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Index > Protein center > Cftr(Gene name) > Mouse
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  • Cftr (Gene name),
  • Cystic fibrosis transmembrane conductance regulator (Protein name ),  CFTR_MOUSE from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Gene name:
    Cftr(Abcc7);
    Protein name:
    Cystic fibrosis transmembrane conductance regulator(CFTR);
    Alternative:
    3.6.3.49;Channel conductance-controlling ATPase);ATP-binding cassette sub-family C member 7;cAMP-dependent chloride channel;
    Organism:
    Mouse (Mus musculus). 
    General Annotation
    Sub Unit:
    Interacts with MYO6, SLC9A3R1 and GOPC. Interacts with SLC4A7 through SLC9A3R1. Interacts with SHANK2 (By similarity). Found in a complex with MYO5B and RAB11A.
    Function:
    Involved in the transport of chloride ions. May regulate bicarbonate secretion and salvage in epithelial cells by regulating the SLC4A7 transporter.
    Subcellular Location:
    Early endosome membrane Multi-pass membrane protein
    Protein Attributes:
    Sequence length:
    1476
    Sequence:
    50:
    MQKSPLEKAS | FISKLFFSWT | TPILRKGYRH | HLELSDIYQA | PSADSADHLS | 
    100:
    EKLEREWDRE | QASKKNPQLI | HALRRCFFWR | FLFYGILLYL | GEVTKAVQPV | 
    150:
    LLGRIIASYD | PENKVERSIA | IYLGIGLCLL | FIVRTLLLHP | AIFGLHRIGM | 
    200:
    QMRTAMFSLI | YKKTLKLSSR | VLDKISIGQL | VSLLSNNLNK | FDEGLALAHF | 
    250:
    IWIAPLQVTL | LMGLLWDLLQ | FSAFCGLGLL | IILVIFQAIL | GKMMVKYRDQ | 
    300:
    RAAKINERLV | ITSEIIDNIY | SVKAYCWESA | MEKMIENLRE | VELKMTRKAA | 
    350:
    YMRFFTSSAF | FFSGFFVVFL | SVLPYTVING | IVLRKIFTTI | SFCIVLRMSV | 
    400:
    TRQFPTAVQI | WYDSFGMIRK | IQDFLQKQEY | KVLEYNLMTT | GIIMENVTAF | 
    450:
    WEEGFGELLE | KVQQSNGDRK | HSSDENNVSF | SHLCLVGNPV | LKNINLNIEK | 
    500:
    GEMLAITGST | GSGKTSLLML | ILGELEASEG | IIKHSGRVSF | CSQFSWIMPG | 
    550:
    TIKENIIFGV | SYDEYRYKSV | VKACQLQQDI | TKFAEQDNTV | LGEGGVTLSG | 
    600:
    GQRARISLAR | AVYKDADLYL | LDSPFGYLDV | FTEEQVFESC | VCKLMANKTR | 
    650:
    ILVTSKMEHL | RKADKILILH | QGSSYFYGTF | SELQSLRPDF | SSKLMGYDTF | 
    700:
    DQFTEERRSS | ILTETLRRFS | VDDSSAPWSK | PKQSFRQTGE | VGEKRKNSIL | 
    750:
    NSFSSVRKIS | IVQKTPLCID | GESDDLQEKR | LSLVPDSEQG | EAALPRSNMI | 
    800:
    ATGPTFPGRR | RQSVLDLMTF | TPNSGSSNLQ | RTRTSIRKIS | LVPQISLNEV | 
    850:
    DVYSRRLSQD | STLNITEEIN | EEDLKECFLD | DVIKIPPVTT | WNTYLRYFTL | 
    900:
    HKGLLLVLIW | CVLVFLVEVA | ASLFVLWLLK | NNPVNSGNNG | TKISNSSYVV | 
    950:
    IITSTSFYYI | FYIYVGVADT | LLALSLFRGL | PLVHTLITAS | KILHRKMLHS | 
    1000:
    ILHAPMSTIS | KLKAGGILNR | FSKDIAILDD | FLPLTIFDFI | QLVFIVIGAI | 
    1050:
    IVVSALQPYI | FLATVPGLVV | FILLRAYFLH | TAQQLKQLES | EGRSPIFTHL | 
    1100:
    VTSLKGLWTL | RAFRRQTYFE | TLFHKALNLH | TANWFMYLAT | LRWFQMRIDM | 
    1150:
    IFVLFFIVVT | FISILTTGEG | EGTAGIILTL | AMNIMSTLQW | AVNSSIDTDS | 
    1200:
    LMRSVSRVFK | FIDIQTEESM | YTQIIKELPR | EGSSDVLVIK | NEHVKKSDIW | 
    1250:
    PSGGEMVVKD | LTVKYMDDGN | AVLENISFSI | SPGQRVGLLG | RTGSGKSTLL | 
    1300:
    SAFLRMLNIK | GDIEIDGVSW | NSVTLQEWRK | AFGVITQKVF | IFSGTFRQNL | 
    1350:
    DPNGKWKDEE | IWKVADEVGL | KSVIEQFPGQ | LNFTLVDGGY | VLSHGHKQLM | 
    1400:
    CLARSVLSKA | KIILLDEPSA | HLDPITYQVI | RRVLKQAFAG | CTVILCEHRI | 
    1450:
    EAMLDCQRFL | VIEESNVWQY | DSLQALLSEK | SIFQQAISSS | EKMRFFQGRH | 
    1476:
    SSKHKPRTQI | TALKEETEEE | VQETRL
    3D Structure:
    N/A
    Predicted Eptitope:
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    EIAab Sequence  Vaild Sequence:
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    Related Databases
    SMR:
    KEGG:
    Pfam:
    String:
    UniGene:
    Uniprot:
     
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    Polyclonal Antibody for Mouse CFTR
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    Protein for Mouse CFTR
    Protein for Mouse CFTR
    Protein for Mouse CFTR
    Protein for Mouse CFTR
    Protein for Mouse CFTR
    Protein for Mouse CFTR
    Protein for Mouse CFTR

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    References
    1. 1.
      "Cloning the mouse homolog of the human cystic fibrosis transmembrane conductance regulator gene."
      Tata F. , Stanier P. , Wicking C. , Halford S. , Kruyer H. , Lench N.J. , Scambler P.J. , Hansen C. , Braman J.C. , Williamson R. , Wainwright B.J.
      Genomics10:301-307(1991) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
    2. 2.
      "Molecular cloning and sequence analysis of the murine cDNA for the cystic fibrosis transmembrane conductance regulator."
      Yorifuji T. , Lemna W.K. , Ballard C.F. , Rosenbloom C.L. , Rozmahel R. , Plavsic N. , Tsui L.-C. , Beaudet A.L.
      Genomics10:547-550(1991) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
      strain: BALB/c.
    3. 3.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
    4. 4.
      "Analysis of the mouse and rat CFTR promoter regions."
      Denamur E. , Chehab F.F.
      Hum. Mol. Genet.3:1089-1094(1994) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-17
    5. 5.
      "Cystic fibrosis transmembrane conductance regulator splice variants are not conserved and fail to produce chloride channels."
      Delaney S.J. , Rich D.P. , Thomson S.A. , Hargrave M.R. , Lovelock P.K. , Welsh M.J. , Wainwright B.J.
      Nat. Genet.4:426-431(1993) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 549-600;ALTERNATIVE SPLICING
      tissue: Testis.
    6. 6.
      "Participation of the Cl-/HCO(3)- exchangers SLC26A3 and SLC26A6, the Cl- channel CFTR, and the regulatory factor SLC9A3R1 in mouse sperm capacitation."
      Chavez J.C. , Hernandez-Gonzalez E.O. , Wertheimer E. , Visconti P.E. , Darszon A. , Trevino C.L.
      Biol. Reprod.86:1-14(2012) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH SLC26A3; SLC26A6 AND SLC9A3R1
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