Protein name:
Cartilage intermediate layer protein 1 (CILP-1) ;
Alternative:
Organism:
Mouse (Mus musculus).
General Annotation
Sub Unit:
Monomer. Interacts with TGFB1.
Function:
Probably plays a role in cartilage scaffolding. May act by antagonizing TGF-beta1 (TGFB1) and IGF1 functions. Has the ability to suppress IGF1-induced proliferation and sulfated proteoglycan synthesis, and inhibits ligand-induced IGF1R autophosphorylation. May inhibit TGFB1-mediated induction of cartilage matrix genes via its interaction with TGFB1. Overexpression may lead to impair chondrocyte growth and matrix repair and indirectly promote inorganic pyrophosphate (PPi) supersaturation in aging and osteoarthritis cartilage.
Subcellular Location:
Secreted
extracellular space
extracellular matrix
Protein Attributes:
50:
MAAIKTWVFS | FLVLEVTTVL | GRQTMLAQSV | RRVQPVKRTP | KTLAKPADSQ |
100:
ESPGEWTTWF | NIDHPGGQGD | YERLDAIRFY | YGERVCARPL | RLEARTTDWM |
150:
PAGSTGQVVH | GSPREGFWCL | NREQRPGQNC | SNYTVRFLCP | PGSLRGDAEH |
200:
IWSSWSPWSK | CSAACGHTGV | QTRTRTCLAQ | TVSLCSEATE | EGQLCMSQAC |
250:
TACDLTCPMG | QVNADCDACM | CQDFMLHGAI | SLPGGGPAPG | AAVYLLAKAP |
300:
KMLTRTDSSG | RFRVPGLCPD | GKTILKITKT | KFAPIMITMP | KTSLKSATIN |
350:
AEFVRAETPY | IVMNPEMKAR | RAGQSVSLCC | KATGKPSPDK | YFWYHNNTLL |
400:
DPSLYKHESK | LVLRNLQQDQ | AGEYFCKAQS | DAGAVKSKVT | QLTVIAHDET |
450:
PCNPTPESYL | IRLPHDCFQN | ASNSFYYDVG | RCPIKTCAGQ | QDNGIRCRDA |
500:
VENCCGISRT | EEREIQCSGY | TLPTKVAVEC | SCQRCAETRS | IVRGRVTATD |
550:
NGEPMRFGHV | YMGNNRVSMT | GYKGTFTLHI | PQDTERLVLT | FVDRLQKFVN |
600:
TTKVLPFNKK | GSAVFHEIKM | LRQKEPITLE | AMETNIIPLG | EVIGEDPVAE |
650:
LEIPSKSFYR | QNGEPFTGKV | KASVTFLDPR | NISTATAAQS | DLNFINDEGD |
700:
TFPLRTYGMF | SVDFRDEATS | ESLNAGKVKV | HLDSTQVKMP | EHVPAMKLWS |
750:
LNPDTGLWEE | EGDFKFESQR | RNKREERTFL | VGNMEIRERR | LFNLDVPESR |
800:
RCFIKVRTYR | SERFLPSEQI | QGVVVSVINL | EPRTGFSSNP | RAWGRFDSVI |
850:
TGPNGACLPA | FCDDQSPDAY | SVYVLASLSG | EELEAVESSP | KFNPNAIGVP |
900:
QPYLNKLKYR | RTDHEDPRVK | KTAFQISMAK | PRPNSAEESN | GPIYAFENLR |
950:
ACEEAPPSAA | HFRFYQIEGD | RYDYNTVPFN | EDDPMSWTED | YLAWWPKPME |
1000:
FRACYIKVKI | VGPLEVNVRS | RNMGGTHRQT | VGKLYGIRDV | KSTRDRDQPN |
1050:
VSSACLEFKC | SGMLYDQDRV | DRTLVKVIPQ | GSCHRASVNS | MLHEYLVNHL |
1100:
PLAVNNDTSE | YTMLAPLDPL | GHNYGIYTVT | DQDPRTAKEI | ALGRCFDGTS |
1150:
DGSSRIMKSN | VGVALTFNCA | ERQVGRQSAF | QYLQSTPARS | PATGTVQGRV |
1184:
PAMRQQRASR | GGLRRRGSMA | PLRFSGVAQQ | PLSN
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Mouse
Human
Pig
ELISA Kit for Mouse CILP-1
ELISA Kit for Mouse CILP-1
ELISA Kit for Mouse CILP-1
CLIA Kit for Mouse CILP-1
CLIA Kit for Mouse CILP-1
CLIA Kit for Mouse CILP-1
Polyclonal Antibody for Mouse CILP-1
Polyclonal Antibody for Mouse CILP-1
Polyclonal Antibody for Mouse CILP-1
Monoclonal Antibody for Mouse CILP-1
Monoclonal Antibody for Mouse CILP-1
Monoclonal Antibody for Mouse CILP-1
R&D Technical Data
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Precision
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Recovery
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Linearity
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more...
Science309:1559-1563(2005)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
strain :
C57BL/6J .
tissue :
Head .
2.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
strain :
NMRI .
tissue :
Mammary tumor .
3.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-51 AND 344-1184
strain :
129/SvJ .