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Index > Protein center > Chka(Gene name) > Mouse
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  • Chka (Gene name),
  • Choline kinase alpha (Protein name ),  CHKA_MOUSE from NCBI database.
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  • Gene name:
    Chka(Chk);
    Protein name:
    Choline kinase alpha(CK);
    Alternative:
    2.7.1.82;Ethanolamine kinase;(EK);CHETK-alpha;
    Organism:
    Mouse (Mus musculus). 
    General Annotation
    Sub Unit:
    Homodimer, and heterodimer with CHKB.
    Function:
    Has a key role in phospholipid biosynthesis and may contribute to tumor cell growth. Catalyzes the first step in phosphatidylcholine biosynthesis. Contributes to phosphatidylethanolamine biosynthesis. Phosphorylates choline and ethanolamine. Has higher activity with choline.
    Subcellular Location:
    Cytoplasm
    Protein Attributes:
    Sequence length:
    453
    Sequence:
    50:
    MKTKFCTGGE | AEPSPLGLLL | SCGGNAAPTP | GVGQQRDAAG | ELESKQLGGR | 
    100:
    TQPLALPPPP | PPPLPLPPPP | SPPLADEQPE | PRTRRRAYLW | CKEFLPGAWR | 
    150:
    GLREDQFHIS | VIRGGLSNML | FQCSLPDSIA | SVGDEPRKVL | LRLYGAILKM | 
    200:
    RSCNKEGSEQ | AQNENEFQGA | EAMVLESVMF | AILAERSLGP | KLYGIFPQGR | 
    250:
    LEQFIPSRRL | DTEELRLPDI | SAEIAEKMAT | FHGMKMPFNK | EPKWLFGTME | 
    300:
    KYLNQVLRLK | FSREARVQQL | HKILSYNLPL | ELENLRSLLQ | YTRSPVVFCH | 
    350:
    NDCQEGNILL | LEGQENSERR | KLMLIDFEYS | SYNYRGFDIG | NHFCEWMYDY | 
    400:
    TYEKYPFFRA | NIQKYPSRKQ | QLHFISSYLT | TFQNDFESLS | SEEQFATKED | 
    450:
    MLLEVNRFAL | ASHFLWGLWS | IVQAKISSIE | FGYMEYAQAR | FEAYFDQKRK | 
    453:
    LGV
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    SMR:
    Pfam:
    UniGene:
    KEGG:
    String:
    Uniprot:
     
    FOR
    ELISA Kit for Mouse CK
    Cat.:
    E1985m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    ELISA Kit for Mouse CK
    Cat.:
    E1985r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    ELISA Kit for Mouse CK
    Cat.:
    E1985h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Mouse CK
    Cat.:
    U1985h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Mouse CK
    Cat.:
    U1985m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Mouse CK
    Cat.:
    U1985r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Polyclonal Antibody for Mouse CK
    Cat.:
    P1985Rb-m
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Mouse CK
    Cat.:
    P1985Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Mouse CK
    Cat.:
    P1985Rb-r
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Mouse CK
    Monoclonal Antibody for Mouse CK
    Monoclonal Antibody for Mouse CK
    Protein for Mouse CK
    Protein for Mouse CK
    Cat.:
    R1985h
    Price:
    Please sign in first.
    Packing:
    1mg
    Purity:
    >90%
    Protein for Mouse CK

    R&D Technical Data
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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      "Molecular cloning of mouse choline kinase and choline/ethanolamine kinase: their sequence comparison to the respective rat homologs."
      Aoyama C. , Nakashima K. , Ishidate K.
      Biochim. Biophys. Acta1393:179-185(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2)
      strain: Swiss Webster / NIH.
    2. 2.
      "Structure and characterization of the genes for murine choline/ethanolamine kinase isozymes alpha and beta."
      Aoyama C. , Yamazaki N. , Terada H. , Ishidate K.
      J. Lipid Res.41:452-464(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORMS 1 AND 2)
      strain: 129/Sv.
      tissue: Liver.
    3. 3.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
      strain: C57BL/6J.
    4. 4.
      Mural R.J. , Adams M.D. , Myers E.W. , Smith H.O. , Venter J.C.
      Submitted (2005-07) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    5. 5.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-371 (ISOFORM 2);NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-150 (ISOFORM 1)
      strain: C57BL/6.
      tissue: Brain.
      tissue: Limb.
    6. 6.
      "The transcriptional landscape of the mammalian genome."
      Carninci P. , Kasukawa T. , Katayama S. , Gough J. , Frith M.C. , Maeda N. , Oyama R. , Ravasi T. , Lenhard B. , Wells C. , Kodzius R. , Shimokawa K. , Bajic V.B. , Brenner S.E. , Batalov S. , Forrest A.R. , Zavolan M. , Davis M.J. , more...
      Science309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-168 (ISOFORM 1)
      strain: C57BL/6J.
      tissue: Embryonic eye.
      tissue: Embryonic head.
      tissue: Eye.
    7. 7.
      "Deletion and alanine mutation analyses for the formation of active homo-or hetero-dimer complexes of mouse choline kinase-alpha and -beta."
      Liao H. , Aoyama C. , Ishidate K. , Teraoka H.
      Biochim. Biophys. Acta1761:111-120(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBUNIT
    8. 8.
      "Early embryonic lethality caused by disruption of the gene for choline kinase alpha, the first enzyme in phosphatidylcholine biosynthesis."
      Wu G. , Aoyama C. , Young S.G. , Vance D.E.
      J. Biol. Chem.283:1456-1462(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: DISRUPTION PHENOTYPE
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