Chd8 ELISA Kit for Rat(Rattus norvegicus) | EIAab.comChd8 ELISA Kit for Rat(Rattus norvegicus)

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Chd8 (Gene name),

Chromodomain-helicase-DNA-binding protein 8 (Protein name ), CHD8_RAT from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

Chd8;

Protein name:

Chromodomain-helicase-DNA-binding protein 8(CHD-8);

Alternative:

Axis duplication inhibitor(Duplin);ATP-dependent helicase CHD8;

Organism:

Rat (Rattus norvegicus).

General Annotation

Sub Unit:

Interacts with p53/TP53, histone H1 and CTCF. Component of some MLL1/MLL complex, at least composed of the core components MLL, ASH2L, HCFC1/HCF1, WDR5 and RBBP5, as well as the facultative components C17orf49, CHD8, E2F6, HSP70, IN80C, KIAA1267, LAS1L, MAX, MCRS1, MGA, MYST1/MOF, PELP1, PHF20, PRP31, RING2, RUVB1/TIP49A, RUVB2/TIP49B, SENP3, TAF1, TAF4, TAF6, TAF7, TAF9 and TEX10 (By similarity). Interacts with CTNNB1 and PIAS3.

Function:

DNA helicase that acts as a chromatin remodeling factor and regulates transcription. Acts as a transcription repressor by remodeling chromatin structure and recruiting histone H1 to target genes. Suppresses p53/TP53-mediated apoptosis by recruiting histone H1 and preventing p53/TP53 transactivation activity. Acts as a negative regulator of Wnt signaling pathway by regulating beta-catenin (CTNNB1) activity. Negatively regulates CTNNB1-targeted gene expression by being recruited specifically to the promoter regions of several CTNNB1 responsive genes. Involved in both enhancer blocking and epigenetic remodeling at chromatin boundary via its interaction with CTCF. Acts as a suppressor of STAT3 activity by suppressing the LIF-induced STAT3 transcriptional activity. Also acts as a transcription activator via its interaction with ZNF143 by participating to efficient U6 RNA polymerase III transcription.

Subcellular Location:

Nucleus Localizes to the promoter regions of several CTNNB1-responsive genes. Also present at known CTCF target sites.

Protein Attributes:

Sequence length:

2581

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SQGYDSSERD | FSLIDDPMMP | ANSDSSDDAD | D

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

Pfam:

PF07533

KEGG:

rno:65027

STRING:

10116.ENSRNOP00000022593

String:

Q9JIX5

UniGene:

Rn.98337

Uniprot:

Q9JIX5

FOR

ELISA Kit for Rat CHD-8

Cat.:

E11393r

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MSDS:

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Packing:

96T

ELISA Kit for Rat CHD-8

Cat.:

E11393m

Price:

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MSDS:

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Packing:

96T

ELISA Kit for Rat CHD-8

Cat.:

E11393h

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MSDS:

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Packing:

96T

CLIA Kit for Rat CHD-8

Cat.:

U11393m

Price:

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MSDS:

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Packing:

96T

CLIA Kit for Rat CHD-8

Cat.:

U11393r

Price:

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MSDS:

Please sign in first.

Packing:

96T

CLIA Kit for Rat CHD-8

Cat.:

U11393h

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MSDS:

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Packing:

96T

Polyclonal Antibody for Rat CHD-8

Cat.:

P11393Rb-m

Price:

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Packing:

40ug/0.2ml

Polyclonal Antibody for Rat CHD-8

Cat.:

P11393Rb-h

Price:

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Packing:

40ug/0.2ml

Polyclonal Antibody for Rat CHD-8

Cat.:

P11393Rb-r

Price:

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Packing:

40ug/0.2ml

Monoclonal Antibody for Rat CHD-8

Protein for Rat CHD-8

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

References

1.

"A novel beta-catenin-binding protein inhibits beta-catenin-dependent Tcf activation and axis formation."
Sakamoto I. , Kishida S. , Fukui A. , Kishida M. , Yamamoto H. , Hino S. , Michiue T. , Takada S. , Asashima M. , Kikuchi A.
J. Biol. Chem.275:32871-32878(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2);SUBCELLULAR LOCATION;INTERACTION WITH CTNNB1
2.

Mural R.J. , Adams M.D. , Myers E.W. , Smith H.O. , Venter J.C.
Submitted (2005-08) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
3.

"Nuclear localization of Duplin, a beta-catenin-binding protein, is essential for its inhibitory activity on the Wnt signaling pathway."
Kobayashi M. , Kishida S. , Fukui A. , Michiue T. , Miyamoto Y. , Okamoto T. , Yoneda Y. , Asashima M. , Kikuchi A.
J. Biol. Chem.277:5816-5822(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION
4.

"Suppression of STAT3 activity by Duplin, which is a negative regulator of the Wnt signal."
Yamashina K. , Yamamoto H. , Chayama K. , Nakajima K. , Kikuchi A.
J. Biochem.139:305-314(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUMOYLATION AT LYS-609;INTERACTION WITH PIAS3;MUTAGENESIS OF LYS-457; LYS-512; LYS-609 AND LYS-654

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