CHMP4C ELISA Kit for Human(Homo sapiens) | EIAab.comCHMP4C ELISA Kit for Human(Homo sapiens) | EIAab.com

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CHMP4C (Gene name),

Charged multivesicular body protein 4c (Protein name ), CHM4C_HUMAN from NCBI database.

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General Annotation

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Antigen Annotation

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3D

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Predicted Eptitope

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Vaild Sequence

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Related Databases

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Gene name:

CHMP4C(SHAX3);

Protein name:

Charged multivesicular body protein 4c;

Alternative:

SNF7 homolog associated with Alix 3;Chromatin-modifying protein 4c(CHMP4c);Vacuolar protein sorting-associated protein 32-3(Vps32-3;hVps32-3);SNF7-3(hSnf7-3);

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Probable core component of the endosomal sorting required for transport complex III (ESCRT-III). ESCRT-III components are thought to multimerize to form a flat lattice on the perimeter membrane of the endosome. Several assembly forms of ESCRT-III may exist that interact and act sequentally. Self-associates. Interacts with CHMP2A. Interacts with CHMP4A. Interacts with CHMP4B. Interacts with CHMP6. Interacts with VPS4A. Interacts with PDCD6IP; the interaction is direct.

Function:

Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and the budding of enveloped viruses (HIV-1 and other lentiviruses). ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities, possibly in conjunction with the AAA ATPase VPS4. Involved in HIV-1 p6- and p9-dependent virus release.

Subcellular Location:

Cytoplasm cytosol Late endosome membrane Peripheral membrane protein

Protein Attributes:

Sequence length:

233

Sequence:

50:

MSKLGKFFKG | GGSSKSRAAP | SPQEALVRLR | ETEEMLGKKQ | EYLENRIQRE |

100:

IALAKKHGTQ | NKRAALQALK | RKKRFEKQLT | QIDGTLSTIE | FQREALENSH |

150:

TNTEVLRNMG | FAAKAMKSVH | ENMDLNKIDD | LMQEITEQQD | IAQEISEAFS |

200:

QRVGFGDDFD | EDELMAELEE | LEQEELNKKM | TNIRLPNVPS | SSLPAQPNRK |

233:

PGMSSTARRS | RAASSQRAEE | EDDDIKQLAA | WAT

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

MIM:

SMR:

String:

Pfam:

STRING:

9606.ENSP00000297265

UniGene:

KEGG:

Uniprot:

FOR

ELISA Kit for Human Charged multivesicular body protein 4c

ELISA Kit for Human Charged multivesicular body protein 4c

ELISA Kit for Human Charged multivesicular body protein 4c

CLIA Kit for Human Charged multivesicular body protein 4c

CLIA Kit for Human Charged multivesicular body protein 4c

CLIA Kit for Human Charged multivesicular body protein 4c

Polyclonal Antibody for Human Charged multivesicular body protein 4c

Polyclonal Antibody for Human Charged multivesicular body protein 4c

Polyclonal Antibody for Human Charged multivesicular body protein 4c

Monoclonal Antibody for Human Charged multivesicular body protein 4c

Monoclonal Antibody for Human Charged multivesicular body protein 4c

Monoclonal Antibody for Human Charged multivesicular body protein 4c

Protein for Human Charged multivesicular body protein 4c

Protein for Human Charged multivesicular body protein 4c

Protein for Human Charged multivesicular body protein 4c

R&D Technical Data

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Precision

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Recovery

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Linearity

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References

1.

"CHMP4b is a major binding partner of the ALG-2-interacting protein Alix among the three CHMP4 isoforms."
Katoh K. , Shibata H. , Hatta K. , Maki M.
Arch. Biochem. Biophys.421:159-165(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];TISSUE SPECIFICITY;INTERACTION WITH PDCD6IP
2.

"Structure and function of human Vps20 and Snf7 proteins."
Peck J.W. , Bowden E.T. , Burbelo P.D.
Biochem. J.377:693-700(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];SUBCELLULAR LOCATION;TISSUE SPECIFICITY;INTERACTION WITH PDCD6IP
3.

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
tissue: Small intestine.
4.

Mural R.J. , Istrail S. , Sutton G.G. , Florea L. , Halpern A.L. , Mobarry C.M. , Lippert R. , Walenz B. , Shatkay H. , Dew I. , Miller J.R. , Flanigan M.J. , Edwards N.J. , Bolanos R. , Fasulo D. , Halldorsson B.V. , Hannenhalli S. , Turner R. , more...
Submitted (2005-07) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
5.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
tissue: Kidney.
6.

"AIP1/ALIX is a binding partner for HIV-1 p6 and EIAV p9 functioning in virus budding."
Strack B. , Calistri A. , Craig S. , Popova E. , Goettlinger H.G.
Cell114:689-699(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN HIV-1 BUDDING;INTERACTION WITH PDCD6IP
7.

"The protein network of HIV budding."
von Schwedler U.K. , Stuchell M. , Mueller B. , Ward D.M. , Chung H.-Y. , Morita E. , Wang H.E. , Davis T. , He G.P. , Cimbora D.M. , Scott A. , Kraeusslich H.-G. , Kaplan J. , Morham S.G. , Sundquist W.I.
Cell114:701-713(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN HIV-1 BUDDING;SELF-ASSOCIATION;INTERACTION WITH CHMPC4A; CHMPC4B; VPS4A AND PDCD6IP
8.

"Divergent retroviral late-budding domains recruit vacuolar protein sorting factors by using alternative adaptor proteins."
Martin-Serrano J. , Yarovoy A. , Perez-Caballero D. , Bieniasz P.D.
Proc. Natl. Acad. Sci. U.S.A.100:12414-12419(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN HIV-1 BUDDING;SELF-ASSOCIATION;INTERACTION WITH CHMP2A; CHMP4A; CHMP4B; CHMP6 AND PDCD6IP
9.

Martin-Serrano J. , Yarovoy A. , Perez-Caballero D. , Bieniasz P.D.
Proc. Natl. Acad. Sci. U.S.A.100:152845-152845(2003)

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ERRATUM
10.

"ESCRT-III governs the Aurora B-mediated abscission checkpoint through CHMP4C."
Carlton J.G. , Caballe A. , Agromayor M. , Kloc M. , Martin-Serrano J.
Science336:220-225(2012) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION;PHOSPHORYLATION AT SER-210;MUTAGENESIS OF SER-210
11.

"ANCHR mediates Aurora-B-dependent abscission checkpoint control through retention of VPS4."
Thoresen S.B. , Campsteijn C. , Vietri M. , Schink K.O. , Liestoel K. , Andersen J.S. , Raiborg C. , Stenmark H.
Nat. Cell Biol.16:550-560(2014) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
12.

"ALIX-CHMP4 interactions in the human ESCRT pathway."
McCullough J. , Fisher R.D. , Whitby F.G. , Sundquist W.I. , Hill C.P.
Proc. Natl. Acad. Sci. U.S.A.105:7687-7691(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.02 ANGSTROMS) OF 221-233 IN COMPLEX WITH PDCD6IP

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