Celf2 ELISA Kit for Rat(Rattus norvegicus) | EIAab.comCelf2 ELISA Kit for Rat(Rattus norvegicus)

Search Protein-oriented Product center.

For antibodies, ELISA/CLIA, proteins... Product center

Tips

Index > Protein center > Celf2(Gene name) > Rat

Celf2 (Gene name),

CUGBP Elav-like family member 2 (Protein name ), CELF2_RAT from NCBI database.

top

General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

Feedback

Gene name:

Celf2(Cugbp2;Etr3;Napor);

Protein name:

CUGBP Elav-like family member 2(CELF-2);

Alternative:

CUG triplet repeat RNA-binding protein 2(CUG-BP2);Bruno-like protein 3;ELAV-type RNA-binding protein 3(ETR-3;Protein ETR-R3);CUG-BP- and ETR-3-like factor 2;RNA-binding protein BRUNOL-3;Neuroblastoma apoptosis-related RNA-binding protein(rNapor);

Organism:

Rat (Rattus norvegicus).

General Annotation

Sub Unit:

Interacts with A1CF.

Function:

RNA-binding protein implicated in the regulation of several post-transcriptional events. Involved in pre-mRNA alternative splicing, mRNA translation and stability. Mediates exon inclusion and/or exclusion in pre-mRNA that are subject to tissue-specific and developmentally regulated alternative splicing. Specifically activates exon 5 inclusion of TNNT2 in embryonic, but not adult, skeletal muscle. Activates TNNT2 exon 5 inclusion by antagonizing the repressive effect of PTB. Acts as both an activator and repressor of a pair of coregulated exons: promotes inclusion of the smooth muscle (SM) exon but exclusion of the non-muscle (NM) exon in actinin pre-mRNAs. Promotes inclusion of exonS 21 and exclusion of exon 5 of the NMDA receptor R1 pre-mRNA. Involved in the apoB RNA editing activity. Increases COX2 mRNA stability and inhibits COX2 mRNA translation in epithelial cells after radiation injury. Modulates the cellular apoptosis program by regulating COX2-mediated prostaglandin E2 (PGE2) expression. Binds to (CUG)n triplet repeats in the 3'-UTR of transcripts such as DMPK. Binds to the muscle-specific splicing enhancer (MSE) intronic sites flanking the TNNT2 alternative exon 5. Binds preferentially to UG-rich sequences, in particular UG repeat and UGUU motifs. Binds to apoB mRNA, specifically to AU-rich sequences located immediatly upstream of the edited cytidine. Binds AU-rich sequences in the 3'-UTR of COX2 mRNA. Binds to an intronic RNA element responsible for the silencing of exon 21 splicing. Binds to (CUG)n repeats.

Subcellular Location:

Nucleus Cytoplasm Accumulates in the cytoplasm after ionizing radiation. Colocalizes with APOBEC1 and A1CF. RNA-binding activity is detected in both nuclear and cytoplasmic compartments.

Protein Attributes:

Sequence length:

508

Sequence:

50:

100:

150:

200:

250:

300:

350:

400:

450:

500:

508:

SKNDSKPY

3D Structure:

N/A

Predicted Eptitope:

Please Sign in.

Vaild Sequence:

Please Sign in.

Related Databases

String:

Q792H5

UniGene:

Rn.162247

SMR:

Q792H5

KEGG:

rno:29428

Pfam:

PF00076

Uniprot:

Q792H5

FOR

ELISA Kit for Rat CELF-2

CLIA Kit for Rat CELF-2

Polyclonal Antibody for Rat CELF-2

Monoclonal Antibody for Rat CELF-2

Protein for Rat CELF-2

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

References

1.

"Developmentally-regulated expression of mNapor encoding an apoptosis-induced ELAV-type RNA binding protein."
Choi D.-K. , Ito T. , Tsukahara F. , Hirai M. , Sakaki Y.
Gene237:135-142(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
tissue: Hippocampus.
2.

"The expression of the ETR-R3 RNA binding proteins in the central nervous system."
Tait S. , Birling M.C. , Brophy P.J.
Submitted (1998-08) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 3 AND 4)
3.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)
tissue: Brain.
4.

"Region-specific alternative splicing in the nervous system: implications for regulation by the RNA-binding protein NAPOR."
Zhang W. , Liu H. , Han K. , Grabowski P.J.
RNA8:671-685(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: TISSUE SPECIFICITY

Product Feedback Wall

* Email:
*Comments: