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Index > Protein center > CLEC4M(Gene name) > Human
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  • CLEC4M (Gene name),
  • C-type lectin domain family 4 member M (Protein name ),  CLC4M_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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    • Gene name:
    CLEC4M(CD209L;CD209L1;CD299);
    Protein name:
    C-type lectin domain family 4 member M;
    Alternative:
    DC-SIGN-related protein(DC-SIGNR);CD209 antigen-like protein 1;Liver/lymph node-specific ICAM-3-grabbing non-integrin(L-SIGN);Dendritic cell-specific ICAM-3-grabbing non-integrin 2(DC-SIGN2);
    CD:
    CD299;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Homotetramer. Binds to many viral surface glycoproteins such as HIV-1 gp120, HIV-2 gp120, SIV gp120, ebolavirus glycoproteins, HCV E2, and human SARS coronavirus S protein.
    Function:
    Probable pathogen-recognition receptor involved in peripheral immune surveillance in liver. May mediate the endocytosis of pathogens which are subsequently degraded in lysosomal compartments. Probably recognizes in a calcium-dependent manner high mannose N-linked oligosaccharides in a variety of pathogen antigens, including HIV-1 gp120, HIV-2 gp120, SIV gp120, ebolavirus glycoproteins, HCV E2, and human SARS coronavirus protein S. Is a receptor for ICAM3, probably by binding to mannose-like carbohydrates. Is presumably a coreceptor for the SARS coronavirus.
    Subcellular Location:
    Isoform 10 Secreted
    Protein Attributes:
    Sequence length:
    399
    Sequence:
    50:
    MSDSKEPRVQ | QLGLLEEDPT | TSGIRLFPRD | FQFQQIHGHK | SSTGCLGHGA | 
    100:
    LVLQLLSFML | LAGVLVAILV | QVSKVPSSLS | QEQSEQDAIY | QNLTQLKAAV | 
    150:
    GELSEKSKLQ | EIYQELTQLK | AAVGELPEKS | KLQEIYQELT | RLKAAVGELP | 
    200:
    EKSKLQEIYQ | ELTRLKAAVG | ELPEKSKLQE | IYQELTRLKA | AVGELPEKSK | 
    250:
    LQEIYQELTE | LKAAVGELPE | KSKLQEIYQE | LTQLKAAVGE | LPDQSKQQQI | 
    300:
    YQELTDLKTA | FERLCRHCPK | DWTFFQGNCY | FMSNSQRNWH | DSVTACQEVR | 
    350:
    AQLVVIKTAE | EQNFLQLQTS | RSNRFSWMGL | SDLNQEGTWQ | WVDGSPLSPS | 
    399:
    FQRYWNSGEP | NNSGNEDCAE | FSGSGWNDNR | CDVDNYWICK | KPAACFRDE
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    MIM:
    605872
    String:
    Q9H2X3
    SMR:
    Q9H2X3
    KEGG:
    hsa:10332
    Pfam:
    PF00059
    UniGene:
    Hs.421437
    Uniprot:
    Q9H2X3
     
    FOR
    ELISA Kit for Human C-type lectin domain family 4 member M
    CLIA Kit for Human C-type lectin domain family 4 member M
    Polyclonal Antibody for Human C-type lectin domain family 4 member M
    Monoclonal Antibody for Human C-type lectin domain family 4 member M
    Protein for Human C-type lectin domain family 4 member M

    R&D Technical Data
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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      "Selection of cDNAs encoding putative type II membrane proteins on the cell surface from a human full-length cDNA bank."
      Yokoyama-Kobayashi M. , Yamaguchi T. , Sekine S. , Kato S.
      Gene228:161-167(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 9)
      tissue: Liver.
    2. 2.
      "DC-SIGN, a related gene, DC-SIGNR, and CD23 form a cluster on 19p13."
      Soilleux E.J. , Barten R. , Trowsdale J.
      J. Immunol.165:2937-2942(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORM 1)
    3. 3.
      "Extensive repertoire of membrane-bound and soluble dendritic cell-specific ICAM-3-grabbing nonintegrin 1 (DC-SIGN1) and DC-SIGN2 isoforms. Inter-individual variation in expression of DC-SIGN transcripts."
      Mummidi S. , Catano G. , Lam L. , Hoefle A. , Telles V. , Begum K. , Jimenez F. , Ahuja S.S. , Ahuja S.K.
      J. Biol. Chem.276:33196-33212(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2; 4; 5; 6 AND 7);ALTERNATIVE SPLICING (ISOFORM 3);POLYMORPHISM;VARIANT GLN-164
    4. 4.
      "A dendritic cell-specific intercellular adhesion molecule 3-grabbing nonintegrin (DC-SIGN)-related protein is highly expressed on human liver sinusoidal endothelial cells and promotes HIV-1 infection."
      Bashirova A.A. , Geijtenbeek T.B.H. , van Duijnhoven G.C.F. , van Vliet S.J. , Eilering J.B.G. , Martin M.P. , Wu L. , Martin T.D. , Viebig N. , Knolle P.A. , Kewalramani V.N. , van Kooyk Y. , Carrington M.
      J. Exp. Med.193:671-678(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 8);TISSUE SPECIFICITY;FUNCTION;INTERACTION WITH ICAM3 AND HIV-1 GP120;POLYMORPHISM
    5. 5.
      "L-SIGN interaction with HIV-1."
      Bruen S. , Bashirova A. , Carrington M. , KewalRamani V.
      Submitted (2003-07) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);VARIANT ASN-291
    6. 6.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 8 AND 10)
      tissue: Placenta.
      tissue: Testis.
    7. 7.
      "The DNA sequence and biology of human chromosome 19."
      Grimwood J. , Gordon L.A. , Olsen A.S. , Terry A. , Schmutz J. , Lamerdin J.E. , Hellsten U. , Goodstein D. , Couronne O. , Tran-Gyamfi M. , Aerts A. , Altherr M. , Ashworth L. , Bajorek E. , Black S. , Branscomb E. , Caenepeel S. , Carrano A.V. , more...
      Nature428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    8. 8.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
      tissue: Brain.
    9. 9.
      "DC-SIGNR, a DC-SIGN homologue expressed in endothelial cells, binds to human and simian immunodeficiency viruses and activates infection in trans."
      Poehlmann S. , Soilleux E.J. , Baribaud F. , Leslie G.J. , Morris L.S. , Trowsdale J. , Lee B. , Coleman N. , Doms R.W.
      Proc. Natl. Acad. Sci. U.S.A.98:2670-2675(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: TISSUE SPECIFICITY;INTERACTION WITH HIV-1 GP120;ROLE IN HIV-1 INFECTION
    10. 10.
      "A novel mechanism of carbohydrate recognition by the C-type lectins DC-SIGN and DC-SIGNR. Subunit organization and binding to multivalent ligands."
      Mitchell D.A. , Fadden A.J. , Drickamer K.
      J. Biol. Chem.276:28939-28945(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBUNIT;LIGAND-BINDING
    11. 11.
      "Differential N-linked glycosylation of human immunodeficiency virus and Ebola virus envelope glycoproteins modulates interactions with DC-SIGN and DC-SIGNR."
      Lin G. , Simmons G. , Poehlmann S. , Baribaud F. , Ni H. , Leslie G.J. , Haggarty B.S. , Bates P. , Weissman D. , Hoxie J.A. , Doms R.W.
      J. Virol.77:1337-1346(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH HIV-1 GP120; HIV-2 GP120; SIV GP120 AND EBOLA GLYCOPROTEINS
    12. 12.
      "L-SIGN (CD209L) and DC-SIGN (CD209) mediate transinfection of liver cells by hepatitis C virus."
      Cormier E.G. , Durso R.J. , Tsamis F. , Boussemart L. , Manix C. , Olson W.C. , Gardner J.P. , Dragic T.
      Proc. Natl. Acad. Sci. U.S.A.101:14067-14072(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH HCV E2 GLYCOPROTEIN
    13. 13.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH SARS CORONAVIRUS S PROTEIN;TISSUE SPECIFICITY
    14. 14.
      "Structural basis for selective recognition of oligosaccharides by DC-SIGN and DC-SIGNR."
      Feinberg H. , Mitchell D.A. , Drickamer K. , Weis W.I.
      Science294:2163-2166(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.9 ANGSTROMS) OF 265-394 IN COMPLEX WITH GLCNAC(2)-MAN(3) PENTASACCHARIDE
    15. 15.
      "Extended neck regions stabilize tetramers of the receptors DC-SIGN and DC-SIGNR."
      Feinberg H. , Guo Y. , Mitchell D.A. , Drickamer K. , Weis W.I.
      J. Biol. Chem.280:1327-1335(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.25 ANGSTROMS) OF 216-399;DISULFIDE BONDS
    16. 16.
      "The structure of DC-SIGNR with a portion of its repeat domain lends insights to modeling of the receptor tetramer."
      Snyder G.A. , Colonna M. , Sun P.D.
      J. Mol. Biol.347:979-989(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.41 ANGSTROMS) OF 250-399;DISULFIDE BONDS
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