CFI ELISA Kit for Human(Homo sapiens) | EIAab.comCFI ELISA Kit for Human(Homo sapiens)

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Index > Protein center > CFI(Gene name) > Human

CFI (Gene name),

Complement factor I (Protein name ), CFAI_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

CFI(IF);

Protein name:

Complement factor I;

Alternative:

C3B/C4B inactivator;

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Heterodimer of a light and heavy chains linked by disulfide bonds.

Function:

Responsible for cleaving the alpha-chains of C4b and C3b in the presence of the cofactors C4-binding protein and factor H respectively.

Subcellular Location:

Secreted extracellular space

Protein Attributes:

Sequence length:

583

Sequence:

50:

100:

150:

200:

250:

300:

350:

400:

450:

500:

550:

583:

GKPEFPGVYT | KVANYFDWIS | YHVGRPFISQ | YNV

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

SMR:

P05156

MIM:

217030

STRING:

9606.ENSP00000378130

Pfam:

PF00057

UniGene:

Hs.312485

String:

P05156

KEGG:

hsa:3426

Uniprot:

P05156

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ELISA Kit for Human Complement factor I

Cat.:

E0982h

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96T

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ELISA Kit for Human Complement factor I

Cat.:

E0982m

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96T

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ELISA Kit for Human Complement factor I

Cat.:

E0982r

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96T

CLIA Kit for Human Complement factor I

Cat.:

U0982m

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96T

CLIA Kit for Human Complement factor I

Cat.:

U0982r

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MSDS:

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Packing:

96T

CLIA Kit for Human Complement factor I

Cat.:

U0982h

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Manual:

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MSDS:

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96T

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Polyclonal Antibody for Human Complement factor I

Cat.:

P0982Rb-r

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40ug/0.2ml

Polyclonal Antibody for Human Complement factor I

Cat.:

P0982Rb-m

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Packing:

40ug/0.2ml

Polyclonal Antibody for Human Complement factor I

Cat.:

P0982Rb-h

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Packing:

40ug/0.2ml

Monoclonal Antibody for Human Complement factor I

Protein for Human Complement factor I

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

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References

1.

"Characterization of primary amino acid sequence of human complement control protein factor I from an analysis of cDNA clones."
Catterall C.F. , Lyons A. , Sim R.M. , Day A.J. , Harris T.J.R.
Biochem. J.242:849-856(1987) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];VARIANT ALA-300
tissue: Liver.
2.

"Human complement factor I: analysis of cDNA-derived primary structure and assignment of its gene to chromosome 4."
Goldberger G. , Bruns G.A.P. , Rits M. , Edge M.D. , Kwiatkowski D.J.
J. Biol. Chem.262:10065-10071(1987) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];VARIANT ALA-300
3.

"Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
Hillier L.W. , Graves T.A. , Fulton R.S. , Fulton L.A. , Pepin K.H. , Minx P. , Wagner-McPherson C. , Layman D. , Wylie K. , Sekhon M. , Becker M.C. , Fewell G.A. , Delehaunty K.D. , Miner T.L. , Nash W.E. , Kremitzki C. , Oddy L. , Du H. , more...
Nature434:724-731(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
4.

"Cloning and characterization of the promoter for the human complement factor I (C3b/C4b inactivator) gene."
Minta J.O. , Fung M. , Turner S. , Eren R. , Zemach L. , Rits M. , Goldberger G.
Gene208:17-24(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-18
tissue: Liver.
5.

"Beta-sheet secondary structure of an LDL receptor domain from complement factor I by consensus structure predictions and spectroscopy."
Ullman C.G. , Haris P.I. , Smith K.F. , Sim R.B. , Emery V.C. , Perkins S.J.
FEBS Lett.371:199-203(1995) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 258-269
6.

"Screening for N-glycosylated proteins by liquid chromatography mass spectrometry."
Bunkenborg J. , Pilch B.J. , Podtelejnikov A.V. , Wisniewski J.R.
Proteomics4:454-465(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-464
tissue: Plasma.
7.

"Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry."
Liu T. , Qian W.-J. , Gritsenko M.A. , Camp D.G. II , Monroe M.E. , Moore R.J. , Smith R.D.
J. Proteome Res.4:2070-2080(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-70; ASN-103; ASN-177; ASN-464 AND ASN-536
tissue: Plasma.
8.

"Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
Chen R. , Jiang X. , Sun D. , Han G. , Wang F. , Ye M. , Wang L. , Zou H.
J. Proteome Res.8:651-661(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-103
tissue: Liver.
9.

"A strategy for precise and large scale identification of core fucosylated glycoproteins."
Jia W. , Lu Z. , Fu Y. , Wang H.P. , Wang L.H. , Chi H. , Yuan Z.F. , Zheng Z.B. , Song L.N. , Han H.H. , Liang Y.M. , Wang J.L. , Cai Y. , Zhang Y.K. , Deng Y.L. , Ying W.T. , He S.M. , Qian X.H.
Mol. Cell. Proteomics8:913-923(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION AT ASN-103
10.

"Enrichment of glycopeptides for glycan structure and attachment site identification."
Nilsson J. , Rueetschi U. , Halim A. , Hesse C. , Carlsohn E. , Brinkmalm G. , Larson G.
Nat. Methods6:809-811(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-103;STRUCTURE OF CARBOHYDRATES
tissue: Cerebrospinal fluid.
11.

"Structural basis for complement factor I control and its disease-associated sequence polymorphisms."
Roversi P. , Johnson S. , Caesar J.J. , McLean F. , Leath K.J. , Tsiftsoglou S.A. , Morgan B.P. , Harris C.L. , Sim R.B. , Lea S.M.
Proc. Natl. Acad. Sci. U.S.A.108:12839-12844(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.69 ANGSTROMS) OF 19-583;CALCIUM-BINDING;SUBUNIT;DISULFIDE BONDS
12.

"The molecular basis of hereditary complement factor I deficiency."
Vyse T.J. , Morley B.J. , Bartok I. , Theodoridis E.L. , Davies K.A. , Webster A.D.B. , Walport M.J.
J. Clin. Invest.97:925-933(1996) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT CFI DEFICIENCY LEU-418
13.

"Molecular characterization of homozygous hereditary factor I deficiency."
Baracho G.V. , Nudelman V. , Isaac L.
Clin. Exp. Immunol.131:280-286(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INVOLVEMENT IN CFI DEFICIENCY
14.

"Complement factor I: a susceptibility gene for atypical haemolytic uraemic syndrome."
Fremeaux-Bacchi V. , Dragon-Durey M.-A. , Blouin J. , Vigneau C. , Kuypers D. , Boudailliez B. , Loirat C. , Rondeau E. , Fridman W.H.
J. Med. Genet.41:E84-E84(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT AHUS3 VAL-524
15.

"Genetics of HUS: the impact of MCP, CFH, and IF mutations on clinical presentation, response to treatment, and outcome."
The international registry of recurrent and familial HUS/TTP , Caprioli J. , Noris M. , Brioschi S. , Pianetti G. , Castelletti F. , Bettinaglio P. , Mele C. , Bresin E. , Cassis L. , Gamba S. , Porrati F. , Bucchioni S. , Monteferrante G. , Fang C.J. , Liszewski M.K. , Kavanagh D. , Atkinson J.P. , more...
Blood108:1267-1279(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS AHUS3 TRP-317 AND ASN-519
16.

"Primary glomerulonephritis with isolated C3 deposits: a new entity which shares common genetic risk factors with haemolytic uraemic syndrome."
Servais A. , Fremeaux-Bacchi V. , Lequintrec M. , Salomon R. , Blouin J. , Knebelmann B. , Gruenfeld J.-P. , Lesavre P. , Noeel L.-H. , Fakhouri F.
J. Med. Genet.44:193-199(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT CFI DEFICIENCY ASP-243
17.

"A missense mutation in factor I (IF) predisposes to atypical haemolytic uraemic syndrome."
Geelen J. , van den Dries K. , Roos A. , van de Kar N. , de Kat Angelino C. , Klasen I. , Monnens L. , van den Heuvel L.
Pediatr. Nephrol.22:371-375(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT AHUS3 THR-340
18.

"Mutations in alternative pathway complement proteins in American patients with atypical hemolytic uremic syndrome."
Maga T.K. , Nishimura C.J. , Weaver A.E. , Frees K.L. , Smith R.J.H.
Hum. Mutat.31:E1445-E1460(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS AHUS3 LEU-64; ARG-119; ARG-183; ARG-287; LEU-416 AND THR-522
19.

"A functional variant in the CFI gene confers a high risk of age-related macular degeneration."
van de Ven J.P. , Nilsson S.C. , Tan P.L. , Buitendijk G.H. , Ristau T. , Mohlin F.C. , Nabuurs S.B. , Schoenmaker-Koller F.E. , Smailhodzic D. , Campochiaro P.A. , Zack D.J. , Duvvari M.R. , Bakker B. , Paun C.C. , Boon C.J. , Uitterlinden A.G. , Liakopoulos S. , Klevering B.J. , more...
Nat. Genet.45:813-817(2013) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT ARMD13 ARG-119;VARIANT ALA-188;CHARACTERIZATION VARIANT ARMD13 ARG-119

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