Clec6a ELISA Kit for Mouse(Mus musculus) | EIAab.comClec6a ELISA Kit for Mouse(Mus musculus)

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Index > Protein center > Clec6a(Gene name) > Mouse

Clec6a (Gene name),

C-type lectin domain family 6 member A (Protein name ), CLC6A_MOUSE from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

Clec6a(Clec4n;Clecsf10;Dectin2);

Protein name:

C-type lectin domain family 6 member A;

Alternative:

Dendritic cell-associated C-type lectin 2(DC-associated C-type lectin 2;Dectin-2);C-type lectin superfamily member 10;

Organism:

Mouse (Mus musculus).

General Annotation

Sub Unit:

Associated with FCER1G.

Function:

Binds high-mannose carbohydrates in a Ca(2+)-dependent manner. Functionnal receptor for alpha-mannans on C. albicans hypheas. Plays an important role in the host defense against C. albicans infection by inducing TH17 cell differentiation. Recognizes also, in a manose dependent manner, allergens from house dust mite and fungi, by promoting cysteinyl leukotriene production. Recognizes soluble elements from the eggs of Shistosoma mansoni altering adaptative immune responses. Transduces signals through an Fc receptor gamma chain /FCER1G and Syk-CARD9-NF-kappa-B-dependent pathway.

Subcellular Location:

Membrane Single-pass type II membrane protein Ligand binding leads to internalization.

Protein Attributes:

Sequence length:

209

Sequence:

50:

100:

150:

200:

209:

ICEMKKIYL

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

Pfam:

PF00059

String:

Q9JKF4

KEGG:

mmu:56620

SMR:

Q9JKF4

STRING:

10090.ENSMUSP00000024118

UniGene:

Mm.271782

Uniprot:

Q9JKF4

FOR

ELISA Kit for Mouse C-type lectin domain family 6 member A

CLIA Kit for Mouse C-type lectin domain family 6 member A

Polyclonal Antibody for Mouse C-type lectin domain family 6 member A

Monoclonal Antibody for Mouse C-type lectin domain family 6 member A

Protein for Mouse C-type lectin domain family 6 member A

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

References

1.

"Cloning of a second dendritic cell-associated C-type lectin (dectin-2) and its alternatively spliced isoforms."
Ariizumi K. , Shen G.-L. , Shikano S. , Ritter R. III , Zukas P. , Edelbaum D. , Morita A. , Takashima A.
J. Biol. Chem.275:11957-11963(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2 AND 3);TISSUE SPECIFICITY
strain: BALB/c.
2.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
strain: FVB/N-3.
tissue: Mammary tumor.
3.

"Dectin-2 is a pattern recognition receptor for fungi that couples with the Fc receptor gamma chain to induce innate immune responses."
Sato K. , Yang X.L. , Yudate T. , Chung J.S. , Wu J. , Luby-Phelps K. , Kimberly R.P. , Underhill D. , Cruz P.D. Jr. , Ariizumi K.
J. Biol. Chem.281:38854-38866(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH FCER1G;MUTAGENESIS OF ARG-17
4.

"Dectin-2 is a Syk-coupled pattern recognition receptor crucial for Th17 responses to fungal infection."
Robinson M.J. , Osorio F. , Rosas M. , Freitas R.P. , Schweighoffer E. , Gross O. , Verbeek J.S. , Ruland J. , Tybulewicz V. , Brown G.D. , Moita L.F. , Taylor P.R. , Reis e Sousa C.
J. Exp. Med.206:2037-2051(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
5.

"Dectin-2 recognition of house dust mite triggers cysteinyl leukotriene generation by dendritic cells."
Barrett N.A. , Maekawa A. , Rahman O.M. , Austen K.F. , Kanaoka Y.
J. Immunol.182:1119-1128(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
6.

"Dectin-2 recognition of alpha-mannans and induction of Th17 cell differentiation is essential for host defense against Candida albicans."
Saijo S. , Ikeda S. , Yamabe K. , Kakuta S. , Ishigame H. , Akitsu A. , Fujikado N. , Kusaka T. , Kubo S. , Chung S.H. , Komatsu R. , Miura N. , Adachi Y. , Ohno N. , Shibuya K. , Yamamoto N. , Kawakami K. , Yamasaki S. , more...
Immunity32:681-691(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: DISRUPTION PHENOTYPE;FUNCTION
7.

"Schistosoma mansoni triggers Dectin-2, which activates the Nlrp3 inflammasome and alters adaptive immune responses."
Ritter M. , Gross O. , Kays S. , Ruland J. , Nimmerjahn F. , Saijo S. , Tschopp J. , Layland L.E. , Prazeres da Costa C.
Proc. Natl. Acad. Sci. U.S.A.107:20459-20464(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION

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