Protein name:
Clusterin ;
Alternative:
Sulfated glycoprotein 2 (SGP-2) ;Dimeric acid glycoprotein (DAG) ;Testosterone repressed prostate message 2 (TRPM-2) ;
Organism:
Rat (Rattus norvegicus).
General Annotation
Sub Unit:
Antiparallel disulfide-linked heterodimer of an alpha chain and a beta chain. Self-associates and forms higher oligomers. Interacts with a broad range of misfolded proteins, including APP, APOC2 and LYZ. Slightly acidic pH promotes interaction with misfolded proteins. Forms high-molecular weight oligomers upon interaction with misfolded proteins. Interacts with APOA1, LRP2, CLUAP1 AND PON1. Interacts with the complement complex. Interacts with SYVN1, COMMD1, BTRC, CUL1 and with ubiquitin and SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes. Interacts (via alpha chain) with BAX in stressed cells, where BAX undergoes a conformation change leading to association with the mitochondrial membrane. Does not interact with BAX in unstressed cells. Interacts (via alpha chain) with XRCC6.
Function:
Functions as extracellular chaperone that prevents aggregation of nonnative proteins. Prevents stress-induced aggregation of blood plasma proteins. Inhibits formation of amyloid fibrils by APP, APOC2, B2M, CALCA, CSN3, SNCA and aggregation-prone LYZ variants (in vitro). Does not require ATP. Maintains partially unfolded proteins in a state appropriate for subsequent refolding by other chaperones, such as HSPA8/HSC70. Does not refold proteins by itself. Binding to cell surface receptors triggers internalization of the chaperone-client complex and subsequent lysosomal or proteasomal degradation. When secreted, protects cells against apoptosis and against cytolysis by complement. Intracellular forms interact with ubiquitin and SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes and promote the ubiquitination and subsequent proteasomal degradation of target proteins. Promotes proteasomal degradation of COMMD1 and IKBKB. Modulates NF-kappa-B transcriptional activity. Promotes apoptosis when in the nucleus. Inhibits apoptosis when associated with the mitochondrial membrane by interference with BAX-dependent release of cytochrome c into the cytoplasm. Plays a role in the regulation of cell proliferation.
Subcellular Location:
Secreted
Nucleus
Cytoplasm
Mitochondrion membrane
Peripheral membrane protein
Cytoplasmic side
Cytoplasm
cytosol
Microsome
Endoplasmic reticulum
Cytoplasmic vesicle
secretory vesicle
chromaffin granule
Can retrotranslocate from the secretory compartments to the cytosol upon cellular stress. Detected in perinuclear foci that may be aggresomes containing misfolded, ubiquitinated proteins. Detected at the mitochondrion membrane upon induction of apoptosis.
Protein Attributes:
50:
MKILLLCVAL | LLTWDNGMVL | GEQEFSDNEL | QELSTQGSRY | VNKEIQNAVQ |
100:
GVKHIKTLIE | KTNAERKSLL | NSLEEAKKKK | EGALDDTRDS | EMKLKAFPEV |
150:
CNETMMALWE | ECKPCLKHTC | MKFYARVCRS | GSGLVGRQLE | EFLNQSSPFY |
200:
FWMNGDRIDS | LLESDRQQSQ | VLDAMQDSFT | RASGIIDTLF | QDRFFTHEPQ |
250:
DIHHFSPMGF | PHKRPHFLYP | KSRLVRSLMP | LSHYGPLSFH | NMFQPFFDMI |
300:
HQAQQAMDVQ | LHSPALQFPD | VDFLKEGEDD | PTVCKEIRHN | STGCLKMKGQ |
350:
CEKCQEILSV | DCSTNNPAQA | NLRQELNDSL | QVAERLTQQY | NELLHSLQSK |
400:
MLNTSSLLEQ | LNDQFTWVSQ | LANLTQGDDQ | YLRVSTVTTH | SSDSEVPSRV |
447:
TEVVVKLFDS | DPITVVLPEE | VSKDNPKFMD | TVAEKALQEY | RRKSRME
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Rat
Human
Dog
Pig
Mouse
Bovine
Rabbit
ELISA Kit for Rat Clusterin
ELISA Kit for Rat Clusterin
ELISA Kit for Rat Clusterin
ELISA Kit for Rat Clusterin
ELISA Kit for Rat Clusterin
ELISA Kit for Rat Clusterin
ELISA Kit for Rat Clusterin
CLIA Kit for Rat Clusterin
CLIA Kit for Rat Clusterin
CLIA Kit for Rat Clusterin
CLIA Kit for Rat Clusterin
CLIA Kit for Rat Clusterin
CLIA Kit for Rat Clusterin
CLIA Kit for Rat Clusterin
Polyclonal Antibody for Rat Clusterin
Polyclonal Antibody for Rat Clusterin
Polyclonal Antibody for Rat Clusterin
Polyclonal Antibody for Rat Clusterin
Polyclonal Antibody for Rat Clusterin
Polyclonal Antibody for Rat Clusterin
Polyclonal Antibody for Rat Clusterin
Monoclonal Antibody for Rat Clusterin
Monoclonal Antibody for Rat Clusterin
Monoclonal Antibody for Rat Clusterin
Monoclonal Antibody for Rat Clusterin
Monoclonal Antibody for Rat Clusterin
Monoclonal Antibody for Rat Clusterin
Monoclonal Antibody for Rat Clusterin
Protein for Rat Clusterin
Protein for Rat Clusterin
Protein for Rat Clusterin
Protein for Rat Clusterin
Protein for Rat Clusterin
Protein for Rat Clusterin
Protein for Rat Clusterin
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
1.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA];PROTEIN SEQUENCE OF 22-45 AND 227-241;PROTEOLYTIC PROCESSING;GLYCOSYLATION;SUBCELLULAR LOCATION;TISSUE SPECIFICITY
2.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA]
strain :
Sprague-Dawley .
tissue :
Prostate .
3.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA]
strain :
Sprague-Dawley .
4.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PROTEIN SEQUENCE OF 22-51 AND 227-256;SUBCELLULAR LOCATION;SUBUNIT;PROTEOLYTIC PROCESSING
5.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : CHARACTERIZATION OF TRPM-2