CDT1 ELISA Kit for Human(Homo sapiens) | EIAab.comCDT1 ELISA Kit for Human(Homo sapiens)

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CDT1 (Gene name),

DNA replication factor Cdt1 (Protein name ), CDT1_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

CDT1;

Protein name:

DNA replication factor Cdt1;

Alternative:

Double parked homolog(DUP);

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Interacts with GMNN; inhibits both binding of the MCM complex to origins of replication and DNA-binding activity. Interacts with PCNA.

Function:

Cooperates with CDC6 to promote the loading of the mini-chromosome maintenance complex onto chromatin to form the pre-replication complex necessary to initiate DNA replication. Binds DNA in a sequence-, strand-, and conformation-independent manner. Potential oncogene.

Subcellular Location:

Nucleus

Protein Attributes:

Sequence length:

546

Sequence:

50:

100:

150:

200:

250:

300:

350:

400:

450:

500:

546:

LLSELLPDWL | SLHRIRTDTY | VKLDKAADLA | HITARLAHQT | RAEEGL

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

UniGene:

Hs.122908

MIM:

605525

STRING:

9606.ENSP00000301019

SMR:

Q9H211

Pfam:

PF08839

String:

Q9H211

KEGG:

hsa:81620

Uniprot:

Q9H211

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ELISA Kit for Human DNA replication factor Cdt1

Cat.:

E14045h

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Manual:

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MSDS:

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Packing:

96T

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ELISA Kit for Human DNA replication factor Cdt1

Cat.:

E14045m

Price:

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MSDS:

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Packing:

96T

CLIA Kit for Human DNA replication factor Cdt1

Cat.:

U14045m

Price:

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MSDS:

Please sign in first.

Packing:

96T

CLIA Kit for Human DNA replication factor Cdt1

Cat.:

U14045h

Price:

Please sign in first.

Manual:

Looking for manual.

MSDS:

Please sign in first.

Packing:

96T

Range:

Please sign in first.

Polyclonal Antibody for Human DNA replication factor Cdt1

Monoclonal Antibody for Human DNA replication factor Cdt1

Protein for Human DNA replication factor Cdt1

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

References

1.

"Inhibition of eukaryotic DNA replication by geminin binding to Cdt1."
Wohlschlegel J.A. , Dwyer B.T. , Dhar S.K. , Cvetic C. , Walter J.C. , Dutta A.
Science290:2309-2312(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];FUNCTION;DEVELOPMENTAL STAGE;SUBCELLULAR LOCATION;INTERACTION WITH GMNN;VARIANTS ARG-234 AND ALA-262
2.

"The Cdt1 protein is required to license DNA for replication in fission yeast."
Nishitani H. , Lygerou Z. , Nishimoto T. , Nurse P.
Nature404:625-628(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];VARIANTS ARG-234 AND ALA-262
3.

"The sequence and analysis of duplication-rich human chromosome 16."
Martin J. , Han C. , Gordon L.A. , Terry A. , Prabhakar S. , She X. , Xie G. , Hellsten U. , Chan Y.M. , Altherr M. , Couronne O. , Aerts A. , Bajorek E. , Black S. , Blumer H. , Branscomb E. , Brown N.C. , Bruno W.J. , more...
Nature432:988-994(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
4.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA];VARIANTS ARG-234 AND ALA-262
tissue: Brain.
tissue: Cervix.
tissue: Eye.
tissue: Kidney.
tissue: Liver.
tissue: Uterus.
5.

Yu W. , Gibbs R.A.
Submitted (1998-06) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 136-546;VARIANT ARG-234
tissue: Brain.
6.

"A quantitative atlas of mitotic phosphorylation."
Dephoure N. , Zhou C. , Villen J. , Beausoleil S.A. , Bakalarski C.E. , Elledge S.J. , Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A.105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-394;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Cervix carcinoma.
7.

"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
Mayya V. , Lundgren D.H. , Hwang S.-I. , Rezaul K. , Wu L. , Eng J.K. , Rodionov V. , Han D.K.
Sci. Signal.2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-318;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Leukemic T-cell.
8.

"JNK1 phosphorylation of Cdt1 inhibits recruitment of HBO1 histone acetylase and blocks replication licensing in response to stress."
Miotto B. , Struhl K.
Mol. Cell44:62-71(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT THR-29 BY MAPK8/JNK1;FUNCTION
9.

"Human geminin promotes pre-RC formation and DNA replication by stabilizing CDT1 in mitosis."
Ballabeni A. , Melixetian M. , Zamponi R. , Masiero L. , Marinoni F. , Helin K.
EMBO J.23:3122-3132(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: UBIQUITINATION;INTERACTION WITH GMNN
10.

"The regulated association of Cdt1 with minichromosome maintenance proteins and Cdc6 in mammalian cells."
Cook J.G. , Chasse D.A.D. , Nevins J.R.
J. Biol. Chem.279:9625-9633(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH MCM2; GMNN AND CDC6
11.

"Cdt1 phosphorylation by cyclin A-dependent kinases negatively regulates its function without affecting geminin binding."
Sugimoto N. , Tatsumi Y. , Tsurumi T. , Matsukage A. , Kiyono T. , Nishitani H. , Fujita M.
J. Biol. Chem.279:19691-19697(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;PHOSPHORYLATION;MUTAGENESIS OF 68-ARG--LEU-70;INTERACTION WITH SKP2; GMNN AND CYCLIN A-DEPENDENT KINASES
12.

"L2DTL/CDT2 interacts with the CUL4/DDB1 complex and PCNA and regulates CDT1 proteolysis in response to DNA damage."
Higa L.A. , Banks D. , Wu M. , Kobayashi R. , Sun H. , Zhang H.
Cell Cycle5:1675-1680(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: UBIQUITINATION;INTERACTION WITH PCNA
13.

"DTL/CDT2 is essential for both CDT1 regulation and the early G2/M checkpoint."
Sansam C.L. , Shepard J.L. , Lai K. , Ianari A. , Danielian P.S. , Amsterdam A. , Hopkins N. , Lees J.A.
Genes Dev.20:3117-3129(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: UBIQUITINATION
14.

"A family of diverse Cul4-Ddb1-interacting proteins includes Cdt2, which is required for S phase destruction of the replication factor Cdt1."
Jin J. , Arias E.E. , Chen J. , Harper J.W. , Walter J.C.
Mol. Cell23:709-721(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: UBIQUITINATION
15.

"Idas, a novel phylogenetically conserved geminin-related protein, binds to geminin and is required for cell cycle progression."
Pefani D.E. , Dimaki M. , Spella M. , Karantzelis N. , Mitsiki E. , Kyrousi C. , Symeonidou I.E. , Perrakis A. , Taraviras S. , Lygerou Z.
J. Biol. Chem.286:23234-23246(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH GMNN;MUTAGENESIS OF TYR-170
16.

"Dynamic association of ORCA with prereplicative complex components regulates DNA replication initiation."
Shen Z. , Chakraborty A. , Jain A. , Giri S. , Ha T. , Prasanth K.V. , Prasanth S.G.
Mol. Cell. Biol.32:3107-3120(2012) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH LRWD1;PHOSPHORYLATION DURING MITOSIS
17.

"Mutations in the pre-replication complex cause Meier-Gorlin syndrome."
Bicknell L.S. , Bongers E.M. , Leitch A. , Brown S. , Schoots J. , Harley M.E. , Aftimos S. , Al-Aama J.Y. , Bober M. , Brown P.A. , van Bokhoven H. , Dean J. , Edrees A.Y. , Feingold M. , Fryer A. , Hoefsloot L.H. , Kau N. , Knoers N.V. , more...
Nat. Genet.43:356-359(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS MGORS4 THR-66; HIS-117; TRP-453 AND GLN-462
18.

"Mutations in origin recognition complex gene ORC4 cause Meier-Gorlin syndrome."
Guernsey D.L. , Matsuoka M. , Jiang H. , Evans S. , Macgillivray C. , Nightingale M. , Perry S. , Ferguson M. , LeBlanc M. , Paquette J. , Patry L. , Rideout A.L. , Thomas A. , Orr A. , McMaster C.R. , Michaud J.L. , Deal C. , Langlois S. , more...
Nat. Genet.43:360-364(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT MGORS4 LYS-468

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