Protein name:
Centromere protein N (CENP-N) ;
Alternative:
Organism:
Rat (Rattus norvegicus).
General Annotation
Sub Unit:
Component of the CENPA-NAC complex, at least composed of CENPA, CENPC, CENPH, CENPM, CENPN, CENPT and MLF1IP/CENPU. The CENPA-NAC complex interacts with the CENPA-CAD complex, composed of CENPI, CENPK, CENPL, CENPO, CENPP, CENPQ, CENPR and CENPS.
Function:
Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres. CENPN is the first protein to bind specifically to CENPA nucleosomes and the direct binding of CENPA nucleosomes by CENPN is required for centromere assembly. Required for chromosome congression and efficiently align the chromosomes on a metaphase plate.
Subcellular Location:
Nucleus
Chromosome
centromere
Chromosome
centromere
kinetochore
Localizes exclusively in the kinetochore domain of centromeres (By similarity). Kinetochore-bound levels decrease when cells enter mitosis and increase again when cells exit mitosis.
Protein Attributes:
50:
MDENVAEFLR | RIILKIPLCE | MKTILEAWDF | LSEDQLQSIN | LKQRKEFLAQ |
100:
EVILLCEDKC | ASLDDMALLD | LMYTQFHRHQ | KLWNVFQMSK | EPGGNDVDLF |
150:
DMEQFQSSFK | RILQRALKNV | TVSFRVYEKN | SVWIRVAWGT | QYSQPNQYKP |
200:
TFVVYYPQTP | YVFISSCYLK | STVPLLHQAL | KVASKHHQMA | QLDLRSRHLD |
250:
SLTAIVFNEY | DQTFENYNST | ASWREGSLGL | KTDLDSKIIH | ENTEEKVRIH |
300:
RATQEAFGAY | PQPQLEFAQY | KLETKFKSDV | GGGILADRKE | PLRCLVKFSS |
340:
PHLLEALKSL | APAGIADTPL | SPLLTCIPSK | KMNYFKIRDK |
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Bovine
Human
Rat
Chicken
Mouse
Polyclonal Antibody for Rat CENP-N
Polyclonal Antibody for Rat CENP-N
Polyclonal Antibody for Rat CENP-N
Polyclonal Antibody for Rat CENP-N
Polyclonal Antibody for Rat CENP-N
Monoclonal Antibody for Rat CENP-N
Monoclonal Antibody for Rat CENP-N
Monoclonal Antibody for Rat CENP-N
Monoclonal Antibody for Rat CENP-N
Monoclonal Antibody for Rat CENP-N
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
1.
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Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
tissue :
Testis .