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Index > Protein center > Cdc20(Gene name) > Mouse
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  • Cdc20 (Gene name),
  • Cell division cycle protein 20 homolog (Protein name ),  CDC20_MOUSE from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    Cdc20;
    Protein name:
    Cell division cycle protein 20 homolog(mmCdc20);
    Alternative:
    p55CDC;
    Organism:
    Mouse (Mus musculus). 
    General Annotation
    Sub Unit:
    Interacts with MAD2L1 and BUB1B. The phosphorylated form interacts with APC/C. Interacts with NINL and MAD2L1. Interacts with CDK5RAP2 (By similarity). Found in a complex with CDC20, CDC27, SPATC1 and TUBG1. Interacts with SPATC1. Interacts with NEUROD2. Interacts with NEK2.
    Function:
    Required for full ubiquitin ligase activity of the anaphase promoting complex/cyclosome (APC/C) and may confer substrate specificity upon the complex. Is regulated by MAD2L1. In metaphase the MAD2L1-CDC20-APC/C ternary complex is inactive and in anaphase the CDC20-APC/C binary complex is active in degrading substrates. The CDC20-APC/C complex positively regulates the formation of synaptic vesicle clustering at active zone to the presynaptic membrane in postmitotic neurons. CDC20-APC/C-induced degradation of NEUROD2 induces presynaptic differentiation.
    Subcellular Location:
    Cytoplasm cytoskeleton centrosome Cytoplasm cytoskeleton spindle pole
    Protein Attributes:
    Sequence length:
    499
    Sequence:
    50:
    MAQFVFESDL | HSLLQLDAPI | PNAPVARWQR | KAKEATGPAP | SPMRAANRSH | 
    100:
    SAGRTPGRTP | GKSSSKVQTT | PSKPGGDRFI | PQRSASQMEV | ASFLLSKENQ | 
    150:
    PEDRGTPTKK | EHQKAWSLNL | NGFDVEEAKI | LRLSGKPQNA | PEGYQNRLKV | 
    200:
    LYSQKATPGS | SRKTCRYIPS | LPDRILDAPE | IRNDYYLNLV | DWSSGNVLAV | 
    250:
    ALDNSVYLWN | AGSGDILQLL | QMEQPGDYIS | SVAWIKEGNY | LAVGTSNAEV | 
    300:
    QLWDVQQQKR | LRNMTSHSAR | VSSLSWNSYI | LSSGSRSGHI | HHHDVRVAEH | 
    350:
    HVATLSGHSQ | EVCGLRWAPD | GRHLASGGND | NIVNVWPSGP | GESGWAPLQT | 
    400:
    FTQHQGAVKA | VAWCPWQSNI | LATGGGTSDR | HIRIWNVCSG | ACLSAVDVHS | 
    450:
    QVCSILWSPH | YKELISGHGF | AQNQLVIWKY | PTMAKVAELK | GHTARVLGLT | 
    499:
    MSPDGATVAS | AAADETLRLW | RCFEMDPALR | REREKASVAK | SSLIHQGIR
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    SMR:
    UniGene:
    Pfam:
    String:
    Uniprot:
     
    FOR
    ELISA Kit for Mouse mmCdc20
    ELISA Kit for Mouse mmCdc20
    ELISA Kit for Mouse mmCdc20
    ELISA Kit for Mouse mmCdc20
    CLIA Kit for Mouse mmCdc20
    CLIA Kit for Mouse mmCdc20
    CLIA Kit for Mouse mmCdc20
    CLIA Kit for Mouse mmCdc20
    Polyclonal Antibody for Mouse mmCdc20
    Polyclonal Antibody for Mouse mmCdc20
    Polyclonal Antibody for Mouse mmCdc20
    Polyclonal Antibody for Mouse mmCdc20
    Monoclonal Antibody for Mouse mmCdc20
    Monoclonal Antibody for Mouse mmCdc20
    Monoclonal Antibody for Mouse mmCdc20
    Monoclonal Antibody for Mouse mmCdc20
    Protein for Mouse mmCdc20
    Protein for Mouse mmCdc20
    Protein for Mouse mmCdc20
    Protein for Mouse mmCdc20

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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      "Mus musculus CDC20 mRNA, complete cds."
      Kuroda M. , Oikawa K. , Ohbayashi T. , Iwata R. , Kameta A. , Ebine K.
      Submitted (2000-06) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
    2. 2.
      "Ssc1/Elovl1 and p55Cdc genes are co-expressed in a tail-to-tail array in proliferating cells."
      Asadi A. , Jacobsson A.
      Submitted (2000-10) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
    3. 3.
      "The transcriptional landscape of the mammalian genome."
      Carninci P. , Kasukawa T. , Katayama S. , Gough J. , Frith M.C. , Maeda N. , Oyama R. , Ravasi T. , Lenhard B. , Wells C. , Kodzius R. , Shimokawa K. , Bajic V.B. , Brenner S.E. , Batalov S. , Forrest A.R. , Zavolan M. , Davis M.J. , more...
      Science309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      strain: C57BL/6J.
      tissue: Kidney.
    4. 4.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      tissue: Mammary tumor.
    5. 5.
      Lubec G. , Sunyer B. , Chen W.-Q.
      Submitted (2009-01) to the UniProtKB
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 59-66;IDENTIFICATION BY MASS SPECTROMETRY
      strain: OF1.
      tissue: Hippocampus.
    6. 6.
      "Speriolin is a novel spermatogenic cell-specific centrosomal protein associated with the seventh WD motif of Cdc20."
      Goto M. , Eddy E.M.
      J. Biol. Chem.279:42128-42138(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH SPATC1;IDENTIFICATION IN A COMPLEX WITH CDC27; SPATC1 AND TUBG1
    7. 7.
      "A Cdc20-APC ubiquitin signaling pathway regulates presynaptic differentiation."
      Yang Y. , Kim A.H. , Yamada T. , Wu B. , Bilimoria P.M. , Ikeuchi Y. , de la Iglesia N. , Shen J. , Bonni A.
      Science326:575-578(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH NEUROD2
    8. 8.
      "SIRT2 maintains genome integrity and suppresses tumorigenesis through regulating APC/C activity."
      Kim H.S. , Vassilopoulos A. , Wang R.H. , Lahusen T. , Xiao Z. , Xu X. , Li C. , Veenstra T.D. , Li B. , Yu H. , Ji J. , Wang X.W. , Park S.H. , Cha Y.I. , Gius D. , Deng C.X.
      Cancer Cell20:487-499(2011) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ACETYLATION;DEACETYLATION BY SIRT2;INTERACTION WITH SIRT2
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