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Index > Protein center > CHIA(Gene name) > Human
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  • CHIA (Gene name),
  • Acidic mammalian chitinase (Protein name ),  CHIA_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Gene name:
    CHIA;
    Protein name:
    Acidic mammalian chitinase(AMCase);
    Alternative:
    Lung-specific protein TSA1902;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Interacts with EGFR.
    Function:
    Degrades chitin and chitotriose. May participate in the defense against nematodes, fungi and other pathogens. Plays a role in T helper cell type 2 (Th2) immune response. Contributes to the response to IL-13 and inflammation in response to IL-13. Stimulates chemokine production by pulmonary epithelial cells. Protects lung epithelial cells against apoptosis and promotes phosphorylation of AKT1. Its function in the inflammatory response and in protecting cells against apoptosis is inhibited by allosamidin, suggesting that the function of this protein depends on carbohydrate binding.
    Subcellular Location:
    Isoform 3 Cytoplasm
    Protein Attributes:
    Sequence length:
    476
    Sequence:
    50:
    MTKLILLTGL | VLILNLQLGS | AYQLTCYFTN | WAQYRPGLGR | FMPDNIDPCL | 
    100:
    CTHLIYAFAG | RQNNEITTIE | WNDVTLYQAF | NGLKNKNSQL | KTLLAIGGWN | 
    150:
    FGTAPFTAMV | STPENRQTFI | TSVIKFLRQY | EFDGLDFDWE | YPGSRGSPPQ | 
    200:
    DKHLFTVLVQ | EMREAFEQEA | KQINKPRLMV | TAAVAAGISN | IQSGYEIPQL | 
    250:
    SQYLDYIHVM | TYDLHGSWEG | YTGENSPLYK | YPTDTGSNAY | LNVDYVMNYW | 
    300:
    KDNGAPAEKL | IVGFPTYGHN | FILSNPSNTG | IGAPTSGAGP | AGPYAKESGI | 
    350:
    WAYYEICTFL | KNGATQGWDA | PQEVPYAYQG | NVWVGYDNIK | SFDIKAQWLK | 
    400:
    HNKFGGAMVW | AIDLDDFTGT | FCNQGKFPLI | STLKKALGLQ | SASCTAPAQP | 
    450:
    IEPITAAPSG | SGNGSGSSSS | GGSSGGSGFC | AVRANGLYPV | ANNRNAFWHC | 
    476:
    VNGVTYQQNC | QAGLVFDTSC | DCCNWA
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
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    Related Databases
    SMR:
    KEGG:
    UniGene:
    MIM:
    String:
    Pfam:
    Uniprot:
     
    FOR
    ELISA Kit for Human AMCase
    Cat.:
    E9061m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    ELISA Kit for Human AMCase
    Cat.:
    E9061h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    ELISA Kit for Human AMCase
    Cat.:
    E9061r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    ELISA Kit for Human AMCase
    Cat.:
    E9061b
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human AMCase
    Cat.:
    U9061r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human AMCase
    Cat.:
    U9061b
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human AMCase
    Cat.:
    U9061m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Human AMCase
    Cat.:
    U9061h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Polyclonal Antibody for Human AMCase
    Polyclonal Antibody for Human AMCase
    Cat.:
    P9061Rb-m
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human AMCase
    Polyclonal Antibody for Human AMCase
    Cat.:
    P9061Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Human AMCase
    Monoclonal Antibody for Human AMCase
    Monoclonal Antibody for Human AMCase
    Monoclonal Antibody for Human AMCase
    Protein for Human AMCase
    Protein for Human AMCase
    Protein for Human AMCase
    Protein for Human AMCase

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    References
    1. 1.
      "Isolation and mapping of a human lung-specific gene, TSA1902, encoding a novel chitinase family member."
      Saito A. , Ozaki K. , Fujiwara T. , Nakamura Y. , Tanigami A.
      Gene239:325-331(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 2 AND 3);VARIANTS VAL-339 AND GLY-432
      tissue: Lung.
    2. 2.
      "Identification of a novel acidic mammalian chitinase distinct from chitotriosidase."
      Boot R.G. , Blommaart E.F.C. , Swart E. , Ghauharali-van der Vlugt K. , Bijl N. , Moe C. , Place A. , Aerts J.M.F.G.
      J. Biol. Chem.276:6770-6778(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);FUNCTION;TISSUE SPECIFICITY
    3. 3.
      "A novel chitinase family member."
      Chen X.H. , Cai G.P.
      Submitted (2004-10) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 2 AND 3)
      tissue: Kidney.
    4. 4.
      "The DNA sequence and biological annotation of human chromosome 1."
      Gregory S.G. , Barlow K.F. , McLay K.E. , Kaul R. , Swarbreck D. , Dunham A. , Scott C.E. , Howe K.L. , Woodfine K. , Spencer C.C.A. , Jones M.C. , Gillson C. , Searle S. , Zhou Y. , Kokocinski F. , McDonald L. , Evans R. , Phillips K. , more...
      Nature441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    5. 5.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)
    6. 6.
      "Acidic mammalian chitinase in asthmatic Th2 inflammation and IL-13 pathway activation."
      Zhu Z. , Zheng T. , Homer R.J. , Kim Y.K. , Chen N.Y. , Cohn L. , Hamid Q. , Elias J.A.
      Science304:1678-1682(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INDUCTION;TISSUE SPECIFICITY
    7. 7.
      "Acidic mammalian chitinase is secreted via an ADAM17/epidermal growth factor receptor-dependent pathway and stimulates chemokine production by pulmonary epithelial cells."
      Hartl D. , He C.H. , Koller B. , Da Silva C.A. , Homer R. , Lee C.G. , Elias J.A.
      J. Biol. Chem.283:33472-33482(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;CATALYTIC ACTIVITY;INTERACTION WITH EGFR;SUBCELLULAR LOCATION
    8. 8.
      "Acidic mammalian chitinase regulates epithelial cell apoptosis via a chitinolytic-independent mechanism."
      Hartl D. , He C.H. , Koller B. , Da Silva C.A. , Kobayashi Y. , Lee C.G. , Flavell R.A. , Elias J.A.
      J. Immunol.182:5098-5106(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;MUTAGENESIS OF ASP-138
    9. 9.
      "Triad of polar residues implicated in pH specificity of acidic mammalian chitinase."
      Olland A.M. , Strand J. , Presman E. , Czerwinski R. , Joseph-McCarthy D. , Krykbaev R. , Schlingmann G. , Chopra R. , Lin L. , Fleming M. , Kriz R. , Stahl M. , Somers W. , Fitz L. , Mosyak L.
      Protein Sci.18:569-578(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.7 ANGSTROMS) OF 22-408 IN COMPLEX WITH METHYLALLOSAMIDIN;CATALYTIC ACTIVITY;DISULFIDE BONDS
    10. 10.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS ASP-45; ASN-47; MET-61; ARG-102; ARG-125; VAL-339; SER-354 AND GLY-432;CATALYTIC ACTIVITY;FUNCTION;CHARACTERIZATION OF VARIANTS ASP-45; ASN-47 AND MET-61
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