Cdk12 ELISA Kit for Mouse(Mus musculus) | EIAab.comCdk12 ELISA Kit for Mouse(Mus musculus)

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Index > Protein center > Cdk12(Gene name) > Mouse

Cdk12 (Gene name),

Cyclin-dependent kinase 12 (Protein name ), CDK12_MOUSE from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

Cdk12(Crk7;Crkrs;Kiaa0904);

Protein name:

Cyclin-dependent kinase 12;

Alternative:

Cell division cycle 2-related protein kinase 7(CDC2-related protein kinase 7);Cdc2-related kinase, arginine/serine-rich(CrkRS);Cell division protein kinase 12;

Organism:

Mouse (Mus musculus).

General Annotation

Sub Unit:

Interacts with CCNL1 and CCNL2.

Function:

Cyclin-dependent kinase which displays CTD kinase activity and is required for RNA splicing. Has CTD kinase activity by hyperphosphorylating the C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit RPB1, thereby acting as a key regulator of transcription elongation. Required for RNA splicing, possibly by phosphorylating SRSF1/SF2. Involved in regulation of MAP kinase activity, possibly leading to affect the response to estrogn inhibitors.

Subcellular Location:

Nucleus Nucleus speckle Colocalized with nuclear speckles throughout interphase.

Protein Attributes:

Sequence length:

1484

Sequence:

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1484:

TTLQWGGPAQ | SYGKPYRGAA | RVLPRGGRGR | GVPY

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

KEGG:

mmu:69131

SMR:

Q14AX6

UniGene:

Mm.260516

Pfam:

PF00069

Uniprot:

Q14AX6

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ELISA Kit for Mouse Cyclin-dependent kinase 12

Cat.:

E6889m

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96T

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ELISA Kit for Mouse Cyclin-dependent kinase 12

Cat.:

E6889r

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96T

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ELISA Kit for Mouse Cyclin-dependent kinase 12

Cat.:

E6889h

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ELISA Kit for Mouse Cyclin-dependent kinase 12

Cat.:

E6889b

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Packing:

96T

CLIA Kit for Mouse Cyclin-dependent kinase 12

Cat.:

U6889h

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Looking for manual.

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96T

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CLIA Kit for Mouse Cyclin-dependent kinase 12

Cat.:

U6889m

Price:

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MSDS:

Please sign in first.

Packing:

96T

CLIA Kit for Mouse Cyclin-dependent kinase 12

Cat.:

U6889b

Price:

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MSDS:

Please sign in first.

Packing:

96T

CLIA Kit for Mouse Cyclin-dependent kinase 12

Cat.:

U6889r

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96T

Polyclonal Antibody for Mouse Cyclin-dependent kinase 12

Cat.:

P6889Rb-m

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Packing:

40ug/0.2ml

Polyclonal Antibody for Mouse Cyclin-dependent kinase 12

Cat.:

P6889Rb-h

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Packing:

40ug/0.2ml

Polyclonal Antibody for Mouse Cyclin-dependent kinase 12

Monoclonal Antibody for Mouse Cyclin-dependent kinase 12

Protein for Mouse Cyclin-dependent kinase 12

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

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References

1.

"Characterization of a putative SR-related protein kinase that is differentially expressed in the embryonic nervous system."
Lin S.-F. , Chen H.-H. , Fann M.-J.
Submitted (2002-01) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2)
strain: BALB/c.
2.

"Lineage-specific biology revealed by a finished genome assembly of the mouse."
Church D.M. , Goodstadt L. , Hillier L.W. , Zody M.C. , Goldstein S. , She X. , Bult C.J. , Agarwala R. , Cherry J.L. , DiCuccio M. , Hlavina W. , Kapustin Y. , Meric P. , Maglott D. , Birtle Z. , Marques A.C. , Graves T. , Zhou S. , more...
PLoS Biol.7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
strain: C57BL/6J.
3.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)
4.

"Prediction of the coding sequences of mouse homologues of KIAA gene: III. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
Okazaki N. , Kikuno R. , Ohara R. , Inamoto S. , Koseki H. , Hiraoka S. , Saga Y. , Nagase T. , Ohara O. , Koga H.
DNA Res.10:167-180(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 425-1484 (ISOFORM 3)
tissue: Embryonic tail.
5.

"Large-scale phosphorylation analysis of mouse liver."
Villen J. , Beausoleil S.A. , Gerber S.A. , Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A.104:1488-1493(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-382; SER-384 AND SER-1079;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Liver.
6.

"Large scale localization of protein phosphorylation by use of electron capture dissociation mass spectrometry."
Sweet S.M. , Bailey C.M. , Cunningham D.L. , Heath J.K. , Cooper H.J.
Mol. Cell. Proteomics8:904-912(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-382 AND SER-384;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Embryonic fibroblast.
7.

"The Cyclin K/Cdk12 complex maintains genomic stability via regulation of expression of DNA damage response genes."
Blazek D. , Kohoutek J. , Bartholomeeusen K. , Johansen E. , Hulinkova P. , Luo Z. , Cimermancic P. , Ule J. , Peterlin B.M.
Genes Dev.25:2158-2172(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBUNIT;SUBCELLULAR LOCATION

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