"A new human p34 protein kinase, CDK2, identified by complementation of a cdc28 mutation in Saccharomyces cerevisiae, is a homolog of Xenopus Eg1."
Elledge S.J. , Spottswood M.R.
EMBO J.10:2653-2659(1991) [PubMed] [Europe PMC] [Abstract]

"Isolation of the human cdk2 gene that encodes the cyclin A- and adenovirus E1A-associated p33 kinase."
Tsai L.-H. , Harlow E. , Meyerson M.
Nature353:174-177(1991) [PubMed] [Europe PMC] [Abstract]

"Cloning of a human cDNA encoding a CDC2-related kinase by complementation of a budding yeast cdc28 mutation."
Ninomiya-Tsuji J. , Nomoto S. , Yasuda H. , Reed S.I. , Matsumoto K.
Proc. Natl. Acad. Sci. U.S.A.88:9006-9010(1991) [PubMed] [Europe PMC] [Abstract]

"Sequence of deletion type cdk2 variant in human breast cancer."
Nishikawa T. , Ohta T. , Fukuda M. , Ogata H. , Okamoto K. , Isohashi F. , Arima K. , Yamaguchi S.
Submitted (1998-03) to the EMBL/GenBank/DDBJ databases

"Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
Kalnine N. , Chen X. , Rolfs A. , Halleck A. , Hines L. , Eisenstein S. , Koundinya M. , Raphael J. , Moreira D. , Kelley T. , LaBaer J. , Lin Y. , Phelan M. , Farmer A.
Submitted (2003-05) to the EMBL/GenBank/DDBJ databases

NIEHS SNPs program
Submitted (2002-05) to the EMBL/GenBank/DDBJ databases

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , Yamamoto J. , Saito K. , Kawai Y. , Isono Y. , Nakamura Y. , Nagahari K. , Murakami K. , Yasuda T. , Iwayanagi T. , Wagatsuma M. , Shiratori A. , Sudo H. , Hosoiri T. , Kaku Y. , Kodaira H. , Kondo H. , Sugawara M. , Takahashi M. , Kanda K. , Yokoi T. , Furuya T. , Kikkawa E. , Omura Y. , Abe K. , Kamihara K. , Katsuta N. , Sato K. , Tanikawa M. , Yamazaki M. , Ninomiya K. , Ishibashi T. , Yamashita H. , Murakawa K. , Fujimori K. , Tanai H. , Kimata M. , Watanabe M. , Hiraoka S. , Chiba Y. , Ishida S. , Ono Y. , Takiguchi S. , Watanabe S. , Yosida M. , Hotuta T. , Kusano J. , Kanehori K. , Takahashi-Fujii A. , Hara H. , Tanase T.-O. , Nomura Y. , Togiya S. , Komai F. , Hara R. , Takeuchi K. , Arita M. , Imose N. , Musashino K. , Yuuki H. , Oshima A. , Sasaki N. , Aotsuka S. , Yoshikawa Y. , Matsunawa H. , Ichihara T. , Shiohata N. , Sano S. , Moriya S. , Momiyama H. , Satoh N. , Takami S. , Terashima Y. , Suzuki O. , Nakagawa S. , Senoh A. , Mizoguchi H. , Goto Y. , Shimizu F. , Wakebe H. , Hishigaki H. , Watanabe T. , Sugiyama A. , Takemoto M. , Kawakami B. , Yamazaki M. , Watanabe K. , Kumagai A. , Itakura S. , Fukuzumi Y. , Fujimori Y. , Komiyama M. , Tashiro H. , Tanigami A. , Fujiwara T. , Ono T. , Yamada K. , Fujii Y. , Ozaki K. , Hirao M. , Ohmori Y. , Kawabata A. , Hikiji T. , Kobatake N. , Inagaki H. , Ikema Y. , Okamoto S. , Okitani R. , Kawakami T. , Noguchi S. , Itoh T. , Shigeta K. , Senba T. , Matsumura K. , Nakajima Y. , Mizuno T. , Morinaga M. , Sasaki M. , Togashi T. , Oyama M. , Hata H. , Watanabe M. , Komatsu T. , Mizushima-Sugano J. , Satoh T. , Shirai Y. , Takahashi Y. , Nakagawa K. , Okumura K. , Nagase T. , Nomura N. , Kikuchi H. , Masuho Y. , Yamashita R. , Nakai K. , Yada T. , Nakamura Y. , Ohara O. , Isogai T. , Sugano S. more...
Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

"The finished DNA sequence of human chromosome 12."
Scherer S.E. , Muzny D.M. , Buhay C.J. , Chen R. , Cree A. , Ding Y. , Dugan-Rocha S. , Gill R. , Gunaratne P. , Harris R.A. , Hawes A.C. , Hernandez J. , Hodgson A.V. , Hume J. , Jackson A. , Khan Z.M. , Kovar-Smith C. , Lewis L.R. , Lozado R.J. , Metzker M.L. , Milosavljevic A. , Miner G.R. , Montgomery K.T. , Morgan M.B. , Nazareth L.V. , Scott G. , Sodergren E. , Song X.-Z. , Steffen D. , Lovering R.C. , Wheeler D.A. , Worley K.C. , Yuan Y. , Zhang Z. , Adams C.Q. , Ansari-Lari M.A. , Ayele M. , Brown M.J. , Chen G. , Chen Z. , Clerc-Blankenburg K.P. , Davis C. , Delgado O. , Dinh H.H. , Draper H. , Gonzalez-Garay M.L. , Havlak P. , Jackson L.R. , Jacob L.S. , Kelly S.H. , Li L. , Li Z. , Liu J. , Liu W. , Lu J. , Maheshwari M. , Nguyen B.-V. , Okwuonu G.O. , Pasternak S. , Perez L.M. , Plopper F.J.H. , Santibanez J. , Shen H. , Tabor P.E. , Verduzco D. , Waldron L. , Wang Q. , Williams G.A. , Zhang J. , Zhou J. , Allen C.C. , Amin A.G. , Anyalebechi V. , Bailey M. , Barbaria J.A. , Bimage K.E. , Bryant N.P. , Burch P.E. , Burkett C.E. , Burrell K.L. , Calderon E. , Cardenas V. , Carter K. , Casias K. , Cavazos I. , Cavazos S.R. , Ceasar H. , Chacko J. , Chan S.N. , Chavez D. , Christopoulos C. , Chu J. , Cockrell R. , Cox C.D. , Dang M. , Dathorne S.R. , David R. , Davis C.M. , Davy-Carroll L. , Deshazo D.R. , Donlin J.E. , D'Souza L. , Eaves K.A. , Egan A. , Emery-Cohen A.J. , Escotto M. , Flagg N. , Forbes L.D. , Gabisi A.M. , Garza M. , Hamilton C. , Henderson N. , Hernandez O. , Hines S. , Hogues M.E. , Huang M. , Idlebird D.G. , Johnson R. , Jolivet A. , Jones S. , Kagan R. , King L.M. , Leal B. , Lebow H. , Lee S. , LeVan J.M. , Lewis L.C. , London P. , Lorensuhewa L.M. , Loulseged H. , Lovett D.A. , Lucier A. , Lucier R.L. , Ma J. , Madu R.C. , Mapua P. , Martindale A.D. , Martinez E. , Massey E. , Mawhiney S. , Meador M.G. , Mendez S. , Mercado C. , Mercado I.C. , Merritt C.E. , Miner Z.L. , Minja E. , Mitchell T. , Mohabbat F. , Mohabbat K. , Montgomery B. , Moore N. , Morris S. , Munidasa M. , Ngo R.N. , Nguyen N.B. , Nickerson E. , Nwaokelemeh O.O. , Nwokenkwo S. , Obregon M. , Oguh M. , Oragunye N. , Oviedo R.J. , Parish B.J. , Parker D.N. , Parrish J. , Parks K.L. , Paul H.A. , Payton B.A. , Perez A. , Perrin W. , Pickens A. , Primus E.L. , Pu L.-L. , Puazo M. , Quiles M.M. , Quiroz J.B. , Rabata D. , Reeves K. , Ruiz S.J. , Shao H. , Sisson I. , Sonaike T. , Sorelle R.P. , Sutton A.E. , Svatek A.F. , Svetz L.A. , Tamerisa K.S. , Taylor T.R. , Teague B. , Thomas N. , Thorn R.D. , Trejos Z.Y. , Trevino B.K. , Ukegbu O.N. , Urban J.B. , Vasquez L.I. , Vera V.A. , Villasana D.M. , Wang L. , Ward-Moore S. , Warren J.T. , Wei X. , White F. , Williamson A.L. , Wleczyk R. , Wooden H.S. , Wooden S.H. , Yen J. , Yoon L. , Yoon V. , Zorrilla S.E. , Nelson D. , Kucherlapati R. , Weinstock G. , Gibbs R.A. more...
Nature440:346-351(2006) [PubMed] [Europe PMC] [Abstract]

Mural R.J. , Istrail S. , Sutton G.G. , Florea L. , Halpern A.L. , Mobarry C.M. , Lippert R. , Walenz B. , Shatkay H. , Dew I. , Miller J.R. , Flanigan M.J. , Edwards N.J. , Bolanos R. , Fasulo D. , Halldorsson B.V. , Hannenhalli S. , Turner R. , Yooseph S. , Lu F. , Nusskern D.R. , Shue B.C. , Zheng X.H. , Zhong F. , Delcher A.L. , Huson D.H. , Kravitz S.A. , Mouchard L. , Reinert K. , Remington K.A. , Clark A.G. , Waterman M.S. , Eichler E.E. , Adams M.D. , Hunkapiller M.W. , Myers E.W. , Venter J.C. more...
Submitted (2005-07) to the EMBL/GenBank/DDBJ databases

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Cell cycle regulation of CDK2 activity by phosphorylation of Thr160 and Tyr15."
Gu Y. , Rosenblatt J. , O'Morgan D.O.
EMBO J.11:3995-4005(1992) [PubMed] [Europe PMC] [Abstract]

"Biochemical and cellular effects of roscovitine, a potent and selective inhibitor of the cyclin-dependent kinases cdc2, cdk2 and cdk5."
Meijer L. , Borgne A. , Mulner O. , Chong J.P.J. , Blow J.J. , Inagaki N. , Inagaki M. , Delcros J.-G. , Moulinoux J.-P.
Eur. J. Biochem.243:527-536(1997) [PubMed] [Europe PMC] [Abstract]

"Cdk phosphorylation triggers sequential intramolecular interactions that progressively block Rb functions as cells move through G1."
Harbour J.W. , Luo R.X. , Dei Santi A. , Postigo A.A. , Dean D.C.
Cell98:859-869(1999) [PubMed] [Europe PMC] [Abstract]

"Nucleophosmin/B23 is a target of CDK2/cyclin E in centrosome duplication."
Okuda M. , Horn H.F. , Tarapore P. , Tokuyama Y. , Smulian A.G. , Chan P.K. , Knudsen E.S. , Hofmann I.A. , Snyder J.D. , Bove K.E. , Fukasawa K.
Cell103:127-140(2000) [PubMed] [Europe PMC] [Abstract]

"NPAT links cyclin E-Cdk2 to the regulation of replication-dependent histone gene transcription."
Zhao J. , Kennedy B.K. , Lawrence B.D. , Barbie D.A. , Matera A.G. , Fletcher J.A. , Harlow E.
Genes Dev.14:2283-2297(2000) [PubMed] [Europe PMC] [Abstract]

"Cell cycle-regulated phosphorylation of p220(NPAT) by cyclin E/Cdk2 in Cajal bodies promotes histone gene transcription."
Ma T. , Van Tine B.A. , Wei Y. , Garrett M.D. , Nelson D. , Adams P.D. , Wang J. , Qin J. , Chow L.T. , Harper J.W.
Genes Dev.14:2298-2313(2000) [PubMed] [Europe PMC] [Abstract]

"The C-terminal regulatory domain of p53 contains a functional docking site for cyclin A."
Luciani M.G. , Hutchins J.R.A. , Zheleva D. , Hupp T.R.
J. Mol. Biol.300:503-518(2000) [PubMed] [Europe PMC] [Abstract]

"Reciprocal activation by cyclin-dependent kinases 2 and 7 is directed by substrate specificity determinants outside the T loop."
Garrett S. , Barton W.A. , Knights R. , Jin P. , Morgan D.O. , Fisher R.P.
Mol. Cell. Biol.21:88-99(2001) [PubMed] [Europe PMC] [Abstract]

"Characterization and expression of mammalian cyclin b3, a prepachytene meiotic cyclin."
Nguyen T.B. , Manova K. , Capodieci P. , Lindon C. , Bottega S. , Wang X.-Y. , Refik-Rogers J. , Pines J. , Wolgemuth D.J. , Koff A.
J. Biol. Chem.277:41960-41969(2002) [PubMed] [Europe PMC] [Abstract]

"Human Speedy: a novel cell cycle regulator that enhances proliferation through activation of Cdk2."
Porter L.A. , Dellinger R.W. , Tynan J.A. , Barnes E.A. , Kong M. , Lenormand J.-L. , Donoghue D.J.
J. Cell Biol.157:357-366(2002) [PubMed] [Europe PMC] [Abstract]

"Human Spy1 promotes survival of mammalian cells following DNA damage."
Barnes E.A. , Porter L.A. , Lenormand J.-L. , Dellinger R.W. , Donoghue D.J.
Cancer Res.63:3701-3707(2003) [PubMed] [Europe PMC] [Abstract]

"Spy1 interacts with p27Kip1 to allow G1/S progression."
Porter L.A. , Kong-Beltran M. , Donoghue D.J.
Mol. Biol. Cell14:3664-3674(2003) [PubMed] [Europe PMC] [Abstract]

"NIRF induces G1 arrest and associates with Cdk2."
Li Y. , Mori T. , Hata H. , Homma Y. , Kochi H.
Biochem. Biophys. Res. Commun.319:464-468(2004) [PubMed] [Europe PMC] [Abstract]

"p42, a novel cyclin-dependent kinase-activating kinase in mammalian cells."
Liu Y. , Wu C. , Galaktionov K.
J. Biol. Chem.279:4507-4514(2004) [PubMed] [Europe PMC] [Abstract]

"Identification and comparative analysis of multiple mammalian Speedy/Ringo proteins."
Cheng A. , Xiong W. , Ferrell J.E. Jr. , Solomon M.J.
Cell Cycle4:155-165(2005) [PubMed] [Europe PMC] [Abstract]

"CDK-dependent phosphorylation of BRCA2 as a regulatory mechanism for recombinational repair."
Esashi F. , Christ N. , Gannon J. , Liu Y. , Hunt T. , Jasin M. , West S.C.
Nature434:598-604(2005) [PubMed] [Europe PMC] [Abstract]

"Recognition of Cdk2 by Cdk7."
Lolli G. , Johnson L.N.
Proteins67:1048-1059(2007) [PubMed] [Europe PMC] [Abstract]

"Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
Daub H. , Olsen J.V. , Bairlein M. , Gnad F. , Oppermann F.S. , Korner R. , Greff Z. , Keri G. , Stemmann O. , Mann M.
Mol. Cell31:438-448(2008) [PubMed] [Europe PMC] [Abstract]

"Cyclin A/cdk2 coordinates centrosomal and nuclear mitotic events."
De Boer L. , Oakes V. , Beamish H. , Giles N. , Stevens F. , Somodevilla-Torres M. , Desouza C. , Gabrielli B.
Oncogene27:4261-4268(2008) [PubMed] [Europe PMC] [Abstract]

"Identification and characterization of CAC1 as a novel CDK2-associated cullin."
Kong Y. , Nan K. , Yin Y.
Cell Cycle8:3544-3553(2009) [PubMed] [Europe PMC] [Abstract]

"Large-scale proteomics analysis of the human kinome."
Oppermann F.S. , Gnad F. , Olsen J.V. , Hornberger R. , Greff Z. , Keri G. , Mann M. , Daub H.
Mol. Cell. Proteomics8:1751-1764(2009) [PubMed] [Europe PMC] [Abstract]

"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
Mayya V. , Lundgren D.H. , Hwang S.-I. , Rezaul K. , Wu L. , Eng J.K. , Rodionov V. , Han D.K.
Sci. Signal.2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]

"Lysine acetylation targets protein complexes and co-regulates major cellular functions."
Choudhary C. , Kumar C. , Gnad F. , Nielsen M.L. , Rehman M. , Walther T.C. , Olsen J.V. , Mann M.
Science325:834-840(2009) [PubMed] [Europe PMC] [Abstract]

"Nuclear targeting of cyclin-dependent kinase 2 reveals essential roles of cyclin-dependent kinase 2 localization and cyclin E in vitamin D-mediated growth inhibition."
Flores O. , Wang Z. , Knudsen K.E. , Burnstein K.L.
Endocrinology151:896-908(2010) [PubMed] [Europe PMC] [Abstract]

"Cdk2 nitrosylation and loss of mitochondrial potential mediate NO-dependent biphasic effect on HL-60 cell cycle."
Kumar S. , Barthwal M.K. , Dikshit M.
Free Radic. Biol. Med.48:851-861(2010) [PubMed] [Europe PMC] [Abstract]

"Cdc25 phosphatases are required for timely assembly of CDK1-cyclin B at the G2/M transition."
Timofeev O. , Cizmecioglu O. , Settele F. , Kempf T. , Hoffmann I.
J. Biol. Chem.285:16978-16990(2010) [PubMed] [Europe PMC] [Abstract]

"Cyclin-dependent kinases regulate epigenetic gene silencing through phosphorylation of EZH2."
Chen S. , Bohrer L.R. , Rai A.N. , Pan Y. , Gan L. , Zhou X. , Bagchi A. , Simon J.A. , Huang H.
Nat. Cell Biol.12:1108-1114(2010) [PubMed] [Europe PMC] [Abstract]

"Cdk2 is required for p53-independent G2/M checkpoint control."
Chung J.H. , Bunz F.
PLoS Genet.6:E1000863-E1000863(2010) [PubMed] [Europe PMC] [Abstract]

"Phosphorylation by Cdk2 is required for Myc to repress Ras-induced senescence in cotransformation."
Hydbring P. , Bahram F. , Su Y. , Tronnersjoe S. , Hoegstrand K. , von der Lehr N. , Sharifi H.R. , Lilischkis R. , Hein N. , Wu S. , Vervoorts J. , Henriksson M. , Grandien A. , Luescher B. , Larsson L.-G.
Proc. Natl. Acad. Sci. U.S.A.107:58-63(2010) [PubMed] [Europe PMC] [Abstract]

"Initial characterization of the human central proteome."
Burkard T.R. , Planyavsky M. , Kaupe I. , Breitwieser F.P. , Buerckstuemmer T. , Bennett K.L. , Superti-Furga G. , Colinge J.
BMC Syst. Biol.5:17-17(2011) [PubMed] [Europe PMC] [Abstract]

"Cep63 recruits Cdk1 to the centrosome: implications for regulation of mitotic entry, centrosome amplification, and genome maintenance."
Loffler H. , Fechter A. , Matuszewska M. , Saffrich R. , Mistrik M. , Marhold J. , Hornung C. , Westermann F. , Bartek J. , Kramer A.
Cancer Res.71:2129-2139(2011) [PubMed] [Europe PMC] [Abstract]

"Compartmentalized CDK2 is connected with SHP-1 and beta-catenin and regulates insulin internalization."
Fiset A. , Xu E. , Bergeron S. , Marette A. , Pelletier G. , Siminovitch K.A. , Olivier M. , Beauchemin N. , Faure R.L.
Cell. Signal.23:911-919(2011) [PubMed] [Europe PMC] [Abstract]

"Discovery of a novel class of 2-aminopyrimidines as CDK1 and CDK2 inhibitors."
Lee J. , Kim K.H. , Jeong S.
Bioorg. Med. Chem. Lett.21:4203-4205(2011) [PubMed] [Europe PMC] [Abstract]

"Deubiquitinase USP37 is activated by CDK2 to antagonize APC(CDH1) and promote S phase entry."
Huang X. , Summers M.K. , Pham V. , Lill J.R. , Liu J. , Lee G. , Kirkpatrick D.S. , Jackson P.K. , Fang G. , Dixit V.M.
Mol. Cell42:511-523(2011) [PubMed] [Europe PMC] [Abstract]

"An important role for CDK2 in G1 to S checkpoint activation and DNA damage response in human embryonic stem cells."
Neganova I. , Vilella F. , Atkinson S.P. , Lloret M. , Passos J.F. , von Zglinicki T. , O'Connor J.-E. , Burks D. , Jones R. , Armstrong L. , Lako M.
Stem Cells29:651-659(2011) [PubMed] [Europe PMC] [Abstract]

"A dual role of Cdk2 in DNA damage response."
Satyanarayana A. , Kaldis P.
Cell Div.4:9-9(2009) [PubMed] [Europe PMC] [Abstract]

"Cell cycle, CDKs and cancer: a changing paradigm."
Malumbres M. , Barbacid M.
Nat. Rev. Cancer9:153-166(2009) [PubMed] [Europe PMC] [Abstract]

"Mammalian cell-cycle regulation: several Cdks, numerous cyclins and diverse compensatory mechanisms."
Satyanarayana A. , Kaldis P.
Oncogene28:2925-2939(2009) [PubMed] [Europe PMC] [Abstract]

"Tipping the balance: Cdk2 enables Myc to suppress senescence."
Hydbring P. , Larsson L.-G.
Cancer Res.70:6687-6691(2010) [PubMed] [Europe PMC] [Abstract]

"Cyclin dependent kinase 1 inhibitors: a review of recent progress."
Wang Q. , Su L. , Liu N. , Zhang L. , Xu W. , Fang H.
Curr. Med. Chem.18:2025-2043(2011) [PubMed] [Europe PMC] [Abstract]

"N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."
Van Damme P. , Lasa M. , Polevoda B. , Gazquez C. , Elosegui-Artola A. , Kim D.S. , De Juan-Pardo E. , Demeyer K. , Hole K. , Larrea E. , Timmerman E. , Prieto J. , Arnesen T. , Sherman F. , Gevaert K. , Aldabe R.
Proc. Natl. Acad. Sci. U.S.A.109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]

"Crystal structure of cyclin-dependent kinase 2."
de Bondt H.L. , Rosenblatt J. , Jancarik J. , Jones H.D. , Morgan D.O. , Kim S.-H.
Nature363:595-602(1993) [PubMed] [Europe PMC] [Abstract]

"Mechanism of CDK activation revealed by the structure of a cyclinA-CDK2 complex."
Jeffrey P.D. , Russo A.A. , Polyak K. , Gibbs E. , Hurwitz J. , Massague J. , Pavletich N.P.
Nature376:313-320(1995) [PubMed] [Europe PMC] [Abstract]

"Crystal structure and mutational analysis of the human CDK2 kinase complex with cell cycle-regulatory protein CksHs1."
Bourne Y. , Watson M.H. , Hickey M.J. , Holmes W. , Rocque W. , Reed S.I. , Tainer J.A.
Cell84:863-874(1996) [PubMed] [Europe PMC] [Abstract]

"High-resolution crystal structures of human cyclin-dependent kinase 2 with and without ATP: bound waters and natural ligand as guides for inhibitor design."
Schulze-Gahmen U. , de Bondt H.L. , Kim S.-H.
J. Med. Chem.39:4540-4546(1996) [PubMed] [Europe PMC] [Abstract]

"Crystal structure of the p27Kip1 cyclin-dependent-kinase inhibitor bound to the cyclin A-Cdk2 complex."
Russo A.A. , Jeffrey P.D. , Patten A.K. , Massague J. , Pavletich N.P.
Nature382:325-331(1996) [PubMed] [Europe PMC] [Abstract]

"Structural basis of cyclin-dependent kinase activation by phosphorylation."
Russo A.A. , Jeffrey P.D. , Pavletich N.P.
Nat. Struct. Biol.3:696-700(1996) [PubMed] [Europe PMC] [Abstract]

"Structural basis for specificity and potency of a flavonoid inhibitor of human CDK2, a cell cycle kinase."
de Azevedo W.F. Jr. , Mueller-Dieckmann H.-J. , Schulze-Gahmen U. , Worland P.J. , Sausville E. , Kim S.-H.
Proc. Natl. Acad. Sci. U.S.A.93:2735-2740(1996) [PubMed] [Europe PMC] [Abstract]

"Protein kinase inhibition by staurosporine revealed in details of the molecular interaction with CDK2."
Lawrie A.M. , Noble M.E.M. , Tunnah P. , Brown N.R. , Johnson L.N. , Endicott J.A.
Nat. Struct. Biol.4:796-801(1997) [PubMed] [Europe PMC] [Abstract]

"Exploiting chemical libraries, structure, and genomics in the search for kinase inhibitors."
Gray N.S. , Wodicka L. , Thunnissen A.-M.W.H. , Norman T.C. , Kwon S. , Espinoza F.H. , Morgan D.O. , Barnes G. , Leclerc S. , Meijer L. , Kim S.H. , Lockhart D.J. , Schultz P.G.
Science281:533-538(1998) [PubMed] [Europe PMC] [Abstract]

"Triazolo[1,5-a]pyrimidines as novel CDK2 inhibitors: protein structure-guided design and SAR."
Richardson C.M. , Williamson D.S. , Parratt M.J. , Borgognoni J. , Cansfield A.D. , Dokurno P. , Francis G.L. , Howes R. , Moore J.D. , Murray J.B. , Robertson A. , Surgenor A.E. , Torrance C.J.
Bioorg. Med. Chem. Lett.16:1353-1357(2006) [PubMed] [Europe PMC] [Abstract]

"Discovery of a potent CDK2 inhibitor with a novel binding mode, using virtual screening and initial, structure-guided lead scoping."
Richardson C.M. , Nunns C.L. , Williamson D.S. , Parratt M.J. , Dokurno P. , Howes R. , Borgognoni J. , Drysdale M.J. , Finch H. , Hubbard R.E. , Jackson P.S. , Kierstan P. , Lentzen G. , Moore J.D. , Murray J.B. , Simmonite H. , Surgenor A.E. , Torrance C.J.
Bioorg. Med. Chem. Lett.17:3880-3885(2007) [PubMed] [Europe PMC] [Abstract]

"Cyclin B and cyclin A confer different substrate recognition properties on CDK2."
Brown N.R. , Lowe E.D. , Petri E. , Skamnaki V. , Antrobus R. , Johnson L.N.
Cell Cycle6:1350-1359(2007) [PubMed] [Europe PMC] [Abstract]

"How tyrosine 15 phosphorylation inhibits the activity of cyclin-dependent kinase 2-cyclin A."
Welburn J.P.I. , Tucker J.A. , Johnson T. , Lindert L. , Morgan M. , Willis A. , Noble M.E.M. , Endicott J.A.
J. Biol. Chem.282:3173-3181(2007) [PubMed] [Europe PMC] [Abstract]

"Structure-guided discovery of cyclin-dependent kinase inhibitors."
Fischmann T.O. , Hruza A. , Duca J.S. , Ramanathan L. , Mayhood T. , Windsor W.T. , Le H.V. , Guzi T.J. , Dwyer M.P. , Paruch K. , Doll R.J. , Lees E. , Parry D. , Seghezzi W. , Madison V.
Biopolymers89:372-379(2008) [PubMed] [Europe PMC] [Abstract]

"Identification of N-(4-piperidinyl)-4-(2,6-dichlorobenzoylamino)-1H-pyrazole-3-carboxamide (AT7519), a novel cyclin dependent kinase inhibitor using fragment-based X-ray crystallography and structure based drug design."
Wyatt P.G. , Woodhead A.J. , Berdini V. , Boulstridge J.A. , Carr M.G. , Cross D.M. , Davis D.J. , Devine L.A. , Early T.R. , Feltell R.E. , Lewis E.J. , McMenamin R.L. , Navarro E.F. , O'Brien M.A. , O'Reilly M. , Reule M. , Saxty G. , Seavers L.C. , Smith D.M. , Squires M.S. , Trewartha G. , Walker M.T. , Woolford A.J. more...
J. Med. Chem.51:4986-4999(2008) [PubMed] [Europe PMC] [Abstract]

"Briefly bound to activate: transient binding of a second catalytic magnesium activates the structure and dynamics of CDK2 kinase for catalysis."
Bao Z.Q. , Jacobsen D.M. , Young M.A.
Structure19:675-690(2011) [PubMed] [Europe PMC] [Abstract]

"Patterns of somatic mutation in human cancer genomes."
Greenman C. , Stephens P. , Smith R. , Dalgliesh G.L. , Hunter C. , Bignell G. , Davies H. , Teague J. , Butler A. , Stevens C. , Edkins S. , O'Meara S. , Vastrik I. , Schmidt E.E. , Avis T. , Barthorpe S. , Bhamra G. , Buck G. , Choudhury B. , Clements J. , Cole J. , Dicks E. , Forbes S. , Gray K. , Halliday K. , Harrison R. , Hills K. , Hinton J. , Jenkinson A. , Jones D. , Menzies A. , Mironenko T. , Perry J. , Raine K. , Richardson D. , Shepherd R. , Small A. , Tofts C. , Varian J. , Webb T. , West S. , Widaa S. , Yates A. , Cahill D.P. , Louis D.N. , Goldstraw P. , Nicholson A.G. , Brasseur F. , Looijenga L. , Weber B.L. , Chiew Y.-E. , DeFazio A. , Greaves M.F. , Green A.R. , Campbell P. , Birney E. , Easton D.F. , Chenevix-Trench G. , Tan M.-H. , Khoo S.K. , Teh B.T. , Yuen S.T. , Leung S.Y. , Wooster R. , Futreal P.A. , Stratton M.R. more...
Nature446:153-158(2007) [PubMed] [Europe PMC] [Abstract]