Charged multivesicular body protein 2a (Protein name
), CHM2A_HUMAN from NCBI database.
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General Annotation
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Gene name:
CHMP2A(BC2;CHMP2);
Protein name:
Charged multivesicular body protein 2a;
Alternative:
Putative breast adenocarcinoma marker BC-2;Chromatin-modifying protein 2a(CHMP2a);Vacuolar protein sorting-associated protein 2-1(Vps2-1;hVps2-1);
Organism:
Human (Homo sapiens).
General Annotation
Sub Unit:
Probable core component of the endosomal sorting required for transport complex III (ESCRT-III). ESCRT-III components are thought to multimerize to form a flat lattice on the perimeter membrane of the endosome. Several assembly forms of ESCRT-III may exist that interact and act sequentally. In vitro, heteromerizes with CHMP3 (but not CHMP4) to form helical tubular structures that expose membrane-interacting sites on the outside whereas VPS4B can associate on the inside of the tubule. Interacts with CHMP1B, CHMP2B, CHMP3, CHMP4A, CHMP4B, CHMP4C and CHMP5. Interacts with VPS4A; the interaction is direct. Interacts with VPS4B; the interaction is direct. Interacts with MITD1. Interacts with VTA1; the interaction probably involves the open conformation of CHMP2A.
Function:
Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and the budding of enveloped viruses (HIV-1 and other lentiviruses). ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities, possibly in conjunction with the AAA ATPase VPS4. Involved in HIV-1 p6- and p9-dependent virus release.
Subcellular Location:
Late endosome membrane
Peripheral membrane protein
Cytoplasmic side
Localizes to the midbody of dividing cells. Localized in two distinct rings on either side of the Fleming body.
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Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
5.
"Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)." Ebert L.
,
Schick M.
,
Neubert P.
,
Schatten R.
,
Henze S.
,
Korn B.
Submitted (2004-06) to the EMBL/GenBank/DDBJ databases
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Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
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Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 72-222;PROTEIN SEQUENCE OF 75-89 AND 197-205
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Cited for: FUNCTION IN HIV-1 BUDDING;INTERACTION WITH VPS4A AND VPS4B
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Cited for: FUNCTION IN HIV-1 BUDDING;INTERACTION WITH CHMP1B; CHMP2B; CHMP3; CHMP4A; CHMP4B; CHMP4C; CHMP5 AND VPS4A
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Cited for: AUTOINHIBITORY MECHANISM;INTERACTION WITH VPS4B;MUTAGENESIS OF 181-ASN--ASP-222
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Cited for: INTERACTION WITH VTA1;MUTAGENESIS OF 169-ASP-GLU-170; LEU-216 AND 217-LYS--ASP-222
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Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
Vaild Sequence:
