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Index > Protein center > PARK2(Gene name) > Human
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  • PARK2 (Gene name),
  • E3 ubiquitin-protein ligase parkin (Protein name ),  PRKN2_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Gene name:
    PARK2(PRKN);
    Protein name:
    E3 ubiquitin-protein ligase parkin;
    Alternative:
    Parkinson juvenile disease protein 2(Parkinson disease protein 2);
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Forms an E3 ubiquitin ligase complex with UBE2L3 or UBE2L6. Mediates 'Lys-63'-linked polyubiquitination by associating with UBE2V1. Part of a SCF-like complex, consisting of PARK2, CUL1 and FBXW7. Interacts with SNCAIP. Binds to the C2A and C2B domains of SYT11. Interacts and regulates the turnover of SEPT5. Part of a complex, including STUB1, HSP70 and GPR37. The amount of STUB1 in the complex increases during ER stress. STUB1 promotes the dissociation of HSP70 from PARK2 and GPR37, thus facilitating PARK2-mediated GPR37 ubiquitination. HSP70 transiently associates with unfolded GPR37 and inhibits the E3 activity of PARK2, whereas, STUB1 enhances the E3 activity of PARK2 through promotion of dissociation of HSP70 from PARK2-GPR37 complexes. Interacts with PSMD4 and PACRG. Interacts with LRRK2. Interacts with RANBP2. Interacts with SUMO1 but not SUMO2, which promotes nuclear localization and autoubiquitination. Interacts (via first RING-type domain) with AIMP2 (via N-terminus). Interacts with PSMA7 and RNF41. Interacts with PINK1.
    Function:
    Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins, such as BCL2, SYT11, CCNE1, GPR37, STUB1, a 22 kDa O-linked glycosylated isoform of SNCAIP, SEPT5, ZNF746 and AIMP2. Mediates monoubiquitination as well as 'Lys-48'-linked and 'Lys-63'-linked polyubiquitination of substrates depending on the context. Participates in the removal and/or detoxification of abnormally folded or damaged protein by mediating 'Lys-63'-linked polyubiquitination of misfolded proteins such as PARK7: 'Lys-63'-linked polyubiquitinated misfolded proteins are then recognized by HDAC6, leading to their recruitment to aggresomes, followed by degradation. Mediates 'Lys-63'-linked polyubiquitination of SNCAIP, possibly playing a role in Lewy-body formation. Mediates monoubiquitination of BCL2, thereby acting as a positive regulator of autophagy. Promotes the autophagic degradation of dysfunctional depolarized mitochondria. Mediates 'Lys-48'-linked polyubiquitination of ZNF746, followed by degradation of ZNF746 by the proteasome; possibly playing a role in role in regulation of neuron death. Limits the production of reactive oxygen species (ROS). Loss of this ubiquitin ligase activity appears to be the mechanism underlying pathogenesis of PARK2. May protect neurons against alpha synuclein toxicity, proteasomal dysfunction, GPR37 accumulation, and kainate-induced excitotoxicity. May play a role in controlling neurotransmitter trafficking at the presynaptic terminal and in calcium-dependent exocytosis. Regulates cyclin-E during neuronal apoptosis. May represent a tumor suppressor gene.
    Subcellular Location:
    Cytoplasm cytosol Nucleus Endoplasmic reticulum Mitochondrion Mainly localizes in the cytosol. Co-localizes with SYT11 in neutrites. Co-localizes with SNCAIP in brainstem Lewy bodies. Relocates to dysfunctional mitochondria that have lost the mitochondial membrane potential; recruitement to mitochondria is PINK1-dependent.
    Protein Attributes:
    Sequence length:
    465
    Sequence:
    50:
    MIVFVRFNSS | HGFPVEVDSD | TSIFQLKEVV | AKRQGVPADQ | LRVIFAGKEL | 
    100:
    RNDWTVQNCD | LDQQSIVHIV | QRPWRKGQEM | NATGGDDPRN | AAGGCEREPQ | 
    150:
    SLTRVDLSSS | VLPGDSVGLA | VILHTDSRKD | SPPAGSPAGR | SIYNSFYVYC | 
    200:
    KGPCQRVQPG | KLRVQCSTCR | QATLTLTQGP | SCWDDVLIPN | RMSGECQSPH | 
    250:
    CPGTSAEFFF | KCGAHPTSDK | ETSVALHLIA | TNSRNITCIT | CTDVRSPVLV | 
    300:
    FQCNSRHVIC | LDCFHLYCVT | RLNDRQFVHD | PQLGYSLPCV | AGCPNSLIKE | 
    350:
    LHHFRILGEE | QYNRYQQYGA | EECVLQMGGV | LCPRPGCGAG | LLPEPDQRKV | 
    400:
    TCEGGNGLGC | GFAFCRECKE | AYHEGECSAV | FEASGTTTQA | YRVDERAAEQ | 
    450:
    ARWEAASKET | IKKTTKPCPR | CHVPVEKNGG | CMHMKCPQPQ | CRLEWCWNCG | 
    465:
    CEWNRVCMGD | HWFDV
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    MIM:
    SMR:
    Pfam:
    UniGene:
    String:
    KEGG:
    Uniprot:
     
    FOR
    ELISA Kit for Human E3 ubiquitin-protein ligase parkin
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    E2353r
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    ELISA Kit for Human E3 ubiquitin-protein ligase parkin
    Cat.:
    E2353h
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    Packing:
    96T
    ELISA Kit for Human E3 ubiquitin-protein ligase parkin
    Cat.:
    E2353m
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    Packing:
    96T
    CLIA Kit for Human E3 ubiquitin-protein ligase parkin
    Cat.:
    U2353h
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    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human E3 ubiquitin-protein ligase parkin
    Cat.:
    U2353r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human E3 ubiquitin-protein ligase parkin
    Cat.:
    U2353m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Polyclonal Antibody for Human E3 ubiquitin-protein ligase parkin
    Cat.:
    P2353Rb-r
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human E3 ubiquitin-protein ligase parkin
    Cat.:
    P2353Rb-m
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human E3 ubiquitin-protein ligase parkin
    Cat.:
    P2353Rb-h
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    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Human E3 ubiquitin-protein ligase parkin
    Monoclonal Antibody for Human E3 ubiquitin-protein ligase parkin
    Monoclonal Antibody for Human E3 ubiquitin-protein ligase parkin
    Protein for Human E3 ubiquitin-protein ligase parkin
    Protein for Human E3 ubiquitin-protein ligase parkin
    Protein for Human E3 ubiquitin-protein ligase parkin

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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      "Mutations in the parkin gene cause autosomal recessive juvenile parkinsonism."
      Kitada T. , Asakawa S. , Hattori N. , Matsumine H. , Yamamura Y. , Minoshima S. , Yokochi M. , Mizuno Y. , Shimizu N.
      Nature392:605-608(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2);INVOLVEMENT IN PARK2
      tissue: Fetal brain.
      tissue: Skeletal muscle.
    2. 2.
      "Evidence for the presence of full-length PARK2 mRNA and Parkin protein in human blood."
      Kasap M. , Akpinar G. , Sazci A. , Idrisoglu H.A. , Vahaboglu H.
      Neurosci. Lett.460:196-200(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];SUBCELLULAR LOCATION;TISSUE SPECIFICITY;VARIANTS ARG-311 AND THR-371;IDENTIFICATION BY MASS SPECTROMETRY
    3. 3.
      "Functional and molecular diversity of parkin."
      D'Agata V. , Scapagnini G. , Cavallaro S.
      Submitted (2001-05) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 3 AND 4)
    4. 4.
      "Homo sapiens PARK2 transcript variants."
      Campello L. , Esteve-Rudd J. , Cuenca N. , Martin-Nieto J.
      Submitted (2009-12) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 2; 7 AND 8)
      tissue: Retina.
    5. 5.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
      tissue: Testis.
    6. 6.
      "The DNA sequence and analysis of human chromosome 6."
      Mungall A.J. , Palmer S.A. , Sims S.K. , Edwards C.A. , Ashurst J.L. , Wilming L. , Jones M.C. , Horton R. , Hunt S.E. , Scott C.E. , Gilbert J.G.R. , Clamp M.E. , Bethel G. , Milne S. , Ainscough R. , Almeida J.P. , Ambrose K.D. , Andrews T.D. , more...
      Nature425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    7. 7.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    8. 8.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 5)
      tissue: Testis.
    9. 9.
      Zou H.Q. , Chan P.
      Submitted (2004-03) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 312-361
    10. 10.
      "Immunohistochemical and subcellular localization of Parkin protein: absence of protein in autosomal recessive juvenile parkinsonism patients."
      Shimura H. , Hattori N. , Kubo S. , Yoshikawa M. , Kitada T. , Matsumine H. , Asakawa S. , Minoshima S. , Yamamura Y. , Shimizu N. , Mizuno Y.
      Ann. Neurol.45:668-672(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION
    11. 11.
      "Parkin suppresses unfolded protein stress-induced cell death through its E3 ubiquitin-protein ligase activity."
      Imai Y. , Soda M. , Takahashi R.
      J. Biol. Chem.275:35661-35664(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN UBIQUITINATION
    12. 12.
      "Familial Parkinson disease gene product, parkin, is a ubiquitin-protein ligase."
      Shimura H. , Hattori N. , Kubo S. , Mizuno Y. , Asakawa S. , Minoshima S. , Shimizu N. , Iwai K. , Chiba T. , Tanaka K. , Suzuki T.
      Nat. Genet.25:302-305(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;CHARACTERIZATION OF VARIANTS PARK2 PRO-42 AND ARG-240
    13. 13.
      "Parkin functions as an E2-dependent ubiquitin-protein ligase and promotes the degradation of the synaptic vesicle-associated protein, CDCrel-1."
      Zhang Y. , Gao J. , Chung K.K.K. , Huang H. , Dawson V.L. , Dawson T.M.
      Proc. Natl. Acad. Sci. U.S.A.97:13354-13359(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH UBE2L6 AND SEPT5;UBIQUITINATION OF SEPT5
    14. 14.
      "An unfolded putative transmembrane polypeptide, which can lead to endoplasmic reticulum stress, is a substrate of Parkin."
      Imai Y. , Soda M. , Inoue H. , Hattori N. , Mizuno Y. , Takahashi R.
      Cell105:891-902(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: UBIQUITINATION OF GPR37
    15. 15.
      "Parkin ubiquitinates the alpha-synuclein-interacting protein, synphilin-1: implications for Lewy-body formation in Parkinson disease."
      Chung K.K.K. , Zhang Y. , Lim K.L. , Tanaka Y. , Huang H. , Gao J. , Ross C.A. , Dawson V.L. , Dawson T.M.
      Nat. Med.7:1144-1150(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION;UBIQUITINATION OF SNCAIP;CHARACTERIZATION OF VARIANTS PARK2 ARG-240; CYS-256; TRP-275 AND ASN-415;MUTAGENESIS OF CYS-337; CYS-421 AND CYS-431
    16. 16.
      "Ubiquitination of a new form of alpha-synuclein by parkin from human brain: implications for Parkinson's disease."
      Shimura H. , Schlossmacher M.G. , Hattori N. , Frosch M.P. , Trockenbacher A. , Schneider R. , Mizuno Y. , Kosik K.S. , Selkoe D.J.
      Science293:263-269(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: UBIQUITINATION OF AN O-GLYCOSYLATED ISOFORM OF SNCAIP;SUBCELLULAR LOCATION;CHARACTERIZATION OF VARIANTS PARK2 PRO-42 AND ARG-240
    17. 17.
      "Comparative genomics of the RBR family, including the Parkinson's disease-related gene parkin and the genes of the ariadne subfamily."
      Marin I. , Ferrus A.
      Mol. Biol. Evol.19:2039-2050(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PRESENCE OF ATYPICAL RING FINGER DOMAINS
    18. 18.
      "CHIP is associated with Parkin, a gene responsible for familial Parkinson's disease, and enhances its ubiquitin ligase activity."
      Imai Y. , Soda M. , Hatakeyama S. , Akagi T. , Hashikawa T. , Nakayama K. , Takahashi R.
      Mol. Cell10:55-67(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH STUB1 AND HSP70;UBIQUITINATION OF STUB1
    19. 19.
      "The autosomal recessive juvenile Parkinson disease gene product, parkin, interacts with and ubiquitinates synaptotagmin XI."
      Huynh D.P. , Scoles D.R. , Nguyen D. , Pulst S.M.
      Hum. Mol. Genet.12:2587-2597(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH SYT11;CHARACTERIZATION OF VARIANTS PARK2 GLY-289 AND ARG-418
    20. 20.
      "A product of the human gene adjacent to parkin is a component of Lewy bodies and suppresses Pael receptor-induced cell death."
      Imai Y. , Soda M. , Murakami T. , Shoji M. , Abe K. , Takahashi R.
      J. Biol. Chem.278:51901-51910(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH PACRG
    21. 21.
      "Parkin is a component of an SCF-like ubiquitin ligase complex and protects postmitotic neurons from kainate excitotoxicity."
      Staropoli J.F. , McDermott C. , Martinat C. , Schulman B. , Demireva E. , Abeliovich A.
      Neuron37:735-749(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH FBXW7 AND CUL1;UBIQUITINATION OF CYCLIN E
    22. 22.
      "Alterations in the common fragile site gene Parkin in ovarian and other cancers."
      Denison S.R. , Wang F. , Becker N.A. , Schuele B. , Kock N. , Phillips L.A. , Klein C. , Smith D.I.
      Oncogene22:8370-8378(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INVOLVEMENT IN CANCER
    23. 23.
      "Parkin, a gene implicated in autosomal recessive juvenile parkinsonism, is a candidate tumor suppressor gene on chromosome 6q25-q27."
      Cesari R. , Martin E.S. , Calin G.A. , Pentimalli F. , Bichi R. , McAdams H. , Trapasso F. , Drusco A. , Shimizu M. , Masciullo V. , D'Andrilli G. , Scambia G. , Picchio M.C. , Alder H. , Godwin A.K. , Croce C.M.
      Proc. Natl. Acad. Sci. U.S.A.100:5956-5961(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INVOLVEMENT IN CANCER
    24. 24.
      "How does parkin ligate ubiquitin to Parkinson's disease?"
      Kahle P.J. , Haass C.
      EMBO Rep.5:681-685(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW
    25. 25.
      "S-nitrosylation of parkin regulates ubiquitination and compromises parkin's protective function."
      Chung K.K.K. , Thomas B. , Li X. , Pletnikova O. , Troncoso J.C. , Marsh L. , Dawson V.L. , Dawson T.M.
      Science304:1328-1331(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;UBIQUITINATION;S-NITROSYLATION
    26. 26.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH PSMA7
    27. 27.
      "Parkin mediates nonclassical, proteasomal-independent ubiquitination of synphilin-1: implications for Lewy body formation."
      Lim K.L. , Chew K.C. , Tan J.M. , Wang C. , Chung K.K. , Zhang Y. , Tanaka Y. , Smith W. , Engelender S. , Ross C.A. , Dawson V.L. , Dawson T.M.
      J. Neurosci.25:2002-2009(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH SNCAIP
    28. 28.
      "Accumulation of the authentic parkin substrate aminoacyl-tRNA synthetase cofactor, p38/JTV-1, leads to catecholaminergic cell death."
      Ko H.S. , von Coelln R. , Sriram S.R. , Kim S.W. , Chung K.K.K. , Pletnikova O. , Troncoso J. , Johnson B. , Saffary R. , Goh E.L. , Song H. , Park B.-J. , Kim M.J. , Kim S. , Dawson V.L. , Dawson T.M.
      J. Neurosci.25:7968-7978(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH AIMP2
    29. 29.
      "Leucine-rich repeat kinase 2 (LRRK2) interacts with parkin and mutant LRRK2 induces neuronal degeneration."
      Smith W.W. , Pei Z. , Jiang H. , Moore D.J. , Liang Y. , West A.B. , Dawson V.L. , Dawson T.M. , Ross C.A.
      Proc. Natl. Acad. Sci. U.S.A.102:18676-18681(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH LRRK2
    30. 30.
      "Parkin ubiquitinates and promotes the degradation of RanBP2."
      Um J.W. , Min D.S. , Rhim H. , Kim J. , Paik S.R. , Chung K.C.
      J. Biol. Chem.281:3595-3603(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH RANBP2
    31. 31.
      "Functional modulation of parkin through physical interaction with SUMO-1."
      Um J.W. , Chung K.C.
      J. Neurosci. Res.84:1543-1554(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH SUMO1;SUBCELLULAR LOCATION
    32. 32.
      "Parkin-mediated K63-linked polyubiquitination targets misfolded DJ-1 to aggresomes via binding to HDAC6."
      Olzmann J.A. , Li L. , Chudaev M.V. , Chen J. , Perez F.A. , Palmiter R.D. , Chin L.S.
      J. Cell Biol.178:1025-1038(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION
    33. 33.
      "Parkin is recruited selectively to impaired mitochondria and promotes their autophagy."
      Narendra D. , Tanaka A. , Suen D.F. , Youle R.J.
      J. Cell Biol.183:795-803(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN MITOCHONDRIAL AUTOPHAGY;SUBCELLULAR LOCATION
    34. 34.
      "Parkin is ubiquitinated by Nrdp1 and abrogates Nrdp1-induced oxidative stress."
      Yu F. , Zhou J.
      Neurosci. Lett.440:4-8(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH RNF41;UBIQUITINATION;MUTAGENESIS OF CYS-421;FUNCTION
    35. 35.
      "Transcriptional repression of p53 by parkin and impairment by mutations associated with autosomal recessive juvenile Parkinson's disease."
      da Costa C.A. , Sunyach C. , Giaime E. , West A. , Corti O. , Brice A. , Safe S. , Abou-Sleiman P.M. , Wood N.W. , Takahashi H. , Goldberg M.S. , Shen J. , Checler F.
      Nat. Cell Biol.11:1370-1375(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN PROTECTION OF APOPTOSIS;CHARACTERIZATION OF VARIANTS PARK2 ASN-161; CYS-256; TRP-275; ARG-418 AND ARG-441;DOMAIN
    36. 36.
      "The PINK1/Parkin-mediated mitophagy is compromised by PD-associated mutations."
      Geisler S. , Holmstrom K.M. , Treis A. , Skujat D. , Weber S.S. , Fiesel F.C. , Kahle P.J. , Springer W.
      Autophagy6:871-878(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH PINK1
    37. 37.
      "Parkin mono-ubiquitinates Bcl-2 and regulates autophagy."
      Chen D. , Gao F. , Li B. , Wang H. , Xu Y. , Zhu C. , Wang G.
      J. Biol. Chem.285:38214-38223(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH BCL2;SUBCELLULAR LOCATION;CHARACTERIZATION OF VARIANTS PARK2 ASN-161; ARG-240; PHE-431 AND LEU-437
    38. 38.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN MITOCHONDRIAL AUTOPHAGY;SUBCELLULAR LOCATION;INTERACTION WITH PINK1;CHARACTERIZATION OF VARIANTS PARK ASN-415 AND ASP-430
    39. 39.
      "PARIS (ZNF746) repression of PGC-1alpha contributes to neurodegeneration in Parkinson's disease."
      Shin J.H. , Ko H.S. , Kang H. , Lee Y. , Lee Y.I. , Pletinkova O. , Troconso J.C. , Dawson V.L. , Dawson T.M.
      Cell144:689-702(2011) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH ZNF746;CHARACTERIZATION OF VARIANTS PARK2 TRP-275; ASP-430 AND PHE-431
    40. 40.
      "UBCH7 reactivity profile reveals parkin and HHARI to be RING/HECT hybrids."
      Wenzel D.M. , Lissounov A. , Brzovic P.S. , Klevit R.E.
      Nature474:105-108(2011) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;REACTION MECHANISM;INTERACTION WITH UBE2L3
    41. 41.
      "Parkin interacts with Klokin1 for mitochondrial import and maintenance of membrane potential."
      Kuroda Y. , Sako W. , Goto S. , Sawada T. , Uchida D. , Izumi Y. , Takahashi T. , Kagawa N. , Matsumoto M. , Matsumoto M. , Takahashi R. , Kaji R. , Mitsui T.
      Hum. Mol. Genet.21:991-1003(2012) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH CHPF;SUBCELLULAR LOCATION
    42. 42.
      "Parkin-catalyzed ubiquitin-ester transfer is triggered by PINK1-dependent phosphorylation."
      Iguchi M. , Kujuro Y. , Okatsu K. , Koyano F. , Kosako H. , Kimura M. , Suzuki N. , Uchiyama S. , Tanaka K. , Matsuda N.
      J. Biol. Chem.288:22019-22032(2013) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT SER-65;FUNCTION;SUBCELLULAR LOCATION
    43. 43.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION;INTERACTION WITH FBXO7
    44. 44.
      "High-content genome-wide RNAi screens identify regulators of parkin upstream of mitophagy."
      Hasson S.A. , Kane L.A. , Yamano K. , Huang C.H. , Sliter D.A. , Buehler E. , Wang C. , Heman-Ackah S.M. , Hessa T. , Guha R. , Martin S.E. , Youle R.J.
      Nature504:291-295(2013) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH BAG4; BAG5; HSPA1L; HSPA1A AND HSPA8
    45. 45.
      "PINK1-phosphorylated mitofusin 2 is a Parkin receptor for culling damaged mitochondria."
      Chen Y. , Dorn G.W. II
      Science340:471-475(2013) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN MITOPHAGY;INTERACTION WITH MFN2;SUBCELLULAR LOCATION
    46. 46.
      "Parkin is activated by PINK1-dependent phosphorylation of ubiquitin at Ser65."
      Kazlauskaite A. , Kondapalli C. , Gourlay R. , Campbell D.G. , Ritorto M.S. , Hofmann K. , Alessi D.R. , Knebel A. , Trost M. , Muqit M.M.
      Biochem. J.460:127-139(2014) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;PHOSPHORYLATION AT SER-65;UBIQUITIN-BINDING;ENZYME REGULATION;MUTAGENESIS OF SER-65
    47. 47.
      "PINK1 phosphorylates ubiquitin to activate Parkin E3 ubiquitin ligase activity."
      Kane L.A. , Lazarou M. , Fogel A.I. , Li Y. , Yamano K. , Sarraf S.A. , Banerjee S. , Youle R.J.
      J. Cell Biol.205:143-153(2014) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;ENZYME REGULATION
    48. 48.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;PHOSPHORYLATION AT SER-65;UBIQUITIN-BINDING;ENZYME REGULATION;MUTAGENESIS OF SER-65 AND TRP-403
    49. 49.
      "The mitochondrial deubiquitinase USP30 opposes parkin-mediated mitophagy."
      Bingol B. , Tea J.S. , Phu L. , Reichelt M. , Bakalarski C.E. , Song Q. , Foreman O. , Kirkpatrick D.S. , Sheng M.
      Nature510:370-375(2014) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
    50. 50.
      "Parkin binds the Rpn10 subunit of 26S proteasomes through its ubiquitin-like domain."
      Sakata E. , Yamaguchi Y. , Kurimoto E. , Kikuchi J. , Yokoyama S. , Yamada S. , Kawahara H. , Yokosawa H. , Hattori N. , Mizuno Y. , Tanaka K. , Kato K.
      EMBO Rep.4:301-306(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE BY NMR OF 1-76;INTERACTION WITH PSMD4
    51. 51.
      "Structure of the Parkin in-between-ring domain provides insights for E3-ligase dysfunction in autosomal recessive Parkinson's disease."
      Beasley S.A. , Hristova V.A. , Shaw G.S.
      Proc. Natl. Acad. Sci. U.S.A.104:3095-3100(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE BY NMR OF 307-384 IN COMPLEX WITH ZINC IONS;CHARACTERIZATION OF VARIANT PARK2 PRO-351;MUTAGENESIS OF CYS-332 AND CYS-365;IDENTIFICATION BY MASS SPECTROMETRY
    52. 52.
      "Structure of the human Parkin ligase domain in an autoinhibited state."
      Wauer T. , Komander D.
      EMBO J.32:2099-2112(2013) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.25 ANGSTROMS) OF 137-465;ENZYME REGULATION;MUTAGENESIS OF CYS-431; HIS-433 AND GLU-444
    53. 53.
      "Structure and function of Parkin E3 ubiquitin ligase reveals aspects of RING and HECT ligases."
      Riley B.E. , Lougheed J.C. , Callaway K. , Velasquez M. , Brecht E. , Nguyen L. , Shaler T. , Walker D. , Yang Y. , Regnstrom K. , Diep L. , Zhang Z. , Chiou S. , Bova M. , Artis D.R. , Yao N. , Baker J. , Yednock T. , more...
      Nat. Commun.4:1982-1982(2013) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.58 ANGSTROMS) OF 137-465;ACTIVE SITE;ENZYME REGULATION;MUTAGENESIS OF CYS-431; HIS-433 AND GLU-444
    54. 54.
      "Parkin genetics: one model for Parkinson's disease."
      Mata I.F. , Lockhart P.J. , Farrer M.J.
      Hum. Mol. Genet.13:R127-R133(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW ON VARIANTS
    55. 55.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT PARK2 ARG-240
    56. 56.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ERRATUM
    57. 57.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS PARK2 ASN-161; CYS-256; TRP-275 AND ASN-415;VARIANTS ASN-167; LEU-380 AND ASN-394
    58. 58.
      "Association of codon 167 Ser/Asn heterozygosity in the parkin gene with sporadic Parkinson's disease."
      Satoh J. , Kuroda Y.
      NeuroReport10:2735-2739(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT ASN-167
    59. 59.
      "Novel mutations, pseudo-dominant inheritance, and possible familial affects in patients with autosomal recessive juvenile parkinsonism."
      Maruyama M. , Ikeuchi T. , Saito M. , Ishikawa A. , Yuasa T. , Tanaka H. , Hayashi S. , Wakabayashi K. , Takahashi H. , Tsuji S.
      Ann. Neurol.48:245-250(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT PARK2 PHE-431
    60. 60.
      "Polymorphisms of the parkin gene in sporadic Parkinson's disease among Chinese in Taiwan."
      Hu C.-J. , Sung S.-M. , Liu H.-C. , Lee C.-C. , Tsai C.-H. , Chang J.-G.
      Eur. Neurol.44:90-93(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS ASN-167; TRP-366 AND LEU-380
    61. 61.
      "Association between early-onset Parkinson's disease and mutations in the parkin gene."
      Luecking C.B. , Duerr A. , Bonifati V. , Vaughan J.R. , De Michele G. , Gasser T. , Harhangi B.S. , Meco G. , Denefle P. , Wood N.W. , Agid Y. , Brice A.
      N. Engl. J. Med.342:1560-1567(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS PARK2 ASN-161; ASN-211; CYS-256; TRP-275; ASN-280; GLY-289; GLU-328; CYS-334; ASN-415 AND ASP-430
    62. 62.
      "Origin of the mutations in the parkin gene in Europe: exon rearrangements are independent recurrent events, whereas point mutations may result from founder effects."
      Periquet M. , Luecking C.B. , Vaughan J.R. , Bonifati V. , Duerr A. , De Michele G. , Horstink M. , Farrer M. , Illarioshkin S.N. , Pollak P. , Borg M. , Brefel-Courbon C. , Denefle P. , Meco G. , Gasser T. , Breteler M.M. , Wood N.W. , Agid Y. , more...
      Am. J. Hum. Genet.68:617-626(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS PARK2 ARG-211; TRP-275 AND ASP-430
    63. 63.
      "The importance of gene dosage studies: mutational analysis of the parkin gene in early-onset parkinsonism."
      Hedrich K. , Kann M. , Lanthaler A.J. , Dalski A. , Eskelson C. , Landt O. , Schwinger E. , Vieregge P. , Lang A.E. , Breakefield X.O. , Ozelius L.J. , Pramstaller P.P. , Klein C.
      Hum. Mol. Genet.10:1649-1656(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT PARK2 GLU-82
    64. 64.
      "A novel Cys212Tyr founder mutation in parkin and allelic heterogeneity of juvenile parkinsonism in a population from North West Colombia."
      Pineda-Trujillo N. , Carvajal-Carmona L.G. , Buritica O. , Moreno S. , Uribe C. , Pineda D. , Toro M. , Garcia F. , Arias W. , Bedoya G. , Lopera F. , Ruiz-Linares A.
      Neurosci. Lett.298:87-90(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT PARK2 TYR-212
    65. 65.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS PARK2 GLU-82; CYS-256; TRP-275; GLU-328 AND ARG-441
    66. 67.
      "Role of parkin mutations in 111 community-based patients with early-onset parkinsonism."
      Kann M. , Jacobs H. , Mohrmann K. , Schumacher K. , Hedrich K. , Garrels J. , Wiegers K. , Schwinger E. , Pramstaller P.P. , Breakefield X.O. , Ozelius L.J. , Vieregge P. , Klein C.
      Ann. Neurol.51:621-625(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS PARK2 LEU-37 AND PRO-351
    67. 68.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS PARK2 GLU-56 AND TYR-212
    68. 69.
      "Linkage stratification and mutation analysis at the parkin locus identifies mutation positive Parkinson's disease families."
      Nichols W.C. , Pankratz N. , Uniacke S.K. , Pauciulo M.W. , Halter C. , Rudolph A. , Conneally P.M. , Foroud T.
      J. Med. Genet.39:489-492(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS PARK2 ASN-211; TRP-275; ASP-430 AND LEU-437
    69. 70.
      "Relative high frequency of the c.255delA parkin gene mutation in Spanish patients with autosomal recessive parkinsonism."
      Munoz E. , Tolosa E. , Pastor P. , Marti M.J. , Valldeoriola F. , Campdelacreu J. , Oliva R.
      J. Neurol. Neurosurg. Psych.73:582-584(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT PARK2 MET-15;VARIANTS LEU-380 AND ASN-394
    70. 71.
      "Evaluation of 50 probands with early-onset Parkinson's disease for parkin mutations."
      Hedrich K. , Marder K. , Harris J. , Kann M. , Lynch T. , Meija-Santana H. , Pramstaller P.P. , Schwinger E. , Bressman S.B. , Fahn S. , Klein C.
      Neurology58:1239-1246(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS PARK2 PRO-42; LEU-192; CYS-256; TRP-275; ASP-430 AND LEU-437
    71. 72.
      "A new point mutation on exon 2 of parkin gene in Parkinson's disease."
      Xu Y. , Liu Z. , Wang Y. , Tao E. , Chen G. , Chen B.
      Zhonghua Yi Xue Yi Chuan Xue Za Zhi19:409-411(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT PARK2 PRO-46
    72. 73.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS PARK2 GLN-33; GLU-82; ASP-430 AND LEU-437;VARIANTS PARK TYR-253; CYS-256; TRP-275 AND ASN-280;VARIANTS LEU-380 AND ASN-394
    73. 74.
      "Heterozygosity for a mutation in the parkin gene leads to later onset Parkinson disease."
      Foroud T. , Uniacke S.K. , Liu L. , Pankratz N. , Rudolph A. , Halter C. , Shults C. , Marder K. , Conneally P.M. , Nichols W.C.
      Neurology60:796-801(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS PARK2 VAL-192; ASN-211; MET-240 AND LEU-437;VARIANT ASN-167;INVOLVEMENT IN LATE-ONSET PARK
    74. 75.
      "Parkin mutations are rare in patients with young-onset parkinsonism in a US population."
      Chen R. , Gosavi N.S. , Langston J.W. , Chan P.
      Parkinsonism Relat. Disord.9:309-312(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS HIS-100; SER-271 AND SER-339
    75. 76.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS PARK2 PRO-42; CYS-402; ASN-415 AND ARG-418
    76. 77.
      "PINK1 stabilized by mitochondrial depolarization recruits Parkin to damaged mitochondria and activates latent Parkin for mitophagy."
      Matsuda N. , Sato S. , Shiba K. , Okatsu K. , Saisho K. , Gautier C.A. , Sou Y.S. , Saiki S. , Kawajiri S. , Sato F. , Kimura M. , Komatsu M. , Hattori N. , Tanaka K.
      J. Cell Biol.189:211-221(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: CHARACTERIZATION OF VARIANTS PARK2 ASN-161; ASN-211; ARG-240; ASN-280 AND GLU-328
    77. 78.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT PARK2 TRP-275
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