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Index > Protein center > Trip10(Gene name) > Mouse
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  • Trip10 (Gene name),
  • Cdc42-interacting protein 4 (Protein name ),  CIP4_MOUSE from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    Trip10(Cip4);
    Protein name:
    Cdc42-interacting protein 4;
    Alternative:
    Thyroid receptor-interacting protein 10(TR-interacting protein 10;TRIP-10);
    Organism:
    Mouse (Mus musculus). 
    General Annotation
    Sub Unit:
    Interacts with AKAP9, ARHGAP17, DAAM1, DIAPH1, DIAPH2, DNM1, FASLG/FASL, GAPVD1, LYN, microtubules, PDE6G, SRC and WAS/WASP. Interacts with the ligand binding domain of the thyroid receptor (TR) in the presence of thyroid hormone. May interact with CTNNB1 and HD/HTT (By similarity). Interacts specifically with GTP-bound CDC42 and RHOQ. Interacts with DNM2 and WASL.
    Function:
    Required to coordinate membrane tubulation with reorganization of the actin cytoskeleton during endocytosis. Binds to lipids such as phosphatidylinositol 4,5-bisphosphate and phosphatidylserine and promotes membrane invagination and the formation of tubules. Also promotes CDC42-induced actin polymerization by recruiting WASL/N-WASP which in turn activates the Arp2/3 complex. Actin polymerization may promote the fission of membrane tubules to form endocytic vesicles. Required for the formation of podosomes, actin-rich adhesion structures specific to monocyte-derived cells. May be required for the lysosomal retention of FASLG/FASL (By similarity). Required for translocation of GLUT4 to the plasma membrane in response to insulin signaling.
    Subcellular Location:
    Cytoplasm cytoskeleton Cytoplasm cell cortex Lysosome Golgi apparatus Cell membrane Cell projection phagocytic cup Localizes to cortical regions coincident with F-actin, to lysosomes and to sites of phagocytosis in macrophages. Also localizes to the Golgi, and this requires AKAP9 (By similarity). Translocates to the plasma membrane in response to insulin stimulation, and this may require active RHOQ.
    Protein Attributes:
    Sequence length:
    603
    Sequence:
    50:
    MDWGTELWDQ | FEVLERHTQW | GLDLLDKYVK | FVKERAEVEQ | AYAKQLRSLV | 
    100:
    KKYLPKRPTK | DDPEVKFSQQ | QSFVQLLQEV | NDFAGQRELV | AESLGIRVCL | 
    150:
    ELAKYSQEMK | QERKMHFQEG | RRAQQQLENG | FKQLENSKRK | FERDCREAEK | 
    200:
    AAHTAERLDQ | DINATKADVE | KAKQQAHLRN | HMAEESKNEY | AAQLQRFNRD | 
    250:
    QAHFYFSQMP | QIFDKLQDMD | ERRATRLGAG | YGLLSEAELQ | VVPIIGKCLE | 
    300:
    GMKVAAESVD | AKNDSQVLIE | LHKSGFARPG | DLEFEDFSQV | INRVPSDSSL | 
    350:
    GTPDGRPELR | AASSRSRAKR | WPFGKKNKPR | PPSLSLLGGH | LPSTLSDGPS | 
    400:
    SPRSGRDPLA | ILSEISKSVK | PRLASFRSFR | GGRGTVATED | FSHLPPEQQR | 
    450:
    KRLQQQLEER | NRELQKEEDQ | REALKKMKDV | YEKTPQMGDP | ASLEPRIAET | 
    500:
    LGNIERLKLE | VQKYEAWLAE | AESRVLSNRG | DSLSRHARPP | DPPTTAPPDS | 
    550:
    SSSSTNSGSQ | DNKESSSEEP | PSEGQDTPIY | TEFDEDFEEP | ASPIGQCVAI | 
    600:
    YHFEGSSEGT | VSMSEGEDLS | LMEEDKGDGW | TRVRRKQGAE | GYVPTSYLRV | 
    603:
    TLN
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    UniGene:
    Pfam:
    SMR:
    String:
    Uniprot:
     
    FOR
    ELISA Kit for Mouse Cdc42-interacting protein 4
    ELISA Kit for Mouse Cdc42-interacting protein 4
    ELISA Kit for Mouse Cdc42-interacting protein 4
    CLIA Kit for Mouse Cdc42-interacting protein 4
    CLIA Kit for Mouse Cdc42-interacting protein 4
    CLIA Kit for Mouse Cdc42-interacting protein 4
    Polyclonal Antibody for Mouse Cdc42-interacting protein 4
    Polyclonal Antibody for Mouse Cdc42-interacting protein 4
    Polyclonal Antibody for Mouse Cdc42-interacting protein 4
    Monoclonal Antibody for Mouse Cdc42-interacting protein 4
    Monoclonal Antibody for Mouse Cdc42-interacting protein 4
    Monoclonal Antibody for Mouse Cdc42-interacting protein 4
    Protein for Mouse Cdc42-interacting protein 4
    Protein for Mouse Cdc42-interacting protein 4
    Protein for Mouse Cdc42-interacting protein 4

    R&D Technical Data
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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      "Identification and genetic analysis of human and mouse activated Cdc42 interacting protein-4 isoforms."
      Wang L. , Rudert W.A. , Grishin A. , Dombrosky-Ferlan P. , Sullivan K. , Deng X. , Whitcomb D. , Corey S.J.
      Biochem. Biophys. Res. Commun.293:1426-1430(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2)
      strain: C57BL/6.
      tissue: Heart.
    2. 2.
      "The TC10-interacting protein CIP4/2 is required for insulin-stimulated Glut4 translocation in 3T3L1 adipocytes."
      Chang L. , Adams R.D. , Saltiel A.R.
      Proc. Natl. Acad. Sci. U.S.A.99:12835-12840(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);FUNCTION;INTERACTION WITH CDC42 AND RHOQ;SUBCELLULAR LOCATION;MUTAGENESIS OF ILE-454
      tissue: Adipocyte.
    3. 3.
      "The transcriptional landscape of the mammalian genome."
      Carninci P. , Kasukawa T. , Katayama S. , Gough J. , Frith M.C. , Maeda N. , Oyama R. , Ravasi T. , Lenhard B. , Wells C. , Kodzius R. , Shimokawa K. , Bajic V.B. , Brenner S.E. , Batalov S. , Forrest A.R. , Zavolan M. , Davis M.J. , more...
      Science309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4)
      strain: C57BL/6J.
      strain: NOD.
      tissue: Bone marrow.
      tissue: Thymus.
    4. 4.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3)
      strain: FVB/N.
      tissue: Mammary gland.
    5. 5.
      Lubec G. , Sunyer B. , Chen W.-Q.
      Submitted (2009-01) to the UniProtKB
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 98-104;IDENTIFICATION BY MASS SPECTROMETRY
      strain: OF1.
      tissue: Hippocampus.
    6. 6.
      "The cytoskeletal organizing protein Cdc42-interacting protein 4 associates with phosphorylase kinase in skeletal muscle."
      Archila S. , King M.A. , Carlson G.M. , Rice N.A.
      Biochem. Biophys. Res. Commun.345:1592-1599(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION
    7. 7.
      "Coordination between the actin cytoskeleton and membrane deformation by a novel membrane tubulation domain of PCH proteins is involved in endocytosis."
      Tsujita K. , Suetsugu S. , Sasaki N. , Furutani M. , Oikawa T. , Takenawa T.
      J. Cell Biol.172:269-279(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH DNM2 AND WASL;SUBCELLULAR LOCATION
    8. 8.
      "Gapex-5, a Rab31 guanine nucleotide exchange factor that regulates Glut4 trafficking in adipocytes."
      Lodhi I.J. , Chiang S.-H. , Chang L. , Vollenweider D. , Watson R.T. , Inoue M. , Pessin J.E. , Saltiel A.R.
      Cell Metab.5:59-72(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH GAPVD1
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