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Index > Protein center > Clec5a(Gene name) > Mouse
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  • Clec5a (Gene name),
  • C-type lectin domain family 5 member A (Protein name ),  CLC5A_MOUSE from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    Clec5a(Clecsf5;Mdl1);
    Protein name:
    C-type lectin domain family 5 member A;
    Alternative:
    Myeloid DAP12-associating lectin 1(MDL-1);C-type lectin superfamily member 5;
    Organism:
    Mouse (Mus musculus). 
    General Annotation
    Sub Unit:
    Monomer. Homodimer. The majority of CLEC5A is expressed as a monomeric form on macrophages. Interacts with TYROBP/DAP12. The interaction with TYROBP is required for CLEC5 cell surface expression. Interacts with HCST/DAP10. Forms an CLEC5A/TYROBP/HCST trimolecular complex depending almost solely on TYROBP.
    Function:
    Functions as a positive regulator of osteoclastogenesis. Cell surface receptor that signals via TYROBP. Regulates inflammatory responses. Acts as a key regulator of synovial injury and bone erosion during autoimmune joint inflammation. Critical macrophage receptor for dengue virus serotypes 1-4. The binding of dengue virus to CLEC5A triggers signaling through phosphylation of TYROBP, this interaction does not result in viral entry but stimulates proinflammatory cytokine release.
    Subcellular Location:
    Cell membrane Single-pass type II membrane protein
    Protein Attributes:
    Sequence length:
    190
    Sequence:
    50:
    MNWHMIISGL | IVVVIKVVGM | TFFLLYFPQV | FGKSNDGFVP | TESYGTTSVQ | 
    100:
    NVSQIFGRND | ESTMPTRSYG | TVCPRNWDFH | QGKCFFFSFS | ESPWKDSMDY | 
    150:
    CATQGSTLAI | VNTPEKLKYL | QDIAGIENYF | IGLVRQPGEK | KWRWINNSVF | 
    190:
    NGNVTNQDQN | FDCVTIGLTK | TYDAASCEVS | YRWICEMNAK | 
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    SMR:
    UniGene:
    Pfam:
    KEGG:
    String:
    Uniprot:
     
    FOR
    ELISA Kit for Mouse C-type lectin domain family 5 member A
    ELISA Kit for Mouse C-type lectin domain family 5 member A
    ELISA Kit for Mouse C-type lectin domain family 5 member A
    CLIA Kit for Mouse C-type lectin domain family 5 member A
    CLIA Kit for Mouse C-type lectin domain family 5 member A
    CLIA Kit for Mouse C-type lectin domain family 5 member A
    Polyclonal Antibody for Mouse C-type lectin domain family 5 member A
    Polyclonal Antibody for Mouse C-type lectin domain family 5 member A
    Polyclonal Antibody for Mouse C-type lectin domain family 5 member A
    Monoclonal Antibody for Mouse C-type lectin domain family 5 member A
    Monoclonal Antibody for Mouse C-type lectin domain family 5 member A
    Monoclonal Antibody for Mouse C-type lectin domain family 5 member A
    Protein for Mouse C-type lectin domain family 5 member A
    Protein for Mouse C-type lectin domain family 5 member A
    Protein for Mouse C-type lectin domain family 5 member A

    R&D Technical Data
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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      "Myeloid DAP12-associating lectin (MDL)-1 is a cell surface receptor involved in the activation of myeloid cells."
      Bakker A.B.H. , Baker E. , Sutherland G.R. , Phillips J.H. , Lanier L.L.
      Proc. Natl. Acad. Sci. U.S.A.96:9792-9796(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);FUNCTION;TISSUE SPECIFICITY;INTERACTION WITH TYROBP
      strain: BALB/c.
      tissue: Myeloid.
    2. 2.
      "The transcriptional landscape of the mammalian genome."
      Carninci P. , Kasukawa T. , Katayama S. , Gough J. , Frith M.C. , Maeda N. , Oyama R. , Ravasi T. , Lenhard B. , Wells C. , Kodzius R. , Shimokawa K. , Bajic V.B. , Brenner S.E. , Batalov S. , Forrest A.R. , Zavolan M. , Davis M.J. , more...
      Science309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2)
      strain: C57BL/6J.
      tissue: Adipose tissue.
      tissue: Bone.
    3. 3.
      Mural R.J. , Adams M.D. , Myers E.W. , Smith H.O. , Venter J.C.
      Submitted (2005-09) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    4. 4.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3)
    5. 5.
      "CLEC5A is critical for dengue-virus-induced lethal disease."
      Chen S.T. , Lin Y.L. , Huang M.T. , Wu M.F. , Cheng S.C. , Lei H.Y. , Lee C.K. , Chiou T.W. , Wong C.H. , Hsieh S.L.
      Nature453:672-676(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION AS A DENGUE VIRUS RECEPTOR
    6. 6.
      "Expression and functional role of MDL-1 (CLEC5A) in mouse myeloid lineage cells."
      Aoki N. , Kimura Y. , Kimura S. , Nagato T. , Azumi M. , Kobayashi H. , Sato K. , Tateno M.
      J. Leukoc. Biol.85:508-517(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: TISSUE SPECIFICITY;INTERACTION WITH HCST;SUBCELLULAR LOCATION;GLYCOSYLATION;SIALIC ACID CONTENT
    7. 7.
      "Signal adaptor DAP10 associates with MDL-1 and triggers osteoclastogenesis in cooperation with DAP12."
      Inui M. , Kikuchi Y. , Aoki N. , Endo S. , Maeda T. , Sugahara-Tobinai A. , Fujimura S. , Nakamura A. , Kumanogoh A. , Colonna M. , Takai T.
      Proc. Natl. Acad. Sci. U.S.A.106:4816-4821(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH HCST;GLYCOSYLATION;FUNCTION
    8. 8.
      "Myeloid DAP12-associating lectin (MDL)-1 regulates synovial inflammation and bone erosion associated with autoimmune arthritis."
      Joyce-Shaikh B. , Bigler M.E. , Chao C.C. , Murphy E.E. , Blumenschein W.M. , Adamopoulos I.E. , Heyworth P.G. , Antonenko S. , Bowman E.P. , McClanahan T.K. , Phillips J.H. , Cua D.J.
      J. Exp. Med.207:579-589(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: TISSUE SPECIFICITY;FUNCTION
    9. 9.
      "Expression profile of Japanese encephalitis virus induced neuroinflammation and its implication in disease severity."
      Gupta N. , Lomash V. , Rao P.V.
      J. Clin. Virol.49:4-10(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INVOLVEMENT IN JAPANESE ENCEPHALITIS VIRUS INFECTION
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