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Index > Protein center > CLU(Gene name) > Human
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  • CLU (Gene name),
  • Clusterin (Protein name ),  CLUS_HUMAN from NCBI database.
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  • Gene name:
    CLU(AAG4;APOJ;CLI;KUB1);
    Protein name:
    Clusterin;
    Alternative:
    Apolipoprotein J(Apo-J);Aging-associated gene 4 protein;Complement-associated protein SP-40,40;Complement cytolysis inhibitor(CLI);NA1/NA2;Ku70-binding protein 1;Testosterone-repressed prostate message 2(TRPM-2);
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Antiparallel disulfide-linked heterodimer of an alpha chain and a beta chain. Self-associates and forms higher oligomers. Interacts with a broad range of misfolded proteins, including APP, APOC2 and LYZ. Slightly acidic pH promotes interaction with misfolded proteins. Forms high-molecular weight oligomers upon interaction with misfolded proteins. Interacts with APOA1, LRP2, CLUAP1 AND PON1. Interacts with the complement complex. Interacts (via alpha chain) with XRCC6. Interacts with SYVN1, COMMD1, BTRC, CUL1 and with ubiquitin and SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes. Interacts (via alpha chain) with BAX in stressed cells, where BAX undergoes a conformation change leading to association with the mitochondrial membrane. Does not interact with BAX in unstressed cells.
    Function:
    Isoform 1 functions as extracellular chaperone that prevents aggregation of nonnative proteins. Prevents stress-induced aggregation of blood plasma proteins. Inhibits formation of amyloid fibrils by APP, APOC2, B2M, CALCA, CSN3, SNCA and aggregation-prone LYZ variants (in vitro). Does not require ATP. Maintains partially unfolded proteins in a state appropriate for subsequent refolding by other chaperones, such as HSPA8/HSC70. Does not refold proteins by itself. Binding to cell surface receptors triggers internalization of the chaperone-client complex and subsequent lysosomal or proteasomal degradation. Secreted isoform 1 protects cells against apoptosis and against cytolysis by complement. Intracellular isoforms interact with ubiquitin and SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes and promote the ubiquitination and subsequent proteasomal degradation of target proteins. Promotes proteasomal degradation of COMMD1 and IKBKB. Modulates NF-kappa-B transcriptional activity. Nuclear isoforms promote apoptosis. Mitochondrial isoforms suppress BAX-dependent release of cytochrome c into the cytoplasm and inhibit apoptosis. Plays a role in the regulation of cell proliferation.
    Subcellular Location:
    Nucleus Cytoplasm Mitochondrion membrane Peripheral membrane protein Cytoplasmic side Cytoplasm cytosol Microsome Endoplasmic reticulum Cytoplasmic vesicle secretory vesicle chromaffin granule Isoforms lacking the N-terminal signal sequence have been shown to be cytoplasmic and/or nuclear. Secreted isoforms can retrotranslocate from the secretory compartments to the cytosol upon cellular stress. Detected in perinuclear foci that may be aggresomes containing misfolded, ubiquitinated proteins. Detected at the mitochondrion membrane upon induction of apoptosis.
    Protein Attributes:
    Sequence length:
    449
    Sequence:
    50:
    MMKTLLLFVG | LLLTWESGQV | LGDQTVSDNE | LQEMSNQGSK | YVNKEIQNAV | 
    100:
    NGVKQIKTLI | EKTNEERKTL | LSNLEEAKKK | KEDALNETRE | SETKLKELPG | 
    150:
    VCNETMMALW | EECKPCLKQT | CMKFYARVCR | SGSGLVGRQL | EEFLNQSSPF | 
    200:
    YFWMNGDRID | SLLENDRQQT | HMLDVMQDHF | SRASSIIDEL | FQDRFFTREP | 
    250:
    QDTYHYLPFS | LPHRRPHFFF | PKSRIVRSLM | PFSPYEPLNF | HAMFQPFLEM | 
    300:
    IHEAQQAMDI | HFHSPAFQHP | PTEFIREGDD | DRTVCREIRH | NSTGCLRMKD | 
    350:
    QCDKCREILS | VDCSTNNPSQ | AKLRRELDES | LQVAERLTRK | YNELLKSYQW | 
    400:
    KMLNTSSLLE | QLNEQFNWVS | RLANLTQGED | QYYLRVTTVA | SHTSDSDVPS | 
    449:
    GVTEVVVKLF | DSDPITVTVP | VEVSRKNPKF | METVAEKALQ | EYRKKHREE
    3D Structure:
    N/A
    Predicted Eptitope:
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    EIAab Sequence  Vaild Sequence:
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    Related Databases
    KEGG:
    Pfam:
    UniGene:
    MIM:
    String:
    Uniprot:
     
    FOR
    ELISA Kit for Human Clusterin
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    E1180r
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    ELISA Kit for Human Clusterin
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    E1180h
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    96T
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    ELISA Kit for Human Clusterin
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    E1180d
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    ELISA Kit for Human Clusterin
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    E1180p
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    ELISA Kit for Human Clusterin
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    E1180m
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    96T
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    ELISA Kit for Human Clusterin
    Cat.:
    E1180b
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    MSDS:
    Please sign in first.
    Packing:
    96T
    ELISA Kit for Human Clusterin
    MSDS:
    Please sign in first.
    CLIA Kit for Human Clusterin
    Cat.:
    U1180b
    Price:
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    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Clusterin
    Cat.:
    U1180d
    Price:
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    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Clusterin
    Cat.:
    U1180p
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Clusterin
    Cat.:
    U1180m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Clusterin
    MSDS:
    Please sign in first.
    CLIA Kit for Human Clusterin
    Cat.:
    U1180h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Human Clusterin
    Cat.:
    U1180r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    Polyclonal Antibody for Human Clusterin
    Polyclonal Antibody for Human Clusterin
    Cat.:
    P1180Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Clusterin
    Cat.:
    P1180Rb-m
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Clusterin
    Polyclonal Antibody for Human Clusterin
    Polyclonal Antibody for Human Clusterin
    Polyclonal Antibody for Human Clusterin
    Cat.:
    P1180Rb-r
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Human Clusterin
    Monoclonal Antibody for Human Clusterin
    Monoclonal Antibody for Human Clusterin
    Monoclonal Antibody for Human Clusterin
    Monoclonal Antibody for Human Clusterin
    Monoclonal Antibody for Human Clusterin
    Monoclonal Antibody for Human Clusterin
    Protein for Human Clusterin
    Protein for Human Clusterin
    Protein for Human Clusterin
    Protein for Human Clusterin
    Protein for Human Clusterin
    Protein for Human Clusterin
    Protein for Human Clusterin

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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      "Molecular structure and functional characterization of a human complement cytolysis inhibitor found in blood and seminal plasma: identity to sulfated glycoprotein 2, a constituent of rat testis fluid."
      Jenne D.E. , Tschopp J.
      Proc. Natl. Acad. Sci. U.S.A.86:7123-7127(1989) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);PROTEIN SEQUENCE OF N-TERMINUS;SUBUNIT;DISULFIDE BONDS;SUBCELLULAR LOCATION;TISSUE SPECIFICITY
      tissue: Liver.
    2. 2.
      "Molecular characterization of human TRPM-2/clusterin, a gene associated with sperm maturation, apoptosis and neurodegeneration."
      Wong P. , Taillefer D. , Lakins J. , Pineault J. , Chader G. , Tenniswood M.
      Eur. J. Biochem.221:917-925(1994) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];PARTIAL NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2);TISSUE SPECIFICITY
    3. 3.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3);PARTIAL NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)
      tissue: Stomach.
      tissue: Testis.
    4. 4.
      "Full-length cDNA libraries and normalization."
      Li W.B. , Gruber C. , Jessee J. , Polayes D.
      Submitted (2004-07) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)
      tissue: Brain.
    5. 5.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
      tissue: Small intestine.
    6. 6.
      NIEHS SNPs program
      Submitted (2003-07) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];VARIANTS HIS-317; ASN-328 AND LEU-396
    7. 8.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 5);PARTIAL NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)
      tissue: Brain.
      tissue: Spinal ganglion.
    8. 9.
      "Characterization of a human high density lipoprotein-associated protein, NA1/NA2. Identity with SP-40,40, an inhibitor of complement-mediated cytolysis."
      James R.W. , Hochstrasser A.-C. , Borghini I. , Martin B.M. , Pometta D. , Hochstrasser D.F.
      Arterioscler. Thromb.11:645-652(1991) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 23-33; 229-242; 303-317 AND 397-403;SUBUNIT;INTERACTION WITH APOA1
    9. 10.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 23-52 AND 228-257;SUBUNIT;DISULFIDE BOND;PROTEOLYTIC PROCESSING;GLYCOSYLATION;SUBCELLULAR LOCATION;TISSUE SPECIFICITY
    10. 11.
      "The cerebrospinal-fluid soluble form of Alzheimer's amyloid beta is complexed to SP-40,40 (apolipoprotein J), an inhibitor of the complement membrane-attack complex."
      Ghiso J. , Matsubara E. , Koudinov A. , Choi-Miura N.-H. , Tomita M. , Wisniewski T. , Frangione B.
      Biochem. J.293:27-30(1993) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 23-41 AND 228-246;INTERACTION WITH APP;SUBCELLULAR LOCATION;DISULFIDE BOND;TISSUE SPECIFICITY
    11. 12.
      "A serum protein SP40,40 modulates the formation of membrane attack complex of complement on erythrocytes."
      Choi N.H. , Mazda T. , Tomita M.
      Mol. Immunol.26:835-840(1989) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 23-37 AND 228-242
    12. 13.
      "HDL particle associated proteins in plasma and cerebrospinal fluid: identification and partial sequencing."
      Hochstrasser A.-C. , James R.W. , Martin B.M. , Harrington M. , Hochstrasser D.F. , Pometta D. , Merril C.R.
      Appl. Theor. Electrophor.1:73-76(1988) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 23-33 AND 228-240;SUBCELLULAR LOCATION;TISSUE SPECIFICITY
    13. 14.
      "Apolipoprotein J: structure and tissue distribution."
      de Silva H.V. , Harmony J.A.K. , Stuart W.D. , Gil C.M. , Robbins J.
      Biochemistry29:5380-5389(1990) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 34-449 (ISOFORMS 1/2/4);PARTIAL PROTEIN SEQUENCE;SUBUNIT;TISSUE SPECIFICITY
    14. 15.
      "Human gliomas and epileptic foci express high levels of a mRNA related to rat testicular sulfated glycoprotein 2, a purported marker of cell death."
      Danik M. , Chabot J.G. , Mercier C. , Benabid A.L. , Chauvin C. , Quirion R. , Suh M.
      Proc. Natl. Acad. Sci. U.S.A.88:8577-8581(1991) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 61-449
      tissue: Astrocytoma.
    15. 16.
      Glew M.D. , Kirszbaum L. , Bozas S.E. , Walker I.D.
      Submitted (1993-01) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 140-449
      tissue: Fetal liver.
    16. 17.
      "Molecular cloning and characterization of the novel, human complement-associated protein, SP-40,40: a link between the complement and reproductive systems."
      Kirszbaum L. , Sharpe J.A. , Murphy B. , D'Apice J.F.A. , Classon B. , Hudson P. , Walker I.D.
      EMBO J.8:711-718(1989) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PARTIAL NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2);PARTIAL PROTEIN SEQUENCE
      tissue: Liver.
    17. 18.
      "SP-40,40, a protein involved in the control of the complement pathway, possesses a unique array of disulphide bridges."
      Kirszbaum L. , Bozas S.E. , Walker I.D.
      FEBS Lett.297:70-76(1992) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PARTIAL PROTEIN SEQUENCE;DISULFIDE BONDS;GLYCOSYLATION AT ASN-86; ASN-103; ASN-145; ASN-291; ASN-354 AND ASN-374
    18. 19.
      "Identification of human aging-associated gene."
      Kim J.W.
      Submitted (2003-12) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PARTIAL NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)
    19. 20.
      "The apolipoprotein A-I binding protein of placenta and the SP-40,40 protein of human blood are different proteins which both bind to apolipoprotein A-I."
      Ehnholm C. , Bozas S.E. , Tenkanen H. , Kirszbaum L. , Metso J. , Murphy B. , Walker I.D.
      Biochim. Biophys. Acta1086:255-260(1991) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH APOA1
    20. 21.
      "Identification of the disulfide bonds in human plasma protein SP-40,40 (apolipoprotein-J)."
      Choi-Miura N.H. , Takahashi Y. , Nakano Y. , Tobe T. , Tomita M.
      J. Biochem.112:557-561(1992) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: DISULFIDE BONDS
    21. 22.
      "Apolipoprotein J is associated with paraoxonase in human plasma."
      Kelso G.J. , Stuart W.D. , Richter R.J. , Furlong C.E. , Jordan-Starck T.C. , Harmony J.A.K.
      Biochemistry33:832-839(1994) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH PON1;SUBCELLULAR LOCATION;TISSUE SPECIFICITY
    22. 23.
      "Identification and characterization of glycosylation sites in human serum clusterin."
      Kapron J.T. , Hilliard G.M. , Lakins J.N. , Tenniswood M.P. , West K.A. , Carr S.A. , Crabb J.W.
      Protein Sci.6:2120-2133(1997) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION AT ASN-86; ASN-103; ASN-145; ASN-291; ASN-354 AND ASN-374
      tissue: Serum.
    23. 24.
      "Clusterin is an ATP-independent chaperone with very broad substrate specificity that stabilizes stressed proteins in a folding-competent state."
      Poon S. , Easterbrook-Smith S.B. , Rybchyn M.S. , Carver J.A. , Wilson M.R.
      Biochemistry39:15953-15960(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION;ABSENCE OF ATPASE ACTIVITY;TISSUE SPECIFICITY
    24. 25.
      "Suppression of apolipoprotein C-II amyloid formation by the extracellular chaperone, clusterin."
      Hatters D.M. , Wilson M.R. , Easterbrook-Smith S.B. , Howlett G.J.
      Eur. J. Biochem.269:2789-2794(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBUNIT
    25. 26.
      "Mildly acidic pH activates the extracellular molecular chaperone clusterin."
      Poon S. , Rybchyn M.S. , Easterbrook-Smith S.B. , Carver J.A. , Pankhurst G.J. , Wilson M.R.
      J. Biol. Chem.277:39532-39540(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBUNIT;CIRCULAR DICHROISM
    26. 27.
      "Synthesis and functional analyses of nuclear clusterin, a cell death protein."
      Leskov K.S. , Klokov D.Y. , Li J. , Kinsella T.J. , Boothman D.A.
      J. Biol. Chem.278:11590-11600(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ALTERNATIVE SPLICING;IDENTIFICATION OF ISOFORM 4;FUNCTION;INTERACTION WITH XRCC6;SUBCELLULAR LOCATION
    27. 28.
      "Essential requirement of apolipoprotein J (clusterin) signaling for IkappaB expression and regulation of NF-kappaB activity."
      Santilli G. , Aronow B.J. , Sala A.
      J. Biol. Chem.278:38214-38219(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
    28. 29.
      "Identification and quantification of N-linked glycoproteins using hydrazide chemistry, stable isotope labeling and mass spectrometry."
      Zhang H. , Li X.-J. , Martin D.B. , Aebersold R.
      Nat. Biotechnol.21:660-666(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION AT ASN-354
      tissue: Serum.
    29. 30.
      "Isolation and characterization of a novel gene CLUAP1 whose expression is frequently upregulated in colon cancer."
      Takahashi M. , Lin Y.-M. , Nakamura Y. , Furukawa Y.
      Oncogene23:9289-9294(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH CLUAP1
    30. 31.
      "Screening for N-glycosylated proteins by liquid chromatography mass spectrometry."
      Bunkenborg J. , Pilch B.J. , Podtelejnikov A.V. , Wisniewski J.R.
      Proteomics4:454-465(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-354 AND ASN-374
      tissue: Plasma.
    31. 32.
      "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry."
      Liu T. , Qian W.-J. , Gritsenko M.A. , Camp D.G. II , Monroe M.E. , Moore R.J. , Smith R.D.
      J. Proteome Res.4:2070-2080(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-86; ASN-103; ASN-145; ASN-291; ASN-354 AND ASN-374
      tissue: Plasma.
    32. 33.
      "Clusterin inhibits apoptosis by interacting with activated Bax."
      Zhang H. , Kim J.K. , Edwards C.A. , Xu Z. , Taichman R. , Wang C.Y.
      Nat. Cell Biol.7:909-915(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION;INTERACTION WITH BAX
    33. 34.
      "Transcriptomic and proteomic analyses of rhabdomyosarcoma cells reveal differential cellular gene expression in response to enterovirus 71 infection."
      Leong W.F. , Chow V.T.
      Cell. Microbiol.8:565-580(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INDUCTION;IDENTIFICATION BY MASS SPECTROMETRY
    34. 35.
      "Identification of N-linked glycoproteins in human saliva by glycoprotein capture and mass spectrometry."
      Ramachandran P. , Boontheung P. , Xie Y. , Sondej M. , Wong D.T. , Loo J.A.
      J. Proteome Res.5:1493-1503(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-374
      tissue: Saliva.
    35. 36.
      "Elucidation of N-glycosylation sites on human platelet proteins: a glycoproteomic approach."
      Lewandrowski U. , Moebius J. , Walter U. , Sickmann A.
      Mol. Cell. Proteomics5:226-233(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-374
      tissue: Platelet.
    36. 37.
      "Effects of glycosylation on the structure and function of the extracellular chaperone clusterin."
      Stewart E.M. , Aquilina J.A. , Easterbrook-Smith S.B. , Murphy-Durland D. , Jacobsen C. , Moestrup S. , Wilson M.R.
      Biochemistry46:1412-1422(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBUNIT;INTERACTION WITH LRP2;GLYCOSYLATION;SUBCELLULAR LOCATION;IDENTIFICATION BY MASS SPECTROMETRY;CIRCULAR DICHROISM;TISSUE SPECIFICITY
    37. 38.
      "Multiple pathways regulating the anti-apoptotic protein clusterin in breast cancer."
      Ranney M.K. , Ahmed I.S. , Potts K.R. , Craven R.J.
      Biochim. Biophys. Acta1772:1103-1111(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INDUCTION;PROTEASOMAL DEGRADATION;SUBCELLULAR LOCATION
    38. 39.
      "Characterization of an eppin protein complex from human semen and spermatozoa."
      Wang Z. , Widgren E.E. , Richardson R.T. , O'Rand M.G.
      Biol. Reprod.77:476-484(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION IN A COMPLEX WITH LTF; SEMG1 AND EPPIN
    39. 40.
      "The extracellular chaperone clusterin influences amyloid formation and toxicity by interacting with prefibrillar structures."
      Yerbury J.J. , Poon S. , Meehan S. , Thompson B. , Kumita J.R. , Dobson C.M. , Wilson M.R.
      FASEB J.21:2312-2322(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBUNIT;SUBCELLULAR LOCATION;TISSUE SPECIFICITY
    40. 41.
      "Differential regulation of clusterin and its isoforms by androgens in prostate cells."
      Cochrane D.R. , Wang Z. , Muramaki M. , Gleave M.E. , Nelson C.C.
      J. Biol. Chem.282:2278-2287(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ALTERNATIVE SPLICING;IDENTIFICATION OF ISOFORMS 1 AND 2;INDUCTION BY ANDROGEN
    41. 42.
      "The extracellular chaperone clusterin potently inhibits human lysozyme amyloid formation by interacting with prefibrillar species."
      Kumita J.R. , Poon S. , Caddy G.L. , Hagan C.L. , Dumoulin M. , Yerbury J.J. , Stewart E.M. , Robinson C.V. , Wilson M.R. , Dobson C.M.
      J. Mol. Biol.369:157-167(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBUNIT
    42. 43.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ALTERNATIVE SPLICING;IDENTIFICATION OF ISOFORMS 1; 2 AND 5;TISSUE SPECIFICITY
    43. 44.
      "Stress-induced retrotranslocation of clusterin/ApoJ into the cytosol."
      Nizard P. , Tetley S. , Le Drean Y. , Watrin T. , Le Goff P. , Wilson M.R. , Michel D.
      Traffic8:554-565(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION;INTERACTION WITH SYVN1;UBIQUITINATION
    44. 45.
      "Identification of N-linked glycoproteins in human milk by hydrophilic interaction liquid chromatography and mass spectrometry."
      Picariello G. , Ferranti P. , Mamone G. , Roepstorff P. , Addeo F.
      Proteomics8:3833-3847(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-291; ASN-317 AND ASN-374
      tissue: Milk.
    45. 46.
      "Structural characterization of clusterin-chaperone client protein complexes."
      Wyatt A.R. , Yerbury J.J. , Wilson M.R.
      J. Biol. Chem.284:21920-21927(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBUNIT
    46. 47.
      "Clusterin is a short half-life, poly-ubiquitinated protein, which controls the fate of prostate cancer cells."
      Rizzi F. , Caccamo A.E. , Belloni L. , Bettuzzi S.
      J. Cell. Physiol.219:314-323(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION;UBIQUITINATION
    47. 48.
      "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
      Chen R. , Jiang X. , Sun D. , Han G. , Wang F. , Ye M. , Wang L. , Zou H.
      J. Proteome Res.8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-86; ASN-103; ASN-145; ASN-354 AND ASN-374
      tissue: Liver.
    48. 49.
      "A strategy for precise and large scale identification of core fucosylated glycoproteins."
      Jia W. , Lu Z. , Fu Y. , Wang H.P. , Wang L.H. , Chi H. , Yuan Z.F. , Zheng Z.B. , Song L.N. , Han H.H. , Liang Y.M. , Wang J.L. , Cai Y. , Zhang Y.K. , Deng Y.L. , Ying W.T. , He S.M. , Qian X.H.
      Mol. Cell. Proteomics8:913-923(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION AT ASN-86 AND ASN-374
    49. 50.
      "Enrichment of glycopeptides for glycan structure and attachment site identification."
      Nilsson J. , Rueetschi U. , Halim A. , Hesse C. , Carlsohn E. , Brinkmalm G. , Larson G.
      Nat. Methods6:809-811(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-374;STRUCTURE OF CARBOHYDRATES
      tissue: Cerebrospinal fluid.
    50. 51.
      "Identification of human plasma proteins as major clients for the extracellular chaperone clusterin."
      Wyatt A.R. , Wilson M.R.
      J. Biol. Chem.285:3532-3539(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
    51. 52.
      "Clusterin facilitates COMMD1 and I-kappaB degradation to enhance NF-kappaB activity in prostate cancer cells."
      Zoubeidi A. , Ettinger S. , Beraldi E. , Hadaschik B. , Zardan A. , Klomp L.W. , Nelson C.C. , Rennie P.S. , Gleave M.E.
      Mol. Cancer Res.8:119-130(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION;INTERACTION WITH COMMD1; UBIQUITIN; CUL1 ANDBTRC;IDENTIFICATION IN A E3 UBIQUITIN-PROTEIN LIGASE COMPLEX
    52. 53.
      "Clusterin facilitates in vivo clearance of extracellular misfolded proteins."
      Wyatt A.R. , Yerbury J.J. , Berghofer P. , Greguric I. , Katsifis A. , Dobson C.M. , Wilson M.R.
      Cell. Mol. Life Sci.68:3919-3931(2011) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
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