Gene name:
Ncapd2 (Capd2;Cnap1;Kiaa0159) ;
Protein name:
Condensin complex subunit 1 ;
Alternative:
Chromosome-associated protein D2 (mCAP-D2) ;Chromosome condensation-related SMC-associated protein 1 ;XCAP-D2 homolog ;Non-SMC condensin I complex subunit D2 ;
Organism:
Mouse (Mus musculus).
General Annotation
Sub Unit:
Component of the condensin complex, which contains the SMC2 and SMC4 heterodimer, and three non SMC subunits that probably regulate the complex: NCAPH/BRRN1, NCAPD2/CAPD2 and NCAPG. Interacts with histones H1 and H3.
Function:
Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases. May target the condensin complex to DNA via its C-terminal domain.
Subcellular Location:
Nucleus
Cytoplasm
Chromosome
In interphase cells, the majority of the condensin complex is found in the cytoplasm, while a minority of the complex is associated with chromatin. A subpopulation of the complex however remains associated with chromosome foci in interphase cells. During mitosis, most of the condensin complex is associated with the chromatin. At the onset of prophase, the regulatory subunits of the complex are phosphorylated by CDK1, leading to condensin's association with chromosome arms and to chromosome condensation. Dissociation from chromosomes is observed in late telophase.
Protein Attributes:
50:
MSPHNFEFHL | PLSPEELLKS | GGVNQYVVRE | VLPVKHLSSQ | LRAFQSAFRA |
100:
QGPLAILEHF | DTVYSILHHF | RSIEPGLKED | TLEFLKKVVS | RHSQELSSIL |
150:
DDAALSGSDR | SAHLNALKMN | CYALIRLLES | FENMTSQTSL | IDLDIGGKGK |
200:
RARAKATLGF | DWEEERQPVL | QLLTQLLQLD | IRHLWNHSAI | EEEFVSLVTG |
250:
CCYRLLENPT | ISHQKNRSTK | EAIAHLLGVA | LVRYNHMLSA | TVKIIQMLQH |
300:
FEHLPPVLVT | AVSLWATDYG | MKSIVGEIVR | EIGQKCPQEL | SRDTAGAKGF |
350:
AAFLTELAER | IPAVLMANMC | ILLDHLDGEN | YMMRNAVLAA | IAEMVLQVLN |
400:
GDQLEESARE | TRDQFLDILQ | AHGHDVNSFV | RSRVLQLFAR | IVQQKALPLT |
450:
RFQAVVALAV | GRLADKSVLV | CKNAIQLLAS | FLANNPFSCK | LSDIDLAGPL |
500:
QKEIQKLQEM | RAQRRSAAAT | AALDPEEEWD | AMLPELKSTL | QQLLKLPQEE |
550:
GDHQIADAET | AEEVKGRIRQ | LLAKASYKQA | IVLTREATSH | FQESEPFSHT |
600:
EPEENSFLNL | LGLIFKGPEA | STQDSHGDTD | PGLTGSKDSP | SVPEPEGSQS |
650:
NDELVKQEML | VQYLQDAYGF | SQKITEAIGI | ISKMMYENTT | TVVQEVIEFF |
700:
VMVFQFGVPQ | ALFGVRRMLP | LIWSKEPGVR | EAVLNAYRQL | YLNPKGDSAR |
750:
AKAQTLIHNL | SLLLVDASVG | TIQCLEEILC | EFVQKDEVKP | AVIQLLWERA |
800:
TEKVPSSPLE | RCSSVMLLGM | MARGKPEIVG | SNLDALVRVG | LDEKSPQDYR |
850:
LAQQVCLAIA | NISDRRKPSL | GERHPPFRLP | QEHRLFERLQ | DMVTKGFAHP |
900:
DPLWIPFKEV | AVTLTYQLAE | SPDVLCAQML | QGCAKQVLEK | LEKNATEADP |
950:
KETAPRLPTF | LLMNLLSLAG | DVALQQLVHL | EQAVSGELGR | RRVLREEQEH |
1000:
RAKEPKEKTA | SSETTMEEEL | GLVGGATADD | TEAELIRSIC | EKELLDGNQV |
1050:
LAAFVPLLLK | VCNNPGLYSN | PELCAAASLA | LGKFCMISAP | FCDSQLRLLF |
1100:
TMLEKSSLPT | VRSNLMVATG | DLAIRFPNLV | DPWTPHLYAR | LRDPAQQVRK |
1150:
TAGLVMTHLI | LKDMVKVKGQ | VSEMAVLLID | PVPQIAALAK | NFFNELSHKG |
1200:
NAIYNLLPDI | ISRLSDPEGG | VEEEPFHTIM | KQLLSYITKD | KQTESLVEKL |
1250:
CQRFRTARTE | RQYRDLAYCM | SQLPLTERGL | QKMLDNFECF | GDKLLDESVF |
1300:
SAFLSIVGKL | RRGAKPEGKA | IIDEFEQKLR | ACHTRGMDGI | EEFETGQGGS |
1350:
QRALSAKKPS | AVSRLQPLTS | VDSDNDFVTP | KPRRTKPGRP | QTQQRKKSQR |
1392:
KAKVVFLSDE | SSEDELSAEM | TEEETPKRTT | PIRRASGRRH | RS
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Human
Mouse
ELISA Kit for Mouse Condensin complex subunit 1
ELISA Kit for Mouse Condensin complex subunit 1
CLIA Kit for Mouse Condensin complex subunit 1
CLIA Kit for Mouse Condensin complex subunit 1
Polyclonal Antibody for Mouse Condensin complex subunit 1
Polyclonal Antibody for Mouse Condensin complex subunit 1
Monoclonal Antibody for Mouse Condensin complex subunit 1
Monoclonal Antibody for Mouse Condensin complex subunit 1
Protein for Mouse Condensin complex subunit 1
Protein for Mouse Condensin complex subunit 1
R&D Technical Data
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Precision
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Recovery
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Linearity
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
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Embryonic tail .
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
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Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 577-1392 (ISOFORM 1)
strain :
C57BL/6J .
tissue :
Embryo .
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Europe PMC ]
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Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1300;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue :
Embryonic fibroblast .
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1320 AND SER-1323;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue :
Embryonic fibroblast .