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Index > Protein center > Cilp(Gene name) > Mouse
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  • Cilp (Gene name),
  • Cartilage intermediate layer protein 1 (Protein name ),  CILP1_MOUSE from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Gene name:
    Cilp;
    Protein name:
    Cartilage intermediate layer protein 1(CILP-1);
    Alternative:

    Organism:
    Mouse (Mus musculus). 
    General Annotation
    Sub Unit:
    Monomer. Interacts with TGFB1.
    Function:
    Probably plays a role in cartilage scaffolding. May act by antagonizing TGF-beta1 (TGFB1) and IGF1 functions. Has the ability to suppress IGF1-induced proliferation and sulfated proteoglycan synthesis, and inhibits ligand-induced IGF1R autophosphorylation. May inhibit TGFB1-mediated induction of cartilage matrix genes via its interaction with TGFB1. Overexpression may lead to impair chondrocyte growth and matrix repair and indirectly promote inorganic pyrophosphate (PPi) supersaturation in aging and osteoarthritis cartilage.
    Subcellular Location:
    Secreted extracellular space extracellular matrix
    Protein Attributes:
    Sequence length:
    1184
    Sequence:
    50:
    MAAIKTWVFS | FLVLEVTTVL | GRQTMLAQSV | RRVQPVKRTP | KTLAKPADSQ | 
    100:
    ESPGEWTTWF | NIDHPGGQGD | YERLDAIRFY | YGERVCARPL | RLEARTTDWM | 
    150:
    PAGSTGQVVH | GSPREGFWCL | NREQRPGQNC | SNYTVRFLCP | PGSLRGDAEH | 
    200:
    IWSSWSPWSK | CSAACGHTGV | QTRTRTCLAQ | TVSLCSEATE | EGQLCMSQAC | 
    250:
    TACDLTCPMG | QVNADCDACM | CQDFMLHGAI | SLPGGGPAPG | AAVYLLAKAP | 
    300:
    KMLTRTDSSG | RFRVPGLCPD | GKTILKITKT | KFAPIMITMP | KTSLKSATIN | 
    350:
    AEFVRAETPY | IVMNPEMKAR | RAGQSVSLCC | KATGKPSPDK | YFWYHNNTLL | 
    400:
    DPSLYKHESK | LVLRNLQQDQ | AGEYFCKAQS | DAGAVKSKVT | QLTVIAHDET | 
    450:
    PCNPTPESYL | IRLPHDCFQN | ASNSFYYDVG | RCPIKTCAGQ | QDNGIRCRDA | 
    500:
    VENCCGISRT | EEREIQCSGY | TLPTKVAVEC | SCQRCAETRS | IVRGRVTATD | 
    550:
    NGEPMRFGHV | YMGNNRVSMT | GYKGTFTLHI | PQDTERLVLT | FVDRLQKFVN | 
    600:
    TTKVLPFNKK | GSAVFHEIKM | LRQKEPITLE | AMETNIIPLG | EVIGEDPVAE | 
    650:
    LEIPSKSFYR | QNGEPFTGKV | KASVTFLDPR | NISTATAAQS | DLNFINDEGD | 
    700:
    TFPLRTYGMF | SVDFRDEATS | ESLNAGKVKV | HLDSTQVKMP | EHVPAMKLWS | 
    750:
    LNPDTGLWEE | EGDFKFESQR | RNKREERTFL | VGNMEIRERR | LFNLDVPESR | 
    800:
    RCFIKVRTYR | SERFLPSEQI | QGVVVSVINL | EPRTGFSSNP | RAWGRFDSVI | 
    850:
    TGPNGACLPA | FCDDQSPDAY | SVYVLASLSG | EELEAVESSP | KFNPNAIGVP | 
    900:
    QPYLNKLKYR | RTDHEDPRVK | KTAFQISMAK | PRPNSAEESN | GPIYAFENLR | 
    950:
    ACEEAPPSAA | HFRFYQIEGD | RYDYNTVPFN | EDDPMSWTED | YLAWWPKPME | 
    1000:
    FRACYIKVKI | VGPLEVNVRS | RNMGGTHRQT | VGKLYGIRDV | KSTRDRDQPN | 
    1050:
    VSSACLEFKC | SGMLYDQDRV | DRTLVKVIPQ | GSCHRASVNS | MLHEYLVNHL | 
    1100:
    PLAVNNDTSE | YTMLAPLDPL | GHNYGIYTVT | DQDPRTAKEI | ALGRCFDGTS | 
    1150:
    DGSSRIMKSN | VGVALTFNCA | ERQVGRQSAF | QYLQSTPARS | PATGTVQGRV | 
    1184:
    PAMRQQRASR | GGLRRRGSMA | PLRFSGVAQQ | PLSN
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    Pfam:
    SMR:
    UniGene:
    Pfam:
    Uniprot:
     
    FOR
    ELISA Kit for Mouse CILP-1
    Cat.:
    E1182m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    ELISA Kit for Mouse CILP-1
    Cat.:
    E1182h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    ELISA Kit for Mouse CILP-1
    Cat.:
    E1182p
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Mouse CILP-1
    Cat.:
    U1182m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Mouse CILP-1
    Cat.:
    U1182p
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Mouse CILP-1
    Cat.:
    U1182h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Polyclonal Antibody for Mouse CILP-1
    Polyclonal Antibody for Mouse CILP-1
    Cat.:
    P1182Rb-m
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Mouse CILP-1
    Cat.:
    P1182Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Mouse CILP-1
    Monoclonal Antibody for Mouse CILP-1
    Monoclonal Antibody for Mouse CILP-1
    Protein for Mouse CILP-1
    Protein for Mouse CILP-1
    Protein for Mouse CILP-1

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    Linearity
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    References
    1. 1.
      "The transcriptional landscape of the mammalian genome."
      Carninci P. , Kasukawa T. , Katayama S. , Gough J. , Frith M.C. , Maeda N. , Oyama R. , Ravasi T. , Lenhard B. , Wells C. , Kodzius R. , Shimokawa K. , Bajic V.B. , Brenner S.E. , Batalov S. , Forrest A.R. , Zavolan M. , Davis M.J. , more...
      Science309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      strain: C57BL/6J.
      tissue: Head.
    2. 2.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      strain: NMRI.
      tissue: Mammary tumor.
    3. 3.
      "The mouse Cilp gene."
      Lorenzo P. , Heinegaard D.
      Submitted (2002-05) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-51 AND 344-1184
      strain: 129/SvJ.
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