Clec7a ELISA Kit for Mouse(Mus musculus) | EIAab.comClec7a ELISA Kit for Mouse(Mus musculus)

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Index > Protein center > Clec7a(Gene name) > Mouse

Clec7a (Gene name),

C-type lectin domain family 7 member A (Protein name ), CLC7A_MOUSE from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

Clec7a(Bgr;Clecsf12;Dectin1);

Protein name:

C-type lectin domain family 7 member A;

Alternative:

C-type lectin superfamily member 12;Beta-glucan receptor;Dendritic cell-associated C-type lectin 1(DC-associated C-type lectin 1;Dectin-1);

Organism:

Mouse (Mus musculus).

General Annotation

Sub Unit:

Homodimer.

Function:

Lectin that functions as pattern receptor specific for beta-1,3-linked and beta-1,6-linked glucans, such as cell wall constituents from pathogenic bacteria and fungi. Necessary for the TLR2-mediated inflammatory response and for TLR2-mediated activation of NF-kappa-B. Enhances cytokine production in macrophages and dendritic cells. Mediates production of reactive oxygen species in the cell. Mediates phagocytosis of C.albicans conidia. Binds T-cells in a way that does not involve their surface glycans and plays a role in T-cell activation. Stimulates T-cell proliferation.

Subcellular Location:

Cell membrane Single-pass type II membrane protein Enriched on zymosan phagosomes. Enrichment does not depend on opsonization.

Protein Attributes:

Sequence length:

244

Sequence:

50:

100:

150:

200:

244:

PNSFQVRNTV | PQESLLHNCV | WIHGSEVYNQ | ICNTSSYSIC | EKEL

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

SMR:

Q6QLQ4

Pfam:

PF00059

UniGene:

Mm.239516

KEGG:

mmu:56644

String:

Q6QLQ4

Uniprot:

Q6QLQ4

FOR

ELISA Kit for Mouse C-type lectin domain family 7 member A

Cat.:

E14873b

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Packing:

96T

ELISA Kit for Mouse C-type lectin domain family 7 member A

Cat.:

E14873h

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Manual:

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96T

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ELISA Kit for Mouse C-type lectin domain family 7 member A

Cat.:

E14873m

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Packing:

96T

CLIA Kit for Mouse C-type lectin domain family 7 member A

Cat.:

U14873m

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Packing:

96T

CLIA Kit for Mouse C-type lectin domain family 7 member A

Cat.:

U14873h

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Manual:

Looking for manual.

MSDS:

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Packing:

96T

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CLIA Kit for Mouse C-type lectin domain family 7 member A

Cat.:

U14873b

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MSDS:

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Packing:

96T

Polyclonal Antibody for Mouse C-type lectin domain family 7 member A

Cat.:

P14873Rb-h

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Packing:

40ug/0.2ml

Polyclonal Antibody for Mouse C-type lectin domain family 7 member A

Cat.:

P14873Rb-m

Price:

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Packing:

40ug/0.2ml

Polyclonal Antibody for Mouse C-type lectin domain family 7 member A

Monoclonal Antibody for Mouse C-type lectin domain family 7 member A

Protein for Mouse C-type lectin domain family 7 member A

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

References

1.

"Identification of a novel, dendritic cell-associated molecule, dectin-1, by subtractive cDNA cloning."
Ariizumi K. , Shen G.-L. , Shikano S. , Xu S. , Ritter R. III , Kumamoto T. , Edelbaum D. , Morita A. , Bergstresser P.R. , Takashima A.
J. Biol. Chem.275:20157-20167(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];FUNCTION;SUBCELLULAR LOCATION;GLYCOSYLATION;TISSUE SPECIFICITY
strain: BALB/c.
tissue: Dendritic cell.
2.

"Immune recognition. A new receptor for beta-glucans."
Brown G.D. , Gordon S.
Nature413:36-37(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];FUNCTION;TISSUE SPECIFICITY
3.

"Lineage-specific biology revealed by a finished genome assembly of the mouse."
Church D.M. , Goodstadt L. , Hillier L.W. , Zody M.C. , Goldstein S. , She X. , Bult C.J. , Agarwala R. , Cherry J.L. , DiCuccio M. , Hlavina W. , Kapustin Y. , Meric P. , Maglott D. , Birtle Z. , Marques A.C. , Graves T. , Zhou S. , more...
PLoS Biol.7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
strain: C57BL/6J.
4.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
strain: Czech II.
tissue: Mammary gland.
5.

"Collaborative induction of inflammatory responses by dectin-1 and Toll-like receptor 2."
Gantner B.N. , Simmons R.M. , Canavera S.J. , Akira S. , Underhill D.M.
J. Exp. Med.197:1107-1117(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;PHOSPHORYLATION;TISSUE SPECIFICITY
6.

"Characterization of beta-glucan recognition site on C-type lectin, dectin 1."
Adachi Y. , Ishii T. , Ikeda Y. , Hoshino A. , Tamura H. , Aketagawa J. , Tanaka S. , Ohno N.
Infect. Immun.72:4159-4171(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION;MUTAGENESIS OF TRP-221; HIS-223 AND CYS-232
7.

"Dectin-1 mediates macrophage recognition of Candida albicans yeast but not filaments."
Gantner B.N. , Simmons R.M. , Underhill D.M.
EMBO J.24:1277-1286(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
8.

"Syk-dependent cytokine induction by Dectin-1 reveals a novel pattern recognition pathway for C type lectins."
Rogers N.C. , Slack E.C. , Edwards A.D. , Nolte M.A. , Schulz O. , Schweighoffer E. , Williams D.L. , Gordon S. , Tybulewicz V.L. , Brown G.D. , Reis e Sousa C.
Immunity22:507-517(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH SYK
9.

"Innate immunity to the pathogenic fungus Coccidioides posadasii is dependent on Toll-like receptor 2 and Dectin-1."
Viriyakosol S. , Fierer J. , Brown G.D. , Kirkland T.N.
Infect. Immun.73:1553-1560(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
10.

"The beta-glucan receptor dectin-1 functions together with TLR2 to mediate macrophage activation by mycobacteria."
Yadav M. , Schorey J.S.
Blood108:3168-3175(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
11.

"Structure of the fungal beta-glucan-binding immune receptor dectin-1: implications for function."
Brown J. , O'Callaghan C.A. , Marshall A.S. , Gilbert R.J. , Siebold C. , Gordon S. , Brown G.D. , Jones E.Y.
Protein Sci.16:1042-1052(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.5 ANGSTROMS) OF 113-244 IN COMPLEX WITH METAL ION AND BETA-GLUCAN ANALOG LAMINARIN;METAL-BINDING SITES;SUBUNIT;DISULFIDE BONDS

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