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Index > Protein center > CELF3(Gene name) > Human
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  • CELF3 (Gene name),
  • CUGBP Elav-like family member 3 (Protein name ),  CELF3_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    CELF3(BRUNOL1;CAGH4;ERDA4;TNRC4);
    Protein name:
    CUGBP Elav-like family member 3(CELF-3);
    Alternative:
    CAG repeat protein 4;Bruno-like protein 1;ELAV-type RNA-binding protein 1(ETR-1);CUG-BP- and ETR-3-like factor 3;RNA-binding protein BRUNOL-1;Expanded repeat domain protein CAG/CTG 4;Trinucleotide repeat-containing gene 4 protein;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    N/A
    Function:
    RNA-binding protein involved in the regulation of pre-mRNA alternative splicing. Mediates exon inclusion and/or exclusion in pre-mRNA that are subject to tissue-specific and developmentally regulated alternative splicing. Specifically activates exon 5 inclusion of cardiac isoforms of TNNT2 during heart remodeling at the juvenile to adult transition. Activates the splicing of MAPT/Tau exon 10. Binds to muscle-specific splicing enhancer (MSE) intronic sites flanking the alternative exon 5 of TNNT2 pre-mRNA.
    Subcellular Location:
    Nucleus Cytoplasm
    Protein Attributes:
    Sequence length:
    465
    Sequence:
    50:
    MKEPDAIKLF | VGQIPRHLEE | KDLKPIFEQF | GRIFELTVIK | DKYTGLHKGC | 
    100:
    AFLTYCARDS | ALKAQSALHE | QKTLPGMNRP | IQVKPADSES | RGEDRKLFVG | 
    150:
    MLGKQQTDED | VRKMFEPFGT | IDECTVLRGP | DGTSKGCAFV | KFQTHAEAQA | 
    200:
    AINTLHSSRT | LPGASSSLVV | KFADTEKERG | LRRMQQVATQ | LGMFSPIALQ | 
    250:
    FGAYSAYTQA | LMQQQAALVA | AHSAYLSPMA | TMAAVQMQHM | AAINANGLIA | 
    300:
    TPITPSSGTS | TPPAIAATPV | SAIPAALGVN | GYSPVPTQPT | GQPAPDALYP | 
    350:
    NGVHPYPAQS | PAAPVDPLQQ | AYAGMQHYTA | AYPAAYSLVA | PAFPQPPALV | 
    400:
    AQQPPPPPQQ | QQQQQQQQQQ | QQQREGPDGC | NIFIYHLPQE | FTDSEILQMF | 
    450:
    VPFGHVISAK | VFVDRATNQS | KCFGFVSFDN | PASAQAAIQA | MNGFQIGMKR | 
    465:
    LKVQLKRPKD | ANRPY
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    SMR:
    KEGG:
    UniGene:
    String:
    MIM:
    Pfam:
    Uniprot:
     
    FOR
    ELISA Kit for Human CELF-3
    ELISA Kit for Human CELF-3
    ELISA Kit for Human CELF-3
    CLIA Kit for Human CELF-3
    CLIA Kit for Human CELF-3
    CLIA Kit for Human CELF-3
    Polyclonal Antibody for Human CELF-3
    Polyclonal Antibody for Human CELF-3
    Polyclonal Antibody for Human CELF-3
    Monoclonal Antibody for Human CELF-3
    Monoclonal Antibody for Human CELF-3
    Monoclonal Antibody for Human CELF-3
    Protein for Human CELF-3
    Protein for Human CELF-3
    Protein for Human CELF-3

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    Precision
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    Linearity
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    References
    1. 1.
      "The CELF family of RNA binding proteins is implicated in cell-specific and developmentally regulated alternative splicing."
      Ladd A.N. , Charlet-B N. , Cooper T.A.
      Mol. Cell. Biol.21:1285-1296(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);FUNCTION;RNA-BINDING;TISSUE SPECIFICITY
      tissue: Brain.
    2. 2.
      "The RNA binding protein CELF3 associates to the DMPK mRNA and is a negative regulator of mRNA stability involved in neuronal differentiation."
      d'Apolito M. , Savino M. , Grifa A. , Quattrone A.
      Submitted (2002-10) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
      tissue: Brain.
    3. 3.
      "The DNA sequence and biological annotation of human chromosome 1."
      Gregory S.G. , Barlow K.F. , McLay K.E. , Kaul R. , Swarbreck D. , Dunham A. , Scott C.E. , Howe K.L. , Woodfine K. , Spencer C.C.A. , Jones M.C. , Gillson C. , Searle S. , Zhou Y. , Kokocinski F. , McDonald L. , Evans R. , Phillips K. , more...
      Nature441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    4. 4.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    5. 5.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2 AND 3)
      tissue: Brain.
      tissue: Retinoblastoma.
    6. 6.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 109-465 (ISOFORM 1)
      tissue: Fetal brain.
    7. 7.
      "A family of human RNA-binding proteins related to the Drosophila Bruno translational regulator."
      Good P.J. , Chen Q. , Warner S.J. , Herring D.C.
      J. Biol. Chem.275:28583-28592(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 326-465
    8. 8.
      "Tau exon 10, whose missplicing causes frontotemporal dementia, is regulated by an intricate interplay of cis elements and trans factors."
      Wang J. , Gao Q.S. , Wang Y. , Lafyatis R. , Stamm S. , Andreadis A.
      J. Neurochem.88:1078-1090(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
    9. 9.
      "Solution structure of RNA binding domain in trinucleotide repeat containing 4 variant."
      RIKEN structural genomics initiative (RSGI)
      Submitted (2006-10) to the PDB data bank
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE BY NMR OF 90-178
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