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Index > Protein center > Cdk14(Gene name) > Mouse
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  • Cdk14 (Gene name),
  • Cyclin-dependent kinase 14 (Protein name ),  CDK14_MOUSE from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    Cdk14(Kiaa0834;Pftk1);
    Protein name:
    Cyclin-dependent kinase 14;
    Alternative:
    Serine/threonine-protein kinase PFTAIRE-1;Cell division protein kinase 14;
    Organism:
    Mouse (Mus musculus). 
    General Annotation
    Sub Unit:
    Interacts with CCNY; CCNY mediates its recruitment to the plasma membrane and promotes phosphorylation of LRP6. Interacts with CCDN3 and CDKN1A. Interacts with SEPT8. Interacts with 14-3-3 proteina YWHAB, YWHAE, YWHAH and YWHAQ.
    Function:
    Serine/threonine-protein kinase involved in the control of the eukaryotic cell cycle, whose activity is controlled by an associated cyclin. Acts as a cell-cycle regulator of Wnt signaling pathway during G2/M phase by mediating the phosphorylation of LRP6 at 'Ser-1490', leading to the activation of the Wnt signaling pathway. Acts as a regulator of cell cycle progression and cell proliferation via its interaction with CCDN3. Phosphorylates RB1 in vitro, however the relevance of such result remains to be confirmed in vivo. May also play a role in meiosis, neuron differentiation and may indirectly act as a negative regulator of insulin-responsive glucose transport.
    Subcellular Location:
    Cell membrane Peripheral membrane protein Cytoplasm Nucleus Recruited to the cell membrane by CCNY.
    Protein Attributes:
    Sequence length:
    469
    Sequence:
    50:
    MCDLIEPQPA | EKIGKMKKLR | RTLSESFSRI | ALKKEDTTFD | EICVTKMSTR | 
    100:
    NCQGTDSVIK | HLDTIPEDKK | VRVQRTQSTF | DPFEKPANQV | KRVHSENNAC | 
    150:
    INFKSSSAGK | ESPKVRRHSS | PSSPTSPKFG | KADSYEKLEK | LGEGSYATVY | 
    200:
    KGKSKVNGKL | VALKVIRLQE | EEGTPFTAIR | EASLLKGLKH | ANIVLLHDII | 
    250:
    HTKETLTLVF | EYVHTDLCQY | MDKHPGGLHP | DNVKLFLFQL | LRGLSYIHQR | 
    300:
    YILHRDLKPQ | NLLISDTGEL | KLADFGLARA | KSVPSHTYSN | EVVTLWYRPP | 
    350:
    DVLLGSTEYS | TCLDMWGVGC | IFVEMIQGVA | AFPGMKDIQD | QLERIFLVLG | 
    400:
    TPNEDTWPGV | HSLPHFKPER | FTVYSSKSLR | QAWNKLSYVN | HAEDLASKLL | 
    450:
    QCSPKNRLSA | QAALSHEYFS | DLPPRLWELT | DMSSIFTVPN | VRLQPEAGES | 
    469:
    MRAFGKNNSY | GKSLSNSKH
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    UniGene:
    String:
    Pfam:
    KEGG:
    SMR:
    Uniprot:
     
    FOR
    ELISA Kit for Mouse Cyclin-dependent kinase 14
    ELISA Kit for Mouse Cyclin-dependent kinase 14
    ELISA Kit for Mouse Cyclin-dependent kinase 14
    CLIA Kit for Mouse Cyclin-dependent kinase 14
    CLIA Kit for Mouse Cyclin-dependent kinase 14
    CLIA Kit for Mouse Cyclin-dependent kinase 14
    Polyclonal Antibody for Mouse Cyclin-dependent kinase 14
    Polyclonal Antibody for Mouse Cyclin-dependent kinase 14
    Polyclonal Antibody for Mouse Cyclin-dependent kinase 14
    Monoclonal Antibody for Mouse Cyclin-dependent kinase 14
    Monoclonal Antibody for Mouse Cyclin-dependent kinase 14
    Monoclonal Antibody for Mouse Cyclin-dependent kinase 14
    Protein for Mouse Cyclin-dependent kinase 14
    Protein for Mouse Cyclin-dependent kinase 14
    Protein for Mouse Cyclin-dependent kinase 14

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    Linearity
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    References
    1. 1.
      "The identification and characterization of expression of Pftaire-1, a novel Cdk family member, suggest its function in the mouse testis and nervous system."
      Besset V. , Rhee K. , Wolgemuth D.J.
      Mol. Reprod. Dev.50:18-29(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);FUNCTION;SUBCELLULAR LOCATION;TISSUE SPECIFICITY;DEVELOPMENTAL STAGE
      tissue: Testis.
    2. 2.
      "A novel cdc2-related protein kinase expressed in the nervous system."
      Lazzaro M.A. , Albert P.R. , Julien J.-P.
      J. Neurochem.69:348-364(1997) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2);SUBCELLULAR LOCATION;DEVELOPMENTAL STAGE
      strain: NIH Swiss.
      tissue: Brain.
    3. 3.
      "The transcriptional landscape of the mammalian genome."
      Carninci P. , Kasukawa T. , Katayama S. , Gough J. , Frith M.C. , Maeda N. , Oyama R. , Ravasi T. , Lenhard B. , Wells C. , Kodzius R. , Shimokawa K. , Bajic V.B. , Brenner S.E. , Batalov S. , Forrest A.R. , Zavolan M. , Davis M.J. , more...
      Science309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3)
      strain: C57BL/6J.
      tissue: Olfactory bulb.
    4. 4.
      "Prediction of the coding sequences of mouse homologues of KIAA gene: III. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
      Okazaki N. , Kikuno R. , Ohara R. , Inamoto S. , Koseki H. , Hiraoka S. , Saga Y. , Nagase T. , Ohara O. , Koga H.
      DNA Res.10:167-180(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 17-469 (ISOFORM 1)
      tissue: Embryonic tail.
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