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Index > Protein center > CLTCL1(Gene name) > Human
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  • CLTCL1 (Gene name),
  • Clathrin heavy chain 2 (Protein name ),  CLH2_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Predicted Eptitope
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  • Vaild Sequence
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    • Gene name:
    CLTCL1(CLH22;CLTCL;CLTD);
    Protein name:
    Clathrin heavy chain 2;
    Alternative:
    Clathrin heavy chain on chromosome 22(CLH-22);
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Clathrin triskelions, composed of 3 heavy chains and 3 light chains, are the basic subunits of the clathrin coat. In the presence of light chains, hub assembly is influenced by both the pH and the concentration of calcium (By similarity). May interact with OCRL.
    Function:
    Clathrin is the major protein of the polyhedral coat of coated pits and vesicles. Two different adapter protein complexes link the clathrin lattice either to the plasma membrane or to the trans-Golgi network.
    Subcellular Location:
    Cytoplasmic vesicle membrane Peripheral membrane protein Cytoplasmic side Membrane coated pit Peripheral membrane protein Cytoplasmic side Cytoplasmic face of coated pits and vesicles.
    Protein Attributes:
    Sequence length:
    1640
    Sequence:
    50:
    MAQILPVRFQ | EHFQLQNLGI | NPANIGFSTL | TMESDKFICI | REKVGEQAQV | 
    100:
    TIIDMSDPMA | PIRRPISAES | AIMNPASKVI | ALKAGKTLQI | FNIEMKSKMK | 
    150:
    AHTMAEEVIF | WKWVSVNTVA | LVTETAVYHW | SMEGDSQPMK | MFDRHTSLVG | 
    200:
    CQVIHYRTDE | YQKWLLLVGI | SAQQNRVVGA | MQLYSVDRKV | SQPIEGHAAA | 
    250:
    FAEFKMEGNA | KPATLFCFAV | RNPTGGKLHI | IEVGQPAAGN | QPFVKKAVDV | 
    300:
    FFPPEAQNDF | PVAMQIGAKH | GVIYLITKYG | YLHLYDLESG | VCICMNRISA | 
    350:
    DTIFVTAPHK | PTSGIIGVNK | KGQVLSVCVE | EDNIVNYATN | VLQNPDLGLR | 
    400:
    LAVRSNLAGA | EKLFVRKFNT | LFAQGSYAEA | AKVAASAPKG | ILRTRETVQK | 
    450:
    FQSIPAQSGQ | ASPLLQYFGI | LLDQGQLNKL | ESLELCHLVL | QQGRKQLLEK | 
    500:
    WLKEDKLECS | EELGDLVKTT | DPMLALSVYL | RANVPSKVIQ | CFAETGQFQK | 
    550:
    IVLYAKKVGY | TPDWIFLLRG | VMKISPEQGL | QFSRMLVQDE | EPLANISQIV | 
    600:
    DIFMENSLIQ | QCTSFLLDAL | KNNRPAEGLL | QTWLLEMNLV | HAPQVADAIL | 
    650:
    GNKMFTHYDR | AHIAQLCEKA | GLLQQALEHY | TDLYDIKRAV | VHTHLLNPEW | 
    700:
    LVNFFGSLSV | EDSVECLHAM | LSANIRQNLQ | LCVQVASKYH | EQLGTQALVE | 
    750:
    LFESFKSYKG | LFYFLGSIVN | FSQDPDVHLK | YIQAACKTGQ | IKEVERICRE | 
    800:
    SSCYNPERVK | NFLKEAKLTD | QLPLIIVCDR | FGFVHDLVLY | LYRNNLQRYI | 
    850:
    EIYVQKVNPS | RTPAVIGGLL | DVDCSEEVIK | HLIMAVRGQF | STDELVAEVE | 
    900:
    KRNRLKLLLP | WLESQIQEGC | EEPATHNALA | KIYIDSNNSP | ECFLRENAYY | 
    950:
    DSSVVGRYCE | KRDPHLACVA | YERGQCDLEL | IKVCNENSLF | KSEARYLVCR | 
    1000:
    KDPELWAHVL | EETNPSRRQL | IDQVVQTALS | ETRDPEEISV | TVKAFMTADL | 
    1050:
    PNELIELLEK | IVLDNSVFSE | HRNLQNLLIL | TAIKADRTRV | MEYISRLDNY | 
    1100:
    DALDIASIAV | SSALYEEAFT | VFHKFDMNAS | AIQVLIEHIG | NLDRAYEFAE | 
    1150:
    RCNEPAVWSQ | LAQAQLQKDL | VKEAINSYIR | GDDPSSYLEV | VQSASRSNNW | 
    1200:
    EDLVKFLQMA | RKKGRESYIE | TELIFALAKT | SRVSELEDFI | NGPNNAHIQQ | 
    1250:
    VGDRCYEEGM | YEAAKLLYSN | VSNFARLAST | LVHLGEYQAA | VDNSRKASST | 
    1300:
    RTWKEVCFAC | MDGQEFRFAQ | LCGLHIVIHA | DELEELMCYY | QDRGYFEELI | 
    1350:
    LLLEAALGLE | RAHMGMFTEL | AILYSKFKPQ | KMLEHLELFW | SRVNIPKVLR | 
    1400:
    AAEQAHLWAE | LVFLYDKYEE | YDNAVLTMMS | HPTEAWKEGQ | FKDIITKVAN | 
    1450:
    VELCYRALQF | YLDYKPLLIN | DLLLVLSPRL | DHTWTVSFFS | KAGQLPLVKP | 
    1500:
    YLRSVQSHNN | KSVNEALNHL | LTEEEDYQGL | RASIDAYDNF | DNISLAQQLE | 
    1550:
    KHQLMEFRCI | AAYLYKGNNW | WAQSVELCKK | DHLYKDAMQH | AAESRDAELA | 
    1600:
    QKLLQWFLEE | GKRECFAACL | FTCYDLLRPD | MVLELAWRHN | LVDLAMPYFI | 
    1640:
    QVMREYLSKV | DKLDALESLR | KQEEHVTEPA | PLVFDFDGHE | 
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    Pfam:
    PF00637
    String:
    P53675
    MIM:
    601273
    SMR:
    P53675
    UniGene:
    Hs.368266
    STRING:
    9606.ENSP00000263200
    KEGG:
    hsa:8218
    Uniprot:
    P53675
     
    FOR
    ELISA Kit for Human Clathrin heavy chain 2
    CLIA Kit for Human Clathrin heavy chain 2
    Polyclonal Antibody for Human Clathrin heavy chain 2
    Monoclonal Antibody for Human Clathrin heavy chain 2
    Protein for Human Clathrin heavy chain 2

    R&D Technical Data
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    Precision
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    Recovery
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    Linearity
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    References
    1. 1.
      "Isolation of a new clathrin heavy chain gene with muscle-specific expression from the region commonly deleted in velo-cardio-facial syndrome."
      Sirotkin H. , Morrow B. , Dasgupta R. , Goldberg R. , Patangali S.R. , Shi G. , Cannizzaro L. , Shprintzen R. , Weissman S. , Kucherlapati R.
      Hum. Mol. Genet.5:617-624(1996) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
      tissue: Fetal brain.
    2. 2.
      "Characterization of a second human clathrin heavy chain polypeptide gene (CLH-22) from chromosome 22q11."
      Kedra D. , Peyrard M. , Fransson I. , Collins J.E. , Dunham I. , Roe B.A. , Dumanski J.P.
      Hum. Mol. Genet.5:625-631(1996) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);NUCLEOTIDE SEQUENCE [MRNA] OF 1451-1640 (ISOFORM 2)
      tissue: Fetal brain.
      tissue: Skeletal muscle.
    3. 3.
      "Cloning and characterization of a novel human clathrin heavy chain gene (CLTCL)."
      Long K.R. , Trofatter J.A. , Ramesh V. , McCormick M.K. , Buckler A.J.
      Genomics35:466-472(1996) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2);VARIANT LYS-691
    4. 4.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)
      tissue: Testis.
    5. 5.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    6. 6.
      "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V. , Vermeulen M. , Santamaria A. , Kumar C. , Miller M.L. , Jensen L.J. , Gnad F. , Cox J. , Jensen T.S. , Nigg E.A. , Brunak S. , Mann M.
      Sci. Signal.3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Cervix carcinoma.
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