Gene name:
Cep164 (Kiaa1052) ;
Protein name:
Centrosomal protein of 164 kDa (Cep164) ;
Alternative:
Organism:
Mouse (Mus musculus).
General Annotation
Sub Unit:
Interacts (via N-terminus) with ATRIP. Interacts with ATM, ATR and MDC1. Interacts with XPA (via N-terminus) upon UV irradiation.
Function:
Plays a role in microtubule organization and/or maintenance for the formation of primary cilia (PC), a microtubule-based structure that protrudes from the surface of epithelial cells. Plays a critical role in G2/M checkpoint and nuclear divisions. A key player in the DNA damage-activated ATR/ATM signaling cascade since it is required for the proper phosphorylation of H2AX, RPA, CHK2 and CHK1. Plays a critical role in chromosome segregation, acting as a mediator required for the maintenance of genomic stability through modulation of MDC1, RPA and CHK1.
Subcellular Location:
Cytoplasm
cytoskeleton
centrosome
centriole
Nucleus
Localizes specifically to very distally located appendage structures on the mature centriole from which initiate PC formation. Persisted at centrioles throughout mitosis.
Protein Attributes:
50:
MARRPILLGD | QLVLEEDSDE | TYVPSEQEIL | DFARVIGIDP | IKEPELMWLA |
100:
REGIEAPLPK | GWKPCQNITG | DLYYFNFDTG | QSIWDHPCDE | HYRKLVIQER |
150:
ERWSAPGAIK | KKDKKKKKEK | KNKKDKETSK | SPLVLGSPLA | LVQAPLWGLA |
200:
PLRGLGDAPP | SALRGSQSVS | LGSSADSGHL | GEPTLPPQGL | KAAACAKGLL |
250:
ASVHEGKNAL | SLLTLGEETN | EEDEEESDNQ | SVRSSSELLK | NLHLDLGALG |
300:
GNFEYEESPR | TSQPDKKDVS | LDSDADRPPT | PGKLFSQGAD | SSVASANGSK |
350:
SQGRGASPWN | PQKENENSDP | KASSSQMAPE | LDPGGDQPSR | ASKKQQAEDP |
400:
VQAGKEGECR | RESAAKEPKE | ASALENTSDV | SEESEIHGHL | KDARHSGSEA |
450:
SGPKSFLGLD | LGFRSRISEH | LLDGDTLSPV | LGGGHWEAQG | LDQEEQDDSK |
500:
SSIAEPQSKH | TQGSEREHLQ | SSLHSQATEE | GPLQTLEGQP | EWKEAEGPGK |
550:
DSVASPAPLS | LLQREQVLSP | PASPERAEEK | HSQAEELGLE | QPEAEETEEK |
600:
VAVCPSSPVS | PEVQTAEPAA | PQKLFSEAIL | KGMELEEDQR | LLLEFQKEKP |
650:
QQLEERLWEE | EEEEVCQLYQ | QKEKSLSLLK | AQLQKATAEE | KEKEEETKIR |
700:
EEESRRLVCL | RAQVQSRTEA | FENQIRTEQQ | AALQRLREEA | ETLQKAERAS |
750:
LEQKSRRALE | QLREQLEAEE | RSAQAALRAE | KEAEKEAALL | QLREQLEGER |
800:
KEAVAGLEKK | HSAELEQLCS | SLEAKHQEVI | SSLQKKIEGA | QQKEEAQLQE |
850:
SLGWAEQRAH | QKVHQVTEYE | QELSSLLRDK | RQEVEREHER | KMDKMKEEHW |
900:
QEMADARERY | EAEERKQRAD | LLGHLTGELE | RLRRAHEREL | ESMRQEQDQQ |
950:
LEDLRRRHRD | HERKLQDLEV | ELSSRTKDVK | ARLAQLNVQE | ENIRKEKQLL |
1000:
LDAQRQAALE | REEATATHQH | LEEAKKEHTH | LLETKQQLRR | TIDDLRVRRV |
1050:
ELESQVDLLQ | AQSQRLQKHL | SSLEAEVQRK | QDVLKEMAAE | MNASPHPEPG |
1100:
LHIEDLRKSL | DTNKNQEVSS | SLSLSKEEID | LSMESVRQFL | SAEGVAVRNA |
1150:
KEFLVRQTRS | MRRRQTALKA | AQQHWRHELA | SAQEVDEDLP | GTEVLGNMRK |
1200:
NLNEETRHLD | EMKSAMRKGH | DLLKKKEEKL | IQLESSLQEE | VSDEDTLKGS |
1250:
SIKKVTFDLS | DMDDLSSESL | ESSPVLHITP | TPTSADPNKI | HYLSSSLQRI |
1300:
SSELNGVLNV | LGSLNSQPPP | QGLGSQPPPP | LFTSSLRSSK | NVLDPAYSSQ |
1350:
AKLSSLSSIT | PMSTQWAWDP | GQGTKLTSSS | SSQTVDDFLL | EKWRKYFPSG |
1400:
IPLLSGSPPP | PENKLGYVSV | SEQLHFLQRS | HPRVPRTDGV | SIQSLIDSNR |
1446:
KWLEHFRNDP | KVQLFSSAPK | ATTTSNLSNL | LQLGLDENNR | LNVFHY
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Human
Mouse
ELISA Kit for Mouse Cep164
ELISA Kit for Mouse Cep164
CLIA Kit for Mouse Cep164
CLIA Kit for Mouse Cep164
Polyclonal Antibody for Mouse Cep164
Polyclonal Antibody for Mouse Cep164
Monoclonal Antibody for Mouse Cep164
Monoclonal Antibody for Mouse Cep164
R&D Technical Data
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Precision
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Recovery
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Linearity
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Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-114 (ISOFORMS 1/2/3);NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 223-862 (ISOFORM 3);NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1028-1446 (ISOFORM 2)
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION;SUBCELLULAR LOCATION