Protein name:
Cdc42-interacting protein 4 ;
Alternative:
Thyroid receptor-interacting protein 10 (TR-interacting protein 10;TRIP-10) ;
Organism:
Mouse (Mus musculus).
General Annotation
Sub Unit:
Interacts with AKAP9, ARHGAP17, DAAM1, DIAPH1, DIAPH2, DNM1, FASLG/FASL, GAPVD1, LYN, microtubules, PDE6G, SRC and WAS/WASP. Interacts with the ligand binding domain of the thyroid receptor (TR) in the presence of thyroid hormone. May interact with CTNNB1 and HD/HTT (By similarity). Interacts specifically with GTP-bound CDC42 and RHOQ. Interacts with DNM2 and WASL.
Function:
Required to coordinate membrane tubulation with reorganization of the actin cytoskeleton during endocytosis. Binds to lipids such as phosphatidylinositol 4,5-bisphosphate and phosphatidylserine and promotes membrane invagination and the formation of tubules. Also promotes CDC42-induced actin polymerization by recruiting WASL/N-WASP which in turn activates the Arp2/3 complex. Actin polymerization may promote the fission of membrane tubules to form endocytic vesicles. Required for the formation of podosomes, actin-rich adhesion structures specific to monocyte-derived cells. May be required for the lysosomal retention of FASLG/FASL (By similarity). Required for translocation of GLUT4 to the plasma membrane in response to insulin signaling.
Subcellular Location:
Cytoplasm
cytoskeleton
Cytoplasm
cell cortex
Lysosome
Golgi apparatus
Cell membrane
Cell projection
phagocytic cup
Localizes to cortical regions coincident with F-actin, to lysosomes and to sites of phagocytosis in macrophages. Also localizes to the Golgi, and this requires AKAP9 (By similarity). Translocates to the plasma membrane in response to insulin stimulation, and this may require active RHOQ.
Protein Attributes:
50:
MDWGTELWDQ | FEVLERHTQW | GLDLLDKYVK | FVKERAEVEQ | AYAKQLRSLV |
100:
KKYLPKRPTK | DDPEVKFSQQ | QSFVQLLQEV | NDFAGQRELV | AESLGIRVCL |
150:
ELAKYSQEMK | QERKMHFQEG | RRAQQQLENG | FKQLENSKRK | FERDCREAEK |
200:
AAHTAERLDQ | DINATKADVE | KAKQQAHLRN | HMAEESKNEY | AAQLQRFNRD |
250:
QAHFYFSQMP | QIFDKLQDMD | ERRATRLGAG | YGLLSEAELQ | VVPIIGKCLE |
300:
GMKVAAESVD | AKNDSQVLIE | LHKSGFARPG | DLEFEDFSQV | INRVPSDSSL |
350:
GTPDGRPELR | AASSRSRAKR | WPFGKKNKPR | PPSLSLLGGH | LPSTLSDGPS |
400:
SPRSGRDPLA | ILSEISKSVK | PRLASFRSFR | GGRGTVATED | FSHLPPEQQR |
450:
KRLQQQLEER | NRELQKEEDQ | REALKKMKDV | YEKTPQMGDP | ASLEPRIAET |
500:
LGNIERLKLE | VQKYEAWLAE | AESRVLSNRG | DSLSRHARPP | DPPTTAPPDS |
550:
SSSSTNSGSQ | DNKESSSEEP | PSEGQDTPIY | TEFDEDFEEP | ASPIGQCVAI |
600:
YHFEGSSEGT | VSMSEGEDLS | LMEEDKGDGW | TRVRRKQGAE | GYVPTSYLRV |
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Rat
Human
Mouse
ELISA Kit for Mouse Cdc42-interacting protein 4
ELISA Kit for Mouse Cdc42-interacting protein 4
ELISA Kit for Mouse Cdc42-interacting protein 4
CLIA Kit for Mouse Cdc42-interacting protein 4
CLIA Kit for Mouse Cdc42-interacting protein 4
CLIA Kit for Mouse Cdc42-interacting protein 4
Polyclonal Antibody for Mouse Cdc42-interacting protein 4
Polyclonal Antibody for Mouse Cdc42-interacting protein 4
Polyclonal Antibody for Mouse Cdc42-interacting protein 4
Monoclonal Antibody for Mouse Cdc42-interacting protein 4
Monoclonal Antibody for Mouse Cdc42-interacting protein 4
Monoclonal Antibody for Mouse Cdc42-interacting protein 4
Protein for Mouse Cdc42-interacting protein 4
Protein for Mouse Cdc42-interacting protein 4
Protein for Mouse Cdc42-interacting protein 4
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
1.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2)
strain :
C57BL/6 .
tissue :
Heart .
2.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);FUNCTION;INTERACTION WITH CDC42 AND RHOQ;SUBCELLULAR LOCATION;MUTAGENESIS OF ILE-454
tissue :
Adipocyte .
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4)
strain :
C57BL/6J .
strain :
NOD .
tissue :
Bone marrow .
tissue :
Thymus .
4.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3)
strain :
FVB/N .
tissue :
Mammary gland .
5.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PROTEIN SEQUENCE OF 98-104;IDENTIFICATION BY MASS SPECTROMETRY
strain :
OF1 .
tissue :
Hippocampus .
6.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : SUBCELLULAR LOCATION
7.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION;INTERACTION WITH DNM2 AND WASL;SUBCELLULAR LOCATION
8.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH GAPVD1