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Index > Protein center > CFD(Gene name) > Human
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  • CFD (Gene name),
  • Complement factor D (Protein name ),  CFAD_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    CFD(DF;PFD);
    Protein name:
    Complement factor D;
    Alternative:
    C3 convertase activator;Adipsin;Properdin factor D;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Function:
    Factor D cleaves factor B when the latter is complexed with factor C3b, activating the C3bbb complex, which then becomes the C3 convertase of the alternate pathway. Its function is homologous to that of C1s in the classical pathway.
    Subcellular Location:
    Secreted
    Protein Attributes:
    Sequence length:
    253
    Sequence:
    50:
    MHSWERLAVL | VLLGAAACAA | PPRGRILGGR | EAEAHARPYM | ASVQLNGAHL | 
    100:
    CGGVLVAEQW | VLSAAHCLED | AADGKVQVLL | GAHSLSQPEP | SKRLYDVLRA | 
    150:
    VPHPDSQPDT | IDHDLLLLQL | SEKATLGPAV | RPLPWQRVDR | DVAPGTLCDV | 
    200:
    AGWGIVNHAG | RRPDSLQHVL | LPVLDRATCN | RRTHHDGAIT | ERLMCAESNR | 
    250:
    RDSCKGDSGG | PLVCGGVLEG | VVTSGSRVCG | NRKKPGIYTR | VASYAAWIDS | 
    253:
    VLA
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    SMR:
    UniGene:
    MIM:
    String:
    Pfam:
    KEGG:
    Uniprot:
     
    FOR
    ELISA Kit for Human Complement factor D
    Cat.:
    E1833r
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    MSDS:
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    Packing:
    96T
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    ELISA Kit for Human Complement factor D
    Cat.:
    E1833m
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    MSDS:
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    Packing:
    96T
    ELISA Kit for Human Complement factor D
    Cat.:
    E1833p
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    MSDS:
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    Packing:
    96T
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    ELISA Kit for Human Complement factor D
    Cat.:
    E1833h
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    MSDS:
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    Packing:
    96T
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    ELISA Kit for Human Complement factor D
    Cat.:
    E1833b
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    MSDS:
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    Packing:
    96T
    CLIA Kit for Human Complement factor D
    Cat.:
    U1833p
    Price:
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    MSDS:
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    Packing:
    96T
    CLIA Kit for Human Complement factor D
    Cat.:
    U1833h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Human Complement factor D
    Cat.:
    U1833m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Complement factor D
    Cat.:
    U1833b
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Complement factor D
    Cat.:
    U1833r
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    MSDS:
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    Packing:
    96T
    Polyclonal Antibody for Human Complement factor D
    Polyclonal Antibody for Human Complement factor D
    Cat.:
    P1833Rb-r
    Price:
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Complement factor D
    Cat.:
    P1833Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Complement factor D
    Polyclonal Antibody for Human Complement factor D
    Cat.:
    P1833Rb-m
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Human Complement factor D
    Monoclonal Antibody for Human Complement factor D
    Monoclonal Antibody for Human Complement factor D
    Monoclonal Antibody for Human Complement factor D
    Monoclonal Antibody for Human Complement factor D
    Protein for Human Complement factor D
    Protein for Human Complement factor D
    Protein for Human Complement factor D
    Protein for Human Complement factor D
    Protein for Human Complement factor D

    R&D Technical Data
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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      Relle M.
      Submitted (2001-07) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
    2. 2.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      tissue: Small intestine.
    3. 3.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    4. 4.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      tissue: Placenta.
      tissue: Skin.
      tissue: Spleen.
      tissue: Testis.
    5. 5.
      "Human adipsin is identical to complement factor D and is expressed at high levels in adipose tissue."
      White R.T. , Damm D. , Hancock N. , Rosen B.S. , Lowell B.B. , Usher P. , Flier J.S. , Spiegelman B.M.
      J. Biol. Chem.267:9210-9213(1992) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 8-253
    6. 6.
      "Amino acid sequence of human D of the alternative complement pathway."
      Niemann M.A. , Bhown A.S. , Bennett J.C. , Volanakis J.E.
      Biochemistry23:2482-2486(1984) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 26-252
    7. 7.
      "Amino acid sequence of human factor D of the complement system. Similarity in sequence between factor D and proteases of non-plasma origin."
      Johnson D.M.A. , Gagnon J. , Reid K.B.M.
      FEBS Lett.166:347-351(1984) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 26-252
    8. 8.
      "Partial amino acid sequence of human factor D: homology with serine proteases."
      Volanakis J.E. , Bhown A.S. , Bennett J.C. , Mole J.E.
      Proc. Natl. Acad. Sci. U.S.A.77:1116-1119(1980) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 26-82
    9. 9.
      "Active site amino acid sequence of human factor D."
      Davis A.E. III
      Proc. Natl. Acad. Sci. U.S.A.77:4938-4942(1980) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 26-78
    10. 10.
      "Factor D of the alternative pathway of human complement. Purification, alignment and N-terminal amino acid sequences of the major cyanogen bromide fragments, and localization of the serine residue at the active site."
      Johnson D.M.A. , Gagnon J. , Reid K.B.M.
      Biochem. J.187:863-874(1980) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 26-61 AND 194-220
    11. 11.
      "Structure of human factor D. A complement system protein at 2.0-A resolution."
      Narayana S.V.L. , Carson M. , El-Kabbani O. , Kilpatrick J.M. , Moore D. , Chen X. , Bugg C.E. , Volanakis J.E. , Delucas L.J.
      J. Mol. Biol.235:695-708(1994) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS)
    12. 12.
      "Crystal structure of a complement factor D mutant expressing enhanced catalytic activity."
      Kim S. , Narayana S.V. , Volanakis J.E.
      J. Biol. Chem.270:24399-24405(1995) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS)
    13. 13.
      "Deficient alternative complement pathway activation due to factor D deficiency by 2 novel mutations in the complement factor D gene in a family with meningococcal infections."
      Sprong T. , Roos D. , Weemaes C. , Neeleman C. , Geesing C.L. , Mollnes T.E. , van Deuren M.
      Blood107:4865-4870(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS CFDD DEFICIENCY GLY-213 AND ARG-214
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