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Index > Protein center > CLCNKA(Gene name) > Human
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  • CLCNKA (Gene name),
  • Chloride channel protein ClC-Ka (Protein name ),  CLCKA_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    CLCNKA;
    Protein name:
    Chloride channel protein ClC-Ka(Chloride channel Ka);
    Alternative:
    ClC-K1;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Interacts with BSND. Forms heteromers with BSND in the thin ascending limb of Henle.
    Function:
    Voltage-gated chloride channel. Chloride channels have several functions including the regulation of cell volume; membrane potential stabilization, signal transduction and transepithelial transport. May be important in urinary concentrating mechanisms.
    Subcellular Location:
    Membrane Multi-pass membrane protein
    Protein Attributes:
    Sequence length:
    687
    Sequence:
    50:
    MEELVGLREG | FSGDPVTLQE | LWGPCPHIRR | AIQGGLEWLK | QKVFRLGEDW | 
    100:
    YFLMTLGVLM | ALVSYAMNFA | IGCVVRAHQW | LYREIGDSHL | LRYLSWTVYP | 
    150:
    VALVSFSSGF | SQSITPSSGG | SGIPELKTML | AGVILEDYLD | IKNFGAKVVG | 
    200:
    LSCTLATGST | LFLGKVGPFV | HLSVMIAAYL | GRVRTTTIGE | PENKSKQNEM | 
    250:
    LVAAAAVGVA | TVFAAPFSGV | LFSIEVMSSH | FSVRDYWRGF | FAATCGAFIF | 
    300:
    RLLAVFNSEQ | ETITSLYKTS | FRVDVPFDLP | EIFFFVALGG | ICGVLSCAYL | 
    350:
    FCQRTFLSFI | KTNRYSSKLL | ATSKPVYSAL | ATLLLASITY | PPGVGHFLAS | 
    400:
    RLSMKQHLDS | LFDNHSWALM | TQNSSPPWPE | ELDPQHLWWE | WYHPRFTIFG | 
    450:
    TLAFFLVMKF | WMLILATTIP | MPAGYFMPIF | ILGAAIGRLL | GEALAVAFPE | 
    500:
    GIVTGGVTNP | IMPGGYALAG | AAAFSGAVTH | TISTALLAFE | LTGQIVHALP | 
    550:
    VLMAVLAANA | IAQSCQPSFY | DGTIIVKKLP | YLPRILGRNI | GSHHVRVEHF | 
    600:
    MNHSITTLAK | DTPLEEVVKV | VTSTDVTEYP | LVESTESQIL | VGIVQRAQLV | 
    650:
    QALQAEPPSR | APGHQQCLQD | ILARGCPTEP | VTLTLFSETT | LHQAQNLFKL | 
    687:
    LNLQSLFVTS | RGRAVGCVSW | VEMKKAISNL | TNPPAPK
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    UniGene:
    UniGene:
    KEGG:
    MIM:
    SMR:
    String:
    Pfam:
    Uniprot:
     
    FOR
    ELISA Kit for Human Chloride channel Ka
    ELISA Kit for Human Chloride channel Ka
    ELISA Kit for Human Chloride channel Ka
    ELISA Kit for Human Chloride channel Ka
    CLIA Kit for Human Chloride channel Ka
    CLIA Kit for Human Chloride channel Ka
    CLIA Kit for Human Chloride channel Ka
    CLIA Kit for Human Chloride channel Ka
    Polyclonal Antibody for Human Chloride channel Ka
    Polyclonal Antibody for Human Chloride channel Ka
    Polyclonal Antibody for Human Chloride channel Ka
    Polyclonal Antibody for Human Chloride channel Ka
    Monoclonal Antibody for Human Chloride channel Ka
    Monoclonal Antibody for Human Chloride channel Ka
    Monoclonal Antibody for Human Chloride channel Ka
    Monoclonal Antibody for Human Chloride channel Ka
    Protein for Human Chloride channel Ka
    Protein for Human Chloride channel Ka
    Protein for Human Chloride channel Ka
    Protein for Human Chloride channel Ka

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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      "Two highly homologous members of the ClC chloride channel family in both rat and human kidney."
      Kieferle S. , Fong P. , Bens M. , Vandewalle A. , Jentsch T.
      Proc. Natl. Acad. Sci. U.S.A.91:6943-6947(1994) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
      tissue: Kidney.
    2. 2.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2);VARIANT THR-447
      tissue: Kidney.
    3. 3.
      Suzuki Y. , Sugano S. , Totoki Y. , Toyoda A. , Takeda T. , Sakaki Y. , Tanaka A. , Yokoyama S.
      Submitted (2006-07) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3);VARIANTS GLY-83; GLN-357 AND THR-447
      tissue: Kidney.
    4. 4.
      "The DNA sequence and biological annotation of human chromosome 1."
      Gregory S.G. , Barlow K.F. , McLay K.E. , Kaul R. , Swarbreck D. , Dunham A. , Scott C.E. , Howe K.L. , Woodfine K. , Spencer C.C.A. , Jones M.C. , Gillson C. , Searle S. , Zhou Y. , Kokocinski F. , McDonald L. , Evans R. , Phillips K. , more...
      Nature441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    5. 5.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3);VARIANTS ILE-67 AND PHE-315
      tissue: Colon.
    6. 6.
      "Refined chromosomal localization of six human CLCN chloride ion channel genes."
      Schutte B.C. , Malik M.I. , Fingert J. , Barna T.J. , Stone E. , Lamb F.S.
      Submitted (1997-03) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 153-203
    7. 7.
      "Barttin is a Cl- channel beta-subunit crucial for renal Cl-reabsorption and inner ear K+ secretion."
      Estevez R. , Boettger T. , Stein V. , Birkenhaeger R. , Otto E. , Hildebrandt F. , Jentsch T.J.
      Nature414:558-561(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: TISSUE SPECIFICITY
    8. 8.
      "Molecular analysis of digenic inheritance in Bartter syndrome with sensorineural deafness."
      Nozu K. , Inagaki T. , Fu X.J. , Nozu Y. , Kaito H. , Kanda K. , Sekine T. , Igarashi T. , Nakanishi K. , Yoshikawa N. , Iijima K. , Matsuo M.
      J. Med. Genet.45:182-186(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INVOLVEMENT IN BS4B
    9. 9.
      "Dissecting a regulatory calcium-binding site of CLC-K kidney chloride channels."
      Gradogna A. , Fenollar-Ferrer C. , Forrest L.R. , Pusch M.
      J. Gen. Physiol.140:681-696(2012) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: CALCIUM-BINDING SITES
    10. 10.
      "The structure of the cytoplasmic domain of the chloride channel ClC-Ka reveals a conserved interaction interface."
      Markovic S. , Dutzler R.
      Structure15:715-725(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.6 ANGSTROMS) OF 533-687;SUBUNIT
    11. 11.
      "Salt wasting and deafness resulting from mutations in two chloride channels."
      Schlingmann K.P. , Konrad M. , Jeck N. , Waldegger P. , Reinalter S.C. , Holder M. , Seyberth H.W. , Waldegger S.
      N. Engl. J. Med.350:1314-1319(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT BS4B CYS-80
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