA | HPHLLLSFPY | GHLSFGFMQD | LQQKVVYLSY | MAVEYNVSFP | 
    300:
    HAAQWTFSAQ | NASLRDLQAP | LGQSFSCSNS | SIILSPAVHL | DLLSLRLQAA | 
    350:
    QLPHTGVFGQ | SFSCPSDRSI | LLPLIIGLIL | LGLLALVLIA | FCIIRRRPSA | 
    354:
    YQAL
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    SMR:
    MIM:
    KEGG:
    Pfam:
    String:
    UniGene:
    Uniprot:
     
    FOR
    ELISA Kit for Human Macrosialin
    Cat.:
    E2303h
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    MSDS:
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    Packing:
    96T
    Range:
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    ELISA Kit for Human Macrosialin
    Cat.:
    E2303m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Human Macrosialin
    Cat.:
    U2303m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Human Macrosialin
    Cat.:
    U2303h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Polyclonal Antibody for Human Macrosialin
    Cat.:
    P2303Rb-m
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Macrosialin
    Cat.:
    P2303Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Human Macrosialin
    Monoclonal Antibody for Human Macrosialin
    Protein for Human Macrosialin
    Protein for Human Macrosialin

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    Recovery
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    Linearity
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    References
    1. 1.
      "Molecular cloning of CD68, a human macrophage marker related to lysosomal glycoproteins."
      Holness C.L. , Simmons D.L.
      Blood81:1607-1613(1993) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS LONG AND SHORT);VARIANT LYS-254
    2. 2.
      "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
      Kalnine N. , Chen X. , Rolfs A. , Halleck A. , Hines L. , Eisenstein S. , Koundinya M. , Raphael J. , Moreira D. , Kelley T. , LaBaer J. , Lin Y. , Phelan M. , Farmer A.
      Submitted (2003-07) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM LONG)
    3. 3.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS LONG AND 3)
      tissue: Spleen.
      tissue: Umbilical cord blood.
    4. 4.
      Suzuki Y. , Sugano S. , Totoki Y. , Toyoda A. , Takeda T. , Sakaki Y. , Tanaka A. , Yokoyama S.
      Submitted (2005-04) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM LONG)
      tissue: Adipose tissue.
    5. 6.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    6. 7.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM LONG)
      tissue: Skin.
    7. 8.
      "The linked human elongation initiation factor 4A1 (EIF4A1) and CD68 genes map to chromosome 17p13."
      Jones E. , Quinn C.M. , See C.G. , Montgomery D.S. , Ford M.J. , Koelble K. , Gordon S. , Greaves D.R.
      Genomics53:248-250(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-28
    8. 9.
      "Macrophage specificity of three anti-CD68 monoclonal antibodies (KP1, EBM11, and PGM1) widely used for immunohistochemistry and flow cytometry."
      Kunisch E. , Fuhrmann R. , Roth A. , Winter R. , Lungershausen W. , Kinne R.W.
      Ann. Rheum. Dis.63:774-784(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: USE AS A MACROPHAGE MARKER
    9. 10.
      "CD68 is not a macrophage-specific antigen."
      Beranek J.T.
      Ann. Rheum. Dis.64:342-343(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: USE AS A MACROPHAGE MARKER
    10. 11.
      "Elucidation of N-glycosylation sites on human platelet proteins: a glycoproteomic approach."
      Lewandrowski U. , Moebius J. , Walter U. , Sickmann A.
      Mol. Cell. Proteomics5:226-233(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-261
      tissue: Platelet.
    11. 12.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: TISSUE SPECIFICITY
    12. 13.
      "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
      Chen R. , Jiang X. , Sun D. , Han G. , Wang F. , Ye M. , Wang L. , Zou H.
      J. Proteome Res.8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-199; ASN-261 AND ASN-279
      tissue: Liver.
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