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Index > Protein center > CDT1(Gene name) > Human
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  • CDT1 (Gene name),
  • DNA replication factor Cdt1 (Protein name ),  CDT1_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    CDT1;
    Protein name:
    DNA replication factor Cdt1;
    Alternative:
    Double parked homolog(DUP);
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Interacts with GMNN; inhibits both binding of the MCM complex to origins of replication and DNA-binding activity. Interacts with PCNA.
    Function:
    Cooperates with CDC6 to promote the loading of the mini-chromosome maintenance complex onto chromatin to form the pre-replication complex necessary to initiate DNA replication. Binds DNA in a sequence-, strand-, and conformation-independent manner. Potential oncogene.
    Subcellular Location:
    Nucleus
    Protein Attributes:
    Sequence length:
    546
    Sequence:
    50:
    MEQRRVTDFF | ARRRPGPPRI | APPKLACRTP | SPARPALRAP | ASATSGSRKR | 
    100:
    ARPPAAPGRD | QARPPARRRL | RLSVDEVSSP | STPEAPDIPA | CPSPGQKIKK | 
    150:
    STPAAGQPPH | LTSAQDQDTI | SELASCLQRA | RELGARVRAL | KASAQDAGES | 
    200:
    CTPEAEGRPE | EPCGEKAPAY | QRFHALAQPG | LPGLVLPYKY | QVLAEMFRSM | 
    250:
    DTIVGMLHNR | SETPTFAKVQ | RGVQDMMRRR | FEECNVGQIK | TVYPASYRFR | 
    300:
    QERSVPTFKD | GTRRSDYQLT | IEPLLEQEAD | GAAPQLTASR | LLQRRQIFSQ | 
    350:
    KLVEHVKEHH | KAFLASLSPA | MVVPEDQLTR | WHPRFNVDEV | PDIEPAALPQ | 
    400:
    PPATEKLTTA | QEVLARARNL | ISPRMEKALS | QLALRSAAPS | SPGSPRPALP | 
    450:
    ATPPATPPAA | SPSALKGVSQ | DLLERIRAKE | AQKQLAQMTR | CPEQEQRLQR | 
    500:
    LERLPELARV | LRSVFVSERK | PALSMEVACA | RMVGSCCTIM | SPGEMEKHLL | 
    546:
    LLSELLPDWL | SLHRIRTDTY | VKLDKAADLA | HITARLAHQT | RAEEGL
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    Pfam:
    MIM:
    SMR:
    KEGG:
    UniGene:
    String:
    Uniprot:
     
    FOR
    ELISA Kit for Human DNA replication factor Cdt1
    Cat.:
    E14045h
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    Packing:
    96T
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    ELISA Kit for Human DNA replication factor Cdt1
    Cat.:
    E14045m
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    MSDS:
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    Packing:
    96T
    CLIA Kit for Human DNA replication factor Cdt1
    Cat.:
    U14045m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human DNA replication factor Cdt1
    Cat.:
    U14045h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    Polyclonal Antibody for Human DNA replication factor Cdt1
    Polyclonal Antibody for Human DNA replication factor Cdt1
    Monoclonal Antibody for Human DNA replication factor Cdt1
    Monoclonal Antibody for Human DNA replication factor Cdt1
    Protein for Human DNA replication factor Cdt1
    Protein for Human DNA replication factor Cdt1

    R&D Technical Data
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    Precision
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    Recovery
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    Linearity
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    References
    1. 1.
      "Inhibition of eukaryotic DNA replication by geminin binding to Cdt1."
      Wohlschlegel J.A. , Dwyer B.T. , Dhar S.K. , Cvetic C. , Walter J.C. , Dutta A.
      Science290:2309-2312(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];FUNCTION;DEVELOPMENTAL STAGE;SUBCELLULAR LOCATION;INTERACTION WITH GMNN;VARIANTS ARG-234 AND ALA-262
    2. 2.
      "The Cdt1 protein is required to license DNA for replication in fission yeast."
      Nishitani H. , Lygerou Z. , Nishimoto T. , Nurse P.
      Nature404:625-628(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];VARIANTS ARG-234 AND ALA-262
    3. 3.
      "The sequence and analysis of duplication-rich human chromosome 16."
      Martin J. , Han C. , Gordon L.A. , Terry A. , Prabhakar S. , She X. , Xie G. , Hellsten U. , Chan Y.M. , Altherr M. , Couronne O. , Aerts A. , Bajorek E. , Black S. , Blumer H. , Branscomb E. , Brown N.C. , Bruno W.J. , more...
      Nature432:988-994(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    4. 4.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA];VARIANTS ARG-234 AND ALA-262
      tissue: Brain.
      tissue: Cervix.
      tissue: Eye.
      tissue: Kidney.
      tissue: Liver.
      tissue: Uterus.
    5. 5.
      Yu W. , Gibbs R.A.
      Submitted (1998-06) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 136-546;VARIANT ARG-234
      tissue: Brain.
    6. 6.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-394;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Cervix carcinoma.
    7. 7.
      "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
      Mayya V. , Lundgren D.H. , Hwang S.-I. , Rezaul K. , Wu L. , Eng J.K. , Rodionov V. , Han D.K.
      Sci. Signal.2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-318;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Leukemic T-cell.
    8. 8.
      "JNK1 phosphorylation of Cdt1 inhibits recruitment of HBO1 histone acetylase and blocks replication licensing in response to stress."
      Miotto B. , Struhl K.
      Mol. Cell44:62-71(2011) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT THR-29 BY MAPK8/JNK1;FUNCTION
    9. 9.
      "Human geminin promotes pre-RC formation and DNA replication by stabilizing CDT1 in mitosis."
      Ballabeni A. , Melixetian M. , Zamponi R. , Masiero L. , Marinoni F. , Helin K.
      EMBO J.23:3122-3132(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: UBIQUITINATION;INTERACTION WITH GMNN
    10. 10.
      "The regulated association of Cdt1 with minichromosome maintenance proteins and Cdc6 in mammalian cells."
      Cook J.G. , Chasse D.A.D. , Nevins J.R.
      J. Biol. Chem.279:9625-9633(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH MCM2; GMNN AND CDC6
    11. 11.
      "Cdt1 phosphorylation by cyclin A-dependent kinases negatively regulates its function without affecting geminin binding."
      Sugimoto N. , Tatsumi Y. , Tsurumi T. , Matsukage A. , Kiyono T. , Nishitani H. , Fujita M.
      J. Biol. Chem.279:19691-19697(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;PHOSPHORYLATION;MUTAGENESIS OF 68-ARG--LEU-70;INTERACTION WITH SKP2; GMNN AND CYCLIN A-DEPENDENT KINASES
    12. 12.
      "L2DTL/CDT2 interacts with the CUL4/DDB1 complex and PCNA and regulates CDT1 proteolysis in response to DNA damage."
      Higa L.A. , Banks D. , Wu M. , Kobayashi R. , Sun H. , Zhang H.
      Cell Cycle5:1675-1680(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: UBIQUITINATION;INTERACTION WITH PCNA
    13. 13.
      "DTL/CDT2 is essential for both CDT1 regulation and the early G2/M checkpoint."
      Sansam C.L. , Shepard J.L. , Lai K. , Ianari A. , Danielian P.S. , Amsterdam A. , Hopkins N. , Lees J.A.
      Genes Dev.20:3117-3129(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: UBIQUITINATION
    14. 14.
      "A family of diverse Cul4-Ddb1-interacting proteins includes Cdt2, which is required for S phase destruction of the replication factor Cdt1."
      Jin J. , Arias E.E. , Chen J. , Harper J.W. , Walter J.C.
      Mol. Cell23:709-721(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: UBIQUITINATION
    15. 15.
      "Idas, a novel phylogenetically conserved geminin-related protein, binds to geminin and is required for cell cycle progression."
      Pefani D.E. , Dimaki M. , Spella M. , Karantzelis N. , Mitsiki E. , Kyrousi C. , Symeonidou I.E. , Perrakis A. , Taraviras S. , Lygerou Z.
      J. Biol. Chem.286:23234-23246(2011) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH GMNN;MUTAGENESIS OF TYR-170
    16. 16.
      "Dynamic association of ORCA with prereplicative complex components regulates DNA replication initiation."
      Shen Z. , Chakraborty A. , Jain A. , Giri S. , Ha T. , Prasanth K.V. , Prasanth S.G.
      Mol. Cell. Biol.32:3107-3120(2012) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH LRWD1;PHOSPHORYLATION DURING MITOSIS
    17. 17.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS MGORS4 THR-66; HIS-117; TRP-453 AND GLN-462
    18. 18.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT MGORS4 LYS-468
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