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Index > Protein center > CFTR(Gene name) > Rabbit
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  • CFTR (Gene name),
  • Cystic fibrosis transmembrane conductance regulator (Protein name ),  CFTR_RABIT from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Gene name:
    CFTR(ABCC7);
    Protein name:
    Cystic fibrosis transmembrane conductance regulator(CFTR);
    Alternative:
    3.6.3.49;Channel conductance-controlling ATPase);ATP-binding cassette sub-family C member 7;cAMP-dependent chloride channel;
    Organism:
    Rabbit (Oryctolagus cuniculus). 
    General Annotation
    Sub Unit:
    Interacts with MYO6, SLC9A3R1 and GOPC. Interacts with SLC4A7 through SLC9A3R1. Interacts with SHANK2 (By similarity). Found in a complex with MYO5B and RAB11A.
    Function:
    Involved in the transport of chloride ions. May regulate bicarbonate secretion and salvage in epithelial cells by regulating the SLC4A7 transporter.
    Subcellular Location:
    Early endosome membrane Multi-pass membrane protein
    Protein Attributes:
    Sequence length:
    1481
    Sequence:
    50:
    MQKSPLEKAG | VLSKLFFSWT | RPILRKGYRQ | RLELSDIYQI | PSADSADNLS | 
    100:
    EKLEREWDRE | LASKKKPKLI | NALRRCFFWR | FMFYGILLYL | GEVTKAVQPL | 
    150:
    LLGRIIASYD | PDNKVERSIA | IYLGIGLCLL | FVVRTLLLHP | AIFGLHHIGM | 
    200:
    QMRIAMFSLI | YKKTLKLSSR | VLDKISIGQL | ISLLSNNLNK | FDEGLALAHF | 
    250:
    VWISPLQVTL | LMGLLWELLQ | ASAFCGLAFL | IVLALVQAGL | GRMMMKYRDQ | 
    300:
    RAGKINERLV | ITSEMIENIQ | SVKAYCWEEA | MEKMIENLRQ | TELKLTRKAA | 
    350:
    YVRYFNSSAF | FFSGFFVVFL | SVLPYALTKG | IILRKIFTTI | SFCIVLRMAV | 
    400:
    TRQFPWAVQT | WYDSLGAINK | IQDFLQKQEY | KTLEYNLTTT | EVVMDNVTAF | 
    450:
    WEEGFGELFE | KAKQNNSDRK | ISNGDNNLFF | SNFSLLGAPV | LKDISFKIER | 
    500:
    GQLLAVAGST | GAGKTSLLMM | IMGELEPSEG | KIKHSGRISF | CSQFSWIMPG | 
    550:
    TIKENIIFGV | SYDEYRYKSV | IKACQLEEDI | SKFTEKDNTV | LGEGGITLSG | 
    600:
    GQRARISLAR | AVYKDADLYL | LDSPFGYLDV | LTEKEIFESC | VCKLMANKTR | 
    650:
    ILVTSKMEHL | KKADKILILH | EGSSYFYGTF | SELQSLRPDF | SSKLMGYDSF | 
    700:
    DQFSAERRNS | ILTETLRRFS | LEGDASISWN | DTRKQSFKQN | GELGEKRKNS | 
    750:
    ILNPVNSMRK | FSIVPKTPLQ | MNGIEEDSDA | SIERRLSLVP | DSEQGEAILP | 
    800:
    RSNMINTGPM | LQGCRRQSVL | NLMTHSVSQG | PSIYRRTTTS | ARKMSLAPQT | 
    850:
    NLTEMDIYSR | RLSQESGLEI | SEEINEEDLK | ECFIDDVDSI | PTVTTWNTYL | 
    900:
    RYITVHRSLI | FVLIWCIVIF | LAEVAASLVV | LWLFGNTAPQ | DKENSTKSGN | 
    950:
    SSYAVIITNT | SSYYFFYIYV | GVADTLLALG | LFRGLPLVHT | LITVSKILHH | 
    1000:
    KMLHSVLQAP | MSTLNTLKAG | GILNRFSKDI | AILDDLLPLT | IFDFIQLLLI | 
    1050:
    VVGAIAVVSV | LQPYIFLATV | PVIAAFILLR | AYFLHTSQQL | KQLESEGRSP | 
    1100:
    IFTHLVTSLK | GLWTLRAFGR | QPYFETLFHK | ALNLHTANWF | LYLSTLRWFQ | 
    1150:
    MRIEMIFVLF | FIAVAFISIL | TTGEGEGRVG | IILTLAMNIM | STLQWAVNSS | 
    1200:
    IDVDSLMRSV | SRVFKFIDMP | TEETKSTKSI | KPSSNCQLSK | VMIIENQHVK | 
    1250:
    KDDVWPSGGQ | MTVKGLTAKY | IDSGNAILEN | ISFSISPGQR | VGLLGRTGSG | 
    1300:
    KSTLLSAFLR | LLNTEGEIQI | DGVSWDSITL | QQWRKAFGVI | PQKVFIFSGT | 
    1350:
    FRKNLDPYEQ | WSDQEIWKVA | DEVGLRSVIE | QFPGKLDFVL | VDGGYVLSHG | 
    1400:
    HKQLMCLARS | VLSKAKILLL | DEPSAHLDPI | TYQIIRRTLK | QAFADCTVIL | 
    1450:
    CEHRIEAMLE | CQRFLVIEEN | TVRQYESIQK | LLSEKSLFRQ | AISSSDRAKL | 
    1481:
    FPHRNSSKHK | SRPQITALKE | EAEEEVQGTR | L
    3D Structure:
    N/A
    Predicted Eptitope:
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    EIAab Sequence  Vaild Sequence:
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    Related Databases
    UniGene:
    String:
    Pfam:
    SMR:
    Uniprot:
     
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    References
    1. 1.
      "Cystic fibrosis gene encodes a cAMP-dependent chloride channel in heart."
      Hart P.H. , Warth J.D. , Levesque P.C. , Collier M.L. , Geary Y. , Horowitz B. , Hume J.R.
      Proc. Natl. Acad. Sci. U.S.A.93:6343-6348(1996) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2)
      tissue: Heart ventricle.
    2. 2.
      "Oryctolagus cuniculus cornea epithelium CFTR chloride channel mRNA."
      Rae J.L.
      Submitted (1999-09) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
      strain: New Zealand white.
      tissue: Cornea.
    3. 3.
      "NISC comparative sequencing initiative."
      Antonellis A. , Ayele K. , Benjamin B. , Blakesley R.W. , Boakye A. , Bouffard G.G. , Brinkley C. , Brooks S. , Chu G. , Coleman H. , Engle J. , Gestole M. , Greene A. , Guan X. , Gupta J. , Haghighi P. , Han J. , Hansen N. , more...
      Submitted (2006-09) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    4. 4.
      "Alternative splicing of CFTR Cl- channels in heart."
      Horowitz B. , Tsung S.S. , Hart P. , Levesque P.C. , Hume J.R.
      Am. J. Physiol.264:H2214-H2220(1993) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 90-339 AND 847-1156 (ISOFORM 2);TISSUE SPECIFICITY
      tissue: Heart ventricle.
    5. 5.
      "Partial cDNA sequence of the rabbit colonic chloride channel, CFTR."
      Selvaraj N. , Prasad R. , Rao M.C.
      Submitted (1999-09) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 127-287 (ISOFORM 1)
      strain: New Zealand white.
      tissue: Colon.
    6. 6.
      "Expression of cystic fibrosis transmembrane regulator Cl- channels in heart."
      Levesque P.C. , Hart P.J. , Hume J.R. , Kenyon J.L. , Horowitz B.
      Circ. Res.71:1002-1007(1992) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 423-592;TISSUE SPECIFICITY
      tissue: Heart ventricle.
    7. 7.
      "A cross-species analysis of the cystic fibrosis transmembrane conductance regulator. Potential functional domains and regulatory sites."
      Diamond G. , Scanlin T.F. , Zasloff M.A. , Bevins C.L.
      J. Biol. Chem.266:22761-22769(1991) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 604-776
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