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Index > Protein center > CIR1(Gene name) > Human
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  • CIR1 (Gene name),
  • Corepressor interacting with RBPJ 1 (Protein name ),  CIR1_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    CIR1(CIR);
    Protein name:
    Corepressor interacting with RBPJ 1;
    Alternative:
    Recepin;CBF1-interacting corepressor;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Interacts with RP9, SNW1, SFRS1, SFRS2 and U2AF1 (By similarity). Interacts with Epstein-Barr virus RPMS1. Component of the histone deacetylase complex. Component of the Notch corepressor complex. Interacts with RBPJ, SAP30 and HDAC2 and NKAP. Interacts with NEK6.
    Function:
    May modulate splice site selection during alternative splicing of pre-mRNAs (By similarity). Regulates transcription and acts as corepressor for RBPJ. Recruits RBPJ to the Sin3-histone deacetylase complex (HDAC). Required for RBPJ-mediated repression of transcription.
    Subcellular Location:
    Nucleus speckle Cytoplasm cytoskeleton centrosome Co-localizes with NEK6 in the centrosome.
    Protein Attributes:
    Sequence length:
    450
    Sequence:
    50:
    MGKSFANFMC | KKDFHPASKS | NIKKVWMAEQ | KISYDKKKQE | ELMQQYLKEQ | 
    100:
    ESYDNRLLMG | DERVKNGLNF | MYEAPPGAKK | ENKEKEETEG | ETEYKFEWQK | 
    150:
    GAPREKYAKD | DMNIRDQPFG | IQVRNVRCIK | CHKWGHVNTD | RECPLFGLSG | 
    200:
    INASSVPTDG | SGPSMHPSEL | IAEMRNSGFA | LKRNVLGRNL | TANDPSQEYV | 
    250:
    ASEGEEDPEV | EFLKSLTTKQ | KQKLLRKLDR | LEKKKKKKDR | KKKKFQKSRS | 
    300:
    KHKKHKSSSS | SSSSSSSSSS | TETSESSSES | ESNNKEKKIQ | RKKRKKNKCS | 
    350:
    GHNNSDSEEK | DKSKKRKLHE | ELSSSHHNRE | KAKEKPRFLK | HESSREDSKW | 
    400:
    SHSDSDKKSR | THKHSPEKRG | SERKEGSSRS | HGREERSRRS | RSRSPGSYKQ | 
    450:
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    UniGene:
    KEGG:
    Pfam:
    MIM:
    String:
    Uniprot:
     
    FOR
    ELISA Kit for Human Corepressor interacting with RBPJ 1
    ELISA Kit for Human Corepressor interacting with RBPJ 1
    ELISA Kit for Human Corepressor interacting with RBPJ 1
    ELISA Kit for Human Corepressor interacting with RBPJ 1
    CLIA Kit for Human Corepressor interacting with RBPJ 1
    CLIA Kit for Human Corepressor interacting with RBPJ 1
    CLIA Kit for Human Corepressor interacting with RBPJ 1
    CLIA Kit for Human Corepressor interacting with RBPJ 1
    Polyclonal Antibody for Human Corepressor interacting with RBPJ 1
    Polyclonal Antibody for Human Corepressor interacting with RBPJ 1
    Polyclonal Antibody for Human Corepressor interacting with RBPJ 1
    Polyclonal Antibody for Human Corepressor interacting with RBPJ 1
    Monoclonal Antibody for Human Corepressor interacting with RBPJ 1
    Monoclonal Antibody for Human Corepressor interacting with RBPJ 1
    Monoclonal Antibody for Human Corepressor interacting with RBPJ 1
    Monoclonal Antibody for Human Corepressor interacting with RBPJ 1
    Protein for Human Corepressor interacting with RBPJ 1
    Protein for Human Corepressor interacting with RBPJ 1
    Protein for Human Corepressor interacting with RBPJ 1
    Protein for Human Corepressor interacting with RBPJ 1

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    References
    1. 1.
      "CIR, a corepressor linking the DNA binding factor CBF1 to the histone deacetylase complex."
      Hsieh J.J.-D. , Zhou S. , Chen L. , Young D.B. , Hayward S.D.
      Proc. Natl. Acad. Sci. U.S.A.96:23-28(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);FUNCTION;INTERACTION WITH RBPJ; SAP30 AND HDAC2;SUBCELLULAR LOCATION;TISSUE SPECIFICITY
    2. 2.
      Chai K.X. , Li L. , Chao J. , Chao L.
      Submitted (1993-11) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
      tissue: Liver.
    3. 3.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
      tissue: Testis.
    4. 4.
      "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
      Hillier L.W. , Graves T.A. , Fulton R.S. , Fulton L.A. , Pepin K.H. , Minx P. , Wagner-McPherson C. , Layman D. , Wylie K. , Sekhon M. , Becker M.C. , Fewell G.A. , Delehaunty K.D. , Miner T.L. , Nash W.E. , Kremitzki C. , Oddy L. , Du H. , more...
      Nature434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    5. 5.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2)
      tissue: Eye.
      tissue: Lymph.
      tissue: Testis.
      tissue: Uterus.
    6. 6.
      "A role for SKIP in EBNA2 activation of CBF1-repressed promoters."
      Zhou S. , Fujimuro M. , Hsieh J.J. , Chen L. , Hayward S.D.
      J. Virol.74:1939-1947(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH SNW1
    7. 7.
      "Epstein-Barr virus BamHi-a rightward transcript-encoded RPMS protein interacts with the CBF1-associated corepressor CIR to negatively regulate the activity of EBNA2 and NotchIC."
      Zhang J. , Chen H. , Weinmaster G. , Hayward S.D.
      J. Virol.75:2946-2956(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH EPSTEIN-BARR VIRUS RPMS1;SUBCELLULAR LOCATION
    8. 8.
      "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
      Olsen J.V. , Blagoev B. , Gnad F. , Macek B. , Kumar C. , Mortensen P. , Mann M.
      Cell127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-202;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Cervix carcinoma.
    9. 9.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-202;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Cervix carcinoma.
    10. 10.
      "NKAP is a transcriptional repressor of notch signaling and is required for T cell development."
      Pajerowski A.G. , Nguyen C. , Aghajanian H. , Shapiro M.J. , Shapiro V.S.
      Immunity30:696-707(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH NKAP
    11. 11.
      "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
      Mayya V. , Lundgren D.H. , Hwang S.-I. , Rezaul K. , Wu L. , Eng J.K. , Rodionov V. , Han D.K.
      Sci. Signal.2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-202;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Leukemic T-cell.
    12. 12.
      "Characterization of hNek6 interactome reveals an important role for its short N-terminal domain and colocalization with proteins at the centrosome."
      Vaz Meirelles G. , Ferreira Lanza D.C. , da Silva J.C. , Santana Bernachi J. , Paes Leme A.F. , Kobarg J.
      J. Proteome Res.9:6298-6316(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION;INTERACTION WITH NEK6;PHOSPHORYLATION
    13. 13.
      "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
      Rigbolt K.T. , Prokhorova T.A. , Akimov V. , Henningsen J. , Johansen P.T. , Kratchmarova I. , Kassem M. , Mann M. , Olsen J.V. , Blagoev B.
      Sci. Signal.4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-202;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
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