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Index > Protein center > Cdc20(Gene name) > Rat
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  • Cdc20 (Gene name),
  • Cell division cycle protein 20 homolog (Protein name ),  CDC20_RAT from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    Cdc20;
    Protein name:
    Cell division cycle protein 20 homolog;
    Alternative:
    p55CDC;
    Organism:
    Rat (Rattus norvegicus). 
    General Annotation
    Sub Unit:
    Found in a complex with CDC20, CDC27, SPATC1 and TUBG1. Interacts with MAD2L1, BUB1B and SPATC1. The phosphorylated form interacts with APC/C. Interacts with NINL and MAD2L1 (By similarity). Interacts with CDK5RAP2. Interacts with NEUROD2.
    Function:
    Required for full ubiquitin ligase activity of the anaphase promoting complex/cyclosome (APC/C) and may confer substrate specificity upon the complex. Is regulated by MAD2L1. In metaphase the MAD2L1-CDC20-APC/C ternary complex is inactive and in anaphase the CDC20-APC/C binary complex is active in degrading substrates. The CDC20-APC/C complex positively regulates the formation of synaptic vesicle clustering at active zone to the presynaptic membrane in postmitotic neurons. CDC20-APC/C-induced degradation of NEUROD2 induces presynaptic differentiation (By similarity). Interacts with NEK2.
    Subcellular Location:
    Cytoplasm cytoskeleton centrosome Cytoplasm cytoskeleton spindle pole
    Protein Attributes:
    Sequence length:
    499
    Sequence:
    50:
    MAQFVFESDL | HSLLQLDAPI | PNAPIARWQR | KAKEATGPAP | SPMRAANRSH | 
    100:
    SAGRTPGRTP | GKSNSKVQTT | PSKPGGDRYI | PQRSASQMEV | ASFLLSKENQ | 
    150:
    PEDGGTPTKK | EHQKAWARNL | NGFDVEEAKI | LRLSGKPQNA | PEGYQNRLKV | 
    200:
    LYSQKATPGS | SRKACRYIPS | LPDRILDAPE | IRNDYYLNLV | DWSSGNVLAV | 
    250:
    ALDNSVYLWN | AGSGDILQLL | QMEQPGDYIS | SVAWIKEGNY | LAVGTSNAEV | 
    300:
    QLWDVQQQKR | LRNMTSHSAR | VSSLSWNSYI | LSSGSRSGHI | HHHDVRVAEH | 
    350:
    HVATLSGHSQ | EVCGLRWAPD | GRHLASGGND | NIVNVWPSGP | GESGWVPLQT | 
    400:
    FTQHQGAVKA | VAWCPWQSNI | LATGGGTSDR | HIRIWNVCSG | ACLSAVDVHS | 
    450:
    QVCSILWSPH | YKELISGHGF | AQNQLVIWKY | PTMAKVAELK | GHTARVLSLT | 
    499:
    MSPDGATVAS | AAADETLRLW | RCFELDPALR | REREKASTSK | SSLIHQGIR
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    String:
    Pfam:
    UniGene:
    KEGG:
    Uniprot:
     
    FOR
    ELISA Kit for Rat Cell division cycle protein 20 homolog
    ELISA Kit for Rat Cell division cycle protein 20 homolog
    ELISA Kit for Rat Cell division cycle protein 20 homolog
    ELISA Kit for Rat Cell division cycle protein 20 homolog
    CLIA Kit for Rat Cell division cycle protein 20 homolog
    CLIA Kit for Rat Cell division cycle protein 20 homolog
    CLIA Kit for Rat Cell division cycle protein 20 homolog
    CLIA Kit for Rat Cell division cycle protein 20 homolog
    Polyclonal Antibody for Rat Cell division cycle protein 20 homolog
    Polyclonal Antibody for Rat Cell division cycle protein 20 homolog
    Polyclonal Antibody for Rat Cell division cycle protein 20 homolog
    Polyclonal Antibody for Rat Cell division cycle protein 20 homolog
    Monoclonal Antibody for Rat Cell division cycle protein 20 homolog
    Monoclonal Antibody for Rat Cell division cycle protein 20 homolog
    Monoclonal Antibody for Rat Cell division cycle protein 20 homolog
    Monoclonal Antibody for Rat Cell division cycle protein 20 homolog
    Protein for Rat Cell division cycle protein 20 homolog
    Protein for Rat Cell division cycle protein 20 homolog
    Protein for Rat Cell division cycle protein 20 homolog
    Protein for Rat Cell division cycle protein 20 homolog

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    References
    1. 1.
      "A novel mammalian protein, p55CDC, present in dividing cells is associated with protein kinase activity and has homology to the Saccharomyces cerevisiae cell division cycle proteins Cdc20 and Cdc4."
      Weinstein J. , Jacobsen F.W. , Hsu-Chen J. , Wu T. , Baum L.G.
      Mol. Cell. Biol.14:3350-3363(1994) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
      tissue: Spleen.
    2. 2.
      "Genomic organization, 5' flanking enhancer region, and chromosomal assignment of the cell cycle gene, p55Cdc."
      Weinstein J. , Karim J. , Geschwind D.H. , Nelson S.F. , Krumm J. , Sakamoto K.M.
      Mol. Genet. Metab.64:52-57(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
    3. 3.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      tissue: Testis.
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