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Index > Protein center > CENPI(Gene name) > Human
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  • CENPI (Gene name),
  • Centromere protein I (Protein name ),  CENPI_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Gene name:
    CENPI(FSHPRH1;ICEN19;LRPR1);
    Protein name:
    Centromere protein I(CENP-I);
    Alternative:
    Follicle-stimulating hormone primary response protein;FSH primary response protein 1;Leucine-rich primary response protein 1;Interphase centromere complex protein 19;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Component of the CENPA-CAD complex, composed of CENPI, CENPK, CENPL, CENPO, CENPP, CENPQ, CENPR and CENPS. The CENPA-CAD complex interacts with the CENPA-NAC complex, at least composed of CENPA, CENPC, CENPH, CENPM, CENPN, CENPT and MLF1IP/CENPU. Interact with SENP6.
    Function:
    Component of the CENPA-CAD (nucleosome distal) complex, a complex recruited to centromeres which is involved in assembly of kinetochore proteins, mitotic progression and chromosome segregation. May be involved in incorporation of newly synthesized CENPA into centromeres via its interaction with the CENPA-NAC complex. Required for the localization of CENPF, MAD1L1 and MAD2 (MAD2L1 or MAD2L2) to kinetochores. Involved in the response of gonadal tissues to follicle-stimulating hormone.
    Subcellular Location:
    Nucleus Chromosome centromere Localizes exclusively in the centromeres. The CENPA-CAD complex is probably recruited on centromeres by the CENPA-NAC complex.
    Protein Attributes:
    Sequence length:
    756
    Sequence:
    50:
    MSPQKRVKNV | QAQNRTSQGS | SSFQTTLSAW | KVKQDPSNSK | NISKHGQNNP | 
    100:
    VGDYEHADDQ | AEEDALQMAV | GYFEKGPIKA | SQNKDKTLEK | HLKTVENVAW | 
    150:
    KNGLASEEID | ILLNIALSGK | FGNAVNTRIL | KCMIPATVIS | EDSVVKAVSW | 
    200:
    LCVGKCSGST | KVLFYRWLVA | MFDFIDRKEQ | INLLYGFFFA | SLQDDALCPY | 
    250:
    VCHLLYLLTK | KENVKPFRVR | KLLDLQAKMG | MQPHLQALLS | LYKFFAPALI | 
    300:
    SVSLPVRKKI | YFKNSENLWK | TALLAVKQRN | RGPSPEPLKL | MLGPANVRPL | 
    350:
    KRKWNSLSVI | PVLNSSSYTK | ECGKKEMSLS | DCLNRSGSFP | LEQLQSFPQL | 
    400:
    LQNIHCLELP | SQMGSVLNNS | LLLHYINCVR | DEPVLLRFYY | WLSQTLQEEC | 
    450:
    IWYKVNNYEH | GKEFTNFLDT | IIRAECFLQE | GFYSCEAFLY | KSLPLWDGLC | 
    500:
    CRSQFLQLVS | WIPFSSFSEV | KPLLFDHLAQ | LFFTSTIYFK | CSVLQSLKEL | 
    550:
    LQNWLLWLSM | DIHMKPVTNS | PLETTLGGSM | NSVSKLIHYV | GWLSTTAMRL | 
    600:
    ESNNTFLLHF | ILDFYEKVCD | IYINYNLPLV | VLFPPGIFYS | ALLSLDTSIL | 
    650:
    NQLCFIMHRY | RKNLTAAKKN | ELVQKTKSEF | NFSSKTYQEF | NHYLTSMVGC | 
    700:
    LWTSKPFGKG | IYIDPEILEK | TGVAEYKNSL | NVVHHPSFLS | YAVSFLLQES | 
    750:
    PEERTVNVSS | IRGKKWSWYL | DYLFSQGLQG | LKLFIRSSVH | HSSIPRAEGI | 
    756:
    NCNNQY
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    Pfam:
    KEGG:
    UniGene:
    String:
    MIM:
    UniGene:
    Uniprot:
     
    FOR
    ELISA Kit for Human CENP-I
    ELISA Kit for Human CENP-I
    ELISA Kit for Human CENP-I
    ELISA Kit for Human CENP-I
    CLIA Kit for Human CENP-I
    CLIA Kit for Human CENP-I
    CLIA Kit for Human CENP-I
    CLIA Kit for Human CENP-I
    Polyclonal Antibody for Human CENP-I
    Polyclonal Antibody for Human CENP-I
    Polyclonal Antibody for Human CENP-I
    Polyclonal Antibody for Human CENP-I
    Monoclonal Antibody for Human CENP-I
    Monoclonal Antibody for Human CENP-I
    Monoclonal Antibody for Human CENP-I
    Monoclonal Antibody for Human CENP-I
    Protein for Human CENP-I
    Protein for Human CENP-I
    Protein for Human CENP-I
    Protein for Human CENP-I

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    References
    1. 1.
      "Sequence and chromosomal location of a human homologue of LRPR1, an FSH primary response gene."
      Roberts R.G. , Kendall E. , Vetrie D. , Bobrow M.
      Genomics37:122-124(1996) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
    2. 2.
      "The DNA sequence of the human X chromosome."
      Ross M.T. , Grafham D.V. , Coffey A.J. , Scherer S. , McLay K. , Muzny D. , Platzer M. , Howell G.R. , Burrows C. , Bird C.P. , Frankish A. , Lovell F.L. , Howe K.L. , Ashurst J.L. , Fulton R.S. , Sudbrak R. , Wen G. , Jones M.C. , more...
      Nature434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    3. 3.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)
      tissue: Testis.
    4. 4.
      "Human CENP-I specifies localization of CENP-F, MAD1 and MAD2 to kinetochores and is essential for mitosis."
      Liu S.-T. , Hittle J.C. , Jablonski S.A. , Campbell M.S. , Yoda K. , Yen T.J.
      Nat. Cell Biol.5:341-345(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION
    5. 5.
      "Comprehensive analysis of the ICEN (Interphase Centromere Complex) components enriched in the CENP-A chromatin of human cells."
      Izuta H. , Ikeno M. , Suzuki N. , Tomonaga T. , Nozaki N. , Obuse C. , Kisu Y. , Goshima N. , Nomura F. , Nomura N. , Yoda K.
      Genes Cells11:673-684(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY
    6. 6.
      "The CENP-H-I complex is required for the efficient incorporation of newly synthesized CENP-A into centromeres."
      Okada M. , Cheeseman I.M. , Hori T. , Okawa K. , McLeod I.X. , Yates J.R. III , Desai A. , Fukagawa T.
      Nat. Cell Biol.8:446-457(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY;IDENTIFICATION IN A COMPLEX WITH CENPH; CENPK; CENPN; CENPO; CENPP; CENPQ; CENPR AND CENPU;FUNCTION;SUBCELLULAR LOCATION
    7. 7.
      "The human CENP-A centromeric nucleosome-associated complex."
      Foltz D.R. , Jansen L.E.T. , Black B.E. , Bailey A.O. , Yates J.R. III , Cleveland D.W.
      Nat. Cell Biol.8:458-469(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY;IDENTIFICATION IN THE CENPA-CAD COMPLEX WITH CENPK; CENPL; CENPO; CENPP; CENPQ; CENPR AND CENPS
    8. 8.
      "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
      Gauci S. , Helbig A.O. , Slijper M. , Krijgsveld J. , Heck A.J. , Mohammed S.
      Anal. Chem.81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    9. 9.
      "The SUMO protease SENP6 is essential for inner kinetochore assembly."
      Mukhopadhyay D. , Arnaoutov A. , Dasso M.
      J. Cell Biol.188:681-692(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUMOYLATION;UBIQUITINATION BY RNF4;DESUMOYLATION BY SENP6;INTERACTION WITH SENP6
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