Protein name:
    Cyclin-dependent kinase 12 ;
    
    Alternative:
    
    Cell division protein kinase 12 ;
    
    
 
    Organism:
        
        
        
        
        
        
    
        Bovine  (Bos taurus).  
    
 
General Annotation
    Sub Unit:
    Interacts with CCNL1 and CCNL2.
    
 
    Function:
    Cyclin-dependent kinase which displays CTD kinase activity and is required for RNA splicing. Has CTD kinase activity by hyperphosphorylating the C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit RPB1, thereby acting as a key regulator of transcription elongation. Required for RNA splicing, possibly by phosphorylating SRSF1/SF2. Involved in regulation of MAP kinase activity, possibly leading to affect the response to estrogn inhibitors.
    
 
    
        
        Subcellular Location:
        
    
     
     
      Nucleus 
      
     
      Nucleus speckle 
      
    Colocalized with nuclear speckles throughout interphase. 
  
    
 
    
    Protein Attributes:
    
    50:
    MPNPERHGGK |  KDGSGGASGT |  LQPSSGGGSS |  NSRERHRLGS |  KHKRHKSKHS |  
    
 
    100:
    KDMGLVTPEA |  APLGTVIKPL |  VEYDDISSDS |  DTFSDDLAFK |  VDRRENDERR |  
    
 
    150:
    GTDRSDRLHK |  HRHHQHRRTR |  DLLKTKQTEK |  EKNLEASSKS |  GSTKDRISGS |  
    
 
    200:
    SKRSNEENDD |  HGKAQISKSS |  NKESRSSKLH |  KEKTRKEREL |  KSGHKDRSKS |  
    
 
    250:
    HRKRETPKSY |  KTVDSPKRRS |  RSPHRKWSDS |  PKQDDSPSGA |  SYGQDYDLSP |  
    
 
    300:
    PRSHTSSNYD |  SYKKSPGSTS |  RRQSISPPYK |  EPSAYQSSTR |  SPSPYSRRQR |  
    
 
    350:
    SVSPYSRRRS |  SSYERSGSYS |  GRSPSPYGRR |  RSSSPFLSKR |  SLSRSPLPSR |  
    
 
    400:
    KSMKSRSRSP |  AYSRHSSSHS |  KKKRSGSRSR |  HSSISPVRLP |  LNSSLGAELS |  
    
 
    450:
    RKKKERAAAA |  AAAKMDGKES |  KGSPIFLPKK |  ENSSVEAKDS |  GLEPKKLPRG |  
    
 
    500:
    VKLEKSAPDT |  ELVNVTHLNT |  EVKNSLDTGK |  VKLDENSEKH |  PVLKDTKVQG |  
    
 
    550:
    TKDSKPVALK |  EEIVTPKETE |  TSEKETLPPL |  PTVTSPPPLP |  TTTPPPQTPP |  
    
 
    600:
    LPPLPPLPAI |  PQQPPLPPPQ |  PTFSQVLSSS |  TSTLPPSVHP |  RTSTLSSQAN |  
    
 
    650:
    SQPSVQVSVK |  TQVSVTAAIP |  HLKTSTLPPL |  PLPPLLLGDD |  DMDSPKETLP |  
    
 
    700:
    SKPVKKEKEQ |  RPRHLLTDLP |  LPPELPGGDP |  SPPDSPEPKA |  ITPPQQPYKK |  
    
 
    750:
    RPKICCPRYG |  ERRQTESDWG |  KRCVDKFDII |  GIIGEGTYGQ |  VYKAKDKDTG |  
    
 
    800:
    ELVALKKVRL |  DNEKEGFPIT |  AIREIKILRQ |  LIHRSVVNMK |  EIVTDKQDAL |  
    
 
    850:
    DFKKDKGAFY |  LVFEYMDHDL |  MGLLESGLVH |  FSEDHIKSFM |  KQLMEGLDYC |  
    
 
    900:
    HKKNFLHRDI |  KCSNILLNNS |  GQIKLADFGL |  ARLYNSEESR |  PYTNKVITLW |  
    
 
    950:
    YRPPELLLGE |  ERYTPAIDVW |  SCGCILGELF |  TKKPIFQANL |  ELAQLELISR |  
    
 
    1000:
    LCGSPCPAVW |  PDVIKLPYFN |  TMKPKKQYRR |  RLREEFSFFF |  LPWGALDLLD |  
    
 
    1050:
    HMLTLDPSKR |  CTAEQTLQSD |  FLKDVELSKM |  DPPDLPHWQD |  CHELWSKKRR |  
    
 
    1100:
    RQRQSGVLVE |  EPPPPKASRK |  ETISGTSAEP |  VKNSSPAPPQ |  PAPGKVEPGA |  
    
 
    1150:
    GDAIGLGDIT |  QQLNQSELAV |  LLNLLQSQTD |  LSIPQMAQLL |  NIHSNPEMQQ |  
    
 
    1200:
    QLEALNQSIS |  ALTAATSQQQ |  DSEPTAPEES |  LKEIAPAPAV |  QPSAEQTTPE |  
    
 
    1250:
    ASSTPADMQN |  MLAVLLSQLM |  KTQEPAGNLE |  ENNSDKNSGP |  QGPRRTPTMP |  
    
 
      Vaild Sequence:
    
 
Related Databases
Uniprot:
 
 
    
        
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        ELISA Kit for Bovine Cyclin-dependent kinase 12
        
     
    
    
    
    
   
    
    
    
    
    
    
    
    
    
    
    
    
 
    
        ELISA Kit for Bovine Cyclin-dependent kinase 12
        
     
    
    
    
    
   
    
    
    
    
    
    
    
    
    
    
    
    
 
    
        ELISA Kit for Bovine Cyclin-dependent kinase 12
        
     
    
    
    
    
   
    
    
    
    
    
    
    
    
    
    
    
    
 
    
        ELISA Kit for Bovine Cyclin-dependent kinase 12
        
     
    
    
    
    
   
    
    
    
    
    
    
    
    
 
    
        CLIA Kit for Bovine Cyclin-dependent kinase 12
        
     
    
    
    
    
   
    
    
    
    
    
    
    
    
    
    
    
    
 
    
        CLIA Kit for Bovine Cyclin-dependent kinase 12
        
     
    
    
    
    
   
    
    
    
    
    
    
    
    
 
    
        CLIA Kit for Bovine Cyclin-dependent kinase 12
        
     
    
    
    
    
   
    
    
    
    
    
    
    
    
 
    
        CLIA Kit for Bovine Cyclin-dependent kinase 12
        
     
    
    
    
    
   
    
    
    
    
    
    
    
    
 
    
        Polyclonal Antibody for Bovine Cyclin-dependent kinase 12
        
     
    
    
    
    
   
    
    
    
    
    
    
 
    
        Polyclonal Antibody for Bovine Cyclin-dependent kinase 12
        
     
    
    
    
    
   
    
    
    
    
    
    
 
    
        Polyclonal Antibody for Bovine Cyclin-dependent kinase 12
        
     
    
    
    
    
    
    
 
    
        Polyclonal Antibody for Bovine Cyclin-dependent kinase 12
        
     
    
    
    
    
    
    
 
    
        Monoclonal Antibody for Bovine Cyclin-dependent kinase 12
        
     
    
    
    
    
    
    
 
    
        Monoclonal Antibody for Bovine Cyclin-dependent kinase 12
        
     
    
    
    
    
    
    
 
    
        Monoclonal Antibody for Bovine Cyclin-dependent kinase 12
        
     
    
    
    
    
    
    
 
    
        Monoclonal Antibody for Bovine Cyclin-dependent kinase 12
        
     
    
    
    
    
    
    
 
    
        Protein for Bovine Cyclin-dependent kinase 12
        
     
    
    
    
    
    
    
 
    
        Protein for Bovine Cyclin-dependent kinase 12
        
     
    
    
    
    
    
    
 
    
        Protein for Bovine Cyclin-dependent kinase 12
        
     
    
    
    
    
    
    
 
    
        Protein for Bovine Cyclin-dependent kinase 12
        
     
    
    
    
    
    
    
 
 
 
 
 
 
 
 
    R&D Technical Data
    
    
    
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    Precision
    
    
    
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    Recovery
    
    
    
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    Linearity
    
    
    
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    References
    
    
        
            
        
            
                1.
                
                    
                    
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                        Cited for NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]