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Index > Protein center > CLDN2(Gene name) > Human
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  • CLDN2 (Gene name),
  • Claudin-2 (Protein name ),  CLD2_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    CLDN2(PSEC0059;SP82;UNQ705/PRO1356);
    Protein name:
    Claudin-2;
    Alternative:
    SP82;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Can form homo- and heteropolymers with other CLDN. Homopolymers interact with CLDN3, but not CLDN1, homopolymers. Directly interacts with TJP1/ZO-1, TJP2/ZO-2 and TJP3/ZO-3.
    Function:
    Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
    Subcellular Location:
    Cell junction tight junction Cell membrane Multi-pass membrane protein
    Protein Attributes:
    Sequence length:
    230
    Sequence:
    50:
    MASLGLQLVG | YILGLLGLLG | TLVAMLLPSW | KTSSYVGASI | VTAVGFSKGL | 
    100:
    WMECATHSTG | ITQCDIYSTL | LGLPADIQAA | QAMMVTSSAI | SSLACIISVV | 
    150:
    GMRCTVFCQE | SRAKDRVAVA | GGVFFILGGL | LGFIPVAWNL | HGILRDFYSP | 
    200:
    LVPDSMKFEI | GEALYLGIIS | SLFSLIAGII | LCFSCSSQRN | RSNYYDAYQA | 
    230:
    QPLATRSSPR | PGQPPKVKSE | FNSYSLTGYV | 
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    String:
    Pfam:
    MIM:
    KEGG:
    UniGene:
    Uniprot:
     
    FOR
    ELISA Kit for Human Claudin-2
    Cat.:
    E11710h
    Price:
    Please sign in first.
    MSDS:
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    Packing:
    96T
    Range:
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    ELISA Kit for Human Claudin-2
    MSDS:
    Please sign in first.
    ELISA Kit for Human Claudin-2
    MSDS:
    Please sign in first.
    ELISA Kit for Human Claudin-2
    Cat.:
    E11710m
    Price:
    Please sign in first.
    MSDS:
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    Packing:
    96T
    CLIA Kit for Human Claudin-2
    MSDS:
    Please sign in first.
    CLIA Kit for Human Claudin-2
    MSDS:
    Please sign in first.
    CLIA Kit for Human Claudin-2
    Cat.:
    U11710h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Human Claudin-2
    Cat.:
    U11710m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Polyclonal Antibody for Human Claudin-2
    Polyclonal Antibody for Human Claudin-2
    Polyclonal Antibody for Human Claudin-2
    Cat.:
    P11710Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Claudin-2
    Monoclonal Antibody for Human Claudin-2
    Monoclonal Antibody for Human Claudin-2
    Monoclonal Antibody for Human Claudin-2
    Monoclonal Antibody for Human Claudin-2
    Protein for Human Claudin-2
    Protein for Human Claudin-2
    Protein for Human Claudin-2
    Protein for Human Claudin-2

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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      "Cloning of the human claudin-2 5'-flanking region revealed a TATA-less promoter with conserved binding sites in mouse and human for caudal-related homeodomain proteins and hepatocyte nuclear factor-1alpha."
      Sakaguchi T. , Gu X. , Golden H.M. , Suh E. , Rhoads D.B. , Reinecker H.-C.
      J. Biol. Chem.277:21361-21370(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
      tissue: Colon epithelium.
    2. 2.
      "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment."
      Clark H.F. , Gurney A.L. , Abaya E. , Baker K. , Baldwin D.T. , Brush J. , Chen J. , Chow B. , Chui C. , Crowley C. , Currell B. , Deuel B. , Dowd P. , Eaton D. , Foster J.S. , Grimaldi C. , Gu Q. , Hass P.E. , more...
      Genome Res.13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
    3. 3.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      tissue: Thalamus.
    4. 4.
      "Large-scale cDNA transfection screening for genes related to cancer development and progression."
      Wan D. , Gong Y. , Qin W. , Zhang P. , Li J. , Wei L. , Zhou X. , Li H. , Qiu X. , Zhong F. , He L. , Yu J. , Yao G. , Jiang H. , Qian L. , Yu Y. , Shu H. , Chen X. , more...
      Proc. Natl. Acad. Sci. U.S.A.101:15724-15729(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
    5. 5.
      "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries."
      Otsuki T. , Ota T. , Nishikawa T. , Hayashi K. , Suzuki Y. , Yamamoto J. , Wakamatsu A. , Kimura K. , Sakamoto K. , Hatano N. , Kawai Y. , Ishii S. , Saito K. , Kojima S. , Sugiyama T. , Ono T. , Okano K. , Yoshikawa Y. , more...
      DNA Res.12:117-126(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      tissue: Teratocarcinoma.
    6. 6.
      "The DNA sequence of the human X chromosome."
      Ross M.T. , Grafham D.V. , Coffey A.J. , Scherer S. , McLay K. , Muzny D. , Platzer M. , Howell G.R. , Burrows C. , Bird C.P. , Frankish A. , Lovell F.L. , Howe K.L. , Ashurst J.L. , Fulton R.S. , Sudbrak R. , Wen G. , Jones M.C. , more...
      Nature434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    7. 7.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    8. 8.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      tissue: Colon.
      tissue: Skin.
    9. 9.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUMOYLATION AT LYS-218
    10. 10.
      "Claudin-2 pore function requires an intramolecular disulfide bond between two conserved extracellular cysteines."
      Li J. , Angelow S. , Linge A. , Zhuo M. , Yu A.S.
      Am. J. Physiol.305:C190-C196(2013) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: DISULFIDE BOND
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