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Index > Protein center > CDK2(Gene name) > Human
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  • CDK2 (Gene name),
  • Cyclin-dependent kinase 2 (Protein name ),  CDK2_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    CDK2(CDKN2);
    Protein name:
    Cyclin-dependent kinase 2;
    Alternative:
    p33 protein kinase;Cell division protein kinase 2;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Found in a complex with CABLES1, CCNA1 and CCNE1. Interacts with CABLES1 (By similarity). Interacts with UHRF2. Part of a complex consisting of UHRF2, CDK2 and CCNE1. Interacts with the Speedy/Ringo proteins SPDYA and SPDYC. Found in a complex with both SPDYA and CDKN1B/KIP1.
    Function:
    Involved in the control of the cell cycle. Interacts with cyclins A, B1, B3, D, or E. Activity of CDK2 is maximal during S phase and G2.
    Subcellular Location:
    Protein Attributes:
    Sequence length:
    298
    Sequence:
    50:
    MENFQKVEKI | GEGTYGVVYK | ARNKLTGEVV | ALKKIRLDTE | TEGVPSTAIR | 
    100:
    EISLLKELNH | PNIVKLLDVI | HTENKLYLVF | EFLHQDLKKF | MDASALTGIP | 
    150:
    LPLIKSYLFQ | LLQGLAFCHS | HRVLHRDLKP | QNLLINTEGA | IKLADFGLAR | 
    200:
    AFGVPVRTYT | HEVVTLWYRA | PEILLGCKYY | STAVDIWSLG | CIFAEMVTRR | 
    250:
    ALFPGDSEID | QLFRIFRTLG | TPDEVVWPGV | TSMPDYKPSF | PKWARQDFSK | 
    298:
    VVPPLDEDGR | SLLSQMLHYD | PNKRISAKAA | LAHPFFQDVT | KPVPHLRL
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    UniGene:
    Pfam:
    SMR:
    MIM:
    String:
    KEGG:
    Uniprot:
     
    FOR
    ELISA Kit for Human Cyclin-dependent kinase 2
    Cat.:
    E1889m
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    MSDS:
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    Packing:
    96T
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    ELISA Kit for Human Cyclin-dependent kinase 2
    Cat.:
    E1889h
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    96T
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    ELISA Kit for Human Cyclin-dependent kinase 2
    Cat.:
    E1889b
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    96T
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    ELISA Kit for Human Cyclin-dependent kinase 2
    Cat.:
    E1889r
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    Packing:
    96T
    CLIA Kit for Human Cyclin-dependent kinase 2
    Cat.:
    U1889r
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    MSDS:
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    Packing:
    96T
    CLIA Kit for Human Cyclin-dependent kinase 2
    Cat.:
    U1889h
    Price:
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    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Human Cyclin-dependent kinase 2
    Cat.:
    U1889m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Human Cyclin-dependent kinase 2
    Cat.:
    U1889b
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    MSDS:
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    Packing:
    96T
    Polyclonal Antibody for Human Cyclin-dependent kinase 2
    Cat.:
    P1889Rb-m
    Price:
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Cyclin-dependent kinase 2
    Polyclonal Antibody for Human Cyclin-dependent kinase 2
    Cat.:
    P1889Rb-r
    Price:
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Cyclin-dependent kinase 2
    Cat.:
    P1889Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Human Cyclin-dependent kinase 2
    Monoclonal Antibody for Human Cyclin-dependent kinase 2
    Monoclonal Antibody for Human Cyclin-dependent kinase 2
    Monoclonal Antibody for Human Cyclin-dependent kinase 2
    Protein for Human Cyclin-dependent kinase 2
    Protein for Human Cyclin-dependent kinase 2
    Protein for Human Cyclin-dependent kinase 2
    Protein for Human Cyclin-dependent kinase 2

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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      "A new human p34 protein kinase, CDK2, identified by complementation of a cdc28 mutation in Saccharomyces cerevisiae, is a homolog of Xenopus Eg1."
      Elledge S.J. , Spottswood M.R.
      EMBO J.10:2653-2659(1991) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
    2. 2.
      "Isolation of the human cdk2 gene that encodes the cyclin A- and adenovirus E1A-associated p33 kinase."
      Tsai L.-H. , Harlow E. , Meyerson M.
      Nature353:174-177(1991) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
    3. 3.
      "Cloning of a human cDNA encoding a CDC2-related kinase by complementation of a budding yeast cdc28 mutation."
      Ninomiya-Tsuji J. , Nomoto S. , Yasuda H. , Reed S.I. , Matsumoto K.
      Proc. Natl. Acad. Sci. U.S.A.88:9006-9010(1991) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
    4. 4.
      "Sequence of deletion type cdk2 variant in human breast cancer."
      Nishikawa T. , Ohta T. , Fukuda M. , Ogata H. , Okamoto K. , Isohashi F. , Arima K. , Yamaguchi S.
      Submitted (1998-03) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE (ISOFORM 2)
    5. 5.
      "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
      Kalnine N. , Chen X. , Rolfs A. , Halleck A. , Hines L. , Eisenstein S. , Koundinya M. , Raphael J. , Moreira D. , Kelley T. , LaBaer J. , Lin Y. , Phelan M. , Farmer A.
      Submitted (2003-05) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
    6. 6.
      NIEHS SNPs program
      Submitted (2002-05) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];VARIANT SER-290
    7. 7.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
    8. 8.
      "The finished DNA sequence of human chromosome 12."
      Scherer S.E. , Muzny D.M. , Buhay C.J. , Chen R. , Cree A. , Ding Y. , Dugan-Rocha S. , Gill R. , Gunaratne P. , Harris R.A. , Hawes A.C. , Hernandez J. , Hodgson A.V. , Hume J. , Jackson A. , Khan Z.M. , Kovar-Smith C. , Lewis L.R. , more...
      Nature440:346-351(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    9. 9.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    10. 10.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
      tissue: Placenta.
    11. 11.
      "Cell cycle regulation of CDK2 activity by phosphorylation of Thr160 and Tyr15."
      Gu Y. , Rosenblatt J. , O'Morgan D.O.
      EMBO J.11:3995-4005(1992) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT THR-14; TYR-15 AND THR-160;MUTAGENESIS OF THR-14; TYR-15 AND THR-160
    12. 12.
      "Biochemical and cellular effects of roscovitine, a potent and selective inhibitor of the cyclin-dependent kinases cdc2, cdk2 and cdk5."
      Meijer L. , Borgne A. , Mulner O. , Chong J.P.J. , Blow J.J. , Inagaki N. , Inagaki M. , Delcros J.-G. , Moulinoux J.-P.
      Eur. J. Biochem.243:527-536(1997) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ENZYME REGULATION BY ROSCOVITINE AND OLOMOUCINE
    13. 13.
      "Cdk phosphorylation triggers sequential intramolecular interactions that progressively block Rb functions as cells move through G1."
      Harbour J.W. , Luo R.X. , Dei Santi A. , Postigo A.A. , Dean D.C.
      Cell98:859-869(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION AS RB1 KINASE;INTERACTION WITH CYCLIN E
    14. 14.
      "Nucleophosmin/B23 is a target of CDK2/cyclin E in centrosome duplication."
      Okuda M. , Horn H.F. , Tarapore P. , Tokuyama Y. , Smulian A.G. , Chan P.K. , Knudsen E.S. , Hofmann I.A. , Snyder J.D. , Bove K.E. , Fukasawa K.
      Cell103:127-140(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION AS NPM1 KINASE
    15. 15.
      "NPAT links cyclin E-Cdk2 to the regulation of replication-dependent histone gene transcription."
      Zhao J. , Kennedy B.K. , Lawrence B.D. , Barbie D.A. , Matera A.G. , Fletcher J.A. , Harlow E.
      Genes Dev.14:2283-2297(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION AS NPAT KINASE
    16. 16.
      "Cell cycle-regulated phosphorylation of p220(NPAT) by cyclin E/Cdk2 in Cajal bodies promotes histone gene transcription."
      Ma T. , Van Tine B.A. , Wei Y. , Garrett M.D. , Nelson D. , Adams P.D. , Wang J. , Qin J. , Chow L.T. , Harper J.W.
      Genes Dev.14:2298-2313(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION AS NPAT KINASE;SUBCELLULAR LOCATION
    17. 17.
      "The C-terminal regulatory domain of p53 contains a functional docking site for cyclin A."
      Luciani M.G. , Hutchins J.R.A. , Zheleva D. , Hupp T.R.
      J. Mol. Biol.300:503-518(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION AS P53/TP53 KINASE;INTERACTION WITH CYCLIN A AND CYCLIN B1
    18. 18.
      "Reciprocal activation by cyclin-dependent kinases 2 and 7 is directed by substrate specificity determinants outside the T loop."
      Garrett S. , Barton W.A. , Knights R. , Jin P. , Morgan D.O. , Fisher R.P.
      Mol. Cell. Biol.21:88-99(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION AS CDK7 KINASE;PHOSPHORYLATION BY CDK7
    19. 19.
      "Characterization and expression of mammalian cyclin b3, a prepachytene meiotic cyclin."
      Nguyen T.B. , Manova K. , Capodieci P. , Lindon C. , Bottega S. , Wang X.-Y. , Refik-Rogers J. , Pines J. , Wolgemuth D.J. , Koff A.
      J. Biol. Chem.277:41960-41969(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH CCNB3
    20. 20.
      "Human Speedy: a novel cell cycle regulator that enhances proliferation through activation of Cdk2."
      Porter L.A. , Dellinger R.W. , Tynan J.A. , Barnes E.A. , Kong M. , Lenormand J.-L. , Donoghue D.J.
      J. Cell Biol.157:357-366(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH SPDYA
    21. 21.
      "Human Spy1 promotes survival of mammalian cells following DNA damage."
      Barnes E.A. , Porter L.A. , Lenormand J.-L. , Dellinger R.W. , Donoghue D.J.
      Cancer Res.63:3701-3707(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH SPDYA
    22. 22.
      "Spy1 interacts with p27Kip1 to allow G1/S progression."
      Porter L.A. , Kong-Beltran M. , Donoghue D.J.
      Mol. Biol. Cell14:3664-3674(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH SPDYA;IDENTIFICATION IN A COMPLEX WITH CDKN1B AND SPDYA
    23. 23.
      "NIRF induces G1 arrest and associates with Cdk2."
      Li Y. , Mori T. , Hata H. , Homma Y. , Kochi H.
      Biochem. Biophys. Res. Commun.319:464-468(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH UHRF2;IDENTIFICATION IN A COMPLEX WITH UHRF2 AND CCNE1
    24. 24.
      "p42, a novel cyclin-dependent kinase-activating kinase in mammalian cells."
      Liu Y. , Wu C. , Galaktionov K.
      J. Biol. Chem.279:4507-4514(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT THR-160
    25. 25.
      "Identification and comparative analysis of multiple mammalian Speedy/Ringo proteins."
      Cheng A. , Xiong W. , Ferrell J.E. Jr. , Solomon M.J.
      Cell Cycle4:155-165(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH SPDYA AND SPDYC
    26. 26.
      "CDK-dependent phosphorylation of BRCA2 as a regulatory mechanism for recombinational repair."
      Esashi F. , Christ N. , Gannon J. , Liu Y. , Hunt T. , Jasin M. , West S.C.
      Nature434:598-604(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION AS BRCA2 KINASE
    27. 27.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION BY CAK;MUTAGENESIS OF LYS-9; 88-LYS-LYS-89 AND LEU-166;INTERACTION WITH CDK7
    28. 28.
      "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
      Daub H. , Olsen J.V. , Bairlein M. , Gnad F. , Oppermann F.S. , Korner R. , Greff Z. , Keri G. , Stemmann O. , Mann M.
      Mol. Cell31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Cervix carcinoma.
    29. 29.
      "Cyclin A/cdk2 coordinates centrosomal and nuclear mitotic events."
      De Boer L. , Oakes V. , Beamish H. , Giles N. , Stevens F. , Somodevilla-Torres M. , Desouza C. , Gabrielli B.
      Oncogene27:4261-4268(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN MITOSE REGULATION;SUBCELLULAR LOCATION
    30. 30.
      "Identification and characterization of CAC1 as a novel CDK2-associated cullin."
      Kong Y. , Nan K. , Yin Y.
      Cell Cycle8:3544-3553(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH CACUL1
    31. 31.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-19;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
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      "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
      Mayya V. , Lundgren D.H. , Hwang S.-I. , Rezaul K. , Wu L. , Eng J.K. , Rodionov V. , Han D.K.
      Sci. Signal.2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-15;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Leukemic T-cell.
    33. 33.
      "Lysine acetylation targets protein complexes and co-regulates major cellular functions."
      Choudhary C. , Kumar C. , Gnad F. , Nielsen M.L. , Rehman M. , Walther T.C. , Olsen J.V. , Mann M.
      Science325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1 AND LYS-6;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
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      "Nuclear targeting of cyclin-dependent kinase 2 reveals essential roles of cyclin-dependent kinase 2 localization and cyclin E in vitamin D-mediated growth inhibition."
      Flores O. , Wang Z. , Knudsen K.E. , Burnstein K.L.
      Endocrinology151:896-908(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN VITAMIN D-MEDIATED GROWTH INHIBITION;SUBCELLULAR LOCATION;ENZYME REGULATION;PHOSPHORYLATION AT THR-160
    35. 35.
      "Cdk2 nitrosylation and loss of mitochondrial potential mediate NO-dependent biphasic effect on HL-60 cell cycle."
      Kumar S. , Barthwal M.K. , Dikshit M.
      Free Radic. Biol. Med.48:851-861(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;S-NITROSYLATION
    36. 36.
      "Cdc25 phosphatases are required for timely assembly of CDK1-cyclin B at the G2/M transition."
      Timofeev O. , Cizmecioglu O. , Settele F. , Kempf T. , Hoffmann I.
      J. Biol. Chem.285:16978-16990(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT THR-160 BY CAK;DEPHOSPHORYLATION BY CDC25A
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      "Cyclin-dependent kinases regulate epigenetic gene silencing through phosphorylation of EZH2."
      Chen S. , Bohrer L.R. , Rai A.N. , Pan Y. , Gan L. , Zhou X. , Bagchi A. , Simon J.A. , Huang H.
      Nat. Cell Biol.12:1108-1114(2010) [PubMed] [Europe PMC] [Abstract]
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      "Cdk2 is required for p53-independent G2/M checkpoint control."
      Chung J.H. , Bunz F.
      PLoS Genet.6:E1000863-E1000863(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN DNA DAMAGE CHECKPOINT
    39. 39.
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    40. 40.
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      "Cep63 recruits Cdk1 to the centrosome: implications for regulation of mitotic entry, centrosome amplification, and genome maintenance."
      Loffler H. , Fechter A. , Matuszewska M. , Saffrich R. , Mistrik M. , Marhold J. , Hornung C. , Westermann F. , Bartek J. , Kramer A.
      Cancer Res.71:2129-2139(2011) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH CEP63
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      "Compartmentalized CDK2 is connected with SHP-1 and beta-catenin and regulates insulin internalization."
      Fiset A. , Xu E. , Bergeron S. , Marette A. , Pelletier G. , Siminovitch K.A. , Olivier M. , Beauchemin N. , Faure R.L.
      Cell. Signal.23:911-919(2011) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION AS CTNNB1 KINASE;SUBCELLULAR LOCATION;INTERACTION WITH PTPN6 AND CTNNB1
    43. 43.
      "Discovery of a novel class of 2-aminopyrimidines as CDK1 and CDK2 inhibitors."
      Lee J. , Kim K.H. , Jeong S.
      Bioorg. Med. Chem. Lett.21:4203-4205(2011) [PubMed] [Europe PMC] [Abstract]
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      "Deubiquitinase USP37 is activated by CDK2 to antagonize APC(CDH1) and promote S phase entry."
      Huang X. , Summers M.K. , Pham V. , Lill J.R. , Liu J. , Lee G. , Kirkpatrick D.S. , Jackson P.K. , Fang G. , Dixit V.M.
      Mol. Cell42:511-523(2011) [PubMed] [Europe PMC] [Abstract]
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      "An important role for CDK2 in G1 to S checkpoint activation and DNA damage response in human embryonic stem cells."
      Neganova I. , Vilella F. , Atkinson S.P. , Lloret M. , Passos J.F. , von Zglinicki T. , O'Connor J.-E. , Burks D. , Jones R. , Armstrong L. , Lako M.
      Stem Cells29:651-659(2011) [PubMed] [Europe PMC] [Abstract]
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      Satyanarayana A. , Kaldis P.
      Cell Div.4:9-9(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW ON DNA REPAIR;INTERACTION WITH CDKN1A/P21
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      Malumbres M. , Barbacid M.
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      Satyanarayana A. , Kaldis P.
      Oncogene28:2925-2939(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW;GENE FAMILY
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      Hydbring P. , Larsson L.-G.
      Cancer Res.70:6687-6691(2010) [PubMed] [Europe PMC] [Abstract]
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      Nature376:313-320(1995) [PubMed] [Europe PMC] [Abstract]
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    54. 54.
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      Bourne Y. , Watson M.H. , Hickey M.J. , Holmes W. , Rocque W. , Reed S.I. , Tainer J.A.
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      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.6 ANGSTROMS) IN COMPLEX WITG CKS1
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      Russo A.A. , Jeffrey P.D. , Patten A.K. , Massague J. , Pavletich N.P.
      Nature382:325-331(1996) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.3 ANGSTROMS) IN COMPLEX WITH CG2A AND KIP1
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    58. 58.
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      de Azevedo W.F. Jr. , Mueller-Dieckmann H.-J. , Schulze-Gahmen U. , Worland P.J. , Sausville E. , Kim S.-H.
      Proc. Natl. Acad. Sci. U.S.A.93:2735-2740(1996) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.33 ANGSTROMS) IN COMPLEX WITH L868276
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      "Protein kinase inhibition by staurosporine revealed in details of the molecular interaction with CDK2."
      Lawrie A.M. , Noble M.E.M. , Tunnah P. , Brown N.R. , Johnson L.N. , Endicott J.A.
      Nat. Struct. Biol.4:796-801(1997) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS) IN COMPLEX WITH STAUROSPORINE;ENZYME REGULATION
    60. 60.
      "Exploiting chemical libraries, structure, and genomics in the search for kinase inhibitors."
      Gray N.S. , Wodicka L. , Thunnissen A.-M.W.H. , Norman T.C. , Kwon S. , Espinoza F.H. , Morgan D.O. , Barnes G. , Leclerc S. , Meijer L. , Kim S.H. , Lockhart D.J. , Schultz P.G.
      Science281:533-538(1998) [PubMed] [Europe PMC] [Abstract]
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    61. 61.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.80 ANGSTROMS) IN COMPLEX WITH INHIBITORS;PHOSPHORYLATION AT THR-160
    62. 62.
      "Discovery of a potent CDK2 inhibitor with a novel binding mode, using virtual screening and initial, structure-guided lead scoping."
      Richardson C.M. , Nunns C.L. , Williamson D.S. , Parratt M.J. , Dokurno P. , Howes R. , Borgognoni J. , Drysdale M.J. , Finch H. , Hubbard R.E. , Jackson P.S. , Kierstan P. , Lentzen G. , Moore J.D. , Murray J.B. , Simmonite H. , Surgenor A.E. , Torrance C.J.
      Bioorg. Med. Chem. Lett.17:3880-3885(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.20 ANGSTROMS) IN COMPLEX WITH INHIBITORS;PHOSPHORYLATION AT THR-160
    63. 63.
      "Cyclin B and cyclin A confer different substrate recognition properties on CDK2."
      Brown N.R. , Lowe E.D. , Petri E. , Skamnaki V. , Antrobus R. , Johnson L.N.
      Cell Cycle6:1350-1359(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.9 ANGSTROMS) OF 1-288 IN COMPLEX WITH CCNB1;FUNCTION
    64. 64.
      "How tyrosine 15 phosphorylation inhibits the activity of cyclin-dependent kinase 2-cyclin A."
      Welburn J.P.I. , Tucker J.A. , Johnson T. , Lindert L. , Morgan M. , Willis A. , Noble M.E.M. , Endicott J.A.
      J. Biol. Chem.282:3173-3181(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.30 ANGSTROMS) IN COMPLEX WITH ATP;PHOSPHORYLATION AT THR-14; TYR-15 AND THR-160
    65. 65.
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      "Identification of N-(4-piperidinyl)-4-(2,6-dichlorobenzoylamino)-1H-pyrazole-3-carboxamide (AT7519), a novel cyclin dependent kinase inhibitor using fragment-based X-ray crystallography and structure based drug design."
      Wyatt P.G. , Woodhead A.J. , Berdini V. , Boulstridge J.A. , Carr M.G. , Cross D.M. , Davis D.J. , Devine L.A. , Early T.R. , Feltell R.E. , Lewis E.J. , McMenamin R.L. , Navarro E.F. , O'Brien M.A. , O'Reilly M. , Reule M. , Saxty G. , Seavers L.C. , more...
      J. Med. Chem.51:4986-4999(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.68 ANGSTROMS) IN COMPLEX WITH INHIBITORS
    67. 67.
      "Briefly bound to activate: transient binding of a second catalytic magnesium activates the structure and dynamics of CDK2 kinase for catalysis."
      Bao Z.Q. , Jacobsen D.M. , Young M.A.
      Structure19:675-690(2011) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.91 ANGSTROMS) OF 1-296 IN COMPLEX WITH ATP AND MAGNESIUM;PHOSPHORYLATION AT THR-160
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