Protein name:
Cystic fibrosis transmembrane conductance regulator (CFTR) ;
Alternative:
3.6.3.49;Channel conductance-controlling ATPase ) ;ATP-binding cassette sub-family C member 7 ;cAMP-dependent chloride channel ;
Organism:
Mouse (Mus musculus).
General Annotation
Sub Unit:
Interacts with MYO6, SLC9A3R1 and GOPC. Interacts with SLC4A7 through SLC9A3R1. Interacts with SHANK2 (By similarity). Found in a complex with MYO5B and RAB11A.
Function:
Involved in the transport of chloride ions. May regulate bicarbonate secretion and salvage in epithelial cells by regulating the SLC4A7 transporter.
Subcellular Location:
Early endosome membrane
Multi-pass membrane protein
Protein Attributes:
50:
MQKSPLEKAS | FISKLFFSWT | TPILRKGYRH | HLELSDIYQA | PSADSADHLS |
100:
EKLEREWDRE | QASKKNPQLI | HALRRCFFWR | FLFYGILLYL | GEVTKAVQPV |
150:
LLGRIIASYD | PENKVERSIA | IYLGIGLCLL | FIVRTLLLHP | AIFGLHRIGM |
200:
QMRTAMFSLI | YKKTLKLSSR | VLDKISIGQL | VSLLSNNLNK | FDEGLALAHF |
250:
IWIAPLQVTL | LMGLLWDLLQ | FSAFCGLGLL | IILVIFQAIL | GKMMVKYRDQ |
300:
RAAKINERLV | ITSEIIDNIY | SVKAYCWESA | MEKMIENLRE | VELKMTRKAA |
350:
YMRFFTSSAF | FFSGFFVVFL | SVLPYTVING | IVLRKIFTTI | SFCIVLRMSV |
400:
TRQFPTAVQI | WYDSFGMIRK | IQDFLQKQEY | KVLEYNLMTT | GIIMENVTAF |
450:
WEEGFGELLE | KVQQSNGDRK | HSSDENNVSF | SHLCLVGNPV | LKNINLNIEK |
500:
GEMLAITGST | GSGKTSLLML | ILGELEASEG | IIKHSGRVSF | CSQFSWIMPG |
550:
TIKENIIFGV | SYDEYRYKSV | VKACQLQQDI | TKFAEQDNTV | LGEGGVTLSG |
600:
GQRARISLAR | AVYKDADLYL | LDSPFGYLDV | FTEEQVFESC | VCKLMANKTR |
650:
ILVTSKMEHL | RKADKILILH | QGSSYFYGTF | SELQSLRPDF | SSKLMGYDTF |
700:
DQFTEERRSS | ILTETLRRFS | VDDSSAPWSK | PKQSFRQTGE | VGEKRKNSIL |
750:
NSFSSVRKIS | IVQKTPLCID | GESDDLQEKR | LSLVPDSEQG | EAALPRSNMI |
800:
ATGPTFPGRR | RQSVLDLMTF | TPNSGSSNLQ | RTRTSIRKIS | LVPQISLNEV |
850:
DVYSRRLSQD | STLNITEEIN | EEDLKECFLD | DVIKIPPVTT | WNTYLRYFTL |
900:
HKGLLLVLIW | CVLVFLVEVA | ASLFVLWLLK | NNPVNSGNNG | TKISNSSYVV |
950:
IITSTSFYYI | FYIYVGVADT | LLALSLFRGL | PLVHTLITAS | KILHRKMLHS |
1000:
ILHAPMSTIS | KLKAGGILNR | FSKDIAILDD | FLPLTIFDFI | QLVFIVIGAI |
1050:
IVVSALQPYI | FLATVPGLVV | FILLRAYFLH | TAQQLKQLES | EGRSPIFTHL |
1100:
VTSLKGLWTL | RAFRRQTYFE | TLFHKALNLH | TANWFMYLAT | LRWFQMRIDM |
1150:
IFVLFFIVVT | FISILTTGEG | EGTAGIILTL | AMNIMSTLQW | AVNSSIDTDS |
1200:
LMRSVSRVFK | FIDIQTEESM | YTQIIKELPR | EGSSDVLVIK | NEHVKKSDIW |
1250:
PSGGEMVVKD | LTVKYMDDGN | AVLENISFSI | SPGQRVGLLG | RTGSGKSTLL |
1300:
SAFLRMLNIK | GDIEIDGVSW | NSVTLQEWRK | AFGVITQKVF | IFSGTFRQNL |
1350:
DPNGKWKDEE | IWKVADEVGL | KSVIEQFPGQ | LNFTLVDGGY | VLSHGHKQLM |
1400:
CLARSVLSKA | KIILLDEPSA | HLDPITYQVI | RRVLKQAFAG | CTVILCEHRI |
1450:
EAMLDCQRFL | VIEESNVWQY | DSLQALLSEK | SIFQQAISSS | EKMRFFQGRH |
1476:
SSKHKPRTQI | TALKEETEEE | VQETRL
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Rat
Dog
Human
Bovine
Rabbit
Mouse
Pig
Polyclonal Antibody for Mouse CFTR
Polyclonal Antibody for Mouse CFTR
Polyclonal Antibody for Mouse CFTR
Polyclonal Antibody for Mouse CFTR
Polyclonal Antibody for Mouse CFTR
Polyclonal Antibody for Mouse CFTR
Polyclonal Antibody for Mouse CFTR
Monoclonal Antibody for Mouse CFTR
Monoclonal Antibody for Mouse CFTR
Monoclonal Antibody for Mouse CFTR
Monoclonal Antibody for Mouse CFTR
Monoclonal Antibody for Mouse CFTR
Monoclonal Antibody for Mouse CFTR
Monoclonal Antibody for Mouse CFTR
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
1.
"Cloning the mouse homolog of the human cystic fibrosis transmembrane conductance regulator gene."
Tata F.
,
Stanier P.
,
Wicking C.
,
Halford S.
,
Kruyer H.
,
Lench N.J.
,
Scambler P.J.
,
Hansen C.
,
Braman J.C.
,
Williamson R.
,
Wainwright B.J.
Genomics10:301-307(1991)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA]
2.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA]
strain :
BALB/c .
3.
"Comparative genomic sequence analysis of the human and mouse cystic fibrosis transmembrane conductance regulator genes."
Ellsworth R.E.
,
Jamison D.C.
,
Touchman J.W.
,
Chissoe S.L.
,
Braden Maduro V.V.
,
Bouffard G.G.
,
Dietrich N.L.
,
Beckstrom-Sternberg S.M.
,
Iyer L.M.
,
Weintraub L.A.
,
Cotton M.
,
Courtney L.
,
Edwards J.
,
Maupin R.
,
Ozersky P.
,
Rohlfing T.
,
Wohldmann P.
,
Miner T.
,
Kemp K.
,
Kramer J.
,
Korf I.
,
Pepin K.
,
Antonacci-Fulton L.
,
Fulton R.S.
,
Minx P.
,
Hillier L.W.
,
Wilson R.K.
,
Waterston R.H.
,
Miller W.
,
Green E.D.
more...
Proc. Natl. Acad. Sci. U.S.A.97:1172-1177(2000)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [GENOMIC DNA]
4.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-17
5.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 549-600;ALTERNATIVE SPLICING
tissue :
Testis .
6.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION;INTERACTION WITH SLC26A3; SLC26A6 AND SLC9A3R1