Protein name:
Chromodomain-helicase-DNA-binding protein 4 (CHD-4) ;
Alternative:
Organism:
Mouse (Mus musculus).
General Annotation
Sub Unit:
Central component of the nucleosome remodeling and histone deacetylase (NuRD) repressor complex. Interacts with TRIM27. Interacts with ZGPAT; the interaction is direct. Part of a complex containing ATR and HDAC2. Interacts with PCNT (By similarity). Interacts with KLF1; the interaction depends on sumoylation of KLF1, and leads to its transcriptional repression. Interacts directly with IKFZ1 in the NuRD complex.
Function:
Component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin by deacetylating histones.
Subcellular Location:
Nucleus
Cytoplasm
cytoskeleton
centrosome
Associates with centrosomes in interphase.
Protein Attributes:
50:
MASGLGSPSP | CSAGSEEEDM | DALLNNSLPP | PHPENEEDPD | EDLSEAETPK |
100:
LKKKKKPKKP | RDPKIPKSKR | QKKELGDSSG | EGPEFVEEEE | EVALRSDSEG |
150:
SDYTPGKKKK | KKLGPKKEKK | SKSKRKEEEE | EEDEDDDSKE | PKSSAQLLED |
200:
WGMEDIDHVF | SEEDYRTLTN | YKAFSQFVRP | LIAAKNPKIA | VSKMMMVLGA |
250:
KWREFSTNNP | FKGSSGASVA | AAAAAAVAVV | ESMVTATEVA | PPPPPVEVPI |
300:
RKAKTKEGKG | PNARRKPKGS | PRVPDAKKPK | PKKVAPLKIK | LGGFGSKRKR |
350:
SSSEDDDLDV | ESDFDDASIN | SYSVSDGSTS | RSSRSRKKLR | TAKKKKKGEE |
400:
EVTAVDGYET | DHQDYCEVCQ | QGGEIILCDT | CPRAYHMVCL | DPDMEKAPEG |
450:
KWSCPHCEKE | GIQWEAKEDN | SEGEEILEEV | GGDPEEEDDH | HMEFCRVCKD |
500:
GGELLCCDTC | PSSYHIHCLN | PPLPEIPNGE | WLCPRCTCPA | LKGKVQKILI |
550:
WKWGQPPSPT | PVPRPPDADP | NTPSPKPLEG | RPERQFFVKW | QGMSYWHCSW |
600:
VSELQLELHC | QVMFRNYQRK | NDMDEPPSGD | FGGDEEKSRK | RKNKDPKFAE |
650:
MEERFYRYGI | KPEWMMIHRI | LNHSVDKKGH | VHYLIKWRDL | PYDQASWESE |
700:
DVEIQDYDLF | KQSYWNHREL | MRGEEGRPGK | KLKKVKLRKL | ERPPETPTVD |
750:
PTVKYERQPE | YLDATGGTLH | PYQMEGLNWL | RFSWAQGTDT | ILADEMGLGK |
800:
TVQTAVFLYS | LYKEGHSKGP | FLVSAPLSTI | INWEREFEMW | APDMYVVTYV |
850:
GDKDSRAIIR | ENEFSFEDNA | IRGGKKASRM | KKEASVKFHV | LLTSYELITI |
900:
DMAILGSIDW | ACLIVDEAHR | LKNNQSKFFR | VLNGYSLQHK | LLLTGTPLQN |
950:
NLEELFHLLN | FLTPERFHNL | EGFLEEFADI | AKEDQIKKLH | DMLGPHMLRR |
1000:
LKADVFKNMP | SKTELIVRVE | LSPMQKKYYK | YILTRNFEAL | NARGGGNQVS |
1050:
LLNVVMDLKK | CCNHPYLFPV | AAMEAPKMPN | GMYDGSALIR | ASGKLLLLQK |
1100:
MLKNLKEGGH | RVLIFSQMTK | MLDLLEDFLE | HEGYKYERID | GGITGNMRQE |
1150:
AIDRFNAPGA | QQFCFLLSTR | AGGLGINLAT | ADTVIIYDSD | WNPHNDIQAF |
1200:
SRAHRIGQNK | KVMIYRFVTR | ASVEERITQV | AKKKMMLTHL | VVRPGLGSKT |
1250:
GSMSKQELDD | ILKFGTEELF | KDEATDGGGD | NKEGEDSSVI | HYDDKAIERL |
1300:
LDRNQDETED | TELQGMNEYL | SSFKVAQYVV | REEEMGEEEE | VEREIIKQEE |
1350:
SVDPDYWEKL | LRHHYEQQQE | DLARNLGKGK | RIRKQVNYND | GSQEDRDWQD |
1400:
DQSDNQSDYS | VASEEGDEDF | DERSEAPRRP | SRKGLRNDKD | KPLPPLLARV |
1450:
GGNIEVLGFN | ARQRKAFLNA | IMRYGMPPQD | AFTTQWLVRD | LRGKSEKEFK |
1500:
AYVSLFMRHL | CEPGADGAET | FADGVPREGL | SRQHVLTRIG | VMSLIRKKVQ |
1550:
EFEHVNGRWS | MPELAEVEEN | KKMSQPGSPS | PKTPTPSTPG | DTQPNTPAPV |
1600:
PPAEDGIKIE | ENSLKEEEST | EGEKEVKSTA | PEATVECAQP | PAPAPATAPA |
1650:
TATAPEDDKA | PAEPPEGEEK | VEKAEVKERT | EEPMETEAKG | TTEVEKVEEK |
1700:
SAVDLTPIVV | EDKEEKKEEE | EKKDVMLQNG | ETPKDLSDEK | QKKNSKQRFM |
1750:
FNIADGGFTE | LHSLWQNEER | AATVTKKTYE | IWHRRHDYWL | LAGIINHGYA |
1800:
RWQDIQNDPR | YAILNEPFKG | EMNRGNFLEI | KNKFLARRFK | LLEQALVIEE |
1850:
QLRRAAYLNM | SEDPSHPSMA | LNTRFAEVEC | LAESHQHLSK | ESMAGNKPAN |
1900:
AVLHKVLKQL | EELLSDMKAD | VTRLPATIAR | IPPVAVRLQM | SERNILSRLA |
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Mouse
Human
ELISA Kit for Mouse CHD-4
ELISA Kit for Mouse CHD-4
Polyclonal Antibody for Mouse CHD-4
Polyclonal Antibody for Mouse CHD-4
Monoclonal Antibody for Mouse CHD-4
Monoclonal Antibody for Mouse CHD-4
R&D Technical Data
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
Precision
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For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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Recovery
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For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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Linearity
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For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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References
1.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
tissue :
Eye .
2.
"An ikaros-containing chromatin-remodeling complex in adult-type erythroid cells."
O'Neill D.W.
,
Schoetz S.S.
,
Lopez R.A.
,
Castle M.
,
Rabinowitz L.
,
Shor E.
,
Krawchuk D.
,
Goll M.G.
,
Renz M.
,
Seelig H.P.
,
Han S.
,
Seong R.H.
,
Park S.D.
,
Agalioti T.
,
Munshi N.
,
Thanos D.
,
Erdjument-Bromage H.
,
Tempst P.
,
Bank A.
more...
Mol. Cell. Biol.20:7572-7582(2000)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH IKFZ1 IN THE NURD COMPLEX
3.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH KLF1;FUNCTION
4.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue :
Liver .
5.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-421 AND SER-1528;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]