CUGBP Elav-like family member 1 (Protein name
), CELF1_HUMAN from NCBI database.
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General Annotation
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Antigen Annotation
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Predicted Eptitope
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Vaild Sequence
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Gene name:
CELF1(BRUNOL2;CUGBP;CUGBP1;NAB50);
Protein name:
CUGBP Elav-like family member 1(CELF-1);
Alternative:
Bruno-like protein 2;50 kDa nuclear polyadenylated RNA-binding protein;CUG-BP- and ETR-3-like factor 1;CUG triplet repeat RNA-binding protein 1(CUG-BP1);Embryo deadenylation element-binding protein homolog(EDEN-BP homolog);Deadenylation factor CUG-BP;RNA-binding protein BRUNOL-2;
Organism:
Human (Homo sapiens).
General Annotation
Sub Unit:
Component of an EIF2 complex at least composed of CELF1/CUGBP1, CALR, CALR3, EIF2S1, EIF2S2, HSP90B1 and HSPA5. Associates with polysomes (By similarity). Interacts with HNRNPH1; the interaction in RNA-dependent. Interacts with PARN.
Function:
RNA-binding protein implicated in the regulation of several post-transcriptional events. Involved in pre-mRNA alternative splicing, mRNA translation and stability. Mediates exon inclusion and/or exclusion in pre-mRNA that are subject to tissue-specific and developmentally regulated alternative splicing. Specifically activates exon 5 inclusion of cardiac isoforms of TNNT2 during heart remodeling at the juvenile to adult transition. Acts as both an activator and repressor of a pair of coregulated exons: promotes inclusion of the smooth muscle (SM) exon but exclusion of the non-muscle (NM) exon in actinin pre-mRNAs. Activates SM exon 5 inclusion by antagonizing the repressive effect of PTB. Promotes exclusion of exon 11 of the INSR pre-mRNA. Inhibits, together with HNRNPH1, insulin receptor (IR) pre-mRNA exon 11 inclusion in myoblast. Increases translation and controls the choice of translation initiation codon of CEBPB mRNA. Increases mRNA translation of CEBPB in aging liver (By similarity). Increases translation of CDKN1A mRNA by antagonizing the repressive effect of CALR3. Mediates rapid cytoplasmic mRNA deadenylation. Recruits the deadenylase PARN to the poly(A) tail of EDEN-containing mRNAs to promote their deadenylation. Required for completion of spermatogenesis (By similarity). Binds to (CUG)n triplet repeats in the 3'-UTR of transcripts such as DMPK and to Bruno response elements (BREs). Binds to muscle-specific splicing enhancer (MSE) intronic sites flanking the alternative exon 5 of TNNT2 pre-mRNA. Binds to AU-rich sequences (AREs or EDEN-like) localized in the 3'-UTR of JUN and FOS mRNAs. Binds to the IR RNA. Binds to the 5'-region of CDKN1A and CEBPB mRNAs. Binds with the 5'-region of CEBPB mRNA in aging liver.
Subcellular Location:
Nucleus
Cytoplasm
RNA-binding activity is detected in both nuclear and cytoplasmic compartments.
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Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2);SUBCELLULAR LOCATION;RNA-BINDING
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Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);RNA-BINDING;TISSUE SPECIFICITY
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Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);RNA-BINDING
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Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 5)
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Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4)
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Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3)
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Cited for: FUNCTION;MUTAGENESIS OF PHE-63; GLY-331 AND LEU-472;RNA-BINDING
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Cited for: SPLICE ISOFORM(S) THAT ARE POTENTIAL NMD TARGET(S)
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Cited for: FUNCTION;INTERACTION WITH HNRNPH1;RNA-BINDING;INDUCTION
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Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
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Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
22.
"Solution structure of RNA-binding domain 3 in CUG triplet repeat RNA-binding protein 1." RIKEN structural genomics initiative (RSGI)
Submitted (2005-11) to the PDB data bank
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Cited for: STRUCTURE BY NMR OF 383-484
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Cited for: X-RAY CRYSTALLOGRAPHY (1.85 ANGSTROMS) OF 14-187 IN COMPLEX WITH MRNA;DOMAINS RRM
Vaild Sequence:
