Protein name:
Centrosomal protein of 55 kDa (Cep55) ;
Alternative:
Organism:
Rat (Rattus norvegicus).
General Annotation
Sub Unit:
Homodimer. Interacts (phosphorylated on Ser-423 and Ser-426) with PLK1. Interacts with AKAP9; the interaction occurs in interphase and is lost upon mitotic entry. Interacts with PCNT; the interaction occurs in interphase and is lost upon mitotic entry. Interacts with PDCD6IP; the interaction is direct; CEP55 binds PDCD6IP in a 2:1 stoechiometry; PDCD6IP competes with TSG101 for the same binding site. Interacts with TSG101; TSG101 competes with PDCD6IP for the same binding site; interaction is required for cytokinesis. Interacts with FAM125A, VPS37B, VPS37C and VPS28.
Function:
Plays a role in mitotic exit and cytokinesis. Not required for microtubule nucleation. Recruits PDCD6IP and TSG101 to midbody during cytokinesis.
Subcellular Location:
Cytoplasm
cytoskeleton
centrosome
centriole
Cytoplasm
cytoskeleton
centrosome
Cleavage furrow
Midbody
Present at the centrosomes at interphase. A small portion is associated preferentially with the mother centriole, whereas the majority localizes to the pericentriolar material. During mitosis, loss of affinity for the centrosome at the onset of prophase and diffusion throughout the cell. Dissociation from the centrosome is phosphorylation-dependent. May remain localized at the centrosome during mitosis in certain cell types. Appears at the cleavage furrow in late anaphase and in the midbody in cytokinesis.
Protein Attributes:
50:
MSSRSPKDLI | KSKWGSRPSS | SKSDTALEKF | KGEIAAFKTS | LDEITNGKGK |
100:
VANKDRSKLL | EKIQVLEAER | EKNVYYLMEK | DKEIQRLKDH | LRSRYSSSSL |
150:
LEQLEEKTKE | CEKKQQLLES | LSRETDILKK | QLSATTKRLS | ELESKASTLH |
200:
LSQSVPANCF | NSSMNSIHEK | EMQLKDALEK | NQQWLVYDQQ | REAYVKGLLA |
250:
KIFELEKRTE | TAAASLPQQM | KKTESEGYLQ | EEKQKYDHLL | ENAKKDLEVE |
300:
RQTVTQLRLE | LDEFRRKYEE | TQKEVEDLNQ | LLSSQRKADI | QHLEEDKHKT |
350:
EKIQKLREES | SVFKGKLEEE | RKKSEELLSQ | VRILYDSLLK | HQEEQSRVAL |
400:
LERQMQACTL | DFENEKLDRQ | NMQHQLYVIL | KELRKAKSQI | TQLESLKQLH |
450:
GFTFTEQPFP | LQGEPENRVK | ATSPKSPTAV | LNESLVECPK | CSVQYPATEH |
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Rat
Mouse
Human
Polyclonal Antibody for Rat Cep55
Polyclonal Antibody for Rat Cep55
Polyclonal Antibody for Rat Cep55
Monoclonal Antibody for Rat Cep55
Monoclonal Antibody for Rat Cep55
Monoclonal Antibody for Rat Cep55
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
1.
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Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
tissue :
Testis .