Cited2 ELISA Kit for Mouse(Mus musculus) | EIAab.comCited2 ELISA Kit for Mouse(Mus musculus)

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Cited2 (Gene name),

Cbp/p300-interacting transactivator 2 (Protein name ), CITE2_MOUSE from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

Cited2(Mrg1;Msg2);

Protein name:

Cbp/p300-interacting transactivator 2;

Alternative:

P35srj;MSG-related protein 1(MRG-1);

Organism:

Mouse (Mus musculus).

General Annotation

Sub Unit:

Interacts (via C-terminus) with EP300 (via CH1 domain); the interaction is stimulated in response to hypoxia. Interacts with PPARA. Interacts (via C-terminus) with TFAP2A, TFAP2B and TFAP2C (By similarity). Interacts (via C-terminus) with SMAD2. Interacts (via C-terminus) with SMAD3 (via MH2 domain). Interacts with LHX2 (via LIM domains). Interacts with WT1 isoform 1 and isoform 3.

Function:

Transcriptional coactivator of the p300/CBP-mediated trancription complex. Acts as a bridge, linking TFAP2 transcription factors and the p300/CBP transcriptional coactivator complex in order to stimulate TFAP2-mediated transcriptional activation. Positively regulates TGF-beta signaling through its association with the SMAD/p300/CBP-mediated transcriptional coactivator complex. Stimulates the peroxisome proliferator-activated receptors PPARA transcriptional activity. Enhances estrogen-dependent transactivation mediated by estrogen receptors. Acts also as a transcriptional corepressor; interferes with the binding of the transcription factors HIF1A or STAT2 and the p300/CBP transcriptional coactivator complex. Participates in sex determination and early gonad development by stimulating transcription activation of SRY. Plays a role in controlling left-right patterning during embryogenesis; potentiates transcriptional activation of NODAL-mediated gene transcription in the left lateral plate mesoderm (LPM). Plays an essential role in differentiation of the adrenal cortex from the adrenogonadal primordium (AGP); stimulates WT1-mediated transcription activation thereby upregulating the nuclear hormone receptor NR5A1 promoter activity. Associates with chromatin to the PITX2 P1 promoter region.

Subcellular Location:

Nucleus Colocalizes with EP300 in dot-like structures.

Protein Attributes:

Sequence length:

269

Sequence:

50:

100:

150:

200:

250:

269:

EFDFMTDFVC | KQQPSRVSC

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

SMR:

O35740

String:

O35740

KEGG:

mmu:17684

Pfam:

PF04487

UniGene:

Mm.272321

Uniprot:

O35740

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ELISA Kit for Mouse Cbp/p300-interacting transactivator 2

Cat.:

E14261m

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96T

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ELISA Kit for Mouse Cbp/p300-interacting transactivator 2

Cat.:

E14261b

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Packing:

96T

ELISA Kit for Mouse Cbp/p300-interacting transactivator 2

Cat.:

E14261h

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Packing:

96T

CLIA Kit for Mouse Cbp/p300-interacting transactivator 2

Cat.:

U14261b

Price:

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MSDS:

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Packing:

96T

CLIA Kit for Mouse Cbp/p300-interacting transactivator 2

Cat.:

U14261h

Price:

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MSDS:

Please sign in first.

Packing:

96T

CLIA Kit for Mouse Cbp/p300-interacting transactivator 2

Cat.:

U14261m

Price:

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Manual:

Looking for manual.

MSDS:

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Packing:

96T

Range:

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Polyclonal Antibody for Mouse Cbp/p300-interacting transactivator 2

Cat.:

P14261Rb-h

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40ug/0.2ml

Polyclonal Antibody for Mouse Cbp/p300-interacting transactivator 2

Cat.:

P14261Rb-m

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Packing:

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Polyclonal Antibody for Mouse Cbp/p300-interacting transactivator 2

Monoclonal Antibody for Mouse Cbp/p300-interacting transactivator 2

Protein for Mouse Cbp/p300-interacting transactivator 2

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

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Recovery

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Linearity

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References

1.

"Msg1 and Mrg1, founding members of a gene family, show distinct patterns of gene expression during mouse embryogenesis."
Dunwoodie S.L. , Rodriguez T.A. , Beddington R.S.P.
Mech. Dev.72:27-40(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2; 3 AND 4)
strain: C57BL/6 X DBA.
2.

"MSG1 and its related protein MRG1 share a transcription activating domain."
Shioda T. , Fenner M.H. , Isselbacher K.J.
Gene204:235-241(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3)
3.

"The transcriptional landscape of the mammalian genome."
Carninci P. , Kasukawa T. , Katayama S. , Gough J. , Frith M.C. , Maeda N. , Oyama R. , Ravasi T. , Lenhard B. , Wells C. , Kodzius R. , Shimokawa K. , Bajic V.B. , Brenner S.E. , Batalov S. , Forrest A.R. , Zavolan M. , Davis M.J. , more...
Science309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
strain: C57BL/6J.
tissue: Placenta.
4.

"Lineage-specific biology revealed by a finished genome assembly of the mouse."
Church D.M. , Goodstadt L. , Hillier L.W. , Zody M.C. , Goldstein S. , She X. , Bult C.J. , Agarwala R. , Cherry J.L. , DiCuccio M. , Hlavina W. , Kapustin Y. , Meric P. , Maglott D. , Birtle Z. , Marques A.C. , Graves T. , Zhou S. , more...
PLoS Biol.7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
strain: C57BL/6J.
5.

Mural R.J. , Adams M.D. , Myers E.W. , Smith H.O. , Venter J.C.
Submitted (2005-07) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
6.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
strain: C57BL/6.
tissue: Brain.
7.

"MRG1 binds to the LIM domain of Lhx2 and may function as a coactivator to stimulate glycoprotein hormone alpha-subunit gene expression."
Glenn D.J. , Maurer R.A.
J. Biol. Chem.274:36159-36167(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH LHX2
8.

"Cardiac malformations, adrenal agenesis, neural crest defects and exencephaly in mice lacking Cited2, a new Tfap2 co-activator."
Bamforth S.D. , Braganca J. , Eloranta J.J. , Murdoch J.N. , Marques F.I. , Kranc K.R. , Farza H. , Henderson D.J. , Hurst H.C. , Bhattacharya S.
Nat. Genet.29:469-474(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: DISRUPTION PHENOTYPE
9.

"Identification of the CREB-binding protein/p300-interacting protein CITED2 as a peroxisome proliferator-activated receptor alpha coregulator."
Tien E.S. , Davis J.W. , Vanden Heuvel J.P.
J. Biol. Chem.279:24053-24063(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: TISSUE SPECIFICITY
10.

"Cited2 controls left-right patterning and heart development through a Nodal-Pitx2c pathway."
Bamforth S.D. , Braganca J. , Farthing C.R. , Schneider J.E. , Broadbent C. , Michell A.C. , Clarke K. , Neubauer S. , Norris D. , Brown N.A. , Anderson R.H. , Bhattacharya S.
Nat. Genet.36:1189-1196(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;ASSOCIATION WITH CHROMATIN;DISRUPTION PHENOTYPE;DEVELOPMENTAL STAGE
11.

"Cited2 modulates TGF-beta-mediated upregulation of MMP9."
Chou Y.T. , Wang H. , Chen Y. , Danielpour D. , Yang Y.C.
Oncogene25:5547-5560(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH SMAD2 AND SMAD3
12.

"Cited2 is required both for heart morphogenesis and establishment of the left-right axis in mouse development."
Weninger W.J. , Lopes Floro K. , Bennett M.B. , Withington S.L. , Preis J.I. , Barbera J.P. , Mohun T.J. , Dunwoodie S.L.
Development132:1337-1348(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;DISRUPTION PHENOTYPE;DEVELOPMENTAL STAGE
13.

"Adrenal development is initiated by Cited2 and Wt1 through modulation of Sf-1 dosage."
Val P. , Martinez-Barbera J.P. , Swain A.
Development134:2349-2358(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH WT1;DISRUPTION PHENOTYPE;DEVELOPMENTAL STAGE
14.

"The transcription co-factor CITED2 functions during sex determination and early gonad development."
Buaas F.W. , Val P. , Swain A.
Hum. Mol. Genet.18:2989-3001(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;DEVELOPMENTAL STAGE
15.

"Loss of Cited2 causes congenital heart disease by perturbing left-right patterning of the body axis."
Lopes Floro K. , Artap S.T. , Preis J.I. , Fatkin D. , Chapman G. , Furtado M.B. , Harvey R.P. , Hamada H. , Sparrow D.B. , Dunwoodie S.L.
Hum. Mol. Genet.20:1097-1110(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;DISRUPTION PHENOTYPE

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